RU2496329C1 - Premix for prevention and treatment of cattle and swine mycotoxicoses and such premix production method - Google Patents

Abstract

FIELD: food industry.

SUBSTANCE: invention relates to farming industry and may be used for prevention and treatment of cattle and swine mycotoxicoses. The proposed premix includes by way of the agent diacetophenonylselenide, beta-carotene, vitamin E and vitamin C (all dissolved in vegetable oil), vegetal phospholipids and wheat offal, at the following ration of components, wt %: diacetophenonylselenide - 0.001 - 0.01; beta-carotene - 0.001 - 0.01; vitamin E - 0.01 - 0.02; vegetal phospholipids - 0.1 - 0.2; vitamin C - 0.01 - 0.02; vegetable oil - 29.0 - 31.0 and wheat offal - balance. The production method involves dissolution of diacetophenonylselenide, beta-carotene, vitamin E and vitamin C in vegetable oil; first one dissolvesvegetal phospholipids at a temperature of 105-110°C during 30-40 minutes, then - the other components; the produced solution is applied onto wheat offal.

EFFECT: usage of the proposed group of inventions will enable treatment and prevention of mycotoxicoses with cattle and swine.

1 ex

Description

The invention relates to the field of animal husbandry, and can be used for the prevention and treatment of mycotoxicosis of cattle and pigs.

At present, industrial cattle breeding is faced with the problem of poor quality feed, which arose in connection with a violation of the technology for the production and storage of animal feed and the seeding of grain fodder with molds that form mycotoxins in the course of life. The consequence of the use of such feeds in cattle and pigs is a metabolic disorder, suppression of the immune system, impaired digestion of food and absorption of nutrients, weakening of the reproductive function and decreased productivity.

Known antitoxic sorbents (Ecosil, Mikosorb) used for the prevention of mycotoxicoses, which are a mixture of organic or mineral substances specially processed and activated for selective sorption of mycotoxins.

The effectiveness of the use of preparations of this type depends on the quality of preparation of the sorbent, the correct identification of mycotoxins for their selective binding with the necessary sorbent, which is very difficult to ensure on the farm, without special tools and personnel. This leads to the inability to obtain stable results in preventive measures.

Known premix for farm birds, in particular laying hens, containing selenium and vitamin E, as a filler containing corn gluten in the following ratio of components: selenium - 0.0014-0.0020 wt.% (0.014-0.020 kg / t premix) , vitamin E - 2.8-4.0 wt.% (28-40 kg / t premix), corn gluten - the rest (Patent RU No. 2332022 C1, A23K 1/00, publ. 08.28.2008).

The disadvantages include the fact that the premix is not intended for the treatment and prevention of mycotoxicosis.

The closest technical solution is the drug Carcesel (patent RU No. 2342119 C2, A61K 31/00, publ. 12/27/2008), which includes diacetophenonyl selenide, beta-carotene, vitamin E, vitamin C. The drug is an effective hepatoprotector, increases immune status.

The disadvantages include the difficulties of uniform distribution of the drug in large amounts of feed with such a small dosage of the drug (1 kg / 1 ton of feed), moreover, when the drug is introduced into ruminant feeds, bioavailability of biologically active substances is low due to their active consumption by the microflora of a multi-chamber stomach.

The technical result of the invention is the creation of a premix for the treatment and prevention of mycotoxicosis of cattle and pigs, increasing the bioavailability of the premix and the manufacturability of its use.

The technical result is achieved in that the premix for the prevention and treatment of mycotoxicosis of cattle and pigs, including diacetophenonyl selenide, beta-carotene, vitamin E, vitamin C dissolved in vegetable oil as an active principle, additionally contains vegetable phospholipids and wheat bran in the following ratio components, wt.%:

diacetophenonyl selenide - 0.001-0.01 beta carotene - 0.001-0.01 vitamin e - 0.01-0.02 plant phospholipids - 0.1-0.2 vitamin C - 0.01-0.02 vegetable oil 29.0-31.0 wheat bran - the rest.

The technical result is also achieved by the fact that in the method for producing a premix, including the dissolution of diacetophenonyl selenide, beta-carotene, vitamin E, vitamin C in vegetable oil, vegetable phospholipids are first dissolved at a temperature of 105-110 ° C for 30-40 minutes, then the rest components, after which the resulting solution is applied to wheat bran.

A significant novelty of the invention is the inclusion in the formulation of plant phospholipids and the application of an oil solution on a porous inert carrier - wheat bran.

The inclusion of plant phospholipids in the formulation allows one to increase the bioavailability of biologically active substances due to the formation of micellar structures that protect the biologically active substances from the aggressive effects of microflora during the passage of food through the multi-chamber stomach of ruminants, and application to wheat bran, which is a structure with a developed surface, leads to fixing micellar formations on the surface of bran particles and additional protection against absorption of microflora in the stomach e.

Applying an oil solution to wheat bran increases the technological effectiveness of the premix and allows you to dissolve small doses of the drug in a large amount of feed.

An example of the method

Example 1. Sunflower oil in an amount of 50 kg is placed in a sealed apparatus with a stirrer, heated to 106 ° C, 0.15% (75 g) of sunflower phospholipids are added, kept under stirring for 30 minutes, cooled to a temperature of 95 ° C and beta carotene (50 g), vitamin E (50 g), diacetophenonyl selenide (25 g), vitamin C (50 g). The resulting solution is applied to wheat bran in the ratio: oil phase - 30%, wheat bran - 70%.

Example 2. Sunflower oil in an amount of 50 kg is placed in a sealed apparatus with a stirrer, heated to 106 ° C, 0.1% (50 g) of soybean phospholipids are introduced, kept under stirring for 30 minutes, cooled to a temperature of 95 ° C and beta carotene (50 g), vitamin E (50 g), diacetophenonyl selenide (25 g), vitamin C (50 g). The resulting solution is applied to wheat bran in the ratio: oil phase - 30%, wheat bran - 70%.

Example 3. Sunflower oil in an amount of 50 kg is placed in a sealed apparatus with a stirrer, heated to 106 ° C, 0.2% (100 g) of rapeseed phospholipids are introduced, kept under stirring for 30 minutes, cooled to a temperature of 95 ° C and beta carotene (50 g), vitamin E (50 g), diacetophenonyl selenide (25 g), vitamin C (50 g). The resulting solution is applied to wheat bran in the ratio: oil phase - 30%, wheat bran - 70%.

The implementation of the proposed method will allow you to create a feed additive with increased bioavailability for the treatment and prevention of mycotoxicosis of cattle and pigs, increasing the biological safety of fed grain fodder, and reduce feed consumption by 0.1 feed unit per unit of production.

Claims (2)

1. Premix for the prevention and treatment of mycotoxicoses in cattle and pigs, including diacetophenonyl selenide, beta-carotene, vitamin E, vitamin C dissolved in vegetable oil as an active principle, characterized in that it additionally contains plant phospholipids and wheat bran in the following the ratio of components, wt.%:
diacetophenonyl selenide 0.001-0.01 beta carotene 0.001-0.01 vitamin e 0.01-0.02 plant phospholipids 0.1-0.2 vitamin C 0.01-0.02 vegetable oil 29.0-31.0 wheat bran rest 2. The method of producing the premix according to claim 1, comprising dissolving diacetophenonyl selenide, beta-carotene, vitamin E, vitamin C in vegetable oil, characterized in that vegetable phospholipids are first dissolved at a temperature of 105-110 ° C for 30-40 minutes, then other components, after which the resulting solution is applied to wheat bran.