RU2476152C2 - Method of predicting risk of development of chronic hyperplastic laryngitis - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to otolaryngology. In order to predict risk of development of chronic hyperplastic laryngitis qualitative and quantitative parameters of dermatographic patterns of both hands are examined with taking into account sex dimorphism. Delta index of Volotskoy is (DL₁₀) is calculated by formula DL₁₀=(L+2W/A+L+W)×10, where A is arches that have triradius, L is loops, which have one triradius, W is whorls, which have two triradii. If value of delta index of Volotskoy in men is 12.4±0.6, total crest score equals 152.7±2.9, and ulnar loop is present on one of fingers - on 3, 5 fingers of right hand and 1, 3, 4, 5 fingers of left hand, and if delta index of Volotskoy in women is 11.6±0.5, ulnar loop is present on one of fingers - on 1, 3, 5 fingers of right hand and 1, 5 finger of right hand of examined people, risk of disease development is predicted.

EFFECT: method makes it possible to predict risk of development of chronic hyperplastic laryngitis by dermatoglyphic signs.

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Description

The invention relates to the field of clinical medicine - otorhinolaryngology, and in particular to the problem of predicting the risk of developing chronic hyperplastic laryngitis based on dermatoglyphic signs.

The relevance of the proposed method due to the growing in recent years, the prevalence of chronic hyperplastic laryngitis in a population of people. Among all diseases of the ear, throat and nose, this pathology is currently about 10%, and in the occupational risk group it reaches 34% (Palchun V.T., 2008). However, chronic hyperplastic laryngitis presents the greatest danger from the point of view of the high probability of malignancy (Sadovsky V.N., 1994).

In this regard, the identification of markers for the development of chronic precancerous disease of the larynx is particularly important, allowing at the preclinical stage to assess the risk of background pathology and take preventive measures.

Since chronic inflammatory processes in the larynx are not accompanied by intoxication syndrome, do not cause changes in laboratory data, patients turn to the otolaryngologist even with the formed pathology. The diagnosis of chronic hyperplastic laryngitis is established on the basis of complaints, anamnesis and examination of the larynx. For this, standard research methods are used: laryngoscopy, fibrolaryngoscopy, video laryngostroboscopy (Vasilenko Yu.S., 2002). In many works, an important place in the diagnosis of laryngeal pathology is given to tomography of the larynx (Sdvizhkov A.M., Kozhanov L.G., Vasiliev P.V., 2006). Lapchenko A.S. et al. (2006) recommend the use of microspectrophotometry in their work.

To date, the main etiological factors of the development of chronic hyperplastic laryngitis, which are largely determined by the stage of ontogenesis, have been studied in sufficient detail, however, those individual characteristics that differ in their initial stability and can serve as a criterion for assessing an individual's predisposition to the development of chronic hyperplastic laryngitis.

Currently, it is proved that the hereditary constitution (genotype) and the external environment take part in the development of most diseases. Although heredity (genotype) plays a decisive role in the development of some signs or diseases, and the external environment is essential in the development of others, there are no signs that would depend only on heredity or only on the environment (Bochkov N.P., 2006). Chronic hyperplastic laryngitis is no exception.

An analysis of the literature showed that the method of dermatoglyphics was widely used to study the role of heredity in the development of diseases.

Despite the large amount of scientific data on the features of the dermal pattern in patients suffering from both somatic and genetic diseases, in the literature available to us we did not find information about the features of dermatoglyphics in chronic diseases of the larynx. Among the ENT pathologies there are descriptions of the features of the finger patterns in case of deafness (Gagaeva L.F., 1975), for otosclerosis (Trikozova L.V., 1975), in patients with juvenile nasopharyngeal angifibroma (Anyutin R.G., Kazey A.A., Guseva I.S., 1981), in patients with chronic otitis media, chronic sinusitis, sensorineural hearing loss, atrophic rhinopharyngitis, optochiasal arachnoiditis (Mazur Z.M., 1994), as well as in patients suffering from congenital sensorineural hearing loss and deafness (Lymarev A. IN 1999).

The novelty of the proposed method is predicting the risk of developing chronic hyperplastic laryngitis according to the characteristics of digital dermatoglyphic patterns at the stage of absence of clinical manifestations of the disease.

A significant difference is that they study the qualitative and quantitative indicators of dermatoglyphic patterns of the fingers of both hands, taking into account sexual dimorphism, and if men have 3, 5 fingers of the right hand and 1, 3, 4, 5 fingers of the left hand, the ulnar loop, the value of the Volotsky index 12.4 ± 0.6, with a total ridge score equal to 152.7 ± 2.9, as well as with the ulnar loop in women on 1, 3, 5 fingers of the right hand and 1.5 fingers of the left hand and with the Volotsky index equal to 11.6 ± 0.5, the subjects are assigned to the group risk of developing the disease.

The material for the study was the dermatoglyphic patterns of the terminal phalanges of the fingers obtained by examining 100 patients with chronic hyperplastic laryngitis. Fingerprints of 100 persons of the same gender and age without pathology of the larynx served as control.

The paper studied indicators of a qualitative analysis of fingerprints:

1) using Henry's classification (Henry, 1905, 1934), we determined the frequency of occurrence of finger patterns:

a) delta-free arc pattern (Arch-A) [figure 1],

b) one-delta patterns - radial or radial loops (Radial loops-R or Lr) and elbow or ulnar loops (Ulnar loops-U or Lu) [figure 2, 2a, 2b],

c) two-delta patterns — true curl (Whorls-W) and complex or compound patterns (C) [figure 3];

2) the study of the prevalence of patterns on the fingers of both hands;

3) making finger patterns of patterns for each and both hands;

4) calculation of indices: Furugates according to the formula I _F = w / L × 100%, Dunkmeyer according to the formula I _D = A / W × 100%, Fields according to the formula I _P = A / L × 100%, Cummins according to the formula L × 2W /one hundred%.

In addition, the indicators of quantitative analysis were studied:

1) determination of the crest count on each finger, in total on five and ten fingers, i.e. the number of scallops located between the triradius and the center of the pattern was calculated [figure 4];

2) the calculation of the Volotsky delta index by the formula DL ₁₀ = (L + 2W / A + L + W) × 10 (T. Gladkova, 1966).

The data obtained were considered taking into account sexual dimorphism separately for the right and left hands. Based on the obtained data, we revealed dermatoglyphic indices in patients with chronic hyperplastic laryngitis, which differ from the control group, which allows us to use them as criteria for diagnosing chronic hyperplastic laryngitis and identifying a group of patients at the preclinical stage of the disease.

If there are no coincidences of the results of the tests performed with the results of the group of patients with chronic hyperplastic laryngitis, then the test person does not have a genetically determined risk of developing this disease.

The following most reliable indicators were identified: the frequency of occurrence of the four most common types of patterns, the prevalence of patterns on the fingers of both hands, the Volotsky delta index, the total ridge count, the results of correlation, factor and regression analyzes.

The results of the qualitative analysis are presented in tables 1-4.

Table 1 Comparative characteristics of the frequency of finger patterns in patients with chronic hyperplastic laryngitis and in the control percentage (men). Patients n-50 Control n = 50 Patients n = 50 Control n = 50 1 finger BUT 0 2 2 four U 60 42 74 ** 52 R 0 0 0 0 W 38 52 22 38 2 finger BUT fourteen 16 fourteen twenty U eighteen 22 38 34 R 38 twenty fourteen 8 W thirty 38 22 36 FROM 0 four 12 2 3 finger BUT 6 16 8 6 U 80 ** 56 78 ** 52 R 0 6 0 2 W 12 twenty 12 36 FROM 2 2 2 four 4 finger BUT 6 fourteen four 6 U 62 58 78 ** 42 R 0 2 0 * fourteen* W 28 24 16 32 FROM four 2 2 6 5 finger BUT 0 four 0 four U 86 ** 72 96 ** 66 * R 0 0 0 0 W fourteen twenty four 26 FROM 0 four 0 four

As can be seen from table 1, for men suffering from chronic hyperplastic laryngitis, the presence of the ulnar loop (U) on 3, 5 fingers of the right hand and on 1, 3, 4, 5 fingers of the left hand is characteristic.

table 2 The prevalence of various types of patterns on the fingers in descending order in patients and in the control group (men). Fingers Sick The control Right Left Right Left I U> W> C> A = R U> W> A = C> R W> U> C> A> R U> W> C> A> R II W> R> U> A> C U> W> A = R> C W> U> R> A> C W> U> A> R> C III U> W> A> C> R U> W> A> C> R U> W> A> R> C U> W> A> C> R IV U> W> A> C> R U> W> A> C> R U> W> A> R = C U> W> R> C> A V U> W> A = R = C U> W> A = R = C U> W> A = C> R U> W> A = C> R I-V U> W> R> A> C U> W> A> C> R U> W> A> C> R U> W> A> C> R IX U> W> A> R> C U> W> A> C> R

Quantitative analysis results: the Volotsky delta index in men suffering from chronic hyperplastic laryngitis was 12.4 ± 0.6 with a control of 7.0 ± 0.4; the total ridge count in patients was 152.7 ± 2.9, and in the control group 113.7 ± 2.8.

Similar studies of finger dermatoglyphic patterns were also carried out in a group of women.

Table 3 Comparative characteristics of the frequency of finger patterns in patients with chronic hyperplastic laryngitis and in the control percentage (women). Pattern type Right hand Left hand Patients n = 50 Control n = 50 Patients n = 50 Control n = 50 1 finger BUT 0 2 2 2 U 86 ** 48 78 ** fifty R 0 2 0 2 W fourteen 36 16 38 FROM 0 12 four 8 2 finger

Pattern type Right hand Left hand Patients n = 50 Control n = 50 Patients n = 50 Control n = 50 A four four 8 22 U 40 36 40 42 R thirty 10 fourteen 2 W 22 48 36 32 FROM four 2 2 2 3 finger A four 16 four 8 U 80 ** 44 68 64 R 0 0 2 2 W fourteen 36 24 22 FROM 2 four 2 four 4 finger A 8 2 four 8 U 56 70 58 42 R 0 0 0 0 W 32 26 32 36 FROM four 2 6 fourteen 5 finger A 0 2 0 four U 94 ** 68 88 62 R 0 0 0 0 W 6 26 12 28 C 0 four 0 6 Note: p <0.05 compared with the control group

As can be seen from table 3 for women suffering from chronic hyperplastic laryngitis, the presence of the ulnar loop (U) on 1,3,5 fingers of the right hand and 1, 5 fingers of the left hand is characteristic.

Table 4 The prevalence of various types of patterns on the fingers in descending order in patients and in control (women). Fingers Sick The control Right Left Right Left I U> W> A = R = C U> W> C> A> R U> W> C> A = R U> W> C> A = R II U> R> W> A = C U> W> R> A> C W> U> R> A> C U> W> A> R = C III U> W> A> C> R U> W> A> R = C U> W> A> C> R U> W> A> C> R

Fingers Sick The control Right Left Right Left IV U> W> A> C> R U> W> C> A> R U> W> A = C> R U> W> C> A> R V U> W> A = R = C U> W> A = R = C U> W> C> A> R U> W> C> A> R I-V U> W> R> A> C U> W> A> R> C U> W> A> OR U> W> A> C> R IX U> W> R> A> C U> W> A> C> R

Quantitative analysis results: the Volotsky delta index in women suffering from chronic hyperplastic laryngitis was 11.6 ± 0.5 with a control of 6.4 ± 0.5; significant differences in the crest count in patients and in the control were not detected.

Example 1

H., 52 years old, male.

Chemist-technologist at the Ural Steel plant, 30 years of experience. Occupational hazards - chrome dust.

Does not smoke, does not abuse alcoholic beverages, moderate voice load.

Diagnosis: chronic hyperplastic laryngitis, prolapse of theorganic ventricle on the right. The experience of the disease is 8 years.

Concomitant diagnosis: arterial hypertension 2 tbsp., II tbsp.

In the study of digital dermatoglyphics revealed:

1) indicators of the qualitative analysis: the right hand is the ulnar loop on the 3rd finger, the left hand is the ulnar loop on the 1st, 3rd, 5th fingers;

2) indicators of quantitative analysis: the Volotsky delta index - 11.9, the total ridge count - 153.5.

Conclusion: the analysis of dermatoglyphics of N. corresponds to the results of a study of dermatoglyphics of men suffering from chronic hyperplastic laryngitis.

Example 2

P., 53 years old, woman.

The janitor in the dormitory for 15 years, before that, for 18 years she worked as a cutter in an atelier. Occupational hazards - none.

Does not smoke, does not abuse alcoholic beverages, moderate voice load.

Diagnosis: chronic diffuse hyperplastic laryngitis.

Disease experience of 6 years.

Concomitant diagnosis: coronary heart disease, arterial hypertension 2 tbsp., II tbsp.

In the study of digital dermatoglyphics revealed:

1) indicators of a qualitative analysis: the right hand is a ulnar loop on 1, 3, 5 fingers; left hand - ulnar loop on the 5th finger;

2) indicators of quantitative analysis: the Volotsky delta index - 11.2, the total ridge count - 107.3.

Conclusion: the analysis of dermatoglyphics of P. corresponds to the results of a study of dermatoglyphics of women suffering from chronic hyperplastic laryngitis.

Example 3

R., 51 years old, man.

Repairman at the Ural Steel plant, 30 years of experience. Occupational hazards - fuels and lubricants, coke dust, increased voice load in a noisy workshop.

Smokes for about 20 years, one pack of filter cigarettes a day, does not abuse alcohol.

Diagnosis: curvature of the nasal septum.

Concomitant diagnosis: duodenal ulcer, remission stage, arterial hypertension 2 tbsp., II tbsp.

In the study of digital dermatoglyphics revealed:

1) indicators of a qualitative analysis: the right hand is a ulnar loop on 1, 4, 5 fingers, arches on 2.3 fingers; left hand - curls on 1, 2, 3, 5 fingers, an arc on 4 fingers;

2) indicators of quantitative analysis: the Volotsky delta index - 6.9, the total ridge count - 112.3.

Conclusion: the analysis of dermatoglyphics of R. does not correspond to the results of a study of dermatoglyphics of men suffering from chronic hyperplastic laryngitis.

Example 4

A., 52 years old, woman.

Laboratory assistant sampler at the Ural Steel plant, 30 years of experience.

Occupational hazards - chrome dust.

Smokes half a pack a day for about 25 years, does not abuse alcoholic beverages, moderate voice load.

Pathology from the ENT organs was not detected.

Concomitant diagnosis: arterial hypertension 2 tbsp., II tbsp., Polyvalent allergy.

In the study of digital dermatoglyphics revealed:

1) indicators of a qualitative analysis: the right hand is a ulnar loop on 1, 2, 4, 5 fingers, an arc on 3 fingers; left hand - a ulnar loop on 1, 5 fingers, an arc on 2, 3 fingers, a curl on 4 fingers;

2) indicators of quantitative analysis: the Volotsky delta index - 6.7, the total ridge count - 108.6.

Conclusion: the analysis of dermatoglyphics of A. does not correspond to the results of a study of dermatoglyphics of women suffering from chronic hyperplastic laryngitis.

The advantages of the proposed method are that it can be expressed in clear quantitative terms and contains several features at the same time, each of which may have diagnostic value. In addition to high information content, this method is relatively inexpensive, quite simple and convenient for practical use as a "genetic screening". The advantages of the method can also include the constancy of dermatoglyphics with age and the ability to conduct a mass examination of large groups of people during professional examinations and professional selection. The level of development of the topic allows us to talk about the possibility of using the results of the work to identify risk groups for the development of chronic hyperplastic laryngitis with their subsequent registration at the dispensary and the development of individual prevention programs.

Literature.

1. Abramova T.F. Finger dermatoglyphics and physical abilities: Abstract. dis. Doct. biologist, sciences / T.F.Abramova. - M. 2003. - 47 p.

2. Anyutin R.G., Kazey N.S., Guseva I.S. Features of dermatoglyphics of patients with youthful angiofibroma of the nasopharynx // Health of Belarus. - 1981. - No. 7. - S. 29-31.

3. Bochkov N.P. Clinical Genetics: A Textbook. - 3rd ed., Rev. - M.: GEOTAR-Media, 2006 .-- 480 p .: ill.

4. Vasilenko Yu.S. Vote. Phoniatric aspects / Yu.S. Vasilenko. - M.: Energoizdat, 2002 .-- 480 p.

5. Vasilenko Yu.S. Diagnosis and therapy of laryngitis associated with gastroesophageal reflux / Yu.S. Vasilenko, I. Paan, G. Witt // Ros. otorhinolaryngology. - 2002. - No. 1. - S. 95-96.

6. Gagaeva L.F. To the analysis of factors affecting embryogenesis: dysplasia of the papillary pattern of hands in patients with deaf-mute // Tr. Crimea. honey. in-that. - 1975.- T.64. - S.99-101.

7. Gagaeva L.F. Materials for the analysis of violations of the morphogenesis of the papillary pattern of the brush (according to dermatoglyphics in patients with deaf mute) // Tr. Crimea. honey. in-that. - 1975.- T.64. - S. 97-98.

8. Gladkova T.D. Skin patterns of the brush and foot of monkeys and humans / T.D. Gladkova. - M .: Nauka, 1966 .-- 151 p.

9. Guseva I.S. Fragments for the study of the genetics of the papillary pattern of fingers. / I.S. Guseva. - Issues of anthropology. - 1967. - No. 27. - S. 123-131.

10. Lapchenko A.S. The possibility of using microspectrophotometry in the diagnosis of chronic hyperplastic laryngitis / A.S. Lapchenko, S.N. Kovalenko, D.L. Muratov // Materials of the XVII Congress of Otorhinolaryngologists of Russia. - SPb., 2006. - P.193.

11. Lymarev A.V. Clinical characteristics of congenital sensorineural hearing loss and deafness in children: Abstract. dis ... cand. honey. sciences. - Orenburg. - 1999. - 21 p.

12. Mazur Z.M. The diagnostic value of the signs of dermatoglyphics in ENT diseases: Author. dis ... cand. honey. sciences. - SPb. - 1994 - 21 p.

13. Sadovsky V.N. Direct microlaryngoscopy in the diagnosis and treatment of benign neoplasms, precancerous diseases and cancer of the larynx: Abstract. dis ... cand. honey. sciences. - Minsk. - 1994 .-- 24 p.

14. Shifts A.M. Clinical and diagnostic value of multispiral X-ray computed tomography with intravenous bolus contrasting in cancer of the larynx and larynx and pharynx / A.M.Sdvizhkov, L.G. Kozhanov, P.V. Vasiliev, etc. // Materials of the VII Congress of Otorhinolaryngologists of Russia. - SPb., 2006. - S.397-398.

15. Trikozova L.V. Dermatoglyphic data for otosclerosis // Non-purulent ear diseases. - Kuybyshev, 1975 .-- P.71-78.

Claims (1)

A method for predicting the risk of developing chronic hyperplastic laryngitis, including a clinical examination, characterized in that qualitative and quantitative indicators of dermatoglyphic finger patterns of both hands are examined taking into account sexual dimorphism, the Volotsky delta index (DL ₁₀ ) is calculated by the formula DL ₁₀ = (L + 2W / A + L + W) · 10, where A are arcs without triradius, L are loops having one triradius, W are curls having two triradius; and when the Volotsky index is 12.4 ± 0.6 for men, the total ridge score is 152.7 ± 2.9, and also if there is a ulnar loop on one of the fingers - on 3, 5 fingers of the right hand and 1, 3 , 4, 5 fingers of the left hand, as well as in women with the Volotsky index equal to 11.6 ± 0.5, the presence of the ulnar loop on one of the fingers - on 1, 3, 5 fingers of the right hand and 1, 5 finger of the left hand of the examined belong to the risk group for the development of the disease.

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