RU2493847C2 - Фармацевтические составы для местного применения, содержащие низкую концентрацию бензоилпероксида в суспензии в воде и смешивающимся с водой органическом растворителе - Google Patents
Фармацевтические составы для местного применения, содержащие низкую концентрацию бензоилпероксида в суспензии в воде и смешивающимся с водой органическом растворителе Download PDFInfo
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- RU2493847C2 RU2493847C2 RU2010146038/15A RU2010146038A RU2493847C2 RU 2493847 C2 RU2493847 C2 RU 2493847C2 RU 2010146038/15 A RU2010146038/15 A RU 2010146038/15A RU 2010146038 A RU2010146038 A RU 2010146038A RU 2493847 C2 RU2493847 C2 RU 2493847C2
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- Prior art keywords
- water
- benzoyl peroxide
- composition
- concentration
- organic solvent
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
- A61K2800/33—Free of surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US61/131,014 | 2008-06-05 | ||
| PCT/US2009/003367 WO2009148584A1 (en) | 2008-06-05 | 2009-06-03 | Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent |
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| RU2013122395A Division RU2645087C2 (ru) | 2008-06-05 | 2013-05-15 | Фармацевтические составы для местного применения, содержащие низкую концентрацию бензоилпероксида в суспензии в воде и смешивающимся с водой органическом растворителе |
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| RU2493847C2 true RU2493847C2 (ru) | 2013-09-27 |
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| RU2013122395A RU2645087C2 (ru) | 2008-06-05 | 2013-05-15 | Фармацевтические составы для местного применения, содержащие низкую концентрацию бензоилпероксида в суспензии в воде и смешивающимся с водой органическом растворителе |
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| CA (1) | CA2723029C (OSRAM) |
| ES (1) | ES2773931T3 (OSRAM) |
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| RU (2) | RU2493847C2 (OSRAM) |
| WO (1) | WO2009148584A1 (OSRAM) |
| ZA (1) | ZA201008265B (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1919606A2 (en) | 2005-08-02 | 2008-05-14 | Sol-Gel Technologies Ltd. | Metal oxide coating of water insoluble ingredients |
| EP2545776A3 (en) | 2007-02-01 | 2014-12-24 | Sol-Gel Technologies Ltd. | Method for preparing particles comprising metal oxide coating and particles with metal oxide coating |
| CN102056481A (zh) * | 2008-06-05 | 2011-05-11 | 陶氏制药科学公司 | 包含低浓度的在水和水混溶性有机溶剂中的悬浮液形式的过氧苯甲酰的局部药物制剂 |
| US11298252B2 (en) | 2008-09-25 | 2022-04-12 | Advanced Bifurcation Systems Inc. | Stent alignment during treatment of a bifurcation |
| US20100099733A1 (en) * | 2008-10-20 | 2010-04-22 | Gordon Jay Dow | Method for obtaining a stable dispersion of benzoyl peroxide |
| MX350488B (es) * | 2009-10-21 | 2017-09-07 | Dow Pharmaceutical Sciences | Metodo para humectar un polvo que contiene peroxido de benzoilo. |
| US9744150B2 (en) * | 2009-10-21 | 2017-08-29 | Dow Pharmaceutical Sciences Inc. | Suspension containing micronized benzoyl peroxide |
| US9687465B2 (en) | 2012-11-27 | 2017-06-27 | Sol-Gel Technologies Ltd. | Compositions for the treatment of rosacea |
| CA2889199C (en) * | 2012-11-27 | 2020-05-19 | Sol-Gel Technologies Ltd. | Compositions for the treatment of rosacea |
| WO2017068673A1 (ja) * | 2015-10-21 | 2017-04-27 | マルホ株式会社 | 皮膚用の医薬組成物 |
| CN107304177B (zh) * | 2016-04-20 | 2020-09-15 | 武汉诺安药业有限公司 | 一种过氧苯甲酰微粉化的化学制备方法 |
| EP3651756B1 (en) | 2017-07-12 | 2025-09-03 | Sol-Gel Technologies Ltd. | Compositions comprising encapsulated tretinoin |
| JP2020527607A (ja) * | 2017-07-21 | 2020-09-10 | アルミラール・リミテッド・ライアビリティ・カンパニーＡｌｍｉｒａｌｌ， Ｌｌｃ | 非炎症性病変の処置 |
| CN107375209A (zh) * | 2017-08-30 | 2017-11-24 | 江苏嘉逸医药有限公司 | 一种过氧苯甲酰的局部药物制剂 |
| CN107737135A (zh) * | 2017-11-28 | 2018-02-27 | 江苏万川医疗健康产业集团有限公司 | 一种药物制剂及其制备方法与应用 |
| JP6811213B2 (ja) * | 2018-07-03 | 2021-01-13 | ソル − ゲル テクノロジーズ リミテッド | 酒さの治療のための組成物 |
| US10933046B2 (en) * | 2019-02-19 | 2021-03-02 | Sol-Gel Technologies, Ltd. | Method for treatment of rosacea in patients aged 65 years and older |
| MX2022001138A (es) * | 2019-08-01 | 2022-02-16 | Bausch Health Ireland Ltd | Composiciones topicas. |
| CN113577022B (zh) * | 2021-05-18 | 2023-03-17 | 南京欣通瑞亿医药科技有限公司 | 一种氨苯砜类化合物混悬液及其制备方法和应用 |
| EP4523677A1 (en) | 2023-09-13 | 2025-03-19 | Dr. Pfleger Arzneimittel GmbH | Topical composition of nadifloxacin and benzoyl peroxide |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993015726A1 (en) * | 1992-02-18 | 1993-08-19 | Baroody Lloyd J | Compositions of clindamycin and benzoyl peroxide for acne treatment |
| US6117843A (en) * | 1992-02-18 | 2000-09-12 | Lloyd J. Baroody | Compositions for the treatment of acne containing clindamycin and benzoyl peroxide |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3535442A (en) | 1967-10-19 | 1970-10-20 | John E Jennings | Anti-shoplifting and surveillance system |
| US4056611A (en) | 1973-04-16 | 1977-11-01 | Stiefel Laboratories, Inc. | Therapeutic composition |
| US4497794A (en) * | 1980-12-08 | 1985-02-05 | Dermik Laboratories, Inc. | Erythromycin/benzoyl peroxide composition for the treatment of acne |
| US4075353A (en) | 1976-06-09 | 1978-02-21 | Dermatologics For Veterinary Medicine, Inc. | Process for the treatment of acarid skin infections in animals |
| FR2378523A1 (fr) | 1977-01-26 | 1978-08-25 | Grupper Charles | Medicament pour le traitement de l'acne |
| US4189501A (en) | 1977-10-07 | 1980-02-19 | A. H. C. Pharmacal, Inc. | Composition and method for the treatment of acne |
| US4387107A (en) | 1979-07-25 | 1983-06-07 | Dermik Laboratories, Inc. | Stable benzoyl peroxide composition |
| NZ194326A (en) | 1979-07-25 | 1982-05-31 | Dermik Lab Inc | Stable aqueous benzoyl peroxide compositions and therapeutic compositions |
| IT1210608B (it) * | 1980-12-08 | 1989-09-14 | Rorer Int Overseas | Composizione per il trattamento topico dell'acne |
| US4411893A (en) | 1981-08-14 | 1983-10-25 | Minnesota Mining And Manufacturing Company | Topical medicament preparations |
| US4401835A (en) | 1981-09-17 | 1983-08-30 | Warner-Lambert Company | Method for preparing small sized benzoyl peroxide crystals |
| US4923900A (en) | 1985-01-24 | 1990-05-08 | Board Of Regents, The University Of Texas System | Therapeutic compositions containing benzoyl peroxide |
| US5446028A (en) * | 1985-12-12 | 1995-08-29 | Dermik Laboratories, Inc. | Anti-acne method and composition |
| FR2604435B1 (fr) | 1986-09-30 | 1988-12-02 | Oreal | Peroxydes aromatiques insatures et leur utilisation en therapeutique et cosmetique |
| IL105217A0 (en) | 1992-04-09 | 1993-07-08 | Allergan Inc | Method and composition for treating acne |
| US5466446A (en) | 1994-02-16 | 1995-11-14 | Stiefel Laboratories, Inc. | Topical compositions containing bensoyl peroxide and clindamycin and method of use thereof |
| US5470884A (en) | 1994-05-19 | 1995-11-28 | Procter & Gamble | Anti-acne compositions |
| DE4418096A1 (de) | 1994-05-24 | 1995-11-30 | Cassella Ag | Verwendung von Pteridin-Derivaten als Hemmstoffe der NO-Synthase |
| US5445823A (en) | 1994-10-20 | 1995-08-29 | The Procter & Gamble Company | Dermatological compositions and method of treatment of skin lesions therewith |
| US20020039561A1 (en) | 1995-11-15 | 2002-04-04 | Doughty Darrell Gene | Topical skin care compositions containing thickened polyol carboxylic acid esters as skin conditioning agents |
| US6071541A (en) * | 1998-07-31 | 2000-06-06 | Murad; Howard | Pharmaceutical compositions and methods for managing skin conditions |
| US6433024B1 (en) | 2000-05-08 | 2002-08-13 | Karl F. Popp | Topical anti-acne composition |
| US6387383B1 (en) | 2000-08-03 | 2002-05-14 | Dow Pharmaceutical Sciences | Topical low-viscosity gel composition |
| US6837383B1 (en) | 2001-01-25 | 2005-01-04 | Mcelhaney Jr Wayne | Tool organizer mounted to a vehicle lift rack |
| US20030064084A1 (en) | 2001-09-24 | 2003-04-03 | Bradley Pharmaceuticals, Inc. | Novel benzoyl peroxide compositions for the treatment of dermatological disorders and methods for their use |
| FR2833841B1 (fr) * | 2001-12-21 | 2005-07-22 | Galderma Res & Dev | Gel comprenant au moins un retinoide et du peroxyde de benzoyle |
| US7820186B2 (en) * | 2001-12-21 | 2010-10-26 | Galderma Research & Development | Gel composition for once-daily treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt |
| US20040101566A1 (en) | 2002-02-04 | 2004-05-27 | Elan Pharma International Limited | Novel benzoyl peroxide compositions |
| AR042906A1 (es) | 2003-01-24 | 2005-07-06 | Connetics Australia Pty Ltd | Espuma de fosfato de clindamicina sensible a la temperatura y metodo de tratamiento de acne que la utiliza |
| GB0403702D0 (en) * | 2004-02-19 | 2004-03-24 | Boots Co Plc | Skincare compositions |
| US20050239723A1 (en) * | 2004-04-27 | 2005-10-27 | Amin Avinash N | Compositions and methods useful for treatment of acne |
| US7153888B2 (en) | 2004-12-21 | 2006-12-26 | Alpharx Inc. | Stabilization of benzoyl peroxide in solution |
| WO2006099187A2 (en) | 2005-03-10 | 2006-09-21 | Jr Chem, Llc | Benzoyl peroxide compositions and methods of use |
| AR054805A1 (es) | 2005-06-29 | 2007-07-18 | Stiefel Laboratories | Composiciones topicas para el tratamiento de la piel |
| EP2206494B1 (en) | 2006-03-31 | 2015-12-02 | Stiefel Research Australia Pty Ltd | Foamable suspension gel |
| MXPA06008988A (es) | 2006-08-08 | 2008-02-07 | Fernando Ahumada Ayala | Preparaciones topicas antiacne que contienen retinoide (tazaroteno o adapaleno), antibiotico (fosfato de clindamicina) y/o queratolitico (peroxido de bonzoilo en microesponjas). |
| FR2910321B1 (fr) * | 2006-12-21 | 2009-07-10 | Galderma Res & Dev S N C Snc | Gel creme comprenant au moins un retinoide et du peroxyde de benzole |
| EP1967180A1 (de) | 2007-03-06 | 2008-09-10 | Almirall Hermal GmbH | Topische Zusammensetzung enthaltend einen Retinoid-Rezeptor-Agonist |
| CN102056481A (zh) * | 2008-06-05 | 2011-05-11 | 陶氏制药科学公司 | 包含低浓度的在水和水混溶性有机溶剂中的悬浮液形式的过氧苯甲酰的局部药物制剂 |
| KR102099993B1 (ko) * | 2011-12-09 | 2020-04-10 | 마리 케이 인코포레이티드 | 피부 케어 제형물 |
| US20200297684A1 (en) * | 2019-03-18 | 2020-09-24 | Bausch Health Ireland Limited | Topical compositions and methods for treating acne vulgaris |
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2009
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- 2009-06-03 MX MX2010013152A patent/MX2010013152A/es active IP Right Grant
- 2009-06-03 BR BRPI0913326A patent/BRPI0913326C1/pt active IP Right Grant
- 2009-06-03 WO PCT/US2009/003367 patent/WO2009148584A1/en not_active Ceased
- 2009-06-03 HR HRP20200450TT patent/HRP20200450T1/hr unknown
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- 2009-06-03 US US12/455,525 patent/US8288434B2/en active Active
- 2009-06-03 AU AU2009255679A patent/AU2009255679B2/en active Active
- 2009-06-03 KR KR1020107028278A patent/KR20110014651A/ko not_active Withdrawn
- 2009-06-03 RU RU2010146038/15A patent/RU2493847C2/ru active
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- 2013-05-15 RU RU2013122395A patent/RU2645087C2/ru active
- 2013-10-28 US US14/065,207 patent/US20140051649A1/en not_active Abandoned
- 2013-10-28 US US14/065,199 patent/US9078870B2/en active Active
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- 2014-09-16 JP JP2014188286A patent/JP6006272B2/ja active Active
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993015726A1 (en) * | 1992-02-18 | 1993-08-19 | Baroody Lloyd J | Compositions of clindamycin and benzoyl peroxide for acne treatment |
| RU2122412C1 (ru) * | 1992-02-18 | 1998-11-27 | Ллойд Дж. Бэруди Гордон Дж. Дау | Композиции клиндамицина и бензоилпероксида для лечения акне, набор для приготовления композиции, способ получения композиции, способ лечения акне |
| US6117843A (en) * | 1992-02-18 | 2000-09-12 | Lloyd J. Baroody | Compositions for the treatment of acne containing clindamycin and benzoyl peroxide |
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