RU2496494C2 - КОМБИНАЦИИ, СОДЕРЖАЩИЕ МОДУЛЯТОРЫ mGluR, ДЛЯ ЛЕЧЕНИЯ БОЛЕЗНИ ПАРКИНСОНА - Google Patents

КОМБИНАЦИИ, СОДЕРЖАЩИЕ МОДУЛЯТОРЫ mGluR, ДЛЯ ЛЕЧЕНИЯ БОЛЕЗНИ ПАРКИНСОНА Download PDF

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RU2496494C2
RU2496494C2 RU2011103083/15A RU2011103083A RU2496494C2 RU 2496494 C2 RU2496494 C2 RU 2496494C2 RU 2011103083/15 A RU2011103083/15 A RU 2011103083/15A RU 2011103083 A RU2011103083 A RU 2011103083A RU 2496494 C2 RU2496494 C2 RU 2496494C2
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hydroxycyclohexyl
chlorophenylethynyl
carboxylic acid
disease
parkinson
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RU2011103083/15A
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Russian (ru)
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RU2011103083A (ru
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Бальтасар ГОМЕС-МАНСИЛЬЯ
Фабрицио ГАСПАРИНИ
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Новартис Аг
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    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/16—Amides, e.g. hydroxamic acids
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    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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RU2011103083/15A 2008-06-30 2009-06-30 КОМБИНАЦИИ, СОДЕРЖАЩИЕ МОДУЛЯТОРЫ mGluR, ДЛЯ ЛЕЧЕНИЯ БОЛЕЗНИ ПАРКИНСОНА RU2496494C2 (ru)

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US7677208P 2008-06-30 2008-06-30
US61//076,772 2008-06-30
PCT/EP2009/058230 WO2010000763A2 (en) 2008-06-30 2009-06-30 Combination products

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RU2011103083A RU2011103083A (ru) 2012-08-10
RU2496494C2 true RU2496494C2 (ru) 2013-10-27

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US (2) US8703809B2 (enExample)
EP (2) EP2320892A2 (enExample)
JP (1) JP2011526596A (enExample)
KR (1) KR20110027817A (enExample)
CN (2) CN102131503A (enExample)
AU (1) AU2009265760B2 (enExample)
BR (1) BRPI0913642A2 (enExample)
CA (1) CA2729595C (enExample)
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EP2655326A1 (en) * 2010-12-20 2013-10-30 Novartis AG 4- (hetero) aryl - ethynyl - octahydro - indole - 1 - carboxylic acid esters
GB201204962D0 (en) 2012-03-21 2012-05-02 Addex Pharmaceuticals Sa Pharmaceutical combination products for parkinsons disease
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GB201312800D0 (en) 2013-07-17 2013-08-28 Heptares Therapeutics Ltd mGlu5 modulators
AU2018310881C1 (en) * 2017-07-31 2021-12-16 Novartis Ag Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use
JP2020529978A (ja) * 2017-07-31 2020-10-15 ノバルティス アーゲー アルコール使用の低減又はアルコール使用再燃の予防におけるマボグルラントの使用
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RU2698330C2 (ru) * 2014-04-21 2019-08-26 Сивитас Терапьютикс, Инк. Быстрое купирование двигательных флуктуаций при болезни паркинсона

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