RU2383548C2 - Соединения в качестве антагонистов ccr-1 - Google Patents
Соединения в качестве антагонистов ccr-1 Download PDFInfo
- Publication number
- RU2383548C2 RU2383548C2 RU2006141702/04A RU2006141702A RU2383548C2 RU 2383548 C2 RU2383548 C2 RU 2383548C2 RU 2006141702/04 A RU2006141702/04 A RU 2006141702/04A RU 2006141702 A RU2006141702 A RU 2006141702A RU 2383548 C2 RU2383548 C2 RU 2383548C2
- Authority
- RU
- Russia
- Prior art keywords
- optionally substituted
- alkyl
- group
- amino
- substituents
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 11
- 239000005557 antagonist Substances 0.000 title abstract 2
- 102000009410 Chemokine receptor Human genes 0.000 claims abstract 5
- 108050000299 Chemokine receptor Proteins 0.000 claims abstract 5
- 150000003839 salts Chemical class 0.000 claims abstract 4
- 206010061218 Inflammation Diseases 0.000 claims abstract 3
- 230000004054 inflammatory process Effects 0.000 claims abstract 3
- 241000124008 Mammalia Species 0.000 claims abstract 2
- 230000002401 inhibitory effect Effects 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims abstract 2
- 125000001424 substituent group Chemical group 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- -1 amino, sulfonyl Chemical group 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000004429 atom Chemical group 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 3
- 239000004215 Carbon black (E152) Substances 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- 229930195733 hydrocarbon Natural products 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 125000003373 pyrazinyl group Chemical group 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- WRYCSMQKUKOKBP-UHFFFAOYSA-N Imidazolidine Chemical compound C1CNCN1 WRYCSMQKUKOKBP-UHFFFAOYSA-N 0.000 claims 2
- PSDYQSWHANEKRV-UHFFFAOYSA-N [S]N Chemical compound [S]N PSDYQSWHANEKRV-UHFFFAOYSA-N 0.000 claims 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 125000006323 alkenyl amino group Chemical group 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 230000003042 antagnostic effect Effects 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0409236.7A GB0409236D0 (en) | 2004-04-26 | 2004-04-26 | Organic compounds |
| GB0409236.7 | 2004-04-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006141702A RU2006141702A (ru) | 2008-06-10 |
| RU2383548C2 true RU2383548C2 (ru) | 2010-03-10 |
Family
ID=32344398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006141702/04A RU2383548C2 (ru) | 2004-04-26 | 2005-04-25 | Соединения в качестве антагонистов ccr-1 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20070196270A1 (https=) |
| EP (1) | EP1794164A2 (https=) |
| JP (1) | JP2007534678A (https=) |
| KR (2) | KR100845356B1 (https=) |
| CN (1) | CN101238131A (https=) |
| AR (1) | AR052397A1 (https=) |
| AU (1) | AU2005235724B2 (https=) |
| BR (1) | BRPI0510313A (https=) |
| CA (1) | CA2559917A1 (https=) |
| GB (1) | GB0409236D0 (https=) |
| MX (1) | MXPA06012380A (https=) |
| RU (1) | RU2383548C2 (https=) |
| TW (1) | TW200603805A (https=) |
| WO (1) | WO2005103054A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2712211T3 (es) | 2013-06-20 | 2019-05-09 | Bayer Cropscience Ag | Derivados de arilsulfuro y arilsulfóxido acaricidas e insecticidas |
| MX368059B (es) | 2013-07-18 | 2019-09-18 | Novartis Ag | Inhibidores de autotaxina que comprenden un núcleo de anillo heteroaromático de bencil-amida cíclica. |
| CN115286637B (zh) * | 2022-08-11 | 2024-03-22 | 成都金博汇康医药科技有限公司 | 三氮杂桥环化合物及其中间体化合物、制备方法和应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998056771A2 (en) * | 1997-06-12 | 1998-12-17 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| WO2002032901A2 (en) * | 2000-10-19 | 2002-04-25 | Pfizer Products Inc. | Bridged piperazine derivatives |
| WO2002036581A1 (en) * | 2000-11-06 | 2002-05-10 | Schering Aktiengesellschaft | Radiopharmaceuticals for diagnosing alzheimer's disease |
| WO2004009588A1 (en) * | 2002-07-18 | 2004-01-29 | Pfizer Products Inc. | Bicyclic piperidine derivatives as antagonists of the ccr1 chemokine receptor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6818643B1 (en) * | 1999-12-08 | 2004-11-16 | Bristol-Myers Squibb Company | Neurotrophic bicyclic diamides |
| JPWO2002100833A1 (ja) * | 2001-06-12 | 2004-09-24 | 住友製薬株式会社 | Ｒｈｏキナーゼ阻害剤 |
| GB0224917D0 (en) * | 2002-10-25 | 2002-12-04 | Novartis Ag | Organic compounds |
-
2004
- 2004-04-26 GB GBGB0409236.7A patent/GB0409236D0/en not_active Ceased
-
2005
- 2005-04-25 CA CA002559917A patent/CA2559917A1/en not_active Abandoned
- 2005-04-25 WO PCT/EP2005/004422 patent/WO2005103054A2/en not_active Ceased
- 2005-04-25 CN CNA2005800132391A patent/CN101238131A/zh active Pending
- 2005-04-25 JP JP2007508868A patent/JP2007534678A/ja not_active Ceased
- 2005-04-25 KR KR1020067022181A patent/KR100845356B1/ko not_active Expired - Fee Related
- 2005-04-25 BR BRPI0510313-4A patent/BRPI0510313A/pt not_active IP Right Cessation
- 2005-04-25 EP EP05737794A patent/EP1794164A2/en not_active Withdrawn
- 2005-04-25 RU RU2006141702/04A patent/RU2383548C2/ru not_active IP Right Cessation
- 2005-04-25 AU AU2005235724A patent/AU2005235724B2/en not_active Ceased
- 2005-04-25 MX MXPA06012380A patent/MXPA06012380A/es not_active Application Discontinuation
- 2005-04-25 US US10/599,819 patent/US20070196270A1/en not_active Abandoned
- 2005-04-25 KR KR1020087002184A patent/KR20080015151A/ko not_active Ceased
- 2005-04-25 AR ARP050101623A patent/AR052397A1/es unknown
- 2005-04-25 TW TW094113108A patent/TW200603805A/zh unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998056771A2 (en) * | 1997-06-12 | 1998-12-17 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| WO2002032901A2 (en) * | 2000-10-19 | 2002-04-25 | Pfizer Products Inc. | Bridged piperazine derivatives |
| WO2002036581A1 (en) * | 2000-11-06 | 2002-05-10 | Schering Aktiengesellschaft | Radiopharmaceuticals for diagnosing alzheimer's disease |
| WO2004009588A1 (en) * | 2002-07-18 | 2004-01-29 | Pfizer Products Inc. | Bicyclic piperidine derivatives as antagonists of the ccr1 chemokine receptor |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20080015151A (ko) | 2008-02-18 |
| US20070196270A1 (en) | 2007-08-23 |
| GB0409236D0 (en) | 2004-05-26 |
| CN101238131A (zh) | 2008-08-06 |
| KR20070014154A (ko) | 2007-01-31 |
| MXPA06012380A (es) | 2007-01-17 |
| WO2005103054A2 (en) | 2005-11-03 |
| EP1794164A2 (en) | 2007-06-13 |
| AR052397A1 (es) | 2007-03-21 |
| AU2005235724A1 (en) | 2005-11-03 |
| BRPI0510313A (pt) | 2007-10-16 |
| CA2559917A1 (en) | 2005-11-03 |
| AU2005235724B2 (en) | 2008-10-30 |
| JP2007534678A (ja) | 2007-11-29 |
| RU2006141702A (ru) | 2008-06-10 |
| WO2005103054A3 (en) | 2007-02-08 |
| KR100845356B1 (ko) | 2008-07-09 |
| TW200603805A (en) | 2006-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20110426 |