RU2326656C2 - Treatment method of calf gastrointestinal deseases - Google Patents

Abstract

FIELD: veterinary science.

SUBSTANCE: calf is orally given medicine once a day during 3-5 days till recovery, which contains tetracycline, tylosin tartate, dietalommonium salt N-metylamino-1- fenyl-metansylphan acid, chloramphenicol, novocaine, cevitamic acid and water with following components relation, mass.%: tetracycline - 1.5 - 2.5, tylosin tartate - 4.5 - 5.5, dietalommonium salt N-metylamino-1- fenyl-metansylphan acid - 4.0 - 4.5, chloramphenicol - 1.5 - 2.5, novocaine - 0.5 - 1.5, cevitamic acid - 0.45 - 0.55, water is the rest.

EFFECT: allows to improve treatment effectiveness; decrease his labour intensity.

4 ex, 2 tbl

Description

The invention relates to the field of veterinary medicine, in particular to methods for treating young farm animals, mainly calves, in case of gastrointestinal diseases.

Gastrointestinal diseases of young animals, in terms of prevalence and damage, occupy a leading place in the infectious pathology of young cattle.

Known methods for treating gastrointestinal diseases of calves with the help of medicines terravetin-500 and vitatetrin (Instructions for the use of terravetin-500, approved. GUV of the USSR Agroprom from 07/11/83 and Manual for the use of vitatetrin granules, approved by the GUV of the USSR Agroprom from 04.04. 87).

A known method of treating gastrointestinal diseases of calves, including the oral administration of a drug sulfatetrine containing tetracycline, thiamine bromide, riboflavin, sulfadimizine, ascorbic acid and fodder yeast, the introduction being carried out at a dose of 0.5-0.7 g / kg of animal weight two once a day until recovery (ed. certificate. No. 1639656, A61K 31/00 for 1991).

In this method, the closest to the proposed is the introduction of sulfatetrin. With this introduction, the normalization of the general condition of the animal was recorded on 4-5 days, however, it is administered 2 times a day and in a sufficiently large dose of 0.5-0.7 g / kg of animal weight.

In addition, the use of these drugs does not provide effective treatment, since the immunosuppressive effect of antibiotics is not excluded and, as a result, morbidity, decreased calf viability and their persistence.

The objective of the invention is to increase the therapeutic effectiveness of the method and identify the frequency and dose of the drug and prevent the immunosuppressive effect of antibiotics.

This is achieved by the fact that in the proposed method, which includes the oral administration of a drug containing tetracycline, tylosin tartrate, ascorbic acid, diethylammonium salt of N-methylamino-1-phenylmethanesulfonic acid, chloramphenicol, novocaine are additionally introduced in the following ratio of components, wt.% :

Tetracycline 1.5-2.5 Tylosin tartrate 4,5-5,5 Diethylammonium salt N-methylamino-1- phenyl methanesulfonic acid 4.0-4.5 Chloramphenicol 1.5-2.5 Novocaine 0.5-1.5 Vitamin C 0.45-0.55 Water Rest,

moreover, the introduction is carried out in a dose of 0.12-0.137 g / kg of animal weight once a day for 3-5 days. If necessary, the treatment is repeated with an interval of 2-3 days.

Distinctive features of the proposed method is the introduction of a medicinal product containing antimicrobial agents: tylosin tartrate, chloramphenicol, a chemically synthesized agent - diethylammonium salt of N-methylamino-1-phenylmethanesulfonic acid (having bactericidal activity and chlamydiostatic effect), ascorbic acid and novocaine in addition to local anesthetic effects, it enhances metabolism, improves folic acid synthesis. The developed complex composition of the drug with combined action and appropriate ratios makes it possible to increase the therapeutic effect, reduce the dose and interval of drug administration. In addition, the introduction of the drug is carried out in the worked out optimal dose of 0.12-0.137 g / kg of animal weight, once a day for 3-5 days.

The resulting preparation is prepared as follows: all components of the preparation are dissolved separately in distilled water, then the resulting solutions are mixed successively, further diluted with distilled water until completely dissolved by mixing the complex composition of the resulting mixture and placed for 8-10 hours in a shuttle machine. Then, the compiled composition is autoclaved at 0.5 atm for 60 minutes and, after cooling, it is poured into sterile 50-250 ml vials.

The finished product - levosulfacin is a dark brown liquid with a faint smell of almonds, mixes well in water. A slight yellow precipitate formed during storage easily dissolves with shaking.

Example 1. After a diagnosis of the disease, the calves are isolated and distributed according to the principle of analogues in two groups. Calves of the first group (experience) are injected with levosulfacin at a dose of 0.137 g / kg of animal weight once a day. Levosulfacin is used in a minimum ratio of components, wt.%: Tetracycline - 1.5; tylosin tartrate - 4.5; diethylammonium salt of N-methylamino-1-phenylmethanesulfonic acid - 4.0; chloramphenicol - 1.5; novocaine - 0.5; ascorbic acid - 0.45; water the rest. The specified dose of the drug is diluted with warm water 1:10 and evaporated from a rubber drinker once a day for 3-5 days. If necessary, the treatment is repeated with an interval of 2-3 days.

Calves of the second group (control) are injected with sulfatetrine according to the instructions for its use (0.6 g / kg of animal weight).

Accounting for the results of monitoring the condition of animals after a course of treatment is carried out for 2-3 months to exclude relapse and complications.

Before giving drugs, calves of both groups noted depression, a weakly expressed sucking reflex, increased heart rate and respiration, a dry nasal mirror, and an upset gastrointestinal tract function (diarrhea).

In the experimental group, a noticeable improvement in general condition occurred after a 5-fold administration of the drug; normalization of clinical signs was observed after a 6-day administration of the drug. The period of the disease in the experimental group was 4-5 days. The treatment efficiency was 93.3%.

In the control group, the normalization of clinical signs was established after a 6-day administration of the drug, the period of illness was 5-6 days, the treatment efficiency was 93.7%.

Example 2. Levosulfacin is used in a (average) ratio of components, wt.%: Tetracycline - 2.0; tylosin tartrate - 5.0; diethylammonium salt of N-methylamino-1-phenylmethanesulfonic acid - 4.25; chloramphenicol - 2.0; novocaine - 1.0; ascorbic acid - 0.50; water the rest.

Calves aged 10-12 days with a characteristic clinic of a gastrointestinal disease (depression, inactivity, rapid breathing, dry nasal mirror, diarrhea) are divided into two groups according to the principle of analogues. The treatment regimen and procedure for recording the results, as in example 1.

In the first group, a noticeable improvement in the general condition is noted after a 4-fold administration of the drug; clinical recovery occurred after a 6-day administration of the drug.

The period of the disease was 5 days. The treatment efficiency was 97.6%.

In the second group, an improvement in the clinical condition is noted after a 7-day administration of the drug. The period of the disease is 5-6 days., The effectiveness of the treatment is 95%.

Example 3. Levosulfacin is used in the maximum ratio of components, wt.%: Tetracycline - 2.5; tylosin tartrate - 5.5; diethylammonium salt of N-methylamino-1-phenylmethanesulfonic acid - 4.5; chloramphenicol - 2.5; novocaine - 1.5; ascorbic acid - 0.55; water the rest.

Calves aged 10 to 12 days, with the appearance of signs of a gastrointestinal disease (depression, inactivity, increased heart rate and respiration, diarrhea) are isolated and divided into two groups according to the principle of analogues. The treatment regimen and procedure for recording the results, as in example 1.

In the first group, an improvement in general condition was noted after a 4-fold administration of the drug. The period of the disease was 3-5 days. The treatment efficiency was 100.0%.

In the second group, the period of the disease was 6 days, the treatment efficiency was 95.0%.

Example 4. Determining the effectiveness of treatment of calves depending on the dose of the drug.

Calves with pronounced signs of a gastrointestinal disease are divided according to the principle of analogues into five groups: four groups - experience, fifth group - control.

The calves of the experimental groups are injected with levosulfacin (with a maximum ratio of components) once a day with an interval of 24 hours in a dose: the first group 0.12; second group 0.125; the third group is 0.13; the fourth group is 0.137 g / kg of animal weight.

Calves of the control group are injected with sulfatetrine at a dose of 0.6 g / kg of animal weight according to the instructions for its use.

The effectiveness of treatment depending on the dose of the drug is shown in the table.

Table 1
Therapeutic efficacy depending on the dose Groups of animals Number of Goals Live Disease diagnosis Dose g / kg Recovered Fell Prod. treatment (days) Total Goals % Total Goals % one fifteen colibacillosis 0.12 fourteen 93.3 one 6.7 4-5 2 16 colibacillosis 0.125 fifteen 93.7 one 6.3 4-5 3 16 colibacillosis 0.13 16 one hundred - - 3-4 four 16 colibacillosis 0.137 16 one hundred - - 3-4 Control (sulfatetrin) 16 colibacillosis 0.6 fifteen 93.7 one 6.3 6

As can be seen from the table, the proposed method for the treatment of gastrointestinal diseases of calves with levosulfacin can reduce the dose of the drug by 3.5 times with a single administration.

The therapeutic efficacy, depending on the dose, is 93.3-100%, with the use of sulfatetrin 93.7%.

Comparative tests of the effectiveness of levosulfacin in production conditions were carried out on the farms of the Vysokogorsky and Arsky regions of Tatarstan.

table 2
The effectiveness of treatment with levosulfacin Experience number Group No. Number of animals Disease diagnosis Treatment results Dose g / kg Duration of treatment, days Recovered Fell Efficiency (%) one 1 experience 25 colibacillosis 0.137 3-4 24 0 96 one hundred 6 one 0 four 2 control 25 colibacillosis 0.6 4-5 22 0 88 96 5-6 2 one 8 2 1 experience 32 salmonellosis 0.137 5-6 28 0 87.5 96.9 7 3 one 9,4 2 control 32 salmonellosis 0.6 6-7 27 0 84.3 90.55 7-8 2 2 6.25 3 1 experience thirty colibacillosis 0.137 3-4 28 0 93.3 one hundred 5-6 2 0 6.7 2 control thirty colibacillosis 0.8 3-5 27 0 90 96.6 5-6 2 one 6.6

As can be seen from table 2, the effectiveness of treatment in the farms of Tatarstan is 96.6-100% when using the drug at a dose of 0.137 g / kg while at the same time using sulfatetrin at a dose of 0.6-0.8 g / kg, the therapeutic effectiveness corresponded to 90 , 55-96.6%, however, it should be noted that the therapeutic dose of levosulfacin was 4.3-5.8 times less than sulfatetrin.

In addition, levosulfacin was used once a day, and sulfatetrine was used 2 times a day according to the instructions for its use. In total, the daily dose of levosulfacin was 0.137 g / kg, sulfatetrine 1.2-1.6 g / kg.

Claims (1)

A method of treating gastrointestinal diseases of calves, comprising oral administration of a drug containing tetracycline and ascorbic acid, characterized in that the drug further comprises tylosin tartrate, diethylammonium salt of N-methylamino-1-phenylmethanesulfonic acid, chloramphenicol, novocaine and water with the following ratio of components, wt.%: Tetracycline 1,5 - 2,5 Tylosin tartrate 4,5 - 5,5 Diethylammonium salt N-methylamino-1-phenyl- methanesulfonic acid 4.0-4.5 Chloramphenicol 1.5-2.5 Novocaine 0.5-1.5 Vitamin C 0.45-0.55 Water Rest, and the introduction is carried out in a dose of 0.12-0.137 g / kg of animal weight once a day for 3-5 days before recovery.