RU2519384C2 - Активируемый дыханием ингалятор - Google Patents
Активируемый дыханием ингалятор Download PDFInfo
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- RU2519384C2 RU2519384C2 RU2011115404/14A RU2011115404A RU2519384C2 RU 2519384 C2 RU2519384 C2 RU 2519384C2 RU 2011115404/14 A RU2011115404/14 A RU 2011115404/14A RU 2011115404 A RU2011115404 A RU 2011115404A RU 2519384 C2 RU2519384 C2 RU 2519384C2
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- Prior art keywords
- opening mechanism
- inhaler
- outlet
- ethyl
- foil
- Prior art date
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- 230000007246 mechanism Effects 0.000 claims abstract description 99
- 239000003814 drug Substances 0.000 claims abstract description 40
- 238000000034 method Methods 0.000 claims abstract description 16
- 230000000694 effects Effects 0.000 claims abstract description 3
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- -1 4-hydroxy-2-oxo-3H-1,3-benzothiazol-7-yl Chemical group 0.000 claims description 37
- 238000000926 separation method Methods 0.000 claims description 35
- 229940079593 drug Drugs 0.000 claims description 32
- 150000003839 salts Chemical class 0.000 claims description 23
- 230000003449 preventive effect Effects 0.000 claims description 10
- 239000004480 active ingredient Substances 0.000 claims description 9
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 9
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims description 8
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims description 8
- 229960004436 budesonide Drugs 0.000 claims description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
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- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical compound O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 claims description 8
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- 238000009826 distribution Methods 0.000 claims description 6
- LBLYYCQCTBFVLH-UHFFFAOYSA-M 2-methylbenzenesulfonate Chemical compound CC1=CC=CC=C1S([O-])(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-M 0.000 claims description 5
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 5
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- QZZUEBNBZAPZLX-QFIPXVFZSA-N indacaterol Chemical compound N1C(=O)C=CC2=C1C(O)=CC=C2[C@@H](O)CNC1CC(C=C(C(=C2)CC)CC)=C2C1 QZZUEBNBZAPZLX-QFIPXVFZSA-N 0.000 claims description 5
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- STTGOFBGRUQUOE-NDEPHWFRSA-N 2-[(4-chlorophenyl)methoxy]ethyl-[[2-[(r)-cyclohexyl-hydroxy-phenylmethyl]-1,3-oxazol-5-yl]methyl]-dimethylazanium Chemical class C=1N=C([C@@](O)(C2CCCCC2)C=2C=CC=CC=2)OC=1C[N+](C)(C)CCOCC1=CC=C(Cl)C=C1 STTGOFBGRUQUOE-NDEPHWFRSA-N 0.000 claims description 4
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
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- 229960005012 aclidinium bromide Drugs 0.000 claims description 3
- XLAKJQPTOJHYDR-QTQXQZBYSA-M aclidinium bromide Chemical compound [Br-].C([C@@H](C(CC1)CC2)OC(=O)C(O)(C=3SC=CC=3)C=3SC=CC=3)[N+]21CCCOC1=CC=CC=C1 XLAKJQPTOJHYDR-QTQXQZBYSA-M 0.000 claims description 3
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- STJMRWALKKWQGH-UHFFFAOYSA-N clenbuterol Chemical compound CC(C)(C)NCC(O)C1=CC(Cl)=C(N)C(Cl)=C1 STJMRWALKKWQGH-UHFFFAOYSA-N 0.000 claims description 3
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- KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 claims description 3
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- RATSWNOMCHFQGJ-TUYNVFRMSA-N (e)-but-2-enedioic acid;n-[2-hydroxy-5-[(1s)-1-hydroxy-2-[[(2s)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide;dihydrate Chemical compound O.O.OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1 RATSWNOMCHFQGJ-TUYNVFRMSA-N 0.000 claims description 2
- 229960000265 cromoglicic acid Drugs 0.000 claims description 2
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- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims description 2
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- FNYFFCOCVNTJCD-NNMXADRKSA-N [(3r)-1-[2-(4-fluorophenyl)ethyl]-1-azoniabicyclo[2.2.2]octan-3-yl] (2s)-2-phenyl-2-piperidin-1-ylpropanoate Chemical compound N1([C@](C)(C(=O)O[C@@H]2C3CC[N+](CC3)(CCC=3C=CC(F)=CC=3)C2)C=2C=CC=CC=2)CCCCC1 FNYFFCOCVNTJCD-NNMXADRKSA-N 0.000 claims 1
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Classifications
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- A—HUMAN NECESSITIES
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- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0003—Details of inhalators; Constructional features thereof with means for dispensing more than one drug
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- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
- A61M15/0025—Mouthpieces therefor with caps
- A61M15/0026—Hinged caps
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- A—HUMAN NECESSITIES
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- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
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- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
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- A61M15/0091—Inhalators mechanically breath-triggered
- A61M15/0098—Activated by exhalation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/06—Containers or packages with special means for dispensing contents for dispensing powdered or granular material
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- A61M15/0096—Hindering inhalation before activation of the dispenser
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/07—General characteristics of the apparatus having air pumping means
- A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
- A61M2205/073—Syringe, piston type
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Mechanical Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Structures Of Non-Positive Displacement Pumps (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10360208P | 2008-10-08 | 2008-10-08 | |
| US61/103,602 | 2008-10-08 | ||
| PCT/SE2009/051111 WO2010042034A1 (en) | 2008-10-08 | 2009-10-07 | A breath activated inhaler |
Publications (2)
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| RU2011115404A RU2011115404A (ru) | 2012-11-20 |
| RU2519384C2 true RU2519384C2 (ru) | 2014-06-10 |
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| RU2011115404/14A RU2519384C2 (ru) | 2008-10-08 | 2009-10-07 | Активируемый дыханием ингалятор |
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| Country | Link |
|---|---|
| US (1) | US9155851B2 (https=) |
| EP (1) | EP2341968B1 (https=) |
| JP (1) | JP5512686B2 (https=) |
| KR (1) | KR20110074765A (https=) |
| CN (1) | CN102245238B (https=) |
| AU (1) | AU2009302957B2 (https=) |
| BR (1) | BRPI0920390A2 (https=) |
| CA (1) | CA2739068A1 (https=) |
| MX (1) | MX2011003690A (https=) |
| NZ (1) | NZ591957A (https=) |
| RU (1) | RU2519384C2 (https=) |
| WO (1) | WO2010042034A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005057685A1 (de) * | 2005-12-01 | 2007-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator und Speicher für eine trockene Arzneimittelformulierung sowie diesbezügliche Verfahren und Verwendung |
| EP2037999B1 (en) | 2006-07-07 | 2016-12-28 | Proteus Digital Health, Inc. | Smart parenteral administration system |
| US9125979B2 (en) | 2007-10-25 | 2015-09-08 | Proteus Digital Health, Inc. | Fluid transfer port information system |
| WO2009067463A1 (en) | 2007-11-19 | 2009-05-28 | Proteus Biomedical, Inc. | Body-associated fluid transport structure evaluation devices |
| KR20110074766A (ko) * | 2008-10-08 | 2011-07-01 | 아스트라제네카 아베 | 흡입 장치 및 의약 분배 방법 |
| KR101798128B1 (ko) | 2010-02-01 | 2017-11-16 | 프로테우스 디지털 헬스, 인코포레이티드 | 데이터 수집 시스템 |
| KR20120114368A (ko) | 2010-02-01 | 2012-10-16 | 프로테우스 디지털 헬스, 인코포레이티드 | 양 손목을 이용한 데이터 수집 시스템 |
| DE102012104850A1 (de) * | 2012-04-05 | 2013-10-10 | Alfred Von Schuckmann | Vorrichtung zur portionierten Ausgabe von Medikamenten |
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- 2009-10-07 JP JP2011530994A patent/JP5512686B2/ja not_active Expired - Fee Related
- 2009-10-07 EP EP09819488.9A patent/EP2341968B1/en not_active Not-in-force
- 2009-10-07 CN CN200980149118.8A patent/CN102245238B/zh not_active Expired - Fee Related
- 2009-10-07 NZ NZ591957A patent/NZ591957A/xx not_active IP Right Cessation
- 2009-10-07 US US13/123,714 patent/US9155851B2/en not_active Expired - Fee Related
- 2009-10-07 BR BRPI0920390A patent/BRPI0920390A2/pt not_active IP Right Cessation
- 2009-10-07 KR KR1020117010403A patent/KR20110074765A/ko not_active Ceased
- 2009-10-07 WO PCT/SE2009/051111 patent/WO2010042034A1/en not_active Ceased
- 2009-10-07 CA CA2739068A patent/CA2739068A1/en not_active Abandoned
- 2009-10-07 RU RU2011115404/14A patent/RU2519384C2/ru not_active IP Right Cessation
- 2009-10-07 AU AU2009302957A patent/AU2009302957B2/en not_active Ceased
- 2009-10-07 MX MX2011003690A patent/MX2011003690A/es not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0920390A2 (pt) | 2019-09-24 |
| JP5512686B2 (ja) | 2014-06-04 |
| AU2009302957A1 (en) | 2010-04-15 |
| NZ591957A (en) | 2013-08-30 |
| CN102245238B (zh) | 2014-09-10 |
| KR20110074765A (ko) | 2011-07-01 |
| WO2010042034A1 (en) | 2010-04-15 |
| RU2011115404A (ru) | 2012-11-20 |
| EP2341968B1 (en) | 2017-05-10 |
| MX2011003690A (es) | 2011-04-27 |
| EP2341968A1 (en) | 2011-07-13 |
| EP2341968A4 (en) | 2014-04-09 |
| AU2009302957B2 (en) | 2013-03-21 |
| JP2012505018A (ja) | 2012-03-01 |
| US9155851B2 (en) | 2015-10-13 |
| CN102245238A (zh) | 2011-11-16 |
| US20120048272A1 (en) | 2012-03-01 |
| CA2739068A1 (en) | 2010-04-15 |
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| Date | Code | Title | Description |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20151008 |