RU2371433C2 - Фенилзамещенные пирролидоны - Google Patents
Фенилзамещенные пирролидоны Download PDFInfo
- Publication number
- RU2371433C2 RU2371433C2 RU2007132259/04A RU2007132259A RU2371433C2 RU 2371433 C2 RU2371433 C2 RU 2371433C2 RU 2007132259/04 A RU2007132259/04 A RU 2007132259/04A RU 2007132259 A RU2007132259 A RU 2007132259A RU 2371433 C2 RU2371433 C2 RU 2371433C2
- Authority
- RU
- Russia
- Prior art keywords
- group
- alkyl
- compound according
- halogen
- cell
- Prior art date
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title claims abstract 6
- 150000004040 pyrrolidinones Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 16
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 13
- 229910052736 halogen Inorganic materials 0.000 claims abstract 9
- 150000002367 halogens Chemical class 0.000 claims abstract 8
- 230000002401 inhibitory effect Effects 0.000 claims abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 3
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 2
- 239000001257 hydrogen Substances 0.000 claims abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 2
- 210000004027 cell Anatomy 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 208000031886 HIV Infections Diseases 0.000 claims 3
- 208000037357 HIV infectious disease Diseases 0.000 claims 3
- 102100034343 Integrase Human genes 0.000 claims 3
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 3
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 1
- 108010078851 HIV Reverse Transcriptase Proteins 0.000 claims 1
- -1 methoxy, vinyl Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000004399 C1-C4 alkenyl group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 0 CC(C)c1cc(*)c(*)c(C)c1 Chemical compound CC(C)c1cc(*)c(*)c(C)c1 0.000 description 3
- LEVLPKHLEWIDJS-INIZCTEOSA-N C[n](c(c1c2)ccc2N(C[C@H](C2)c(cc3)cc(Oc(c(Cl)ccc4)c4C#N)c3Cl)C2=O)nc1N Chemical compound C[n](c(c1c2)ccc2N(C[C@H](C2)c(cc3)cc(Oc(c(Cl)ccc4)c4C#N)c3Cl)C2=O)nc1N LEVLPKHLEWIDJS-INIZCTEOSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64802705P | 2005-01-28 | 2005-01-28 | |
| US60/648,027 | 2005-01-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007132259A RU2007132259A (ru) | 2009-03-10 |
| RU2371433C2 true RU2371433C2 (ru) | 2009-10-27 |
Family
ID=36741146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007132259/04A RU2371433C2 (ru) | 2005-01-28 | 2006-01-30 | Фенилзамещенные пирролидоны |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20080287516A1 (https=) |
| EP (1) | EP1841425A4 (https=) |
| JP (1) | JP2008528624A (https=) |
| KR (2) | KR20090028846A (https=) |
| CN (1) | CN101115481A (https=) |
| AU (1) | AU2006209245A1 (https=) |
| BR (1) | BRPI0606123A2 (https=) |
| CA (1) | CA2594915A1 (https=) |
| MX (1) | MX2007009137A (https=) |
| RU (1) | RU2371433C2 (https=) |
| WO (1) | WO2006081554A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2477604A1 (en) | 2002-03-13 | 2003-09-25 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
| MX2007008974A (es) * | 2005-01-28 | 2007-09-18 | Irm Llc | Sintesis de aril-pirrolidonas. |
| US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| WO2006084033A1 (en) | 2005-02-03 | 2006-08-10 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| JP5164510B2 (ja) * | 2006-10-06 | 2013-03-21 | 日本曹達株式会社 | 含窒素複素環化合物および有害生物防除剤 |
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| JP5607025B2 (ja) | 2008-04-21 | 2014-10-15 | シグナム バイオサイエンシーズ， インコーポレイテッド | 化合物、組成物およびそれらを作製する方法 |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| CN101747253B (zh) * | 2008-12-02 | 2013-01-16 | 中国人民解放军军事医学科学院毒物药物研究所 | 三取代的手性内酰胺类衍生物及其制备方法和用途 |
| EP3053913B1 (en) | 2009-05-01 | 2018-03-07 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| GB2497476B (en) * | 2010-09-06 | 2018-01-10 | Guangzhou Inst Biomed & Health | Amide Compounds |
| CN101979378B (zh) * | 2010-10-13 | 2012-06-27 | 中国科学院上海有机化学研究所 | 一种手性γ-内酰胺化合物的合成方法 |
| DK3811943T3 (da) | 2013-03-15 | 2023-04-03 | Aerie Pharmaceuticals Inc | Forbindelse til anvendelse til behandling af øjenlidelser |
| KR102568079B1 (ko) | 2016-08-31 | 2023-08-17 | 에어리 파마슈티컬즈, 인코포레이티드 | 안과용 조성물 |
| KR20190135027A (ko) * | 2017-03-31 | 2019-12-05 | 에어리 파마슈티컬즈, 인코포레이티드 | 아릴 시클로프로필-아미노-이소퀴놀리닐 아미드 화합물 |
| EP3676255B1 (en) | 2017-08-29 | 2025-04-16 | Rutgers, The State University University Of New Jersey | Therapeutic indazoles |
| AU2019337703B2 (en) | 2018-09-14 | 2023-02-02 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU797219A1 (ru) * | 1979-05-08 | 1995-07-25 | Ленинградский государственный педагогический институт им.А.И.Герцена | N-карбамоилметил-4-фенил-2-пирролидон, обладающий гипотензивной активностью |
| RU2168497C2 (ru) * | 1996-03-08 | 2001-06-10 | Фармация Энд Апджон Компани | Новые производные гидроксамовой кислоты, полезные для лечения заболеваний, связанных с дегенерацией соединительной ткани |
| US20040157859A1 (en) * | 2002-10-21 | 2004-08-12 | Irm Llc, A Delaware Llc | Pyrrolidones with anti-HIV activity |
-
2006
- 2006-01-30 WO PCT/US2006/003217 patent/WO2006081554A2/en not_active Ceased
- 2006-01-30 JP JP2007553324A patent/JP2008528624A/ja active Pending
- 2006-01-30 MX MX2007009137A patent/MX2007009137A/es not_active Application Discontinuation
- 2006-01-30 CA CA002594915A patent/CA2594915A1/en not_active Abandoned
- 2006-01-30 AU AU2006209245A patent/AU2006209245A1/en not_active Abandoned
- 2006-01-30 CN CNA2006800033348A patent/CN101115481A/zh active Pending
- 2006-01-30 US US11/814,480 patent/US20080287516A1/en not_active Abandoned
- 2006-01-30 BR BRPI0606123-0A patent/BRPI0606123A2/pt not_active IP Right Cessation
- 2006-01-30 RU RU2007132259/04A patent/RU2371433C2/ru not_active IP Right Cessation
- 2006-01-30 EP EP06734052A patent/EP1841425A4/en not_active Withdrawn
- 2006-01-30 KR KR1020097004694A patent/KR20090028846A/ko not_active Ceased
- 2006-01-30 KR KR1020077017487A patent/KR100896889B1/ko not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU797219A1 (ru) * | 1979-05-08 | 1995-07-25 | Ленинградский государственный педагогический институт им.А.И.Герцена | N-карбамоилметил-4-фенил-2-пирролидон, обладающий гипотензивной активностью |
| RU2168497C2 (ru) * | 1996-03-08 | 2001-06-10 | Фармация Энд Апджон Компани | Новые производные гидроксамовой кислоты, полезные для лечения заболеваний, связанных с дегенерацией соединительной ткани |
| US20040157859A1 (en) * | 2002-10-21 | 2004-08-12 | Irm Llc, A Delaware Llc | Pyrrolidones with anti-HIV activity |
Also Published As
| Publication number | Publication date |
|---|---|
| KR100896889B1 (ko) | 2009-05-14 |
| KR20070103404A (ko) | 2007-10-23 |
| WO2006081554A3 (en) | 2006-12-14 |
| RU2007132259A (ru) | 2009-03-10 |
| CA2594915A1 (en) | 2006-08-03 |
| EP1841425A2 (en) | 2007-10-10 |
| WO2006081554A2 (en) | 2006-08-03 |
| CN101115481A (zh) | 2008-01-30 |
| JP2008528624A (ja) | 2008-07-31 |
| EP1841425A4 (en) | 2009-02-18 |
| MX2007009137A (es) | 2007-09-12 |
| KR20090028846A (ko) | 2009-03-19 |
| AU2006209245A1 (en) | 2006-08-03 |
| BRPI0606123A2 (pt) | 2009-06-02 |
| US20080287516A1 (en) | 2008-11-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20100131 |