RU2406512C2 - Method of treating alopecia - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to dermatology and can be used for treatment of alopecia. For this purpose massage of scalp and neck area is carried out. Additionally patients are administered "Pantohematogen tonic" in accordance with the following scheme: for internal application 1 capsule 2 times per day 20 min before meal No 20, daily. For external application in form of liquid mask: 1 capsule is diluted with 50 ml of warm water, stood for 3-4 hours at room temperature and applied on head skin for 20-30 min, evenly distributed on hair, No 20, daily. Also applied is scalp darsonvalisation, in contact labile slow manner, in direction from forehead to back of the head, by comb electrode, with weak power, 8-10 min, No 20, daily.

EFFECT: method ensures increase of efficiency, is simple and abailable.

1 ex, 8 dwg

Description

The invention relates to medicine, namely to dermatology, and can be used to treat diffuse or symptomatic alopecia.

Hair loss is a very urgent problem that both men and women face. Factors affecting hair loss can be stress, environmental pollution, malnutrition, etc.

Existing therapeutic and surgical methods of treating this pathology are not effective enough, give a short-term effect, have a number of significant contraindications and side effects that limit the use of known drugs and methods, and in some cases are not economically available.

Therefore, the search for new drugs and treatments for hair loss and hair restoration remains one of the most urgent tasks of modern dermatology.

However, an effective and universal drug and a method for the treatment of hair loss and hair restoration have not yet been created.

A known method of treating alopecia by using a complex herbal preparation CH 5 plus, which includes seven plant extracts.

The method is effective for the treatment of hair loss of various etiologies. However, its effect is short-term and economically inaccessible (E. M. Dolzhikova, E. A. Shuginina and others, the journal “Bulletin of Dermatology and Venereology”, No. 2, 2001).

A known method of treating hair loss by using several ingredients of plant and chemical origin, providing improved hair condition, their restoration (RF patent No. 2215518, A61K 7/06).

However, the known method is effective in a small part of those who use it and is rather laborious.

The closest technical result achieved is the method of treating alopecia according to NB Nikiforova (RF patent No. 2197938) by applying essential vegetable oils to the lesion, massaging the scalp and collar and applying physiotherapy - irradiation with low-intensity laser radiation of biologically active points .

The application of the known method is not always effective, because persistent clinical effect is not achieved, limited due to possible allergic reactions to the use of essential vegetable oils. In addition, the application of the known method is quite time-consuming, expensive and can only be applied to the clinic.

The authors offer a highly effective, simple and affordable way to treat alopecia.

The technical result of the proposed method is to increase efficiency by improving the clinical effect.

The technical result is achieved by creating a comprehensive method for the treatment of alopecia using an animal product, namely antler reindeer herding, “Pantohematogen tonic”.

The method is as follows.

The complex treatment of patients with alopecia is as follows.

1. A diet is prescribed with a predominance of protein products (liver, kidneys, eggs, nuts, mushrooms, dairy products, yogurt, cottage cheese) and restriction of salt and sugar intake; daily eating of fresh vegetables and fruits (carrots, apples);

2. Prevention of psychoemotional stress;

3. The intake of vitamins, for example, the vitamin-mineral complex Complivit, 1 tablet once a day, No. 20, e / d;

4. Massage of the scalp and collar according to Kondrashov A.V .: 10-15 minutes, No. 20, e / d.

5. Darsonvalization of the scalp: contact, labile, slowly from the forehead to the back of the head, with a scallop electrode, weak power, 8-10 min, No. 20, e / d.

Against the background of complex treatment, patients take the biologically active drug “Pantohematogen tonic”. The pathogenetic rationale for the use of “Pantohematogen tonic” in the treatment of patients with alopecia is both the effect on the problem itself and its risk factors (stress, deterioration of hair nutrition, deficiency of vitamins and minerals in the body, impaired microcirculation of the scalp, impaired protein metabolism in the body) . Amino acids, including essential ones, are the material for the growth and formation of new hair. The lipid fraction improves the texture of the hair, giving it elasticity, flexibility and shine. "Pantohematogen tonic" contains a large number of vitamins and minerals.

"Pantohematogen tonic" (certificate No.ROSS RU. AE 96.N 01535 dated February 13, 2007, sanitary and epidemiological report P. 000002.01.07. Dated January 11, 2007) is a gelatin capsule and consists of pure dry maral blood obtained by low temperature vacuum drying.

"Pantohematogen tonic" is taken according to the following scheme:

- for internal use, 1 capsule 2 times a day 20 minutes before meals, No. 20, daily (in case of increased nervous excitement, exclude the evening intake of “Pantohematogen tonic”). For better hair growth, 2-3 courses per year are recommended;

- for external use in the form of a liquid mask: dilute 1 capsule with 50 ml of warm water, insist 3-4 hours at room temperature, apply to the scalp and evenly distribute through the hair for 20-30 minutes, No. 20, daily. 2-3 courses of a liquid mask on the scalp per year are recommended for prophylactic purposes.

Clinical example.

Patient T. Complained of severe hair loss for many years. Upon examination, the hair is dull, thin, revealed two small lesions in the scalp with lack of hair. The patient was repeatedly examined, but neither pathology nor clinical or biochemical analyzes were detected. After the examinations, recommendations are given on the use of complex treatment, including diet therapy, vitamin complex, massage of the scalp and collar region according to A.V. Kondrashov and darsonvalization of the scalp. "Pantohematogen tonic" was taken according to the proposed scheme.

The course of treatment according to the claimed methodology amounted to 20 procedures. Inspection carried out after 2.5 months. An increase in the quality of hair was noted, on the foci of baldness appeared normal rest hair.

Clinical trials were conducted on 100 volunteers aged 18 to 60 years (mean age 34.2 ± 4.1 years) with hair loss (alopecia). The clinical trial program provided for the formation of 2 randomized groups by gender, age, random distribution of groups, treatment, except experimental (figure 1).

The first main group consisted of 60 patients, who were divided into two subgroups. Patients of subgroup A (30 people) received complex treatment (diet therapy with a predominance of protein products, massage, darsonvalization of the scalp, multivitamins, in particular with the complex of minerals “Complivit” and “Pantohematogen tonic” according to the scheme: for internal use, 1 capsule twice per day (morning and evening) and external use in the form of a liquid mask on the scalp.The patients of subgroup B received diet therapy, vitamin therapy, massage, darsonvalization and a liquid mask from Pantogematogen tonic o ”on the scalp.

The second comparison group (40 patients) received complex treatment with the exception of “Pantohematogen tonic”.

All patients of the main group tolerated treatment with Pantogematogen tonic, and none of them had any adverse reactions. Only in one case, the evening intake of the drug was canceled due to disturbed night sleep.

Patients underwent examination for 1-2 days (taking an anamnesis and complaints, determining blood hemoglobin level, microscopy of hair, phototrichgamma, optical increase in UV rays on a SAM diagnostic apparatus, microcirculatory bed examination using conjunctival biomicroscopy using a slit lamp), then the recommended treatment, after which a follow-up examination was prescribed. In the follow-up history, after 2.5 months, the patients underwent a follow-up examination (figure 2).

Patients on admission complained of thinning, lack of shine, brittle, split ends of the hair. The subjects were worried about the presence of dandruff, itchy skin, some patients showed increased greasy hair, another part complained of dry scalp, a third of patients were concerned about the slowdown of hair growth (Fig. 3).

Assessment of the dynamics of clinical complaints of patients with hair loss after 2.5 months showed a significant decrease in the number of patients with thinning, lack of shine, brittle hair in both subgroups of the main group (Fig. 4). The use of Pantogematogen tonic in the treatment helps to improve the texture of the hair, restore the lipid layer, strengthen the connection of the cysteine-containing protein with the cuticle, as a result of the notch of the cortical substance stick together, the hair becomes smooth and shiny. The reduction of complaints of dry scalp, itching, dandruff, greasy hair indicates the normalization of physiological processes in the skin, as evidenced by the data of optical increase in ultraviolet rays on a SAM diagnostic apparatus. A significant decrease in the number of patients with slow hair growth is explained by the activation of microcirculation in the scalp, the strengthening of hair follicles due to its nutrition. The number of patients with gray hair has not decreased in both groups and is explained by the small number and insufficient observation period to assess this problem. In the comparison group, the treatment results were significantly lower, and for such symptoms as thinning hair, dandruff, are insignificant.

When studying the bulbar conjunctiva in patients of both groups before treatment, pronounced deviations were found in all morphofunctional departments of the terminal vascular bed, which was confirmed by the presence of significantly higher values of the conjunctival index (CI) than in healthy individuals (the study of the bulbar conjunctiva was carried out on 10 volunteers). The use of a single treatment complex for the correction of detected microcirculatory changes was not effective enough, as evidenced by only a slight decrease in the values of all KI in the comparison group by the end of the course of treatment (Fig. 5). The inclusion of “Pantohematogen tonic” in the complex treatment of patients with alopecia is accompanied by an improvement in microcirculation due to a decrease in the tortuosity of blood vessels, expansion of venules and capillaries, restoration of arteriovenous ratios, reduction of areas of desolation of capillaries in all vessels, restoration of continuous blood flow and acceleration of blood flow.

In patients of the main group in all subgroups after treatment, a significant decrease in the values of all CIs was observed. However, the most pronounced dynamics was determined in patients of subgroup A, who received “Pantohematogen tonic” both externally and orally.

The figure 6 presents the results of a study of the amount of hemoglobin in the blood of patients with alopecia before, after treatment and follow-up history 2.5 months after treatment.

After treatment, in all groups, there was a tendency to increase hemoglobin, which is explained by balanced diet therapy, vitamin therapy, however, a significant increase in this indicator was observed mainly in the main group of subgroup A, which received complex treatment with the inclusion of “Pantohematogen tonic” both externally and orally, t. to. the drug makes up for iron deficiency in the body and improves its absorption.

Analyzing the dynamics of hair growth (Fig. 7) in the follow-up groups 2.5 months after treatment, the following results were obtained: 98.3% of patients taking "Pantohematogen tonic" noted an improvement in hair growth. Enhanced hair growth (from 21 to 30) mm is observed in 36.7% of the main group of subgroup A, where patients along with the main complex received “Pantohematogen tonic” inside and out in the form of a mask; in subgroup B of such patients was 16.7%. In the comparison group, enhanced hair growth was not registered in any patient. Moderate growth (from 11 to 20) mm of hair was observed in patients of all groups, however, the result was significantly higher in the case of Pantohematogen tonic in the form of a liquid mask, which can be explained by the predominance of enhanced hair growth in patients of the main group of subgroup A.

In the analysis of figure 8, it was noted that after 2.5 months in subgroup A there were no patients with hair loss from 100 to 150, in subgroup B during this period the number of patients decreased by 81.0% (p <0.5), and in the group comparison - by 18.0% (p <0.5). A significant increase with hair loss of up to 50 per day, taking "Pantohematogen tonic" both inside and out, is noteworthy. In the subgroup only with external use of Pantogematogen tonic, such subjects became 33.3% more (p <0.5), in the comparison group - 16.7% (p <0.5).

Thus, the use of “Pantohematogen tonic” in the complex treatment of patients with hair loss (alopecia) both in the combined form (ingestion plus a liquid mask) and as a liquid mask improves hair growth, thickness, density, texture, and reduces hair loss. The drug has an antistress effect, reducing the anxiety of patients. The simultaneous use of "Pantohematogen tonic" inside and out in the form of a liquid mask was more effective than just a liquid mask. The results of treatment in the main group significantly exceed the comparison group in terms of effectiveness, which can be explained by the stimulating and strengthening effect of the “Pantohematogen tonic”.

Claims (1)

A method of treating alopecia, which consists in massaging the scalp and collar, physiotherapy, characterized in that the patients are additionally prescribed “Pantohematogen tonic” according to the following scheme:
for internal use: 1 capsule 2 times a day 20 minutes before meals, No. 20, daily;
for external use in the form of a liquid mask: dilute 1 capsule with 50 ml of warm water, insist 3-4 hours at room temperature and apply on the scalp for 20-30 minutes, evenly distributing through the hair, No. 20, daily, and use as physiotherapy darsonvalization of the scalp is contact, labile, slowly in the direction from the forehead to the back of the head, with a scallop electrode, the power is weak, 8-10 minutes, No. 20, daily.

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