RU2560415C2 - Антитела или их фрагменты, направленные против эпитопа стафилококка золотистого (staphylococcus aureus) - Google Patents

Антитела или их фрагменты, направленные против эпитопа стафилококка золотистого (staphylococcus aureus) Download PDF

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RU2560415C2
RU2560415C2 RU2011146424/10A RU2011146424A RU2560415C2 RU 2560415 C2 RU2560415 C2 RU 2560415C2 RU 2011146424/10 A RU2011146424/10 A RU 2011146424/10A RU 2011146424 A RU2011146424 A RU 2011146424A RU 2560415 C2 RU2560415 C2 RU 2560415C2
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antibody
staphylococcus aureus
functional fragment
antibodies
aureus
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RU2011146424/10A
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Russian (ru)
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RU2011146424A (ru
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Кнут ОЛСЕН
Удо ЛОРЕНЦ
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Юлиус-Максимилианс-Универзитэт Вюрцбург
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • G01N33/56938Staphylococcus
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/924Hydrolases (3) acting on glycosyl compounds (3.2)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00Immunoassays for the detection of microorganisms
    • G01N2469/10Detection of antigens from microorganism in sample from host

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Reproductive Health (AREA)
RU2011146424/10A 2009-05-18 2010-05-18 Антитела или их фрагменты, направленные против эпитопа стафилококка золотистого (staphylococcus aureus) RU2560415C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17913309P 2009-05-18 2009-05-18
US61/179,133 2009-05-18
PCT/EP2010/056827 WO2010133600A1 (en) 2009-05-18 2010-05-18 Antibodies or fragments thereof directed against a staphylococcus aureus epitope of isaa or isab

Publications (2)

Publication Number Publication Date
RU2011146424A RU2011146424A (ru) 2013-06-27
RU2560415C2 true RU2560415C2 (ru) 2015-08-20

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RU2011146424/10A RU2560415C2 (ru) 2009-05-18 2010-05-18 Антитела или их фрагменты, направленные против эпитопа стафилококка золотистого (staphylococcus aureus)

Country Status (13)

Country Link
US (3) US8609102B2 (enExample)
EP (1) EP2432804B1 (enExample)
JP (2) JP5882892B2 (enExample)
CN (1) CN102695724B (enExample)
AU (1) AU2010251156C1 (enExample)
BR (1) BRPI1010911A2 (enExample)
CA (1) CA2761886A1 (enExample)
ES (1) ES2537437T3 (enExample)
MX (1) MX2011012248A (enExample)
PL (1) PL2432804T3 (enExample)
PT (1) PT2432804E (enExample)
RU (1) RU2560415C2 (enExample)
WO (1) WO2010133600A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11970527B2 (en) 2018-07-24 2024-04-30 Medimmune, Llc Antibody directed against S. aureus clumping factor A (ClfA)
RU2818805C2 (ru) * 2018-07-24 2024-05-06 МЕДИММЬЮН, ЭлЭлСи АНТИТЕЛО, НАПРАВЛЕННОЕ ПРОТИВ ФАКТОРА СЛИПАНИЯ А (ClfA) S. aureus

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5882892B2 (ja) * 2009-05-18 2016-03-09 ユリウス・マクシミリアンス−ウニヴェルジテート・ヴュルツブルクJulius Maximilians−Universitaet Wuerzburg 黄色ブドウ球菌エピトープIsaAまたはIsaBに対する抗体またはそれらのフラグメント
WO2013041707A1 (en) 2011-09-23 2013-03-28 Julius-Maximilians-Universität Würzburg Peptide or arrangement of peptides forming a staphylococcus aureus epitope binding site
US9944694B2 (en) 2013-12-13 2018-04-17 Rijksuniversiteit Groningen Antibodies against Staphylococcus aureus and uses therof
KR102341805B1 (ko) * 2019-11-27 2021-12-22 주식회사 하울바이오 황색포도상구균에 특이적으로 반응하는 항-IsaA G4 항체 및 이의 용도
KR102341804B1 (ko) * 2019-11-27 2021-12-22 주식회사 하울바이오 황색포도상구균을 억제하는 항-IsaA F10 항체 및 이의 용도
US20230357373A1 (en) * 2019-12-17 2023-11-09 Mie University Methods and compositions for evaluating and treating fibrosis
WO2022250205A1 (ko) * 2021-05-25 2022-12-01 주식회사 하울바이오 항-IsaA F10 항체의 아토피 피부염 예방 및 개선 용도

Citations (3)

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RU2144190C1 (ru) * 1998-01-13 2000-01-10 Катханов Али Муратович Способ диагностики стафилококковой инфекции
US6340571B1 (en) * 1996-03-21 2002-01-22 Bio Merieux Antibodies specific for Staphylococcus aureus, and use thereof
WO2003046007A2 (en) * 2001-11-22 2003-06-05 Neutec Pharma Plc Treatment of micro-organism infection

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DE4238806A1 (en) * 1991-11-18 1993-05-27 Dainabot Co Methicillin-resistant staphylococcus aureus (MRSA)detection method - by detection of MRSA penicillin binding protein (PBP)2 antigen-antibody complex, and synthetic MRSA PBP2 peptides
GB0014907D0 (en) * 2000-06-20 2000-08-09 Univ Sheffield Antigenic polypeptides
KR20070104590A (ko) * 2005-01-10 2007-10-26 나비 바이오파마슈티컬즈 스타필로코쿠스 아우레우스 감염을 치료하는 방법
JP5882892B2 (ja) * 2009-05-18 2016-03-09 ユリウス・マクシミリアンス−ウニヴェルジテート・ヴュルツブルクJulius Maximilians−Universitaet Wuerzburg 黄色ブドウ球菌エピトープIsaAまたはIsaBに対する抗体またはそれらのフラグメント

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6340571B1 (en) * 1996-03-21 2002-01-22 Bio Merieux Antibodies specific for Staphylococcus aureus, and use thereof
RU2144190C1 (ru) * 1998-01-13 2000-01-10 Катханов Али Муратович Способ диагностики стафилококковой инфекции
WO2003046007A2 (en) * 2001-11-22 2003-06-05 Neutec Pharma Plc Treatment of micro-organism infection

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LORENZ U. et al., Therapeutische EffektivitÄt von monoklonalen AntikÖrpern gegen Staphylococcus aureus in einem Sepsis- und Abszess-Mausmodell, 125. Kongress der Deutschen Gesellschaft fÜr Chirurgie Deutsche Gesellschaft fÜr Chirurgie 22. - 25.04.2008, Berlin. LORENZ U. et al., Human antibody response during sepsis against targets expressed by methicillin resistant Staphylococcus aureus, FEMS Immunology and Medical Microbiology, 2000, Vol. 29, pp. 145-153. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11970527B2 (en) 2018-07-24 2024-04-30 Medimmune, Llc Antibody directed against S. aureus clumping factor A (ClfA)
RU2818805C2 (ru) * 2018-07-24 2024-05-06 МЕДИММЬЮН, ЭлЭлСи АНТИТЕЛО, НАПРАВЛЕННОЕ ПРОТИВ ФАКТОРА СЛИПАНИЯ А (ClfA) S. aureus

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Publication number Publication date
US20120100151A1 (en) 2012-04-26
JP2016047828A (ja) 2016-04-07
RU2011146424A (ru) 2013-06-27
WO2010133600A1 (en) 2010-11-25
EP2432804B1 (en) 2015-02-25
PL2432804T3 (pl) 2015-08-31
US20160109449A1 (en) 2016-04-21
JP2012527423A (ja) 2012-11-08
AU2010251156A1 (en) 2011-11-24
US9658230B2 (en) 2017-05-23
CA2761886A1 (en) 2010-11-25
MX2011012248A (es) 2012-02-29
US9260511B2 (en) 2016-02-16
EP2432804A1 (en) 2012-03-28
ES2537437T3 (es) 2015-06-08
US20140072570A1 (en) 2014-03-13
AU2010251156C1 (en) 2015-02-05
US8609102B2 (en) 2013-12-17
JP5882892B2 (ja) 2016-03-09
CN102695724A (zh) 2012-09-26
CN102695724B (zh) 2016-08-24
PT2432804E (pt) 2015-06-25
AU2010251156B2 (en) 2014-10-09
BRPI1010911A2 (pt) 2019-09-24

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Effective date: 20170519