RU2563141C2 - Терапевтический агент (y-39983) против корнеальной эндотелиальной дисфункции - Google Patents

Терапевтический агент (y-39983) против корнеальной эндотелиальной дисфункции Download PDF

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Publication number
RU2563141C2
RU2563141C2 RU2012132443/15A RU2012132443A RU2563141C2 RU 2563141 C2 RU2563141 C2 RU 2563141C2 RU 2012132443/15 A RU2012132443/15 A RU 2012132443/15A RU 2012132443 A RU2012132443 A RU 2012132443A RU 2563141 C2 RU2563141 C2 RU 2563141C2
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Prior art keywords
corneal endothelial
compound
endothelial cells
corneal
cells
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RU2012132443/15A
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English (en)
Russian (ru)
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RU2012132443A (ru
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Хироаки Такахаси
Юдзи САКАМОТО
Тецуо КИДА
Такеси ТАРУИ
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Сэндзю Фармасьютикал Ко., Лтд.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
RU2012132443/15A 2009-12-29 2010-12-28 Терапевтический агент (y-39983) против корнеальной эндотелиальной дисфункции RU2563141C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2009299180 2009-12-29
JP2009-299180 2009-12-29
JPPCT/JP2010/071424 2010-11-24
PCT/JP2010/071424 WO2011080984A1 (en) 2009-12-29 2010-11-24 Therapeutic agent (y - 39983 ) for corneal endothelial dysfunction
PCT/JP2010/073904 WO2011081221A1 (en) 2009-12-29 2010-12-28 Therapeutic agent (y - 39983 ) for corneal endothelial dysfunction

Publications (2)

Publication Number Publication Date
RU2012132443A RU2012132443A (ru) 2014-02-10
RU2563141C2 true RU2563141C2 (ru) 2015-09-20

Family

ID=43598277

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2012132443/15A RU2563141C2 (ru) 2009-12-29 2010-12-28 Терапевтический агент (y-39983) против корнеальной эндотелиальной дисфункции

Country Status (10)

Country Link
US (1) US20120288482A1 (cg-RX-API-DMAC10.html)
EP (1) EP2519237A1 (cg-RX-API-DMAC10.html)
JP (2) JP5750444B2 (cg-RX-API-DMAC10.html)
KR (1) KR20120099147A (cg-RX-API-DMAC10.html)
CN (1) CN102770136A (cg-RX-API-DMAC10.html)
BR (1) BR112012016128A8 (cg-RX-API-DMAC10.html)
CA (1) CA2785851A1 (cg-RX-API-DMAC10.html)
MX (1) MX2012007671A (cg-RX-API-DMAC10.html)
RU (1) RU2563141C2 (cg-RX-API-DMAC10.html)
WO (2) WO2011080984A1 (cg-RX-API-DMAC10.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201903889T4 (tr) * 2011-12-06 2019-04-22 Astellas Inst For Regenerative Medicine Korneal endotelyal hücreler üreten yönlendirilmiş diferansiyasyona yönelik yöntem.
BR112016011096A2 (pt) 2013-11-27 2017-09-19 Kyoto Prefectural Public Univ Corp Aplicação de laminina à cultura de célula endotelial da córnea
US10959997B2 (en) 2013-12-27 2021-03-30 Kyoto Prefectural Public University Corporation Combined agent for cell therapy of corneal endothelial cell
CN106604730B (zh) * 2014-09-24 2019-12-20 兴和株式会社 角膜厚度调节剂
MX387839B (es) * 2014-10-31 2025-03-04 Senju Pharma Co Laminina para usarse en el tratamiento de una enfermedad, un trastorno o una afección de un endotelio de córnea.
JP6770435B2 (ja) 2014-10-31 2020-10-14 京都府公立大学法人 ラミニンによる網膜および神経の新規治療
EP3416658B1 (en) * 2016-02-15 2023-03-22 Kyoto Prefectural Public University Corporation Human functional corneal endothelial cell and application thereof

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EP1195372A1 (en) 1994-04-18 2002-04-10 Mitsubishi Pharma Corporation N-heterocyclic substituted benzamide derivatives with antihypertensive activity
CA2443918C (en) 2001-04-11 2012-06-05 Senju Pharmaceutical Co., Ltd. Visual function disorder improving agents containing rho kinase inhibitors
JP2004024852A (ja) 2002-04-30 2004-01-29 Amniotec:Kk 角膜内皮様シート、及びその作製方法
US7087237B2 (en) * 2003-09-19 2006-08-08 Advanced Ocular Systems Limited Ocular solutions
EP1752456B1 (en) * 2004-06-03 2015-08-26 Senju Pharmaceutical Co., Ltd. Corneal perception recovery drug containing amide compound
WO2006057270A1 (ja) * 2004-11-26 2006-06-01 Asahi Kasei Pharma Corporation 含窒素３環化合物
JP4766653B2 (ja) * 2005-01-28 2011-09-07 株式会社林原生物化学研究所 眼科用医薬組成物
WO2006095844A1 (ja) * 2005-03-10 2006-09-14 Mitsubishi Pharma Corporation 医薬製剤
WO2007083685A1 (ja) * 2006-01-19 2007-07-26 Senju Pharmaceutical Co., Ltd. 生体内で細胞増殖可能な角膜内皮製剤
WO2008016016A1 (fr) * 2006-07-31 2008-02-07 Senju Pharmaceutical Co., Ltd. Préparation liquide aqueuse contenant un amide
KR20240045364A (ko) 2007-08-29 2024-04-05 센주 세이야꾸 가부시키가이샤 각막 내피 세포 접착 촉진제
JP5251632B2 (ja) 2008-05-13 2013-07-31 新日鐵住金株式会社 耐遅れ破壊特性に優れた高強度鋼材、高強度ボルト及びその製造方法
JP2010071424A (ja) 2008-09-19 2010-04-02 Toyota Motor Corp 変速機の制御装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Okumura N1, ET AL, Enhancement on primate corneal endothelial cell survival in vitro by a ROCK inhibitor, Invest Ophthalmol Vis Sci, 2009 Aug;50(8):3680-7. *

Also Published As

Publication number Publication date
JP2013515676A (ja) 2013-05-09
MX2012007671A (es) 2012-08-23
EP2519237A1 (en) 2012-11-07
BR112012016128A2 (pt) 2016-05-31
WO2011080984A1 (en) 2011-07-07
BR112012016128A8 (pt) 2017-12-05
CA2785851A1 (en) 2011-07-07
JP2015155460A (ja) 2015-08-27
US20120288482A1 (en) 2012-11-15
KR20120099147A (ko) 2012-09-06
RU2012132443A (ru) 2014-02-10
CN102770136A (zh) 2012-11-07
JP5750444B2 (ja) 2015-07-22
WO2011081221A1 (en) 2011-07-07

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Effective date: 20171229