CN105287491A - Application of Kendomycin A in preparation of small intestine peristalsis promoting medicine - Google Patents
Application of Kendomycin A in preparation of small intestine peristalsis promoting medicine Download PDFInfo
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- CN105287491A CN105287491A CN201510755449.3A CN201510755449A CN105287491A CN 105287491 A CN105287491 A CN 105287491A CN 201510755449 A CN201510755449 A CN 201510755449A CN 105287491 A CN105287491 A CN 105287491A
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- kendomycin
- small intestine
- preparation
- intestine peristalsis
- application
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- JAPMJSVZDUYFKL-UHFFFAOYSA-N C1C2C1CCC2 Chemical compound C1C2C1CCC2 JAPMJSVZDUYFKL-UHFFFAOYSA-N 0.000 description 2
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Abstract
The invention relates to and provides application of Kendomycin A in preparation of small intestine peristalsis promoting medicine. It is found from pharmacology experiments that Kendomycin A has a good effect on promoting small intestine peristalsis. The application of Kendomycin A in preparation of small intestine peristalsis promoting medicine is disclosed for the first time; due to the fact that the framework type belongs to a brand-new framework type, Kendomycin A is unexpectedly high in small intestine peristalsis promoting activity, no other compounds give any prompts, remarkable substantive features are achieved, and meanwhile Kendomycin A obviously has a remarkable progress for preparing small intestine peristalsis promoting medicine.
Description
Technical field
The present invention relates to the novelty teabag of compound K endomycinA, particularly relate to the application of KendomycinA in preparation treatment promotion small intestinal peristalsis medicine.
Background technology
The compound K endomycinA that the present invention relates to is one and delivers (KyosukeTanaka in 2014, etal., SynthesisandBiologicalEvaluationofKendomycinandItsAnalog ues.J.Org.Chem.2014, 79, noval chemical compound 9922-9947.), this compound has brand-new framework types, current purposes only relates to antibacterial action (KyosukeTanaka, etal., SynthesisandBiologicalEvaluationofKendomycinandItsAnalog ues.J.Org.Chem.2014, 79, 9922-9947.), in preparation treatment, the KendomycinA that the present invention relates to is promoted that the purposes in small intestinal peristalsis medicine belongs to first public, owing to belonging to brand-new structure type, and it is for promoting that the activity of small intestinal peristalsis cell is unexpectedly strong, there is not the possibility being provided any enlightenment by other compounds, possesses outstanding substantive distinguishing features, simultaneously for promoting that small intestinal peristalsis obviously has significant progress.
Summary of the invention
The present invention proposes the application of KendomycinA in preparation promotion small intestinal peristalsis medicine.Find out from pharmacological evaluation, KendomycinA has the effect promoting small intestinal peristalsis preferably.May be used for the treatment of the bad disease of multiple small intestinal peristalsis.Because the first public KendomycinA of the present invention is promoting the pharmacological action in small intestinal peristalsis.
Described compound K endomycinA structure is as shown in formula I:
The present invention is by finding the pharmacology contrast test of mice, and the intestinal propulsion of KendomycinA low dose group mice is wriggled more blank group and increased to some extent, and difference has significant (P<0.01); More blank group of KendomycinA high dose group, difference has significant.Therefore, KendomycinA, for the preparation of the medicine of the bad disease of multiple small intestinal peristalsis, has good development prospect.
In preparation, the KendomycinA that the present invention relates to promotes that the purposes in small intestinal peristalsis medicine belongs to first public, because framework types belongs to brand-new framework types, and it promotes that small intestinal peristalsis is active unexpectedly strong, there is not the possibility being provided any enlightenment by other compounds, possess outstanding substantive distinguishing features, for the preparation of promotion small intestinal peristalsis medicine, obviously there is significant progress simultaneously.
The present invention is further detailed explanation by the following examples, but protection scope of the present invention is not by any restriction of specific embodiment, but be limited by claim.
Detailed description of the invention
The preparation method of compound K endomycinA involved in the present invention is see document (KyosukeTanaka, etal., SynthesisandBiologicalEvaluationofKendomycinandItsAnalog ues.J.Org.Chem.2014,79,9922-9947.)
The present invention is further detailed explanation by the following examples, but protection scope of the present invention is not by any restriction of specific embodiment, but be limited by claim.
Embodiment 1: the preparation of compound K endomycinA tablet involved in the present invention:
Get 20 g of compound KendomycinA, add the customary adjuvant 180 grams preparing tablet, mixing, conventional tablet presses makes 1000.
Embodiment 2: the preparation of compound K endomycinA capsule involved in the present invention:
Get 20 g of compound KendomycinA, add prepare capsule customary adjuvant as starch 180 grams, mixing, encapsulatedly makes 1000.
Its pharmaceutically active is further illustrated below by pharmacodynamic experiment.
Experimental example: adopt the impact that pharmacological evaluation method assessing compound KendomycinA is wriggled on small intestinal promotion
1, method: get kunming mice 30,20 ± 5g, male and female half and half, by sex, body weight is divided into 3 groups at random, namely blank group, KendomycinA (0.06mg/10g, 0.24mg/10g) two dosage groups.Often organize 10, suspension made by KendomycinA and 5% charcoal end, 10% arabic gum, and blank group does not add medicine directly to charcoal end, arabic gum suspendible, all uses normal saline.Mice fasting 24 hours before experiment.Mouse stomach administration 0.2ml/10g, after administration, 30min puts to death.Get pylorus to ileocecus digestive tube, tiling is with on thin plate without traction, and survey total length and pylorus, to the distance in forward position, charcoal end, extrapolate ink propulsive rate thus.
2. result: statistical result shows that the intestinal propulsion of KendomycinA low dose group mice is wriggled more blank group to be increased to some extent, and difference has significant (P<0.01); More blank group of KendomycinA high dose group, difference has significant (P<0.001) result as table 1.
The impact (x+s) that table 1KendomycinA is wriggled on mouse small intestine pushability
Compare with blank group, * * P<0.001*P<0.01
Shown by above-mentioned experimental example, the intestinal propulsion of KendomycinA low dose group mice of the present invention is wriggled more blank group and is increased to some extent, and difference has significant (P<0.01); More blank group of KendomycinA high dose group, difference has significant.Prove thus, KendomycinA of the present invention has the effect promoting small intestinal peristalsis preferably.May be used for the treatment of the bad disease of multiple small intestinal peristalsis.
Claims (1)
1.KendomycinA promotes the application in small intestinal peristalsis medicine in treatment, and described compound K endomycinA structure is as shown in formula I:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510755449.3A CN105287491A (en) | 2015-11-09 | 2015-11-09 | Application of Kendomycin A in preparation of small intestine peristalsis promoting medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510755449.3A CN105287491A (en) | 2015-11-09 | 2015-11-09 | Application of Kendomycin A in preparation of small intestine peristalsis promoting medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105287491A true CN105287491A (en) | 2016-02-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510755449.3A Pending CN105287491A (en) | 2015-11-09 | 2015-11-09 | Application of Kendomycin A in preparation of small intestine peristalsis promoting medicine |
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| CN (1) | CN105287491A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109810919A (en) * | 2019-01-28 | 2019-05-28 | 中国科学院南海海洋研究所 | A kind of An Shaquan carbocyclic ring polyketide and its application in preparation antibacterials or anti-tumor drug |
-
2015
- 2015-11-09 CN CN201510755449.3A patent/CN105287491A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109810919A (en) * | 2019-01-28 | 2019-05-28 | 中国科学院南海海洋研究所 | A kind of An Shaquan carbocyclic ring polyketide and its application in preparation antibacterials or anti-tumor drug |
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| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160203 |
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| WD01 | Invention patent application deemed withdrawn after publication |