CN105434418A - Use of Lathyranone A in preparation of drug for promoting small intestine peristalsis - Google Patents
Use of Lathyranone A in preparation of drug for promoting small intestine peristalsis Download PDFInfo
- Publication number
- CN105434418A CN105434418A CN201510930555.0A CN201510930555A CN105434418A CN 105434418 A CN105434418 A CN 105434418A CN 201510930555 A CN201510930555 A CN 201510930555A CN 105434418 A CN105434418 A CN 105434418A
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- CN
- China
- Prior art keywords
- lathyranonea
- preparation
- lathyranone
- small intestine
- promoting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a use of Lathyranone A in preparation of a drug for promoting small intestine peristalsis. The invention provides the use of Lathyranone A in preparation of a drug for promoting small intestine peristalsis. A pharmacological experiment proves that Lathyranone A has good effects of promoting small intestine peristalsis. The use of the Lathyranone A in preparation of a drug for promoting small intestine peristalsis is disclosed first. The Lathyranone A has a novel skeleton type and has unexpected small intestine peristalsis promoting activity. The use of the Lathyranone A does not get any enlightenment from other compounds and has outstanding substantive features and substantial progress in small intestine peristalsis promoting.
Description
Technical field
The present invention relates to the novelty teabag of compound L athyranoneA, particularly relate to the application of LathyranoneA in preparation treatment promotion small intestinal peristalsis medicine.
Background technology
The compound L athyranoneA that the present invention relates to is one and delivers (SuoGao in 2007, etal., LathyranoneA:ADiterpenoidPossessinganUnprecedentedSkelet onfromEuphorbialathyris.ORGANICLETTERS, 2007, 9 (17): 3453-3455.) noval chemical compound, this compound has brand-new framework types (SuoGao, etal., LathyranoneA:ADiterpenoidPossessinganUnprecedentedSkelet onfromEuphorbialathyris.ORGANICLETTERS, 2007, 9 (17): 3453-3455.)), in preparation treatment, the LathyranoneA that the present invention relates to is promoted that the purposes in small intestinal peristalsis medicine belongs to first public.
Summary of the invention
The present invention proposes the application of LathyranoneA in preparation promotion small intestinal peristalsis medicine.Find out from pharmacological evaluation, LathyranoneA has the effect promoting small intestinal peristalsis preferably.May be used for the treatment of the bad disease of multiple small intestinal peristalsis.Because the first public LathyranoneA of the present invention is promoting the pharmacological action in small intestinal peristalsis.
Described compound L athyranoneA structure is as shown in formula I:
Described LathyranoneA promotes the application in small intestinal peristalsis medicine in preparation, and LathyranoneA strengthens mouse small intestine pushability and wriggles.
A kind of promotion small intestinal peristalsis medicine, be that active component interpolation adjuvant is prepared from by LathyranoneA, preparation method, for getting 5 g of compound LathyranoneA, adds 195 grams, dextrin, and mixing, Conventional compression makes 1000.
A kind of promote small intestinal peristalsis medicine, be that active component adds adjuvant and is prepared from by LathyranoneA, preparation method, for getting 5 g of compound LathyranoneA, adds starch 195 grams, mixing, encapsulatedly makes 1000.
The present invention is by finding the pharmacology contrast test of mice, and the intestinal propulsion of LathyranoneA low dose group mice is wriggled more blank group and increased to some extent, and difference has significant (P<0.01); More blank group of LathyranoneA high dose group, difference has significant.Therefore, LathyranoneA, for the preparation of the medicine of the bad disease of multiple small intestinal peristalsis, has good development prospect.
In preparation, the LathyranoneA that the present invention relates to promotes that the purposes in small intestinal peristalsis medicine belongs to first public, because framework types belongs to brand-new framework types, and it promotes that small intestinal peristalsis is active unexpectedly strong, there is not the possibility being provided any enlightenment by other compounds, possess outstanding substantive distinguishing features, for the preparation of promotion small intestinal peristalsis medicine, obviously there is significant progress simultaneously.
The present invention is further detailed explanation by the following examples, but protection scope of the present invention is not by any restriction of specific embodiment, but be limited by claim.
Detailed description of the invention
The preparation method of compound L athyranoneA involved in the present invention is see document (SuoGao, etal., LathyranoneA:ADiterpenoidPossessinganUnprecedentedSkelet onfromEuphorbialathyris.ORGANICLETTERS, 2007,9 (17): 3453-3455.))
The present invention is further detailed explanation by the following examples, but protection scope of the present invention is not by any restriction of specific embodiment, but be limited by claim.
Embodiment 1: the preparation of compound L athyranoneA tablet involved in the present invention:
Get 5 g of compound LathyranoneA, add 195 grams, dextrin, mixing, conventional tablet presses makes 1000.
Embodiment 2: the preparation of compound L athyranoneA capsule involved in the present invention:
Get 5 g of compound LathyranoneA, add starch 195 grams, mixing, encapsulatedly makes 1000.
Its pharmaceutically active is further illustrated below by pharmacodynamic experiment.
Experimental example: adopt the impact that pharmacological evaluation method assessing compound LathyranoneA is wriggled on small intestinal promotion
1, method: get kunming mice 30, Nanjing Medical University's Experimental Animal Center, 20 ± 5g, male and female half and half, by sex, body weight is divided into 3 groups at random, namely blank group, LathyranoneA (0.06mg/10g, 0.24mg/10g) two dosage groups.Often organize 10, suspension made by LathyranoneA and 5% charcoal end, 10% arabic gum, and blank group does not add medicine directly to charcoal end, arabic gum suspendible, all uses normal saline.Mice fasting 24 hours before experiment.Mouse stomach administration 0.2ml/10g, after administration, 30min puts to death.Get pylorus to ileocecus digestive tube, tiling is with on thin plate without traction, and survey total length and pylorus, to the distance in forward position, charcoal end, extrapolate ink propulsive rate thus.
2. result: statistical result shows that the intestinal propulsion of LathyranoneA low dose group mice is wriggled more blank group to be increased to some extent, and difference has significant (P<0.01); More blank group of LathyranoneA high dose group, difference has significant (P<0.001) result as table 1.
The impact (x+s) that table 1LathyranoneA is wriggled on mouse small intestine pushability
Compare with blank group, * * P<0.001*P<0.01
Shown by above-mentioned experimental example, the intestinal propulsion of LathyranoneA low dose group mice of the present invention is wriggled more blank group and is increased to some extent, and difference has significant (P<0.01); More blank group of LathyranoneA high dose group, difference has significant.Prove thus, LathyranoneA of the present invention has the effect promoting small intestinal peristalsis preferably.May be used for the treatment of the bad disease of multiple small intestinal peristalsis.
Claims (4)
1.LathyranoneA is promoting the application in small intestinal peristalsis medicine, and described compound L athyranoneA structure is as shown in formula I:
Formula I.
2. LathyranoneA is promoting the application in small intestinal peristalsis medicine as claimed in claim 1, it is characterized in that LathyranoneA strengthens mouse small intestine pushability and wriggles.
3. one kind promotes small intestinal peristalsis medicine, it is characterized in that by LathyranoneA described in claim 1 being that active component interpolation adjuvant is prepared from, preparation method, for getting 5 g of compound LathyranoneA, adds 195 grams, dextrin, mixing, Conventional compression makes 1000.
4. promote a small intestinal peristalsis medicine, it is characterized in that by LathyranoneA described in claim 1 being that active component adds adjuvant and is prepared from, preparation method, for getting 5 g of compound LathyranoneA, adds starch 195 grams, mixing, encapsulatedly makes 1000.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510930555.0A CN105434418A (en) | 2015-12-12 | 2015-12-12 | Use of Lathyranone A in preparation of drug for promoting small intestine peristalsis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510930555.0A CN105434418A (en) | 2015-12-12 | 2015-12-12 | Use of Lathyranone A in preparation of drug for promoting small intestine peristalsis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105434418A true CN105434418A (en) | 2016-03-30 |
Family
ID=55545353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510930555.0A Pending CN105434418A (en) | 2015-12-12 | 2015-12-12 | Use of Lathyranone A in preparation of drug for promoting small intestine peristalsis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105434418A (en) |
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2015
- 2015-12-12 CN CN201510930555.0A patent/CN105434418A/en active Pending
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| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160330 |
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| WD01 | Invention patent application deemed withdrawn after publication |