RU2556205C2 - Очищенные пирролохинолинил-пирролидин-2,5-дионовые композиции и способы их получения и применения - Google Patents

Очищенные пирролохинолинил-пирролидин-2,5-дионовые композиции и способы их получения и применения Download PDF

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Publication number
RU2556205C2
RU2556205C2 RU2012131344/04A RU2012131344A RU2556205C2 RU 2556205 C2 RU2556205 C2 RU 2556205C2 RU 2012131344/04 A RU2012131344/04 A RU 2012131344/04A RU 2012131344 A RU2012131344 A RU 2012131344A RU 2556205 C2 RU2556205 C2 RU 2556205C2
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RU
Russia
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pyrrolo
dihydro
dione
trans
indol
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RU2012131344/04A
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English (en)
Russian (ru)
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RU2012131344A (ru
Inventor
Дэвид П. РИД
Нил Р. БАРНС
Джон К. КЕЙН
Кристофер А. ЛИ
Цзянь-Се ЧЭНЬ
Мартин П. РЕДМОНД
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Аркьюл, Инк.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU2012131344/04A 2009-12-23 2010-12-21 Очищенные пирролохинолинил-пирролидин-2,5-дионовые композиции и способы их получения и применения RU2556205C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28956309P 2009-12-23 2009-12-23
US61/289,563 2009-12-23
PCT/US2010/061625 WO2011079142A2 (en) 2009-12-23 2010-12-21 Purified pyrroloquinolinyl-pyrrolidine-2,5-dione compositions and methods for preparing and using same

Publications (2)

Publication Number Publication Date
RU2012131344A RU2012131344A (ru) 2014-01-27
RU2556205C2 true RU2556205C2 (ru) 2015-07-10

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RU2012131344/04A RU2556205C2 (ru) 2009-12-23 2010-12-21 Очищенные пирролохинолинил-пирролидин-2,5-дионовые композиции и способы их получения и применения

Country Status (19)

Country Link
US (3) US8552192B2 (https=)
EP (2) EP2515904A4 (https=)
JP (2) JP2013515737A (https=)
KR (2) KR20160121602A (https=)
CN (2) CN104910159A (https=)
AU (2) AU2010336533B9 (https=)
BR (1) BR112012015656A2 (https=)
CA (1) CA2785503A1 (https=)
CO (1) CO6561823A2 (https=)
HK (1) HK1215025A1 (https=)
MX (1) MX2012007259A (https=)
MY (2) MY156701A (https=)
NZ (2) NZ628087A (https=)
PH (2) PH12012501293A1 (https=)
RU (1) RU2556205C2 (https=)
SG (1) SG181927A1 (https=)
TW (3) TWI506026B (https=)
WO (1) WO2011079142A2 (https=)
ZA (1) ZA201204759B (https=)

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KR100941205B1 (ko) * 2005-02-09 2010-02-10 아르퀼 인코포레이티드 말레이미드 유도체, 약제학적 조성물 및 암을 치료하는방법
MY156701A (en) * 2009-12-23 2016-03-15 Arqule Inc Purified pyrroloquinolinyl-pyrrolidine-2,5-dione compositions and methods for preparing and using same
TW201315470A (zh) * 2011-07-07 2013-04-16 Arqule Inc 吡咯並喹啉基－吡咯啶－２，５－二酮調製劑類及製備和使用彼等之方法
WO2013162714A1 (en) * 2012-04-23 2013-10-31 Arqule, Inc. Highly pure pyrroloquinolinyl-pyrrole-2,5-dione and pyrroloquinolinyl-pyrrolidine-2,5-dione and methods of preparing same
EP3021849B1 (en) * 2013-07-16 2019-10-09 Dr. Reddy's Laboratories Ltd. Novel crystalline forms of pemetrexed tromethamine salts
CN111247153B (zh) * 2017-08-11 2024-04-02 开动疗法公司 3-(5-氟苯并呋喃-3-基)-4-(5-甲基-5H-[1，3]间二氧杂环戊烯并[4，5-f]吲哚-7-基)吡咯-2，5-二酮的固体形式
CN110806454A (zh) * 2018-08-06 2020-02-18 江苏正大清江制药有限公司 一种盐酸吉西他滨中手性异构体的检测方法
EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2022216870A1 (en) * 2021-04-07 2022-10-13 Ur-1 Therapeutics, Inc. Urat1 inhibitor, pharmaceutical compositions and uses thereof

Citations (1)

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RU2083580C1 (ru) * 1991-08-23 1997-07-10 Кали-Хеми Фарма ГмбХ 1,7-анеллированные производные 3-(пиперазиноалкил)-индола, способ их получения (варианты), содержащая их фармацевтическая композиция и промежуточный продукт для их получения

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US5760237A (en) * 1995-08-25 1998-06-02 California Institute Of Technology Synthesis of l-azatyrosine using pseudoephedrine as a chiral auxiliary
EP1242420A2 (en) * 1999-12-16 2002-09-25 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
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CA2573508A1 (en) * 2004-09-10 2006-03-23 Wyeth Process for the scalable synthesis of 1, 3, 4, 9-tetrahydropyrano[3, 4-b]-indole derivatives
KR100941205B1 (ko) * 2005-02-09 2010-02-10 아르퀼 인코포레이티드 말레이미드 유도체, 약제학적 조성물 및 암을 치료하는방법
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CA2912546A1 (en) * 2007-06-22 2008-12-31 Arqule, Inc. Compositions and methods for treatment of cancer
MY156701A (en) * 2009-12-23 2016-03-15 Arqule Inc Purified pyrroloquinolinyl-pyrrolidine-2,5-dione compositions and methods for preparing and using same
WO2013162714A1 (en) * 2012-04-23 2013-10-31 Arqule, Inc. Highly pure pyrroloquinolinyl-pyrrole-2,5-dione and pyrroloquinolinyl-pyrrolidine-2,5-dione and methods of preparing same

Patent Citations (1)

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RU2083580C1 (ru) * 1991-08-23 1997-07-10 Кали-Хеми Фарма ГмбХ 1,7-анеллированные производные 3-(пиперазиноалкил)-индола, способ их получения (варианты), содержащая их фармацевтическая композиция и промежуточный продукт для их получения

Also Published As

Publication number Publication date
AU2015243015A1 (en) 2015-11-05
MX2012007259A (es) 2015-05-15
EP3081567A2 (en) 2016-10-19
KR101669707B1 (ko) 2016-10-27
US20140031551A1 (en) 2014-01-30
EP2515904A4 (en) 2013-07-03
TWI557125B (zh) 2016-11-11
KR20120113760A (ko) 2012-10-15
CA2785503A1 (en) 2011-06-30
CN102834097A (zh) 2012-12-19
PH12014500310A1 (en) 2015-09-28
NZ628087A (en) 2016-02-26
US8552192B2 (en) 2013-10-08
HK1215025A1 (zh) 2016-08-12
WO2011079142A2 (en) 2011-06-30
AU2010336533B2 (en) 2015-09-10
TW201542546A (zh) 2015-11-16
AU2015243015B2 (en) 2017-02-02
EP3081567A3 (en) 2016-11-16
SG181927A1 (en) 2012-07-30
BR112012015656A2 (pt) 2016-05-10
US9499540B2 (en) 2016-11-22
RU2012131344A (ru) 2014-01-27
CN104910159A (zh) 2015-09-16
NZ600800A (en) 2014-10-31
JP2013515737A (ja) 2013-05-09
US20110160242A1 (en) 2011-06-30
WO2011079142A3 (en) 2011-11-24
EP2515904A2 (en) 2012-10-31
US20160024076A1 (en) 2016-01-28
CN102834097B (zh) 2015-06-17
CO6561823A2 (es) 2012-11-15
MY169232A (en) 2019-03-19
AU2010336533A1 (en) 2012-07-12
KR20160121602A (ko) 2016-10-19
TW201643163A (zh) 2016-12-16
TW201141865A (en) 2011-12-01
TWI506026B (zh) 2015-11-01
MY156701A (en) 2016-03-15
ZA201204759B (en) 2014-03-26
US8871933B2 (en) 2014-10-28
AU2010336533B9 (en) 2015-10-08
JP2016041712A (ja) 2016-03-31
PH12012501293A1 (en) 2013-01-07

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