RU2455039C1 - Method of photodynamic therapy of malignant growths - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention concerns medicine, oncology, and is applicable for photodynamic therapy of malignant growths. That is ensured by photodynamic therapy. For this purpose, a photosensitiser is introduced in suppositories through rectum. The photosensitiser is presented by mixed chlorine derivatives and spirulina platensis with added excipient for suppositories. The suppository ingredients are taken in the following proportions, wt %: chlorine derivatives -0.1-0.4; spirulina platensis -3-4.5; excipient - 95.1-96.9. The new grown is exposed to light at wave length corresponding to a maximum absorption of chlorine derivatives.

EFFECT: method enables higher clinical effectiveness, eliminated disadvantage of the invasive introduction.

7 cl_; 2 ex

Description

The invention relates to medicine and can be used in oncology for the treatment of malignant neoplasms of the skin and mucous membrane, as well as in ophthalmology for the treatment of intraocular neoplasms.

A known method of photodynamic therapy of malignant neoplasms, including the introduction of the drug and laser irradiation of the neoplasm (see RF patent No. 2161053).

The disadvantages of this method are vascular injury with intravenous administration of the drug, the risk of infection with viral diseases, allergic reactions and the high cost of the drug.

According to the technical essence, the closest to the proposed invention is a method for the photodynamic therapy of malignant neoplasms, which includes administering the drug and laser irradiation of the neoplasm, and the drug of plant origin is taken orally on an empty stomach at a dose of 10.0 mg / kg and the laser irradiation is carried out through 3- 4 hours with a wavelength corresponding to the maximum absorption by the porphyrin derivative of light radiation (see RF patent No. 2294224, class A61N 5/067, dated April 26, 2005).

However, the composition of the drug and its implementation in the known method do not allow sufficiently efficient accumulation of the photosensitizer in the critical organ, since the composition of the drug lacks a means of targeted delivery of the photosensitizer to the critical organ. In addition, the method of using the drug is not always effective, since its delivery to a critical organ depends on many parameters.

The technical result is to increase the effectiveness of treatment by optimizing the process of delivery of the photosensitizer to the critical organ.

This is achieved by the fact that in the method of photodynamic therapy of malignant neoplasms, including the introduction of a photosensitizer and light irradiation of the neoplasm, which is carried out after the above administration with a wavelength corresponding to the maximum absorption of chlorine derivatives, according to the invention, candles containing chlorine derivatives mixed with spirulina are used as photosensitizer platensis and with a filler for the formation of suppositories, and the introduction of a photosensitizer is carried out rectally, with nents candles photosensitizer are taken in the following ratio, wt.%:

Chlorine derivatives 0.1-0.4 Spirulina platensis 3-4.5 Filler 95.1-96.9

and cocoa bean oil is used as a filler, moreover, LED or laser irradiation is used as light irradiation, and chlorin e6 in the form of N-methylglucamine salt is used as chlorine derivatives, wherein the wavelength of light irradiation is taken to be 650-670 nm for LED irradiation or 662 nm for laser irradiation, the dose of light irradiation is 300-900 J / cm ² , which is carried out 3-4 hours after the introduction of the photosensitizer.

A comparison of the proposed technical solutions with the known ones allows us to confirm compliance with the criterion of "novelty", and the absence of distinctive features in the analogues indicates the compliance with the criterion of "inventive step". Preliminary tests suggest the possibility of wide industrial use.

The method is as follows.

In the morning after a cleansing enema, a photosensitizer is administered rectally to the patient in the form of a suppository, the components of which are taken in the following weight ratios:

Chlorine derivatives 5-20 mg Spirulina platensis 100-150 mg Filler 3.5-4 g

This corresponds to a ratio in wt.%:

Chlorine derivatives 0.1-0.4 Spirulina platensis 3-4.5 Filler 95.1-96.9

Chlorin e6 in the form of N-methylglucamine salt is used as chlorine derivatives. After that, after 3-4 hours, light irradiation is carried out with a wavelength of 650-670 nm for LED irradiation or 662 nm for laser irradiation, which corresponds to the maximum absorption of light radiation by the chlorine derivatives.

In this case, the radiation dose is 300-900 J / cm ² , and the radiation dose of less than 300 J / cm ^{2 is} not effective, and at a dose of more than 900 J / cm ² damage to surrounding healthy tissues occurs - a burn. In the treatment of tumors with a height of 1-1.5 mm, doses from 300 J / cm ^{2 are used} , in the treatment of tumors with a height of 2-3 mm - up to 600 J / cm ² , and in the treatment of tumors with a height of 5 mm - up to 900 J / cm ² .

It should be noted that, if necessary, the procedure for introducing suppositories and irradiation is permissible to be repeated or repeatedly to establish the objective dynamics of the patient's condition, and depending on the weight of the patient, it is permissible to use several candles in one procedure. It is obvious to a person skilled in the art that the above described actions can be modified within the framework of the present invention, for example, depending on the functional state of the patient and his weight characteristics.

The invention is illustrated by the following examples.

Example No. 1.

Patient D., 50 years old. Diagnosis: basal cell cancer of the left auricle of the 1-2 stage.

The patient was treated according to the proposed method. As a photosensitizer, candles containing chlorine derivatives mixed with spirulina platensis and with a filler in the form of cocoa bean butter were used.

The components of the photosensitizer candles were taken in the following weight ratios, wt.%:

Chlorine derivatives -0.2 Spirulina platensis -four% Filler -95.8

In the morning, a candle was rectally injected, and after 4 hours, laser irradiation was performed with a wavelength of 662 nm at a dose of 600 J / cm ² .

The next day, a candle was also introduced in the morning, and after 4 hours, laser irradiation was performed with a wavelength of 662 nm at a dose of 600 J / cm ² .

The above actions were carried out daily for a week. During the follow-up examination after 1 month, the tumor disappeared. Allergic reactions are not noted.

Example No. 2.

Patient K., 52 years old. Diagnosis: Basal cell carcinoma of the vulva, stage 2. The patient was treated according to the above method.

A candle was introduced rectally. LED irradiation was carried out after 3 hours with a wavelength of 650-670 nm in a dose of 600 J / cm ² .

The above actions were carried out daily for a week. A follow-up examination after 25 days showed a positive trend in the form of the disappearance of the tumor.

Thus, in the proposed method achieved the technical result.

Claims (7)

1. The method of photodynamic therapy of malignant neoplasms, including the introduction of a photosensitizer and light irradiation of the neoplasm, which is carried out after the above introduction with a wavelength corresponding to the maximum absorption of chlorine derivatives, characterized in that candles containing chlorine derivatives mixed with spirulina platensis are used as photosensitizer with a filler for the formation of candles, and the introduction of a photosensitizer is carried out rectally, and the components of the photosensit candle Izator taken in the following ratio, wt.%: chlorine derivatives 0.1-0.4; spirulina platensis 3-4.5; filler 95.1-96.9. 2. The method according to claim 1, characterized in that cocoa bean oil is used as a filler. 3. The method according to claim 1, characterized in that the light irradiation using LED or laser irradiation. 4. The method according to claim 1, characterized in that chlorin e6 in the form of N-methylglucamine salt is used as the chlorine derivatives. 5. The method according to claim 4, characterized in that the wavelength of light irradiation is taken equal to 650-670 nm for LED irradiation or 662 nm for laser irradiation. 6. The method according to claim 1, characterized in that the radiation dose is 300-900 J / cm ² . 7. The method according to claim 1, characterized in that the light irradiation is carried out 3-4 hours after the introduction of the photosensitizer.