CN103446124B - Lycojaponicumin B promotes the application in small intestinal peristalsis medicine in preparation - Google Patents
Lycojaponicumin B promotes the application in small intestinal peristalsis medicine in preparation Download PDFInfo
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- CN103446124B CN103446124B CN201310435226.XA CN201310435226A CN103446124B CN 103446124 B CN103446124 B CN 103446124B CN 201310435226 A CN201310435226 A CN 201310435226A CN 103446124 B CN103446124 B CN 103446124B
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- Prior art keywords
- small intestinal
- intestinal peristalsis
- preparation
- promotes
- lycojaponicumin
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- 230000000968 intestinal effect Effects 0.000 title claims abstract description 23
- 230000008855 peristalsis Effects 0.000 title claims abstract description 22
- 239000003814 drug Substances 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 229930185194 lycojaponicumin Natural products 0.000 title abstract description 6
- 150000001875 compounds Chemical class 0.000 claims abstract description 13
- 230000001737 promoting effect Effects 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 3
- 230000000144 pharmacologic effect Effects 0.000 abstract description 3
- 238000011156 evaluation Methods 0.000 abstract description 2
- 239000003610 charcoal Substances 0.000 description 4
- 235000010489 acacia gum Nutrition 0.000 description 3
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000012449 Kunming mouse Methods 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000001187 pylorus Anatomy 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000001141 propulsive effect Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Do you the present invention relates to Lycojaponicumin? B promotes the application in small intestinal peristalsis medicine in preparation.Does the present invention propose Lycojaponicumin? B promotes the application in small intestinal peristalsis medicine in preparation.Do you find out from pharmacological evaluation, Lycojaponicumin? B has the effect promoting small intestinal peristalsis preferably.The Lycojaponicumin that the present invention relates to? in preparation, B promotes that the purposes in small intestinal peristalsis medicine belongs to first public, because framework types belongs to brand-new framework types, and it promotes that small intestinal peristalsis is active unexpectedly strong, there is not the possibility being provided any enlightenment by other compounds, possess outstanding substantive distinguishing features, for the preparation of promotion small intestinal peristalsis medicine, obviously there is significant progress simultaneously.
Description
Technical field
The present invention relates to the new pharmaceutical uses of a kind of LycojaponicuminB.Be exactly the application promoted in preparation in small intestinal peristalsis medicine specifically, belong to field of medicaments.
Background technology
The compound L ycojaponicuminB that the present invention relates to is one and delivers (Wang in 2012, X.J.etal., 2012.LycojaponicuminsA-C, ThreeAlkaloidswithanUnprecedentedSkeletonfromLycopodiumj aponicum.OrganicLetters14 (10), New skeleton compound 2614-2617.), this compound has brand-new framework types, in preparation, the LycojaponicuminB that the present invention relates to is promoted that the purposes in small intestinal peristalsis medicine belongs to first public, because framework types belongs to brand-new framework types, and it promotes that small intestinal peristalsis is active unexpectedly strong, there is not the possibility being provided any enlightenment by other compounds, possesses outstanding substantive distinguishing features, for the preparation of promotion small intestinal peristalsis medicine, obviously there is significant progress simultaneously.
Summary of the invention
The present invention proposes the application of LycojaponicuminB in preparation promotion small intestinal peristalsis medicine.Find out from pharmacological evaluation, LycojaponicuminB has the effect promoting small intestinal peristalsis preferably.May be used for the treatment of the bad disease of multiple small intestinal peristalsis.
Because the first public LycojaponicuminB of the present invention is promoting the pharmacologic action in small intestinal peristalsis.
Described compound L ycojaponicuminB structure is as shown in formula I:
In preparation, the LycojaponicuminB that the present invention relates to promotes that the purposes in small intestinal peristalsis medicine belongs to first public, because framework types belongs to brand-new framework types, and it promotes that small intestinal peristalsis is active unexpectedly strong, there is not the possibility being provided any enlightenment by other compounds, possess outstanding substantive distinguishing features, for the preparation of promotion small intestinal peristalsis medicine, obviously there is significant progress simultaneously.
Detailed description of the invention
The preparation method of compound L ycojaponicuminB involved in the present invention is see document (Wang, X.J.etal., 2012.LycojaponicuminsA-C, ThreeAlkaloidswithanUnprecedentedSkeletonfromLycopodiumj aponicum.OrganicLetters14 (10), 2614-2617.).
The present invention is further detailed explanation by the following examples, but protection scope of the present invention is not by any restriction of specific embodiment, but be limited by claim.
Embodiment 1: the preparation of compound L ycojaponicuminB tablet involved in the present invention:
Get 20 g of compound LycojaponicuminB, add the customary adjuvant 180 grams preparing tablet, mixing, conventional tablet presses makes 1000.
Embodiment 2: the preparation of compound L ycojaponicuminB capsule involved in the present invention:
Get 20 g of compound LycojaponicuminB, add prepare capsule customary adjuvant as starch 180 grams, mixing, encapsulatedly makes 1000.
Its pharmaceutically active is further illustrated below by pharmacodynamic experiment.
Experimental example:
1, laboratory animal:
Kunming mouse, cleaning grade, body weight 20 ± 2g, male and female share,
Reagent and other medicines:
Arabic gum, charcoal end, normal saline, LycojaponicuminB.
2, experimental technique:
Get kunming mice 30,20 ± 5g, male and female half and half, by sex, body weight is divided into 3 groups at random, namely blank group, LycojaponicuminB (0.06mg/10g, 0.24mg/10g) two dosage groups.Often organize 10, suspension made by LycojaponicuminB and 5% charcoal end, 10% arabic gum, and blank group does not add medicine directly to charcoal end, arabic gum suspendible, all uses normal saline.Mice fasting 24 hours before experiment.Mouse stomach administration 0.2ml/10g, after administration, 30min puts to death.Get pylorus to ileocecus digestive tube, tiling is with on thin plate without traction, and survey total length and pylorus, to the distance in forward position, charcoal end, extrapolate ink propulsive rate thus.
3, experimental result
Statistical result shows that the intestinal propulsion of LycojaponicuminB low dose group mice is wriggled more blank group to be increased to some extent, and difference has significant (P<0.01); More blank group of LycojaponicuminB high dose group, difference has significant (P<0.001) result as table 1.
The impact that table 1LycojaponicuminB is wriggled on mouse small intestine pushability
Compare with blank group, * p<0.01, * * P<0.001
Conclusion: LycojaponicuminB has the effect promoting small intestinal peristalsis preferably.May be used for the treatment of the bad disease of multiple small intestinal peristalsis.
Claims (1)
1.LycojaponicuminB promotes the application in small intestinal peristalsis medicine in preparation, described compound L ycojaponicuminB structure as
formula Ishown in:
formula I.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310435226.XA CN103446124B (en) | 2013-09-23 | 2013-09-23 | Lycojaponicumin B promotes the application in small intestinal peristalsis medicine in preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310435226.XA CN103446124B (en) | 2013-09-23 | 2013-09-23 | Lycojaponicumin B promotes the application in small intestinal peristalsis medicine in preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103446124A CN103446124A (en) | 2013-12-18 |
| CN103446124B true CN103446124B (en) | 2015-11-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310435226.XA Expired - Fee Related CN103446124B (en) | 2013-09-23 | 2013-09-23 | Lycojaponicumin B promotes the application in small intestinal peristalsis medicine in preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103446124B (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1425384A (en) * | 2003-01-05 | 2003-06-25 | 李平亚 | Use of total polygalin in preparing medicine for promoting gastrointestinal peristalsis |
-
2013
- 2013-09-23 CN CN201310435226.XA patent/CN103446124B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1425384A (en) * | 2003-01-05 | 2003-06-25 | 李平亚 | Use of total polygalin in preparing medicine for promoting gastrointestinal peristalsis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103446124A (en) | 2013-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20151023 Address after: 266000 Shandong province Qingdao city Licang District Road No. 1020 Laoshan two unit 302 Applicant after: Li Shulan Address before: Metro Technology Building No. 69 Olympic Avenue in Jianye District of Nanjing city in Jiangsu province 210019 01 5 storey buildings Applicant before: Nanjing Guangkangxie Biomedical Technology Co., Ltd. |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Wang Junmei Inventor after: Shao Xiaohong Inventor before: Jiang Chunping Inventor before: Wu Junyi |
|
| COR | Change of bibliographic data | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170112 Address after: 261000 Shandong, Kuiwei District, happy street, building 3, unit 2, building 401, No., No. 134 Patentee after: Wang Junmei Address before: 266000 Shandong province Qingdao city Licang District Road No. 1020 Laoshan two unit 302 Patentee before: Li Shulan |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151125 Termination date: 20170923 |