RU2577721C1 - Method of treatment of eosinophilic pneumonia in dogs with dirofilariasis - Google Patents

Abstract

FIELD: veterinary.

SUBSTANCE: invention is intended for the treatment of eosinophilic pneumonia in case of heartworm infestation. Apply prednisolone in dose of 0.18 mg / kg intramuscularly, 2 times a day for 5 days. Sodium thiosulfate 30% at 0.3 mg/kg iv 1 times a day for 10 days. Cefotaxime 15 mg/kg intramuscularly, 2 times a day for 10 days. Ivermek 0.5 mg/kg IM once. 7 days after ivermek, prescribed is levamisole 75 in increasing doses intramuscularly within 7 days of 1.5 mg/kg, 2.5 mg/kg, 5.0 mg/kg, 7.5 mg/kg, 7.5 mg/kg, 7.5 mg/kg, 7.5 mg/kg.

EFFECT: claimed invention improves the efficiency of the treatment of dogs with eosinophilic pneumonia in case of heartworm infestation.

1 cl, 1 tbl, 1 ex

Description

The invention relates to the field of veterinary medicine, namely to a new method for the treatment of eosinophilic pneumonia with dirofilariasis.

A known method of treating dirofilariasis in dogs using etiotropic therapy, which does not provide for the treatment of complications and includes a macro- and microfilaricidal method of treatment (Arkhipov I.A. Strategy for therapeutic and preventive measures for dog dirofilariasis / I.A. Arkhipov, D.R. // Mater.dokl. Scientific conference "Theory and practice of combating parasitic diseases (zoonoses)." - M., 2002. - P. 24-26; Arkhipov I.A. Dirofilariasis / I.A. Arkhipov, D .R. Arkhipova // - M., 2004 .-- 194 p.).

However, it should be noted that the high mortality in dirofilariasis is due to complications developing with this disease, and the method of treating dirofilariasis using only etiotropic therapy is unsuitable.

The disadvantage of this method is the lack of diagnosis of complications from lung pathology, which causes the low efficiency of such therapy in the development of eosinophilic pneumonia in dogs with dirofilariasis.

A known method of treating eosinophilic pneumonia using antibiotics of various spectrum of action (penicillins, cephalosporins, aminoglycosides) (Yakovlev S.V. Antibacterial therapy of pneumonia / S.V. Yakovlev // Pulmonology. 1997. - No. 1. - S. 56-60) .

However, the known method in its pure form is unsuitable for the treatment of eosinophilic pneumonia with dirofilariasis without assessing the symptoms of complications of dirofilariasis, the complex treatment of dirofilariasis as an independent disease and its complications with eosinophilic pneumonia, without clinical monitoring and taking into account the pathogenetic features of the course of this type of complications.

The technical result is the recovery of dogs with eosinophilic pneumonia with dirofilariasis with a high percentage of efficiency up to 94.4%.

The technical result is achieved by the treatment method, characterized in that the drug Prednisolone is used at a dose of 0.18 mg / kg intramuscularly 2 times a day for 5 days, sodium thiosulfate 30% at a dose of 0.3 mg / kg intravenously 1 time per day within 10 days, cefotaxime at a dose of 15 mg / kg intramuscularly 2 times a day for 10 days, ivermek at a dose of 0.5 mg / kg intramuscularly once, 7 days after ivermec prescribed levamisole 75 according to the scheme in increasing doses intramuscularly for 7 days, respectively 1.5 mg / kg, 2.5 mg / kg, 5.0 mg / kg, 7.5 mg / kg, 7.5 mg / kg, 7.5 mg / kg, 7.5 mg / kg

The claimed dosage of the drugs in the method of treatment were established experimentally.

Prednisolone is a synthetic hormonal drug that has anti-inflammatory, anti-allergic, immunosuppressive, antiexudative and antipruritic effects. The immunosuppressive effect is associated with inhibition of the release of cytokines from lymphocytes and macrophages. Other effects are caused by stabilization of cell membranes, decreased capillary permeability, and improved microcirculation.

Sodium thiosulfate 30% is a complexing agent, it has detoxification, anti-inflammatory, desensitizing, anti-scab and antiparasitic effects.

Cefotaxime is a semisynthetic cephalosporin III generation antibiotic for parenteral administration. It is bactericidal. It has a wide spectrum of activity against gram-positive and gram-negative bacteria. The bactericidal activity of cefotaxime is due to inhibition of cell wall synthesis.

Ivermek is an antiparasitic drug, the active substance of which is ivermectin. It has a pronounced antiparasitic effect on the larval and sexually mature stages of the nematodes of the gastrointestinal tract and lungs, the larvae of subcutaneous, nasopharyngeal, gastric gadfly, lice, bloodsuckers and sarcoptoid mites. The drug enhances the production of a neurotransmitter inhibition - gamma-aminobutyric acid, which leads to impaired transmission of nerve impulses, paralysis and death of the parasite.

Levamisole 75 is a microfilaricidal preparation, has a wide spectrum of nematicidal action, is active against larval and mature phases of nematode development. The mechanism of action of levamisole is to affect the neuromuscular system and inhibit the activity of the parasite's enzymes, which leads to its paralysis and death. In recommended doses, the drug is well tolerated by animals, does not have local irritant, embryotoxic, teratogenic, mutagenic and sensitizing effects.

Concrete example

36 clinically ill dogs were treated with eosinophilic pneumonia with dirofilariasis. Animals, which were divided into 2 groups, were kept under identical conditions.

The first group of 18 clinically sick animals was treated with the claimed method. Initially, a clinical assessment was made of the manifestation of symptoms of eosinophilic pneumonia, such as low-grade fever, mild cough, pallor of mucous membranes, tachypnea, hard breathing with dry or small bubbling rales, emphasis of the 2nd tone on the pulmonary trunk. When symptoms of eosinophilic pneumonia were manifested, the drug Prednisolone was used at a dose of 0.18 mg / kg intramuscularly 2 times a day for 5 days, sodium thiosulfate 30% at a dose of 0.3 mg / kg intravenously 1 time per day for 10 days, cefotaxime at a dose of 15 mg / kg intramuscularly 2 times a day for 10 days, ivermek at a dose of 0.5 mg / kg intramuscularly once, 7 days after ivermec, levamisole 75 was prescribed according to the scheme in increasing doses intramuscularly for 7 days, respectively 1, 5 mg / kg, 2.5 mg / kg, 5.0 mg / kg, 7.5 mg / kg, 7.5 mg / kg, 7.5 mg / kg, 7.5 mg / kg. Further, monitoring the effectiveness of the therapy, which took into account clinical symptoms, the dynamics of changes in hematological parameters and mandatory control studies of bronchoalveolar lavage 10 days after the start of treatment.

In the second group of 18 clinically sick animals, etiotropic therapy of dirofilariasis was used for eosinophilic pneumonia, which included only macro- and microfilaricidal.

The results showed that when conducting a comprehensive method for the treatment of eosinophilic pneumonia with dirofilariasis, using the claimed method, 17 dogs recovered, i.e. the efficiency was 94.4%. In the second method of treatment, which included only etiotropic therapy of dirofilariasis with eosinophilic pneumonia, the effectiveness was low and amounted to 5.5%.

The clinical effectiveness of the treatment of eosinophilic pneumonia with dirofilariasis is shown in the table.

Claims (1)

A method for the treatment of eosinophilic pneumonia in dogs with dirofilariasis, characterized in that the drug Prednisolone is used at a dose of 0.18 mg / kg intramuscularly 2 times a day for 5 days, sodium thiosulfate 30% at a dose of 0.3 mg / kg intravenously 1 time per day for 10 days, cefotaxime at a dose of 15 mg / kg intramuscularly 2 times a day for 10 days, ivermek at a dose of 0.5 mg / kg intramuscularly once, 7 days after ivermec, levamisole 75 is prescribed according to the scheme in increasing doses intramuscularly for 7 days, respectively 1.5 mg / kg, 2.5 mg / kg, 5.0 mg / kg, 7.5 mg / kg 7.5 mg / kg, 7.5 mg / kg, 7.5 mg / kg.