RU2530569C2 - Treating-preventive mud composition - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the pharmaceutical industry, namely to a treating-preventive mud composition. The treating-preventive mud composition contains preliminarily prepared silt-clayey deposits of lake Tambukan, polyethyleneglycol 4000, polyethyleneglycol 1500, cremophor RH, as well as a carbon dioxide extract of propolis and/or a carbon dioxide vegetable extract, selected from the group, which includes, at least, eucalyptus, dog-rose, hop, laurel, chamomile, licorice and oak, taken in a specified ratio of components.

EFFECT: composition has an increased treating-preventive activity with respect to a patient's organism.

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Description

The invention relates to medicine, in particular to dosage forms - applicators and suppositories, and can be used in the manufacture of mud therapeutic and prophylactic products with a wide spectrum of action (painkiller, anti-inflammatory, antispasmodic).

Known (patent RU 107943, publ. 2011) an applicator for the treatment of fibrocystic mastopathy containing an insert made in the form of a circle having a radius of 5 cm or 7 cm, with a cutout in the center of the circle having a diameter of 3 cm, and with a removed sector, when folding in the form of a truncated cone, the liner is saturated with the medicinal composition of white cabbage juice and covered with a plastic film.

A disadvantage of the known applicator should be recognized as a limited scope.

Also known (patent RU 53902, publ. 2006) is an applicator in the form of a shell made of a material inside of which therapeutic mud is located, which is homogenized silt-clay deposits, particle sizes of which are not more than 0.35 mm, and the shell material is inert to silt sulfide mud and provides the movement of beneficial components of therapeutic mud in any direction to the skin or mucous membrane of the patient.

A disadvantage of the known applicator is the lack of effectiveness.

Known (patent RU 77159, publ. 2008) is an applicator, which is a shell, inside of which is therapeutic mud, which is silt-clay deposits of Lake Tambukan, mechanically cleaned of contaminants and with previously crushed mineral inclusions, the shell material is a non-woven material, wherein the shell is additionally placed in a light and gas impermeable film.

A disadvantage of the known applicator is the lack of effectiveness.

The technical problem solved by the developed device is to expand the assortment of drugs using therapeutic silt-clay deposits.

The technical result obtained by the implementation of the developed composition of the mud therapeutic and prophylactic means is to increase the effectiveness of the impact of the funds made on its basis on the body.

To achieve the technical result, it is proposed to use the composition of a therapeutic mud containing polyethylene glycol 4000, polyethylene glycol 1500, pre-prepared silt-clay deposits of Lake Tambukan, cremophor RH, as well as carbon dioxide plant extracts and / or carbon dioxide extract of propolis in the following ratio of components (% ):

Pre-prepared silt-clay deposits of Lake Tambukan 15-25 Polyethylene glycol 1500 15-25 Cremophor RH 3-5 Carbon dioxide plant extracts and / or propolis carbon dioxide extract 0.5-1.5 Polyethylene glycol 4000 rest

moreover, carbon dioxide extracts of plants selected from the group consisting of at least eucalyptus, rose hips, hops, laurel, chamomile, licorice and oak are used as carbon dioxide plant extracts.

Sludge-clay sediments of Lake Tambukan used in the production of mud therapeutic and prophylactic agents (applicators, candles) contain a crystallo-colloidal complex (20% -50%), mineral salts (sulfites and chlorides of sodium, magnesium and potassium) and macrocells (calcium, iron, etc. .), hydrogen sulfide (0.2-0.4%), trace elements (zinc, copper, manganese, etc.), biologically active substances (lipids, carotenoids, amino acids, humic and vitamin-like compounds).

Before the mud-clay sediments of Lake Tambukan are introduced into the mud treatment and prophylactic agents, they undergo a preparation stage, during which preliminary foreign mechanical inclusions that are part of the initial mud-clay deposits are subsequently separated, followed by grinding particles of silt-clay deposits to a size not exceeding 0, 1 mm, determine the physico-chemical and sanitary-bacteriological indicators of the crushed particles of sediments and correct the identified deviations of indicators from predefined parameters by chemical and / or mechanical action.

It was experimentally established that only when using the silt-clay sediments of Lake Tambukan prepared in this way, mud therapeutic and prophylactic agents, which include silt-clay deposits of Lake Tambukan, can achieve the indicated technical result.

In the production of mud therapeutic and prophylactic agents, the initial components included in the developed composition are mixed and formed from them cylindrical, preferably with pointed ends or flat products.

In the future, the essence and advantages of the developed composition of mud therapeutic and prophylactic agents will be considered using implementation examples.

1. Patient S., 54 years old. Diagnosis: Chronic colitis, stage of incomplete remission. Upon admission, the patient has a mild inflammation of the mucous membrane of the rectum and sigmoid colon. To relieve inflammation in the distal intestines, the patient underwent a course of therapeutic microclysters in combination with the placement of applicators on the abdomen. Treatment with an applicator - the closest analogue for 30 days (daily procedures for 40 minutes) did not lead to a noticeable improvement in the patient's condition. The treatment was carried out by a similar technique (a combination of a rectal applicator - a tampon and applying an applicator to the abdomen on the rectum and sigmoid colon) using an applicator composition (%):

Pre-prepared silt-clay deposits of Lake Tambukan 25 Polyethylene glycol 1500 fifteen Cremophor RH 3 Carbon dioxide rosehip extracts 0.5 Propolis Carbon Dioxide Extract 1,0 Polyethylene glycol 4000 55.5

The procedures were performed every other day. The course of treatment was 8 procedures. As a result of treating a patient using an applicator of a developed composition, it was possible earlier to achieve the disappearance of pathological subjective and objective symptoms and to obtain a stable therapeutic effect with prolonged remission.

2. Patient W., 52 years old. Diagnosis: Chronic combined hemorrhoids. Stage of remission. On an outpatient basis, the patient underwent rectal treatment using an applicator, the closest analogue. The procedures were carried out 2 days in a row with a break on the 3rd day. The course of treatment included 8 procedures. There was no improvement in the patient's condition. Then a similar treatment was carried out using an applicator of the developed composition (%):

Sludge-clay deposits of Lake Tambukan twenty Polyethylene glycol 1500 twenty Cremophor RH 5 Oak Carbon Extract 0.5 Propolis Carbon Dioxide Extract 1,0 Polyethylene glycol 4000 53.5

Improvement of the therapeutic effect in the patient occurred after 4-5 procedures. Discomfort and pain in the rectum decreased.

3. Patient M., 42 years old. Diagnosis: granulating anal fissure. An outpatient underwent rectal treatment using an applicator, the closest analogue. The procedures were carried out 3 days in a row with a break on the 4th day. The course of treatment included 9 procedures. There was no improvement in the patient's condition. Then, treatment was carried out using a candle of developed composition (%):

Pre-prepared silt-clay deposits of Lake Tambukan 22 Polyethylene glycol 1500 17 Cremophor RH four Carbon Dioxide Chamomile Extracts one Polyethylene glycol 4000 56

The patient underwent a course of rectal mud therapy with the developed applicator. The procedures were performed every other day. Conducted 8 procedures. After the 3rd procedure, the pain in the fissure area stopped. After the 7th procedure, when examined, the complete healing of the crack.

4. Patient K., 36 years old. Diagnosis: Salpingoophoritis chronic, stage of remission. Pelvic ganglioneuritis. Upon admission, the patient was disturbed by prolonged cramping pains in the lower abdomen associated with hypothermia, copious discharge. The patient against the background of antibiotic therapy and magnesium electrophoresis on the pelvic organs using an applicator - the closest analogue was additionally treated with vaginal mud tampons at a temperature of 40-42 ° C in combination with single-use mud applicators in combination with thermocompresses at a temperature of 39-41 ° C on the “panty” zone lasting 20-30 minutes. The procedures were performed simultaneously for 2 consecutive days with the next day of a break; 12 treatments per treatment course. The therapeutic effect is weak. Additionally, a similar course was carried out using an applicator of the developed composition (%):

Sludge-clay deposits of Lake Tambukan 25 Polyethylene glycol 1500 twenty Cremophor RH 5 Carbon dioxide hop extracts 0.5 Propolis Carbon Dioxide Extract 0.5 Polyethylene glycol 4000 49

At the end of the course of treatment, a decrease in the frequency of pain and a restoration of the normal menstrual cycle was noted.

5. Patient I., 32 years old. Diagnosis: Condition after surgery for uterine fibroids. Severe infiltrative, extensive adhesions in the pelvic cavity. The patient was treated with mud vaginal swabs - the closest analogue - temperatures 38-42 ° C according to the developed method and the application of disposable temperature applicators 38-42 ° C in combination with thermocompresses on the “panties zone”, lasting 10-20 minutes. The temperature of the mud procedures was gradually increased during the course of treatment. Mud tampons were prescribed after taking 2-3x mud applications. In the first half of the course of treatment, the procedures were applied every other day, in the second - two consecutive days, followed by a rest day. The course of treatment is 12 procedures. The procedures were alternated with the use of shared baths, vaginal irrigation and therapeutic exercises. The therapeutic effect is weak. The treatment was repeated using the developed formulation using an applicator (%):

Sludge-clay deposits of Lake Tambukan 25 Polyethylene glycol 1500 25 Cremophor RH 3 Eucalyptus Carbon Dioxide Extract 0.5 Oak Carbon Extract 0.5 Polyethylene glycol 4000 46

In the patient, as a result of mud therapy, a decrease in pain in the lower abdomen and in the lumbosacral region was noted in the 8th procedure, a decrease in palpation pain and discharge by the 10th procedure. At discharge, a significant improvement in well-being was noted.

6. Patient E., 56 years old. He entered the neurological department of the hospital with a diagnosis of shoulder syndrome of scapular periarthrosis, secondary myogenic contracture of the shoulder joint on the left. During a clinical examination against the background of cervicobrachialgia, the pain was disturbed when the hand was brought to the shoulder blade, the inability to bend the shoulder forward and take it to the side to the horizontal line of the shoulder girdle. Pain was noted in all the muscles involved in the work of the shoulder girdle. The disease is 13 months old. For the treatment of humeroscapular periarthrosis, the developed method of mud therapy with Tambucan mud applicators was used. Initially, the applicator - the closest analogue - was applied to the suprascapular region on the left. Thermocompress with a temperature of 38 ° C was placed on top of the applicator and layered wrapping was performed. The duration of the procedure is 15-30 minutes. The treatment was carried out daily for 10 days, the patient tolerated the procedure well. The therapeutic effect is weak, the mobility of the arm and shoulder has not changed. The course was repeated using the applicator composition (%):

Pre-prepared

Sludge-clay deposits of Lake Tambukan twenty Polyethylene glycol 1500 twenty Cremophor RH 5 Licorice carbon dioxide extracts 0.5 Propolis Carbon Dioxide Extract 0.5 Polyethylene glycol 4000 54

After the 3rd procedure, the patient decreased pain in the shoulder joint, neck muscles, increased range of motion in the cervical spine and shoulder. Dynamic observation showed that after each procedure, the range of motion in the frontal and sagittal planes increased by 5-7 °. By the end of treatment, movement in the shoulder joint increased significantly. After 4 months, the patient was called for a follow-up examination. No complaints.

7. Patient I., 56 years old. Diagnosis: chronic non-specific prostatitis. Complaints during examination: pain, manifested by pain in the lumbosacral region and in the perineum, impaired urination, fatigue, irritability, decreased libido. From the anamnesis: the first diagnosis was made 9 years ago. Frequent exacerbations, especially in the last 4-5 years. Medical treatment. In 2008, spa treatment (radon baths and mud applications "Cowards" for 6 treatments). Short-term improvement was noted. Objectively: clinical blood tests - increased leukocytosis, ECG - without pronounced signs of violation. Transrectal ultrasound revealed an increase in the anteroposterior size up to 3.3 ± 0.5 cm and across to 4.9-0.6 cm, the volume of the prostate on average increased to 58.1 ± 2.1 cm ³ , violations echogenicity of the parenchyma. Rheovasography indicators reliably indicate venous congestion, a decrease in the level of all indicators of well-being, activity, mood, and an increase in the level of reactive anxiety.

The patient was prescribed a course of treatment: rectal tampons (the composition is the closest analogue) with silt sulfide mud injected with a disposable syringe with a volume of 200-250 g, the mud temperature in the first procedure was 38-40 ° C, the subsequent procedures were carried out at a mud temperature of 40-42 ° C, the exposure time for the first procedure is 35 minutes, the subsequent procedures for 40 minutes, the course of treatment was 14 procedures. Improvement did not come. The course of treatment was repeated using the applicator composition (%):

Pre-prepared silt-clay deposits of Lake Tambukan 23 Polyethylene glycol 1500 eighteen Cremophor RH 5 Hops Carbon Dioxide Extract 0.5 Chamomile Carbon Dioxide Extract 0.5 Polyethylene glycol 4000 53

A positive therapeutic effect of the treatment was observed after 4-6 procedures and was accompanied by positive clinical dynamics and an improvement in psychological status according to the SAN and Spielberg tests. Tolerability of the procedure was evaluated by the patient on a five-point scale as “comfortable”. The rheovasography indices after the course of treatment indicated normalization of blood circulation in the pelvic organs, improvement of blood supply due to improved arterial flow and a decrease in vascular hypertension. A marked improvement in the structure of the prostate gland after a course of treatment was also noted with rectal ultrasound examination: a decrease in the size of the prostate gland, the disappearance of compaction of areas of the prostate parenchyma. The patient noted an improvement in the psychoemotional state (SAN test): long-term results (after 6-12 months) were preserved and confirmed by positive clinical and physiological data

8. Patient G., 32 g. Diagnosis: Gallstone disease. Ultrasound in the lumen of the gallbladder is a lot of stones up to 8 mm in diameter. An applicator was placed on the stomach in the area of the gallbladder - the closest analogue for 25-45 minutes daily for 14 days. Positive dynamics in reducing the size of calculi and their size was not observed. Used applicator composition (%):

Pre-prepared silt-clay deposits of Lake Tambukan 25 Polyethylene glycol 1500 fifteen Cremophor RH 3 Licorice Carbon Dioxide Extract 1,5 Polyethylene glycol 4000 55.5

Repeated ultrasounds showed a significant decrease in the number of stones and their sizes up to 4 mm in diameter in the lumen.

9. Patient M., 43 years old. Diagnosis: Generalized form of periodontitis of moderate severity. He complained of bleeding gums, enamel hyperesthesia, tooth mobility of 1-2 degrees in the frontal region, II-III degrees in the group of molars. A comprehensive treatment was carried out, including oral sanitation, removal of supra- and subgingival dental deposits, granulations, and selective grinding of teeth was carried out. In parallel, mud therapy was carried out using the applicator, the closest analogue. The course amounted to 15 daily procedures. The therapeutic effect is not achieved. The course was repeated using the applicator composition (%):

Pre-prepared silt-clay deposits of Lake Tambukan 25 Polyethylene glycol 1500 25 Cremophor RH 5 Carbon Dioxide Laurel Extract 0.5 Oak Carbon Extract 0.5 Polyethylene glycol 4000 44

Before and after the course of treatment, intravital biomicroscopy, rheoparodontography, orthopantomogram were performed. An improvement in microcirculation in the gums with a decrease in venous-lymphatic stasis and an increase in the active surface of the capillaries, a decrease in interstitial edema were revealed. On the orthopantomogram, a tendency to the termination of horizontal and vertical bone resorption is noted. Clinically, the gum has the usual color, the mobility of the teeth decreased to 0-1 degrees, the hyperesthesia of the teeth and bleeding of the gums disappeared.

Applicators and suppositories of a developed composition have a painkiller, anti-inflammatory, antispasmodic effect.

Claims (1)

The therapeutic and prophylactic mud composition, characterized in that it contains pre-prepared silt-clay sediments of Lake Tambukan, polyethylene glycol 4000, polyethylene glycol 1500, cremophor RH, as well as carbon dioxide plant extracts and / or carbon dioxide propolis extract in the following ratio of components (%):
Pre-prepared silt-clay deposits of Lake Tambukan 15-25 Polyethylene glycol 1500 15-25 Cremophor RH 3-5 Carbon dioxide plant extracts and / or Propolis Carbon Dioxide Extract 0.5-1.5 Polyethylene glycol 4000 rest
moreover, carbon dioxide extracts of plants selected from the group consisting of at least eucalyptus, rose hips, hops, laurel, chamomile, licorice and oak are used as carbon dioxide plant extracts.