RU2402344C1 - METHOD FOR PREPARING PHYTOPREPARATIONS OF SOME SPECIES OF HEDYSARUM (Hedysarum theinum, Hedysarum neglectum) - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry. Ground roots are three-stage extracted by aqueous-alcoholic solutions in periodic stirring at room temperature in a dark place with the first fraction prepared by processing of raw material by an aqueous-alcoholic solution in the ratio 2:1 for 8 days, the second fraction prepared by processing of the remained roots by an aqueous-alcoholic solution in the ratio 1:1 for 6 days and the third fraction prepared by processing of the remained vegetative raw materials by an aqueous-alcoholic solution in the ratio 1:2 for 5 days; then fractions are poured out.

EFFECT: invention allows for higher yield of the end product with improved activity.

1 ex

Description

The invention relates to medicine, namely to the chemical and pharmaceutical industry, and can be used in the field of the production of medicines from plant materials, in particular for obtaining tinctures from the roots of certain types of penny - forgotten penny (Hedysarum neglectum) and tea penny (Hedysarum theinum) .

Currently, more than 250 species of penny growing in various regions of the world, including Russia, are known. According to the data of (A.A.Semenov et al., 2004), about 100 varieties of penny grow in Russia, but two species are most often used - forgotten penny (Hedysarum neglectum) and tea penny (Hedysarum theinum).

The chemical composition of this plant material has not been fully studied. According to the review (A.A.Semenov et al., 2004), tartan roots contain tannins, xanton hedizaride, triterpene saponins, coumarins, flavonoids (quercetin, compferol, avcularin, hyperoside), catechins (which stain the root in red color), free amino acids (of which 7 are essential), alkaloids.

The presence of these biological substances causes anti-inflammatory, bactericidal, antispasmodic, vasodilating, immunomodulating, antioxidant, antitumor and mild diuretic effects. That allows the use of herbal preparations obtained from this plant material for the prevention and treatment of various diseases.

Tinctures and extracts from the roots of Hedysarum neglectum and tea penny (Hedysarum theinum) are effective in treating symptoms of the urogenital system in men, as well as in the complex treatment of acute and chronic prostatitis, urethritis and prostate adenoma.

In addition, herbal remedies normalize the activity of the gastrointestinal tract, have a light, stimulating and strengthening effect on the cardiovascular, respiratory and nervous systems. Also used for the successful treatment of atherosclerosis, anemia, leukemia, allergies, asthma, tuberculosis and pneumonia, liver diseases (cholecystitis, all forms of hepatitis), spleen diseases. Herbal preparations normalize blood pressure, have a hemostatic, astringent effect; can be successfully used to treat children from a very young age, to extend the life of people of advanced age. They have an antihypnotic effect.

In folk medicine, the roots of the forgotten penny plant (Hedysarum neglectum) and tea penny (Hedysarum theinum) are known as the Red Root, Bear Root, their decoctions and infusions are used for diseases of the gastrointestinal tract, diarrhea, headaches, nervous and female diseases, as well as a diuretic and as a tonic.

The patent literature describes the use of forgotten roots (Hedysarum neglectum) and tea pennies (Hedysarum theinum) as components of teas, tinctures and balms as an immunostimulating and restorative agent (US Pat. No. 2169481, 93014335, 2057799), for treating tumor diseases .2180232) and the prevention of diseases caused by iodine deficiency (US Pat. No. 2164144).

Currently, all existing preparations based on the roots of the forgotten penny (Hedysarum neglectum) and tea penny (Hedysarum theinum) have different quantitative and qualitative composition, differ in pharmacological properties and the effect of therapeutic use. This is due to the use of various methods of obtaining drugs.

It is known that various technological methods and modes of obtaining herbal preparations have a significant impact on the qualitative and quantitative content of substances and compounds extracted from plant materials, as well as their pharmacological activity and pharmacological effect (V.I. Chueshov, 2002; V.L. Bagirova et al., 2001).

The objective of the present invention is to develop a technological method, using which it is possible to obtain tinctures from medicinal plant materials of certain types of Hedysarum with a higher content of biologically active substances, which leads to an increase in the pharmacological effect when using these herbal preparations.

A known method of producing tinctures and extracts from crushed plant material of certain types of Hedysarum by extraction with roots of forgotten Hedysarum neglectum and / or tea lycophene (Hedysarum theinum) with 10-80% aqueous ethyl alcohol in the ratio of raw material: extractant from 1 : 5 to 1:15 for 1-21 days, followed by sedimentation of the extract for 24-120 hours, after which the extract, if necessary, is concentrated. The extraction is carried out by maceration or percolation.

The result is a tincture with an extractive content of from 0.8% to 2%.

This technical solution was taken by us as a prototype (Patent RU No. 2238747, A61K 35/78, published on October 27, 2004), since it is closest to the claimed invention.

The disadvantage of this method of obtaining tinctures from medicinal plant materials is a significant loss of recoverable substances.

The aim of the invention is to increase the yield of the target product with less loss of recoverable substances.

This goal is achieved in a method for producing tinctures by phased extraction of raw materials with an organic solvent with periodic shaking.

Example: 30 g of crushed plant material of the roots of forgotten root (Hedysarum neglectum) or tea root (Hedysarum theinum) was treated in three stages with a water-alcohol solution with a different concentration of alcohol, with periodic shaking at room temperature in a dark place.

The 1st fraction was obtained after processing the starting material with an aqueous-alcohol solution in a ratio of 2: 1 for 8 days, a total volume of 300 ml. The 2nd fraction was obtained by treating the remainder of the roots of lycophene with an aqueous-alcoholic solution in the ratio 1: 1 for 6 days, the total volume of 300 ml. The 3rd fraction was obtained by treating the remainder of the plant material with an aqueous-alcoholic solution in a ratio of 1: 2 for 5 days, a total volume of 300 ml. As a result, the phytopreparation is formed when all three fractions are drained.

The obtained tinctures are transparent solutions of red-brown color with a pleasant taste and smell, with a quantitative content of extractives from 1.7% to 4.8%.

The proposed method for producing tinctures from plant materials of the roots of the forgotten root (Hedysarum neglectum) and tea root (Hedysarum theinum) can increase the yield of the target product with less loss of recoverable substances, which leads to an increase in pharmacological activity and pharmacological effect.

Since the claimed invention provides a technical result, expressed in an increase in the quantitative content of biologically active substances, leading to an increase in the pharmacological effect when using these phytopreparations, and can be used to obtain a medicinal product, we can conclude that this method of obtaining tinctures from plant materials of some species of penny (Hedysarum) meets the criterion of "industrial applicability".

Claims (1)

A method of obtaining tinctures from the roots of some types of penny - forgotten penny (Hedysarum neglectum) and tea penny (Hedysarum theinum) by extraction with an organic solvent, characterized in that the crushed roots are extracted in three stages with water-alcohol solutions with periodic shaking at room temperature in a dark place, moreover, the first fraction is obtained after processing the starting material with a water-alcohol solution in a ratio of 2: 1 for 8 days, the second fraction is obtained by treating the root residue with a water-alcohol solution in ootnoshenii 1: 1 for 6 days, and the third fraction was obtained by treatment of the residue vegetable raw hydroalcoholic solution in a ratio of 1: 2 for 5 days, then the fraction was discarded.