RU2571490C2 - Новые терапевтические способы применения инекальцитола - Google Patents

Новые терапевтические способы применения инекальцитола Download PDF

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RU2571490C2
RU2571490C2 RU2011151854/15A RU2011151854A RU2571490C2 RU 2571490 C2 RU2571490 C2 RU 2571490C2 RU 2011151854/15 A RU2011151854/15 A RU 2011151854/15A RU 2011151854 A RU2011151854 A RU 2011151854A RU 2571490 C2 RU2571490 C2 RU 2571490C2
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treatment
inecalcitol
cancer
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RU2011151854/15A
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RU2011151854A (ru
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Реми ДЕЛАНСОРН
Жан-Франсуа ДЮФУР-ЛАМАРТИНИ
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Хайбридженикс Са
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5939,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
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    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2011151854/15A 2009-05-20 2010-05-18 Новые терапевтические способы применения инекальцитола RU2571490C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17990609P 2009-05-20 2009-05-20
US61/179,906 2009-05-20
PCT/EP2010/056832 WO2010145903A1 (en) 2009-05-20 2010-05-18 New therapeutical uses of inecalcitol

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Publication Number Publication Date
RU2011151854A RU2011151854A (ru) 2013-06-27
RU2571490C2 true RU2571490C2 (ru) 2015-12-20

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US (1) US8481514B2 (enExample)
EP (1) EP2263677B1 (enExample)
JP (2) JP2012527424A (enExample)
KR (1) KR101845320B1 (enExample)
CN (1) CN102448466A (enExample)
AT (1) ATE505194T1 (enExample)
AU (1) AU2010261967B2 (enExample)
BR (1) BRPI1009056A2 (enExample)
CA (1) CA2762458C (enExample)
DE (1) DE602010000019D1 (enExample)
DK (1) DK2263677T3 (enExample)
ES (1) ES2363070T3 (enExample)
HR (1) HRP20110433T1 (enExample)
IL (1) IL216418A (enExample)
MX (1) MX2011012330A (enExample)
NZ (1) NZ596497A (enExample)
PL (1) PL2263677T3 (enExample)
PT (1) PT2263677E (enExample)
RU (1) RU2571490C2 (enExample)
SG (1) SG176581A1 (enExample)
SI (1) SI2263677T1 (enExample)
UA (1) UA105792C2 (enExample)
WO (1) WO2010145903A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11590117B2 (en) 2016-06-06 2023-02-28 Celgene Corporation Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2360145T3 (pl) 2010-01-26 2012-08-31 Hybrigenics Sa Nowy sposób izomeryzacji skondensowanych struktur bicyklicznych oraz wytwarzania zawierających te struktury analogów witaminy D
EP2407152A1 (en) * 2010-07-15 2012-01-18 Hybrigenics S.A. Formulations of 14-epi-analogues of vitamin D
SI2407155T1 (sl) * 2010-07-15 2013-04-30 Hybrigenics S.A. Preparati na osnovi inekalcitola
US20120015913A1 (en) 2010-07-15 2012-01-19 Delansorne Remi Formulations of 14-EPI-Analogues of Vitamin D
US10111896B2 (en) 2014-06-19 2018-10-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) Composition comprising a combination of DNA methylation inhibitor and a vitamin D receptor agonist for the treatment of drug resistant cancer or for the prevention of tumor relapse
JP2020143008A (ja) * 2019-03-05 2020-09-10 達也 楠堂 新規褐色脂肪細胞分化誘導剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0707566T3 (da) 1993-07-09 2000-09-04 Theramex Hidtil ukendte strukturelle analoger til vitamin D
US6242434B1 (en) * 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
GB0305332D0 (en) * 2003-03-10 2003-04-09 Leuven K U Res & Dev Biological evaluation of novel vitamin D analogues
JP2008514621A (ja) * 2004-09-24 2008-05-08 ビオクセル エッセ ピ ア 20−シクロアルキル,26,27−アルキル/ハロアルキル−ビタミンd3化合物及びその使用方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MOTRICH RD et al. Impact of vitamin D receptor activity on experimental autoimmune prostatitis. J.Autoimmun. 2009 Mar;32(2):140-8 Реферат [on line] [2014-04-01] (найдено из Интернет: www.ncbi.nlm.nih.gov/pubmed/19269787). *
Proming interim results from Hybrigenics' Inecalcitol phase II in combination with taxotere (R) for hormone-refractory prostate cancer. Paris, France April 17th 2009 [on line] [найдено 01.04.2014] (найдено из Интернет: www.drugs.com/clinical_trials/promising-interim-results-hybrigenics-inecalcito..). Hybrigenics acguires worldwide rights to inecalcitol. A vitamin D analogue. Paris, February 7, 2006 [on line] [найдено 01.04.2014] (найдено из Интернет: www.tornado-insider.com/press.asp?pressid=8145). ЭНЦИКЛОПЕДИЯ ЛЕКАРСТВ М., "РЛС-2008" 2007 с.438-439 статья Колекальциферол. Г.-Р.БУРМЕСТЕР и др. Наглядная иммунология М., БИНОМ Лаборатория знаний 2007 с.83(В.). *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11590117B2 (en) 2016-06-06 2023-02-28 Celgene Corporation Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide

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Publication number Publication date
DE602010000019D1 (de) 2011-05-26
CN102448466A (zh) 2012-05-09
SG176581A1 (en) 2012-01-30
DK2263677T3 (da) 2011-06-06
JP2012527424A (ja) 2012-11-08
ES2363070T3 (es) 2011-07-19
RU2011151854A (ru) 2013-06-27
IL216418A (en) 2015-09-24
SI2263677T1 (sl) 2011-07-29
MX2011012330A (es) 2011-12-16
CA2762458C (en) 2018-08-28
PT2263677E (pt) 2011-06-01
PL2263677T3 (pl) 2011-09-30
IL216418A0 (en) 2012-02-29
JP2016179994A (ja) 2016-10-13
EP2263677A1 (en) 2010-12-22
AU2010261967B2 (en) 2016-03-03
US8481514B2 (en) 2013-07-09
CA2762458A1 (en) 2010-12-23
WO2010145903A1 (en) 2010-12-23
AU2010261967A1 (en) 2011-12-08
ATE505194T1 (de) 2011-04-15
UA105792C2 (uk) 2014-06-25
BRPI1009056A2 (pt) 2020-06-02
HRP20110433T1 (hr) 2011-07-31
KR20120017075A (ko) 2012-02-27
KR101845320B1 (ko) 2018-04-04
US20110015276A1 (en) 2011-01-20
NZ596497A (en) 2013-05-31
EP2263677B1 (en) 2011-04-13

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