RU2422513C2 - Способы экспансии популяций миелоидных клеток и их использование - Google Patents
Способы экспансии популяций миелоидных клеток и их использование Download PDFInfo
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- RU2422513C2 RU2422513C2 RU2007119401/10A RU2007119401A RU2422513C2 RU 2422513 C2 RU2422513 C2 RU 2422513C2 RU 2007119401/10 A RU2007119401/10 A RU 2007119401/10A RU 2007119401 A RU2007119401 A RU 2007119401A RU 2422513 C2 RU2422513 C2 RU 2422513C2
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- Prior art keywords
- progenitor cells
- myeloid progenitor
- therapeutic composition
- cells
- expanded
- Prior art date
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- 238000000034 method Methods 0.000 title claims abstract 33
- 210000000066 myeloid cell Anatomy 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract 24
- 230000001225 therapeutic effect Effects 0.000 claims abstract 21
- 210000004027 cell Anatomy 0.000 claims abstract 13
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims abstract 5
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims abstract 5
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims abstract 5
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims abstract 5
- 239000001963 growth medium Substances 0.000 claims abstract 5
- 241000124008 Mammalia Species 0.000 claims abstract 4
- 102000036693 Thrombopoietin Human genes 0.000 claims abstract 4
- 108010041111 Thrombopoietin Proteins 0.000 claims abstract 4
- 239000002243 precursor Substances 0.000 claims abstract 4
- 210000000130 stem cell Anatomy 0.000 claims abstract 4
- 239000002609 medium Substances 0.000 claims abstract 3
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 claims abstract 2
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 claims abstract 2
- 210000003643 myeloid progenitor cell Anatomy 0.000 claims 27
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 9
- 230000000735 allogeneic effect Effects 0.000 claims 5
- 230000000844 anti-bacterial effect Effects 0.000 claims 3
- 230000000843 anti-fungal effect Effects 0.000 claims 3
- 230000000840 anti-viral effect Effects 0.000 claims 3
- 229940121375 antifungal agent Drugs 0.000 claims 3
- 230000011132 hemopoiesis Effects 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 108010002386 Interleukin-3 Proteins 0.000 claims 2
- 210000003714 granulocyte Anatomy 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- 210000002540 macrophage Anatomy 0.000 claims 2
- 210000003593 megakaryocyte Anatomy 0.000 claims 2
- 208000004235 neutropenia Diseases 0.000 claims 2
- 206010043554 thrombocytopenia Diseases 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 1
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 1
- 108090000177 Interleukin-11 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 claims 1
- 238000005138 cryopreservation Methods 0.000 claims 1
- 230000000959 cryoprotective effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000925 erythroid effect Effects 0.000 claims 1
- 210000003013 erythroid precursor cell Anatomy 0.000 claims 1
- 238000011134 hematopoietic stem cell transplantation Methods 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000011084 recovery Methods 0.000 abstract 3
- 230000003394 haemopoietic effect Effects 0.000 abstract 2
- 230000000994 depressogenic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Hematology (AREA)
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- Developmental Biology & Embryology (AREA)
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- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Diabetes (AREA)
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- Communicable Diseases (AREA)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62231804P | 2004-10-25 | 2004-10-25 | |
| US60/622,318 | 2004-10-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007119401A RU2007119401A (ru) | 2008-11-27 |
| RU2422513C2 true RU2422513C2 (ru) | 2011-06-27 |
Family
ID=36228409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007119401/10A RU2422513C2 (ru) | 2004-10-25 | 2005-10-25 | Способы экспансии популяций миелоидных клеток и их использование |
Country Status (14)
| Country | Link |
|---|---|
| US (7) | US8252587B2 (https=) |
| EP (2) | EP1812555B1 (https=) |
| JP (1) | JP5519108B2 (https=) |
| KR (2) | KR101544292B1 (https=) |
| CN (2) | CN105168250B (https=) |
| AU (1) | AU2005299379B2 (https=) |
| BR (1) | BRPI0516969A (https=) |
| CA (1) | CA2585343C (https=) |
| ES (1) | ES2538305T3 (https=) |
| IL (1) | IL182782A (https=) |
| NO (1) | NO342460B1 (https=) |
| RU (1) | RU2422513C2 (https=) |
| WO (1) | WO2006047569A2 (https=) |
| ZA (1) | ZA200704252B (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2814083C2 (ru) * | 2018-11-29 | 2024-02-21 | Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем | Способы ex vivo экспансии естественных клеток-киллеров и их применение |
| US12466867B2 (en) | 2018-02-21 | 2025-11-11 | Board Of Regents, The University Of Texas System | Methods for activation and expansion of natural killer cells and uses thereof |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168250B (zh) | 2004-10-25 | 2019-02-05 | 塞勒兰特治疗公司 | 增殖骨髓细胞群体的方法及其应用 |
| US7811815B2 (en) * | 2004-11-15 | 2010-10-12 | The Board Of Trustees Of The Leland Stanford Junior University | Therapeutic uses of allogeneic myeloid progenitor cells |
| US20060182723A1 (en) * | 2005-01-25 | 2006-08-17 | Spellberg Brad J | Methods for treating refractory infections in neutropenic individuals |
| US8383095B2 (en) * | 2006-02-14 | 2013-02-26 | Cellerant Therapeutics, Inc. | Methods and compositions for enhancing engraftment of hematopoietic stem cells |
| US9394520B2 (en) | 2006-12-08 | 2016-07-19 | University Of Rochester | Expansion of hematopoietic stem cells |
| US20120177610A1 (en) | 2007-09-19 | 2012-07-12 | Kieu Hoang | Manufacturing and Purification Processes of Complex Protein found in Fraction IV to make a separated Apo, Transferrin , and Alpha 1 Anti strepsin (A1AT) or A combined Transferrin / Apo/Human Albumin/A1AT and all new found proteins |
| CA2711549C (en) * | 2008-01-08 | 2016-08-23 | The University Of Queensland | Method of producing a population of cells |
| US20110293574A1 (en) * | 2008-09-26 | 2011-12-01 | Chute John P | Hematopoietic stem cell growth factor |
| CN103540566A (zh) * | 2008-11-14 | 2014-01-29 | 路易斯维尔大学研究基金会有限公司 | 用于长期造血种群恢复的方法和组合物 |
| JP2010193879A (ja) * | 2009-01-27 | 2010-09-09 | Jms Co Ltd | 臍帯血造血幹細胞の増殖制御方法およびその用途 |
| CN102802686A (zh) * | 2009-06-18 | 2012-11-28 | Mc2细胞有限责任公司 | 骨髓胞外基质提取物及其治疗用途 |
| CN102725400A (zh) * | 2009-06-29 | 2012-10-10 | 麻省理工学院 | 制造人源化的非人类哺乳动物的方法 |
| US20130095079A1 (en) * | 2010-04-09 | 2013-04-18 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function without hla matching |
| US20130095080A1 (en) * | 2010-04-09 | 2013-04-18 | Fred Hutchinson Cancer Reserach Center | Compositions and methods for providing hematopoietic function |
| AU2011323729B2 (en) * | 2010-10-25 | 2016-08-04 | The Children's Hospital Of Philadelphia | Compositions and methods for the generation of platelets and methods of use thereof |
| CA3065694A1 (en) * | 2010-11-10 | 2012-05-18 | Inregen | Methods of forming injectable formulations for providing regenerative effects to an organ such as a kidney |
| US9476029B2 (en) * | 2010-11-13 | 2016-10-25 | Lung-Ji Chang | Ex vivo development, expansion and in vivo analysis of a novel lineage of dendritic cells |
| US20140205582A1 (en) * | 2011-07-06 | 2014-07-24 | Cellerant Therapeutics, Inc. | Megakaryocyte progenitor cells for production of platelets |
| EP3785767A1 (en) * | 2011-12-02 | 2021-03-03 | Fate Therapeutics, Inc. | Enhanced stem cell composition |
| CA2858069C (en) | 2011-12-08 | 2020-02-11 | Novartis Ag | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| TW201335181A (zh) * | 2012-01-31 | 2013-09-01 | Kieu Hoang | 55種新發現的蛋白質之序列及其應用 |
| JP6429191B2 (ja) * | 2012-03-06 | 2018-11-28 | セレクト バイオセラピューティクス リミテッド | アポトーシスシグナル伝達抵抗性細胞を選択する装置および方法ならびにその使用 |
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