RU2472360C1 - Biologically active food additive with hypolipidemic effect - Google Patents

Abstract

FIELD: food industry.

SUBSTANCE: invention relates to food and medical industry and may be used for production of a high-quality biologically active additive applied as food to prevent atherosclerosis development or for manufacture of functional food products. The biologically active food additive is represented by phyto tea mixture of milled medicinal plant raw materials and includes the following ingredients: dioscorea caucasica roots, ground burnut herb, cow clover flowers, white mistletoe shoots, blackberry leaves, blackcurrant leaves, origanum herb, caraway fruits at a weight ratio of 2:2:2:2:4:4:2:1 respectively.

EFFECT: invention allows to produce a new biologically active food additive that positively affects the total organism condition, improves rheological properties of blood, has expressed hypolipidemic effect and is effective remedy to prevent atherosclerosis development.

2 cl, 1 tbl, 2 ex

Description

FIELD OF THE INVENTION

The invention relates to the food and medical industries and can be used to obtain high-quality biologically active additives (BAA) used in food as a preventive measure for the development of atherosclerosis and the creation of functional food products. Dietary supplement is a phyto-collection of crushed medicinal plant material that contains eight components: Caucasian dioscorea root, creeping grass, meadow clover flowers, white mistletoe shoots, blackberry leaves, black currant leaves, oregano grass, caraway seeds in proportion, parts by weight 2: 2: 2: 2: 4: 4: 2: 1, respectively. The crushed phyto-collection is packaged in filter bags, which ensures convenience in reception and storage.

Food supplements are a source of flavonoids (rutin, quercetin), saponins (tribusponin), essential oils, vitamins, organic acids (salicylic, coumaric, ursolic), trace elements (calcium, potassium, magnesium, boron).

The aim of the invention is the creation of an effective, convenient to use, with pleasant organoleptic properties of dietary supplements to food lipid-lowering action as a prevention of the development of atherosclerosis, to normalize metabolism and for diet therapy.

State of the art

Currently, the patent of the Russian Federation No. 2020952 C1 for the invention of anti-atherosclerotic fees: “Elena” and “Daria” is known. The collection “Elena” contains clover, licorice root, nettle, shepherd’s bag, motherwort, catnip, oak bark, sage, calendula, chamomile, oregano, and grass. Collection "Daria" contains clover, licorice root, nettle, buckthorn bark, motherwort, mint, flax seed, senna leaf. The disadvantage of these fees is their symptomatic effect on the patient, which does not fully take into account the entire pathogenic chain inherent in this disease.

Known therapeutic drugs in the form of phyto-collection for the treatment of patients with various types of disorders of the cardiovascular system, in particular, patents of the Russian Federation No. 2000807, No. 2019185, No. 2020952, No. 2088250, No. 2104024. However, these phytotherapeutic agents relate to drugs and, therefore, require medical prescription and control, i.e. do not apply to prophylactic drugs that have the status of dietary supplements.

Known drug "Polysponin", which is an extract from the rhizomes and roots of Nippon dioscorea, which is used as a hypocholesterolemic agent.

Known collection for the treatment of cardiovascular diseases (RF patent No. 2163132 C1), which contains clover flowers, Scutellaria root, primrose grass, hawthorn flowers, lilac flowers, cornflower flowers, aerial part of St. John's wort, sweet clover grass, tansy flowers, dried grass, grass motherwort, parsnip grass, thyme grass, white mistletoe, peony root, verbena grass, burdock root, peppermint grass, rue grass, hop cones, knotweed grass, bedstraw grass, elecampane root, godson root, guelder-rose berries, astragalus, root, root jaundice grass a, arnica grass, adonis grass. The collection contains medicinal plants of antisclerotic and general strengthening effect. The main disadvantage of this collection is its multicomponent composition, which creates certain organizational and technological difficulties in production.

The result achieved when using the invention is to obtain a metered dose drug that meets the status of dietary supplement, consisting of highly effective ingredients, the combined effect of which, on the one hand, ensures the effectiveness of lipid-lowering effects, and on the other hand, has an expanded spectrum of preventive and healing effects on the body. Technological features of the production of dietary supplements do not create difficulties in its production, and the consumer form provides the body with the perception of the entire amount of biologically active substances and ease of reception and storage. These requirements correspond to the presented dietary supplement.

SUMMARY OF THE INVENTION

Supplement to food lipid-lowering action contains the following components:

1. Dioscorea of the Caucasian rhizome - 2 parts;

2. Anchors creeping grass - 2 parts;

3. Clover meadow flowers - 2 parts;

4. Mistletoe white shoots - 2 parts;

5. Blackberry leaves - 4 parts;

6. Blackcurrant leaves - 4 parts

7. Oregano grass - 2 parts;

8. Caraway seeds fruits - 1 part.

New and significant is that dietary supplement has a balanced composition, includes these components in an optimal ratio, which allows them to mutually complement and enhance the action in the complex, to exert not a symptomatic, but a regulatory effect on the body. The composition of dietary supplements is made taking into account the contribution of biologically active substances of each component for the prevention of atherosclerosis. The plant components included in the dietary supplement have the following positive effects on the human body:

- Caucasian dioscorea, due to the presence of saponins in the roots, has a pronounced hypocholesterolemic effect;

- tribusponin (steroid glycoside), contained in the grass of the Tribulus, lowers cholesterol, increases the coefficient of lecithin / cholesterol, reduces the degree of hypercoagulation of blood. Long-term use of tribusponin prevents lipid infiltration of the aortic wall and, therefore, the development of the atherosclerotic process;

- meadow clover, due to the presence of glycosides of trifolin and isotrifolin, salicylic and coumaric acids, has anti-atherosclerotic, anticoagulant, desensitizing, anti-inflammatory and analgesic properties;

- shoots of white mistletoe exhibit anti-atherosclerotic, hypotensive, analgesic effect, which is due to the content of acetylcholine, choline, propionylcholine, viscerol, viscose, ursolic and oleanolic acids;

- Blackberry leaves help to improve metabolism and blood composition, reduce nervous tension, which is one of the factors for the development of atherosclerosis, the effect of blackberries is due to the content of flavonoids, tannins, ascorbic and organic acids in the leaves;

- blackcurrant leaves with a high content of ascorbic acid (0.25%) have a pronounced general strengthening effect: they increase redox processes in the body, activate a number of enzyme systems, stabilize the content of adrenaline, catecholamines, favorably affect carbohydrate metabolism and vascular permeability;

- marjoram grass, due to the presence of essential oil, thymol, geranyl acetate, sesquiterpenes, flavonoids, tannins, has anti-inflammatory, antispasmodic, sedative effects, which positively affects the general condition of the body as a whole;

- essential oil of caraway fruits, which includes carvone, has an antispasmodic, anti-inflammatory effect.

The claimed dietary supplement is an effective anti-atherosclerotic agent: it improves the metabolism and blood composition, reduces the degree of blood hypercoagulation, favorably affects lipid and carbohydrate metabolism, and increases redox processes in the body, thereby contributing to the prevention of atherosclerosis and overall strengthening of the body. In addition, dietary supplement has pleasant organoleptic properties.

Food supplements are obtained by mechanical mixing of pre-dried and crushed medicinal plant materials to a particle size of 1.5-2 mm, followed by packing in filter bags.

Supplements are prepared as follows: pour 200 ml of hot water into the filter bag, close the lid and insist for 15 minutes. Take orally in a warm form after eating, 1 glass 3 times a day for 3 weeks, then a week break. The course is 6 months.

Supplements lipid-lowering action showed good results, as evidenced by biochemical research methods, which confirms the effectiveness of the proposed collection.

Example 1. Patient A., 48 years old, complained of weather dependence, headaches and fatigue. As a result of the examination, primary hyperlipidemia was diagnosed. The patient was prescribed dietary supplement lipid-lowering action. After three weeks of using dietary supplements, the condition improved, and the body fatigue decreased. After a week-long break, the course was continued for 3 weeks. Biochemical methods for examining the patient's blood showed a decrease in total cholesterol (cholesterol), triglycerides (TG) and low-density lipoprotein cholesterol (cholesterol-LDL).

Example 2. Patient M., 39 years old, complained of overweight and fatigue. A comprehensive examination and study of the dynamics of the objective signs of the disease was carried out: the level of blood pressure, heart rate, ECG and biochemical parameters of a blood test. Hyperlipoproteinemia has been identified. The patient was prescribed dietary supplement lipid-lowering action. After 3 weeks of admission, the patient's condition improved, there was a decrease in the levels of total cholesterol, TG and LDL-C. Tolerance of dietary supplements was good.

The results of biochemical studies of patients are presented in table 1.

Table 1 Levels of total cholesterol, triglycerides and low-density lipoprotein cholesterol in patients No. p / p Indicators before admission
Dietary supplement Indicators after taking dietary supplements Cholesterol total., Mmol / l TG, mmol / l XL - LDL
mmol / l Cholesterol total., Mmol / l TG, mmol / l Cholesterol - LDL, mmol / l Patient 1 7.4 2,33 4.72 4.3 1.47 2.67 Patient 2 8.2 2.83 4.90 5,0 1,60 2.80

A lipid-lowering dietary supplement can be recommended as a prophylaxis for the development of atherosclerosis, as well as for normalizing metabolism and for diet therapy.

Assessment of the organoleptic properties of dietary supplements was carried out by questionnaire-survey method. Its good organoleptic properties were noted. None of those participating in the tasting noted any unpleasant “aftertaste”.

Thus, as a result of the implementation of the proposed invention, a dietary supplement for food was obtained, which, due to the optimal combination of natural components, has a lipid-lowering effect, has a beneficial effect on the body, and has pleasant organoleptic properties.

The proposed nutritional supplement expands the scope of medicinal plants and can be used in the food industry for the targeted production of new products with preventive properties.

Claims (2)

1. Biologically active food supplement, including the Caucasian dioscorea root, creeping grass, Clover meadow flowers, white mistletoe shoots, blackberry leaves, blackcurrant leaves, oregano grass, caraway fruits in a ratio, parts by weight 2: 2: 2: 2: 4: 4: 2: 1, respectively. 2. Biologically active food supplement according to claim 1, characterized in that the pre-dried and crushed to a particle size of 1.5-2 mm natural components are mixed and packaged in filter bags.