RU2441875C2 - Терапевтические соединения - Google Patents

Терапевтические соединения Download PDF

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Publication number
RU2441875C2
RU2441875C2 RU2009102531/04A RU2009102531A RU2441875C2 RU 2441875 C2 RU2441875 C2 RU 2441875C2 RU 2009102531/04 A RU2009102531/04 A RU 2009102531/04A RU 2009102531 A RU2009102531 A RU 2009102531A RU 2441875 C2 RU2441875 C2 RU 2441875C2
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RU
Russia
Prior art keywords
pain
compound
disease
use according
inflammation
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RU2009102531/04A
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English (en)
Russian (ru)
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RU2009102531A (ru
Inventor
Майкл ХИГГИНБОТТОМ (GB)
Майкл Хиггинботтом
Эдвард Дэниел СЕЙВОРИ (GB)
Эдвард Дэниел СЕЙВОРИ
Джайлз Альберт БРАУН (GB)
Джайлз Альберт БРАУН
Виет-Ан Энн ХОРГАН (урожденная НГУЙЕН) (GB)
Виет-Ан Энн ХОРГАН (урожденная НГУЙЕН)
Эмма Джейн ЧЭПМЭН (GB)
Эмма Джейн ЧЭПМЭН
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СиБиТи ДЕВЕЛОПМЕНТ ЛИМИТЕД
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Publication of RU2009102531A publication Critical patent/RU2009102531A/ru
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
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    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
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    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • AHUMAN NECESSITIES
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    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
RU2009102531/04A 2006-06-27 2007-06-26 Терапевтические соединения RU2441875C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE0601398 2006-06-27
SE0601398-1 2006-06-27
US83714606P 2006-08-11 2006-08-11
US60/837,146 2006-08-11

Publications (2)

Publication Number Publication Date
RU2009102531A RU2009102531A (ru) 2010-08-10
RU2441875C2 true RU2441875C2 (ru) 2012-02-10

Family

ID=38537489

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2009102531/04A RU2441875C2 (ru) 2006-06-27 2007-06-26 Терапевтические соединения

Country Status (9)

Country Link
US (1) US7807685B2 (enExample)
EP (1) EP2081946B1 (enExample)
JP (1) JP2009541438A (enExample)
CN (1) CN101479289A (enExample)
AU (1) AU2007263728A1 (enExample)
CA (1) CA2654375A1 (enExample)
NZ (1) NZ573308A (enExample)
RU (1) RU2441875C2 (enExample)
WO (1) WO2008000745A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2081932A2 (en) * 2006-06-27 2009-07-29 BIOVITRUM AB (publ) 2-o'-methyladenosine derivatives and their use as agonists or antagonists of an adenosine receptor
US20100160351A1 (en) * 2008-12-19 2010-06-24 Nuon Therapeutics, Inc. Pharmaceutical compositions and methods for treating hyperuricemia and related disorders
WO2010071865A1 (en) 2008-12-19 2010-06-24 Nuon Therapeutics, Inc. Pharmaceutical compositions and methods for treating hyperuricemia and related disorders
WO2011032175A1 (en) 2009-09-14 2011-03-17 Nuon Therapeutics, Inc. Combination formulations of tranilast and allopurinol and methods related thereto
CA2830324A1 (en) * 2011-03-31 2012-10-04 Konstanze Schafer Perfluorinated compounds for non-viral transfer of nucleic acids
HK1208598A1 (en) * 2012-02-11 2016-03-11 中央研究院 Methods and compositions for treating pain
KR102692448B1 (ko) * 2019-05-21 2024-08-05 나티아스 인크. 올리고뉴클레오티드 합성에 사용하는 멀티플루오로스블록머 및 이를 사용한 올리고뉴클레오티드 합성방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2396108A (en) * 2002-12-09 2004-06-16 Cambridge Biotechnology Ltd Treatment of pain with spongosine
UA72912C2 (uk) * 1999-02-01 2005-05-16 Юніверсіті Оф Вірджінія Патент Фаундейшн Композиція для лікування запальної реакції

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05504552A (ja) * 1989-10-24 1993-07-15 ギリアド サイエンシズ,インコーポレイテッド 2’位が改変されたオリゴヌクレオチド
EP0601322A3 (en) 1992-10-27 1994-10-12 Nippon Zoki Pharmaceutical Co Adenosine deaminase inhibitor.
US5877180A (en) * 1994-07-11 1999-03-02 University Of Virginia Patent Foundation Method for treating inflammatory diseases with A2a adenosine receptor agonists
GB0305153D0 (en) 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Identification of therapeutic compounds
GB0305149D0 (en) 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Compounds for the treatment of pain
GB0305150D0 (en) 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Use of therapeutic compounds
MXPA06010075A (es) * 2004-03-05 2007-04-10 Cambridge Biotechnology Ltd Compuestos terapeuticos.
EP2081932A2 (en) * 2006-06-27 2009-07-29 BIOVITRUM AB (publ) 2-o'-methyladenosine derivatives and their use as agonists or antagonists of an adenosine receptor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA72912C2 (uk) * 1999-02-01 2005-05-16 Юніверсіті Оф Вірджінія Патент Фаундейшн Композиція для лікування запальної реакції
GB2396108A (en) * 2002-12-09 2004-06-16 Cambridge Biotechnology Ltd Treatment of pain with spongosine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Zhan-Guo Gao et al, "2-Substituted adenosine derivatives: affinity and efficacy at four subtypes of human adenosine receptors", Biochemical Pharmacology, 2004, vol.68, pp.1985-1993. J.M.Rieger et al, "Design, Synthesis and Evaluation of Novel A2A Adenosine Receptor Agonists", Journal of Medicianl Chemistry, 2001, vol.44, pp.531-539. *

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Publication number Publication date
NZ573308A (en) 2012-02-24
US7807685B2 (en) 2010-10-05
US20080076776A1 (en) 2008-03-27
JP2009541438A (ja) 2009-11-26
WO2008000745A3 (en) 2008-04-17
EP2081946B1 (en) 2012-05-30
CA2654375A1 (en) 2008-01-03
AU2007263728A1 (en) 2008-01-03
RU2009102531A (ru) 2010-08-10
EP2081946A2 (en) 2009-07-29
CN101479289A (zh) 2009-07-08
WO2008000745A2 (en) 2008-01-03

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