RU2340345C2 - Схема восполнения эстрогена - Google Patents

Схема восполнения эстрогена Download PDF

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Publication number
RU2340345C2
RU2340345C2 RU2005108977/15A RU2005108977A RU2340345C2 RU 2340345 C2 RU2340345 C2 RU 2340345C2 RU 2005108977/15 A RU2005108977/15 A RU 2005108977/15A RU 2005108977 A RU2005108977 A RU 2005108977A RU 2340345 C2 RU2340345 C2 RU 2340345C2
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RU
Russia
Prior art keywords
doses
estrogen
activity
phases
substance exhibiting
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RU2005108977/15A
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English (en)
Russian (ru)
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RU2005108977A (ru
Inventor
Роберт КАСПЕР (CA)
Роберт КАСПЕР
Гидеон КОПЕРНИК (IL)
Гидеон КОПЕРНИК
Зеев ШОХАМ (IL)
Зеев ШОХАМ
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Роберт КАСПЕР
Гидеон КОПЕРНИК
Зеев ШОХАМ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2005108977/15A 2002-08-28 2003-08-28 Схема восполнения эстрогена RU2340345C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40633102P 2002-08-28 2002-08-28
US60/406,331 2002-08-28

Publications (2)

Publication Number Publication Date
RU2005108977A RU2005108977A (ru) 2005-10-10
RU2340345C2 true RU2340345C2 (ru) 2008-12-10

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ID=31978284

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2005108977/15A RU2340345C2 (ru) 2002-08-28 2003-08-28 Схема восполнения эстрогена

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US (1) US8946198B2 (enExample)
EP (1) EP1539184B1 (enExample)
JP (1) JP2005538150A (enExample)
KR (1) KR20050059092A (enExample)
CN (1) CN1678324A (enExample)
AT (1) ATE345804T1 (enExample)
AU (1) AU2003264203A1 (enExample)
BR (1) BR0313921A (enExample)
CA (1) CA2495330A1 (enExample)
CY (1) CY1106019T1 (enExample)
DE (1) DE60309895T2 (enExample)
DK (1) DK1539184T3 (enExample)
ES (1) ES2277139T3 (enExample)
HR (1) HRP20050291A2 (enExample)
IL (1) IL166585A0 (enExample)
MX (1) MXPA05002294A (enExample)
NO (1) NO20051545L (enExample)
NZ (1) NZ538342A (enExample)
PL (1) PL374762A1 (enExample)
PT (1) PT1539184E (enExample)
RS (1) RS20050184A (enExample)
RU (1) RU2340345C2 (enExample)
UA (1) UA82851C2 (enExample)
WO (1) WO2004019954A1 (enExample)
ZA (1) ZA200501274B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10022384B2 (en) 2011-07-28 2018-07-17 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
US11590147B2 (en) 2015-06-22 2023-02-28 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods

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US8617597B2 (en) 2006-07-06 2013-12-31 Bayer Intellectual Property Gmbh Pharmaceutical composition containing a tetrahydrofolic acid
DE102009007771B4 (de) 2009-02-05 2012-02-16 Bayer Schering Pharma Aktiengesellschaft Bukkales Applikationssystem, 17α-Estradiol enthaltend
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
BR112014012444B1 (pt) 2011-11-23 2021-12-14 Therapeuticsmd, Inc Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
AU2015229421B2 (en) * 2014-03-12 2020-06-04 Allergan Therapeutics LLC Low-dose estradiol cream
RU2016143081A (ru) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. Натуральные комбинированные гормонозаместительные составы и терапии
JP6866561B2 (ja) 2015-06-18 2021-04-28 エステトラ ソシエテ プリーヴ ア レスポンサビリテ リミテ エステトロールを含有する口腔内崩壊錠
HRP20200850T1 (hr) 2015-06-18 2020-10-02 Estetra Sprl Orodisperzibilna jedinica za doziranje koja sadrži komponentu estetrola
EP3106148B1 (en) 2015-06-18 2018-03-14 Mithra Pharmaceuticals S.A. Orodispersible dosage unit containing an estetrol component
HUE054551T2 (hu) 2015-06-18 2021-09-28 Estetra Sprl Ösztetrolt tartalmazó, szájban diszpergálódó tabletta
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
KR20180126582A (ko) 2016-04-01 2018-11-27 쎄러퓨틱스엠디, 인코퍼레이티드 스테로이드 호르몬 약제학적 조성물
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
KR102712911B1 (ko) 2016-08-05 2024-10-04 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 월경통 및 생리통의 관리방법
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
TWI893101B (zh) 2020-04-16 2025-08-11 比利時商埃斯特拉有限責任公司 具有降低之副作用之避孕組成物

Citations (3)

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Publication number Priority date Publication date Assignee Title
RU98100451A (ru) * 1995-06-07 1999-11-27 Сигнус, Инк. Трансдермальный пластырь и способ введения 17-деацетилноргестимата отдельно или в сочетании с эстрогеном
WO2000059577A1 (en) * 1999-03-30 2000-10-12 Jencap Research Ltd. Low dose estrogen interrupted hormone replacement therapy
RU2165259C2 (ru) * 1995-04-08 2001-04-20 Шеринг Акциенгезелльшафт Фармацевтический комбинированный препарат для гормональной контрацепции

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US4900734A (en) * 1987-08-27 1990-02-13 Maxson Wayne S Novel pharmaceutical composition containing estradiol and progesterone for oral administration
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DE10100911A1 (de) * 2001-01-11 2002-08-01 Schering Ag Verfahren zur Hormonersatztherapie und dessen Darreichungsform

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
RU2165259C2 (ru) * 1995-04-08 2001-04-20 Шеринг Акциенгезелльшафт Фармацевтический комбинированный препарат для гормональной контрацепции
RU98100451A (ru) * 1995-06-07 1999-11-27 Сигнус, Инк. Трансдермальный пластырь и способ введения 17-деацетилноргестимата отдельно или в сочетании с эстрогеном
WO2000059577A1 (en) * 1999-03-30 2000-10-12 Jencap Research Ltd. Low dose estrogen interrupted hormone replacement therapy

Non-Patent Citations (2)

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Title
реферат базы данных PubMed: Rebar RW et al. Low-dose esterified estrogens (0.3 mg/day): long-term and shorm-term effects on menopausal symptoms and qualite of life in postmenopausal women. Climacteric. 2000 Sep; 3(3):176-82. {on line] PMID: 11910619 [найдено 28.06.2007]. *
ЭНЦИКЛОПЕДИЯ ЛЕКАРСТВ РЛС 2001, с.919 статья «фемостон» Р.Н.М. van de Weijer et al. Отношение женщин к возобновлению у них менструальных кровотечений в результате ЗГТ и приемлемость для них менструальноподобных реакций. Maturitas 30 1998 р.257-263 [найдено 28.06.2007] Найдено из Интернет: <URL: http://hghltd.yandex.com/yandbtm? url=http%3A%2F%2Fwww.climax.ru%2Fdoctors.... *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10022384B2 (en) 2011-07-28 2018-07-17 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
US11590147B2 (en) 2015-06-22 2023-02-28 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods

Also Published As

Publication number Publication date
MXPA05002294A (es) 2005-09-12
CN1678324A (zh) 2005-10-05
NZ538342A (en) 2007-08-31
US8946198B2 (en) 2015-02-03
DE60309895T2 (de) 2007-10-18
ES2277139T3 (es) 2007-07-01
US20060089337A1 (en) 2006-04-27
DK1539184T3 (da) 2007-03-19
BR0313921A (pt) 2005-07-19
JP2005538150A (ja) 2005-12-15
IL166585A0 (en) 2006-01-15
EP1539184A1 (en) 2005-06-15
DE60309895D1 (de) 2007-01-04
PT1539184E (pt) 2007-02-28
HRP20050291A2 (en) 2005-10-31
CA2495330A1 (en) 2004-03-11
PL374762A1 (en) 2005-10-31
EP1539184B1 (en) 2006-11-22
CY1106019T1 (el) 2011-04-06
WO2004019954A1 (en) 2004-03-11
NO20051545L (no) 2005-03-23
KR20050059092A (ko) 2005-06-17
UA82851C2 (en) 2008-05-26
RS20050184A (sr) 2007-11-15
RU2005108977A (ru) 2005-10-10
ATE345804T1 (de) 2006-12-15
AU2003264203A1 (en) 2004-03-19
ZA200501274B (en) 2006-08-30

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20090829