RU2395126C1 - Use of silicone sealing agents as filling when manufacturing anatomical corrosion preparations - Google Patents

Abstract

FIELD: medicine. ^ SUBSTANCE: to produce anatomical corrosion products monocomponent coating masses are used - industrial silicone sealing agents "Silicon acetat 101e" produced by Kim Tec company, or "Silacryl 121" produced by Kim Tec company, or "Parcett 202" produced by Kim Tec company, or multipurpose adhesive sealant "Germent", or opalescent sealant produced by TYTAN company. ^ EFFECT: method enables to produce high-quality corrosive agents, it is convenient for a worker, cost-efficient. ^ 1 ex

Description

The invention relates to medicine, in particular to anatomy, pathological anatomy, topographic anatomy, can be used in the manufacture of visual aids in the form of corrosive preparations using fillers not previously used for this purpose.

Silicone sealants have all the necessary quality and performance indicators that meet the requirements of modern sealing materials. Of all sealants, it is silicone that is more durable. They are characterized by distinctive features:

1. resistance to UV radiation;

2. resistance to all weather conditions and almost any hostile environment;

3. excellent adhesion to most types of building materials even without the use of primers (primers);

4. excellent accommodation for movement (at least 20%);

5. Increased thermal stability and frost resistance - workable (retain elastic properties) in the temperature range from -50 ° to + 200 ° C;

6. wide temperature range of application (application on the surface from -30 ° to + 60 ° C).

Silicone sealants have the following composition:

basis - silicone rubber (as a rule, dimethylpolysiloxane with terminal hydroxyl groups);

an amplifier that serves to increase strength characteristics and ensure thixotropic properties - lack of stackability from vertical surfaces;

a filler that performs a number of secondary functions,

dye (if necessary);

antifungal supplements (if necessary);

a curing component for converting the initial paste-like consistency of the sealant into a rubber-like material under the influence of air moisture;

adhesion promoters providing strong permanent contact of the sealant with the surface;

silicone plasticizer that improves the elastic properties of the sealant.

Thus, silicone sealant includes: silicone rubber, filler (pigment), thixotropic (fluidity-reducing) agent, plasticizing (increasing plasticity and elasticity) additives, fuigicidal (antifungal) additives, catalyst (polymerization activator). The ratio of these components in the order of listing, as a rule, is as follows: 45%, 45%, 4%, 4%, 1%, 1%.

Scope: KIM-TEC Silicon 101E is especially suitable for jointing, sealing and gluing in the following areas:

- plumbing equipment,

- showcases and window boxes,

- repair and maintenance of ships,

- repair and maintenance of residential trailers,

as well as durable elastic bonding and sealing in crafts.

Restrictions on the use: KIM-TEC Silicon 101E is not applicable for bases made of polyethylene, plastic films or for such surfaces that are capable of reacting with acetic acid released during crosslinking. KIM-TEC Silicon 101E is not applicable for equipping aquariums and where contact with food is possible. KIM-TEC Silicon 101E should not be applied to places where severe abrasion is possible. KIM-TEC Silicon 101E is not suitable for the incorporation of marble and natural stone.

The possibility of using KIM-TEC Silicon 101E as a filler for the manufacture of corrosive preparations is not included in the list of applications declared by the manufacturer (source http://www.kim-tec.ru/type.aspx?f=633676613749843750).

Currently, the following substances are known that are used for the manufacture of corrosive preparations: Protacryl M, AKP7, EAF, Acrela, Girtl mass, acetone-cellloidine mass for “cold injection” and rosin-wax mass for “hot”. Their disadvantages include multicomponent mixtures, the use of components of flammable or toxic substances, brittleness, instability of the resulting anatomical preparation, high cost.

The purpose of the invention is the development of technology for the use of silicone sealants as fillers in the manufacture of anatomical corrosion preparations and confirmation of the excellent performance of such products.

This goal is achieved by the fact that we propose to use an injection medium - Silicon acetat 101E from Kim Tec, used in industrial construction in corrosion engineering.

Silicon acetat 101e Kim Tec is a one-component, universal silicone sealant that forms an elastic, resistant, durable joint. Information provided directly by the manufacturer of this silicone filler:

manufacturer and country of manufacture - Kim Tec (Germany);

polymerization system (type of sealant "acidic" or "neutral") - acid hardening;

Recommended and permitted areas of application - suitable for indoor and outdoor construction work. According to its specification, it is used for sealing and gluing non-porous surfaces. The most typical applications are: kitchen, swimming pools, showers, toilets and bathrooms, sealing joints in the greenhouse, in the boat, etc .;

density (g / cm ³ ) - 1.03 g / cm ³ ;

surface film formation time (min.) - 9 min;

hardening speed -

(23 ° C / 50% RH) (h) - 3.0 mm / 24 h; 6.5 mm / 48 h; 10.0 mm / 72 h;

Shore A hardness - 20;

modulus (MPa) at 100% tension - 0.62 MPa;

tensile strength at break (MPa) - 2.03 MPa;

elongation at break (%) - 450%;

allowable application temperature (° C) - from +5 to +40;

permissible operating temperature (° C) - from -50 to +180;

Warranty period of storage (months) - store at a temperature of 5 ° С to + 50 ° С, 24 months.

The silicone filler we offer has the following positive physicochemical characteristics necessary specifically for the manufacture of corrosive preparations:

1. The single component of the substance, which, undoubtedly, is a positive quality when working with the drug both in the manufacture of single copies and in serial production;

2. The practical ease of introducing silicone filler into the vascular bed or organ cavity, which is achieved by using a special sealant gun (used to apply silicone to the mounted surface), which provides a dense, but at the same time, uniform and metered filling of the vascular bed or organ cavities with injectable substance.

3. This polymer penetrates well into small diameter vessels, contributing to a more complete filling of the microvascular bed.

4. Unlike some substances used in the manufacture of corrosive preparations, Silicon acetat 101e Kim Tec is hydrophilic, which is also its advantage. With increasing environmental humidity (in the aquatic environment), the hardening of silicone accelerates.

5. There are polychrome colored silicone sealants manufactured under industrial conditions, that is, the manufacture of corrosive preparations does not require the addition of dye. In this case, the dye in the hardened mass is resistant to concentrated acids and alkalis, and therefore, the corrosive preparation does not discolor.

6. Provides greater strength and elasticity of the obtained casts, which also acquire a smooth surface due to the absence of gas bubbles, do not change the linear and volumetric dimensions during hardening and storage. In addition, the silicone sealant used contains antifungal additives and, accordingly, has fungicidal properties (an additional option).

7. One of the distinctive properties of the medium used is the relatively long solidification time (12-16 hours), which is especially important when working with a large volume of the vascular bed (cavity) in the manufacture of not only monochrome, but also polychrome corrosion preparations, when a lot of time is needed for the introduction of an injectable substance, as well as the correct laying of the drug.

8. Silicone sealant is cheaper than silicone used in medical practice. The retail price of cartouched (packed in a plastic cartridge with a nose) sealant is 70-80 rubles with a filling volume of 260-310 ml. The price of wholesale importers supplying sealant to Russia is much lower and amounts to 35-40 rubles.

As an example, we give a method for preparing a monochrome corrosion preparation of the venous system of the kidney using industrial silicone sealant as a filler.

The kidney is entirely isolated from the bed of the surrounding fat capsule and is removed from the unfixed corpse with the longest possible renal leg. Through the lumen of the vein, the bloodstream is thoroughly washed with running water until the blood is removed.

The fixed end of the rubber tube is worn on the tube nose with Kim Tec Silicon Acetate 101e, which is inserted into a regular construction sealant gun used to apply silicone and liquid nails to the surface to be mounted. With the help of this gun, a dense, but at the same time, uniform and strictly metered filling with the polymer of the venous network of the kidney is carried out. On the tube containing the injected silicone, we place on the outside a pre-calculated graduated scale (in ml), which allows you to accurately determine the volume of injected filler. In this case, the density and sufficiency of filling is controlled both visually and by palpation. Then the rubber tube is carefully removed and the renal vein is rapidly ligated to prevent silicone leakage.

The kidney preparation so injected is placed in a desiccator with 70% sulfuric acid, where the organ is in a floating state, which prevents its deformation and uneven distribution of the substance, for example, Silicon acetat 101e Kim Tec. In a solution of sulfuric acid, the kidney is located for the time necessary for complete acid hydrolysis of the tissues of the organ (2-3 days). At the end of acid corrosion, the organ is thoroughly rinsed under running tap water until the hydrolyzed tissues are completely removed. Corrosion with concentrated sulfuric acid is a process that allows to obtain imitations of the studied anatomical structures, which as a result acquire strength, durability and elasticity. Due to the high degree of dispersion of silicone, it is possible to produce casts of blood vessels (for example, arteries) with a diameter of up to 0.2-0.3 mm according to the above method.

The high quality of the drugs obtained as a result of the application of the proposed method is its undoubted advantage.

In addition to silicone sealants, we have successfully tested the use of the following sealants as a filler for the manufacture of corrosive preparations: Silacryl 121 from KIM TEC, Parkett 202 from KIM TEC, Multipurpose Germent adhesive sealant, Rainbow sealant from TYTAN using the method described above.

Thus, the technology we developed for using silicone sealants for the manufacture of corrosion anatomical preparations allows us to produce high-quality models, convenient for the contractor, and has a low cost in comparison with the materials currently used.

Claims (1)

A method of manufacturing anatomical corrosion preparations using silicone, characterized in that they use a monocomponent filler mass - industrial silicone sealants "Silicon acetat 101e" from Kim Tec, or Silacryl 121 from Kim Tec, or Parcett 202 from Kim Tec, or multipurpose adhesive sealant "Germent ", or TYTAN rainbow sealant.