RU2519100C1 - Method of treating hypertrophic gingivitis - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: what is used is a preparation in the form of an ointment of the following composition: 70% infusion of Rhaponticum carthamoides rhizomes and roots or Silene tatarica herb - 10.0 ml, 70% infusion of St. John's wort herb - 5.0 ml, 70% infusion of calendula - 5.0 ml, 70% infusion of spiraea - 5.0 ml, clove essence - 1.0 g, Vaseline - 35.0 g, lanolin - 39.0 g used to coat a mucous membrane of the hypertrophied gingiva as an applicate for 15-20 minutes once a day for 14 days; abstaining from food for 2 hours is recommended.

EFFECT: manifested therapeutic effect in treating hypertrophic gingivitis, particularly by providing anabolic, capillary strengthening, anti-inflammatory action with retention of the effect for a long period of time.

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Description

The invention relates to medicine, namely to dentistry, and for the treatment of hypertrophic gingivitis, which is one of the urgent problems of modern dentistry.

According to recent studies, hypertrophic gingivitis is from 5.2 to 41.6% of cases in the overall structure of periodontal disease. This pathology to date refers to diseases that are least successfully treatable.

The reasons for the development of hypertrophic gingivitis can be both local factors and general ones. Poor oral hygiene, malocclusion, irrational orthodontic appliances and orthopedic structures, fillings with violation of the marginal fit are local factors in the etiology of hypertrophic gingivitis.

Hypertrophic gingivitis occurs against the background of drug treatment of diseases such as arterial hypertension, multiple sclerosis, insulin-dependent diabetes mellitus, epilepsy and others, during the hormonal adjustment of the body (pregnancy, menopause, adolescence), in people with somatic pathology.

The mechanism of development of hypertrophic gingivitis depends on the etiological factor. Hypertrophic gingivitis of the edematous form most often occurs during hormonal changes in the body: pregnancy, menopause, adolescence, and also when taking oral contraceptives. A high level of progesterone and estrogen stimulates inflammatory mediators, reduces the regulatory properties of interleukin and, as a result, decreases gum resistance against bacterial products, affects vascular permeability and exudation, and reduces the ability to keratinization and cellular regeneration.

Currently, conservative treatment of hypertrophic gingivitis boils down to professional oral hygiene, the appointment of topically anti-inflammatory, antimicrobial, anabolic, and sclerosing drugs. The arsenal of drugs used to treat hypertrophic gingivitis is great. However, despite the positive results of using various drugs, many of them cause allergic reactions, and the procedures for their use can be painful for the patient.

Our goal was to develop a new method for the treatment of hypertrophic gingivitis using the phytopreparation that we proposed, which would provide anabolizing, capillary-strengthening, anti-inflammatory, antimicrobial effects, was simple to manufacture, relatively inexpensive, and did not have undesirable effects.

This goal was realized with the help of a temporary medicinal product in the form of an ointment of the following composition: 70% tincture of rhizomes with roots of a leuzea or Tatar tar grass - 10.0 ml, 70% tincture of St. John's wort - 5.0 ml, 70% - Calendula tincture - 5.0 ml, 70% tavolga herb tincture - 5.0 ml, clove essential oil - 1.0 g, petrolatum - 35.0 g, lanolin - 39.0 g.

The preparation was prepared as follows: in the prepared mixture of petroleum jelly (35.0 g) and lanolin (39.0 g), taken in the prescribed amount, 10 ml of 70% tincture of rhizomes with roots of a leuzea or grass of a Tatar tar plant, 5.0 ml of 70% was added St. John's wort herb tinctures, 5.0 ml of 70% calendula tincture, 5.0 ml of 70% meadowsweet herb tincture and thoroughly emulsified this mixture. 1.0 g of clove essential oil was added to the resulting ointment and homogenized.

In the roots and rhizomes of safflower levzea, phytoecdysone - ecdysterone with anabolic activity was found. St. John's wort grass has antibacterial, antiseptic, astringent, antispasmodic properties, promotes tissue regeneration, has a beneficial effect on venous and peripheral circulation. Calendula has an anti-inflammatory, wound healing, bactericidal effect. Meadow grass has a bactericidal, hemostatic, anti-inflammatory, wound healing, astringent effect.

All of the above effects are achieved due to the content of phytoecdysteroids in these plants, which are structural analogues of molting hormones and insect metamorphosis and have unique biological properties: a powerful anabolizing effect due to the stimulation of protein synthesis, vasoprotective, immunostimulating, adaptogenic and tonic effects.

Clinical studies of the proposed method of treatment using herbal medicine was carried out at the Department of Therapeutic and Pediatric Dentistry, SBEI HPE Ryazan State Medical University of the Ministry of Health of Russia. We treated 25 patients aged 12 to 30 years with edematous hypertrophic gingivitis, including 5 men (20%) and 20 women (80%).

Patient treatment included local therapy according to the following method: the ducts of the salivary glands in the oral cavity were isolated, applicants of the proposed drug were applied to the mucous membrane of the hypertrophied gum for 15-20 minutes. After the procedure, patients were advised to abstain from food and water for 2 hours. The course of treatment is 14 days, the procedure was carried out 1 time daily.

The results of the study were evaluated in the period from two weeks to 6 months. Both in the short and long term, the results of treatment showed a pronounced therapeutic effect of the proposed method for the treatment of edematous form hypertrophic gingivitis: mild (100%), moderate (97.1%).

To assess oral hygiene, the Silness - Loe plaque index was used (Silness, Loe, 1964), orthopantomography was used to determine the condition of the bone tissue of the alveolar ridge and differential diagnosis with periodontitis.

Using a plaque index according to Silness and Loe (Silness, Loe, 1964), the degree of plaque intensity and its thickness in the area of the neck of the tooth, namely in the gingival groove, tooth surface and gingival margin, is estimated. In this case, a probe and a dental mirror are used. In the plaque index according to Silness and Loe, 4 degrees of evaluation are used: 0 degree - no plaque was detected during examination and probing; 1 degree - the presence of a thin film of plaque invisible during examination, which is detected only when the probe is scraped off the tooth surface; 2 degree - moderate deposition of plaque visible upon examination; plaque does not cover the interdental space; 3 points - intensive plaque deposition, also covering interdental space.

Index calculation for one tooth:

PLI of teeth = (∑ points of 4 surfaces) / 4.

Calculation of the index for a group of teeth:

PLI individual (∑ = teeth) / n teeth.

Example 1

04/07/2010 year. I visit.

Patient M., 18 years old, turned to the Department of Therapeutic and Pediatric Dentistry, GBOU VPO Ryazan State Medical University of the Ministry of Health of Russia with complaints of flaking of the gums from the teeth, bleeding of the gums when brushing the teeth in the front of the lower jaw.

Medical history: complaints of this nature are disturbing for 2 months.

Anamnesis of life: without features.

Objectively: In the area of teeth 33, 32, 31, 41, 42, 43, the gingival papillae are swollen, enlarged by 1/3 of the tooth crowns, bluish in color, with a shiny smooth surface, they bleed when probed. There are no gingival pockets.

Silness index and Loe = 2.

On the orthopantomogram - no bone changes are observed.

Diagnosis: 33, 32, 31, 41, 42, 43 mild hypertrophic gingivitis, edematous form.

Treatment: dental plaque was removed using the ultrasound method, a circular brush and Detartrin Z paste. The herbal preparation was applied to the mucous membrane of the gums in the tooth area 33, 32, 31, 41, 42, 43 for 20 minutes. A course of treatment was prescribed - 1 time daily, 14 days.

When you visit again after completing the course of treatment with the drug (04/22/2010): no complaints. Objectively: there is a decrease in gum volume, lack of bleeding, gingival papillae in the tooth area 33, 32, 31, 41, 42, 43 of a pale pink color, normal size, moderately moistened, do not bleed when probed. Silness and Loe Index = 1.3.

Six months after the treatment (November 7, 2010) there were no complaints; the gingival papillae in the area of the teeth 33, 32, 31, 41, 42, 43 were of a pale pink color, of normal size, moderately moistened, and did not bleed when probed. Silness and Loe Index = 1.5.

Example 2

02.24.2011 year. I visit.

Patient 3., 25 years old, turned to the Department of Therapeutic and Pediatric Dentistry, GBOU VPO Ryazan State Medical University of the Ministry of Health of Russia with complaints of proliferation of gums of the upper and lower jaw, bleeding gums when eating.

Medical history: complaints of this nature have been troubling for 6 months.

Anamnesis of life: the patient is at the 8th month of pregnancy.

Objectively: in the area of all teeth, the gingival papillae are increased in size to ½ of the tooth crowns, bluish in color, with a shiny smooth surface, bleed when probed.

Silness and Loe Index = 2.5.

On the orthopantomogram - no bone changes are observed. Diagnosis: generalized hypertrophic gingivitis of moderate severity, edematous form.

Treatment: dental plaque was removed using the ultrasound method, a circular brush with Detartrin Z paste. The herbal preparation was applied to the mucous membrane of the gums in the area of all teeth for 20 minutes. A course of treatment was prescribed - 1 time daily, 14 days.

When you visit again after completing the course of treatment with the drug (03/11/2011): no complaints, there is a decrease in gum volume, lack of bleeding, gingival papillae in the area of all teeth of a pale pink color, normal size, moderately moistened, do not bleed when probed. Silness and Loe Index = 1.5.

Six months after the treatment (August 24, 2011), there were no complaints; the gingival papillae in the area of the teeth were of a pale pink color, normal size, moderately moistened, and did not bleed when probed. Silness and Loe Index = 1.5.

Thus, the patented method of treating hypertrophic gingivitis using the preparation proposed by the authors provides a pronounced anabolizing, capillary-strengthening, anti-inflammatory effect with preserving the effect for a long time.

During the treatment, there was not a single case of undesirable complications.

The treatment method is convenient to use, physiological, indicating a complete recovery.

Literature

1. N.V. Kuryakina. Periodontal disease. Third edition, revised and supplemented. - Moscow, 2007.-S.77-81.

2. G.R. Bayramov. The study of periodontal pathogenic microflora and its etiological significance in the formation of various clinical forms of inflammatory periodontal diseases. - 2010. - No. 2 (54) .- P.84-86.

3. L. M. Tsepov, A. I. Nikolayev, E. A. Mikheeva. Diagnosis, treatment and prevention of periodontal disease. Third edition.- Moscow, 2008.-S.25-87.

Claims (1)

A method of treating hypertrophic gingivitis, characterized in that the preparation is in the form of an ointment, having the following composition: 70% tincture of rhizomes with roots of a leuzea or grass of Tatar tar sap - 10.0 ml, 70% tincture of St. John's wort - 5.0 ml, 70% tincture of calendula - 5.0 ml, 70% tincture of meadowsweet herb - 5.0 ml, clove essential oil - 1.0 g, petrolatum - 35.0 g, lanolin - 39.0 g, applied to as an application on the mucous membrane of hypertrophied gums for 15-20 minutes once a day for 14 days, recommending that patients refrain from eating for 2 hours.