RU2475240C2 - Method for correction of immunobiochemical status in ante- and postpartum cows - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to veterinary science. The preparation metallosuccinate 10 ml is introduced intramuscularly three times before calving and two times after every 10 days.

EFFECT: method is effective for correction of the immunobiochemical status in ante- and postpartum cows, preventing reproduction pathologies and producing high-resistant newborn calves.

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Description

The invention relates to veterinary medicine, relates to a method for normalizing the immunobiochemical status of cows in the prenatal and postpartum period and can be used for therapeutic and prophylactic protection of cows from mass diseases of the reproductive organs and for obtaining a physiologically healthy offspring.

According to a number of authors [1, 2], obstetric pathology in the physiological periods of reproduction can take on a massive nature and is accompanied by a decrease in reproductive function.

The etiopathogenesis of mass obstetric pathology in cows is based on a state of stress maladaptation, accompanied by a decrease in immunological resistance.

The value of the status of the immunobiochemical status as a pathogenic factor in obstetric pathology of cows is confirmed by the low efficiency of methods of prophylaxis with the use of drugs without taking into account immunobiochemical processes [1].

A known method for the correction of metabolic pathologies, treatment and prevention of their consequences, including the use of a universal complex preparation containing sodium selenite, vitamin E, succinic acid, zinc sulfate and pharmazin, which is administered intramuscularly 45, 30, 15 days before delivery and on the day of delivery [ 3]. Also known is a method of normalizing the immunobiochemical status of cows in the prenatal and postpartum periods, including a single intramuscular injection of sodium selenite solution 20-25 days before calving. Twice administration before and twice after calving with an interval of 10 days is tetravita with a content of vitamin A, D, E and F. At the same time, succinic acid is administered orally for 20–25 days before calving [2].

However, the known methods are difficult to implement and do not ensure the normalization of the immunobiochemical status in full, acting on its individual indicators without taking into account the mechanisms of metabolic disorders depending on the physiological state of the animal.

The purpose of the invention is the normalization of the immunobiochemical status of cows in the prenatal and postpartum periods.

The task is achieved by intramuscular administration to cows of the drug “metallosuccinate” [4], containing ASD-F No. 2, succinic acid, water-soluble salts of trace elements, novocaine, polyethylene glycol in the following ratio,%: ASD-F No. 2 - 4.0; succinic acid - 1.0; iron sulfate - 0.2; copper sulfate - 0.01; zinc sulfate - 0.01; cobalt sulfate - 0.1; novocaine - 0.25; polyethylene glycol - 3.0; distilled water - the rest.

The method is as follows.

Cows are given three times before delivery and twice after delivery, with an interval of 10 days intramuscularly metallosuccinate 10 ml.

The feasibility of the method was determined in the scientific and industrial experience on cows, in the conditions of the Znamenskoye training experimental farm of the Kursk State Agricultural Academy, with the incidence of reproductive organs after calving.

All animals were in equal conditions (humidity, gas, temperature, grooming, feeding).

Cows of all groups were observed from the first day after they were transferred to the deadwood group until fruitful insemination. Calves were observed for 30 days after birth. In this case, the general condition of the animals, the incidence of postpartum complications, gynecological diseases, the weight of newborn calves, their incidence and safety during the first month of life were taken into account.

The essence of the method is illustrated by examples.

Example 1. To study the effect of various biologically active agents (metallosuccinate and tetravite) on the state of immunobiochemical status and reproductive organs, three groups of deep-skinned cows were formed on the basis of analogues.

Cows of the first group three times before birth and twice after birth with an interval of 10 days were injected intramuscularly with 10 ml of metallosuccinate.

The second group of cows was intramuscularly injected with 10 ml tetravit per a similar pattern.

The third group was the control (table 1 and 2).

It should be noted that the introduction of metallosuccinate 1.8-3.8 times reduces the number of postpartum diseases, accelerates the separation of the placenta and significantly increases the effectiveness of the first insemination. The weight of the fetus at birth is 2-3 kg more compared to calves of groups 2 and 3. The incidence of young gastrointestinal diseases during the observation period decreased.

The use of the drug metallosuccinate positively affects the hematological parameters of cows and carries out the correction of metabolism towards normalization, creating the basis for the effective protection of cows from mass diseases of the reproductive organs.

The positive effect of metallosuccinate on the immunobiochemical parameters of the blood of mother cows had an impact on the health status and immune status of the calves received from them.

Thus, the research results indicate that metallosuccinate has a high immunostimulating activity, quickly and effectively normalizes metabolic processes, has a beneficial effect on fetal development, increases its viability at birth and resistance to disease.

The dose of metallosuccinate administration was selected experimentally.

The original composition of metallosuccinate allows for targeted, highly effective correction of the immunobiochemical processes of the mother's body and to obtain a healthy highly resistant offspring.

table 2 The effect of metallosuccinate on the state of immunobiological homeostasis of cows Indicators groups one 2 3 metallosuccinate tetravite the control Hemoglobin, g / l

Red blood cells, 10 ¹² / L

Total serum protein, g / l

Glucose, mmol / L

Calcium, mmol / L

Phosphorus, mmol / L

Note: in the numerator - indicators 25-30 days before calving; in the denominator - indicators 20-25 days after calving.

Literature

1. Erokhin, A.S., Fedorchenko, O.A., Kuvshinov, V.S. Prevention of impaired reproductive function of cows / Veterinary medicine. - 1998. - No. 3. - S. 37-38.

2. RF patent No. 2252767 C1, 05.27.2005.

3. RF patent No. 2268033 C2, 01.20.2006.

4. RF patent No. 2351323 C2, 04/10/2009.

Claims (1)

A method for correcting the immunobiochemical status of cows in the prenatal and postpartum periods, which consists in the fact that the animals are intramuscularly injected with the drug metallosuccinate three times before calving and twice after calving with an interval of 10 days, 10 ml.