RU2304981C2 - Синергетическая композиция наполнителя - Google Patents
Синергетическая композиция наполнителя Download PDFInfo
- Publication number
- RU2304981C2 RU2304981C2 RU2004105268/15A RU2004105268A RU2304981C2 RU 2304981 C2 RU2304981 C2 RU 2304981C2 RU 2004105268/15 A RU2004105268/15 A RU 2004105268/15A RU 2004105268 A RU2004105268 A RU 2004105268A RU 2304981 C2 RU2304981 C2 RU 2304981C2
- Authority
- RU
- Russia
- Prior art keywords
- tablet
- copolymer
- microcrystalline cellulose
- composition
- pvp
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 24
- 230000002195 synergetic effect Effects 0.000 title claims description 11
- 239000000945 filler Substances 0.000 title abstract description 6
- 229920001577 copolymer Polymers 0.000 claims abstract description 20
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 18
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 18
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 14
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 14
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 7
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229940079593 drug Drugs 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 14
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 8
- 239000000126 substance Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 7
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 4
- 229960001138 acetylsalicylic acid Drugs 0.000 description 4
- 238000007906 compression Methods 0.000 description 4
- 230000006835 compression Effects 0.000 description 4
- GUBGYTABKSRVRQ-UHFFFAOYSA-N 2-(hydroxymethyl)-6-[4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Chemical compound OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O GUBGYTABKSRVRQ-UHFFFAOYSA-N 0.000 description 3
- 229910004298 SiO 2 Inorganic materials 0.000 description 3
- 229960004166 diltiazem Drugs 0.000 description 3
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
- 229960005489 paracetamol Drugs 0.000 description 3
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 3
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 101001022170 Homo sapiens FYN-binding protein 2 Proteins 0.000 description 1
- 101000990990 Homo sapiens Midkine Proteins 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 102100030335 Midkine Human genes 0.000 description 1
- 208000029618 autoimmune pulmonary alveolar proteinosis Diseases 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- 229910000393 dicalcium diphosphate Inorganic materials 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- FYUWIEKAVLOHSE-UHFFFAOYSA-N ethenyl acetate;1-ethenylpyrrolidin-2-one Chemical compound CC(=O)OC=C.C=CN1CCCC1=O FYUWIEKAVLOHSE-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Seeds, Soups, And Other Foods (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/915,057 US6524617B1 (en) | 2001-07-25 | 2001-07-25 | Synergistic filler composition |
| US09/915,057 | 2001-07-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004105268A RU2004105268A (ru) | 2005-03-10 |
| RU2304981C2 true RU2304981C2 (ru) | 2007-08-27 |
Family
ID=25435143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004105268/15A RU2304981C2 (ru) | 2001-07-25 | 2002-05-10 | Синергетическая композиция наполнителя |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6524617B1 (en:Method) |
| EP (1) | EP1416918B1 (en:Method) |
| JP (1) | JP4805537B2 (en:Method) |
| CN (1) | CN1268320C (en:Method) |
| AT (1) | ATE327738T1 (en:Method) |
| BR (1) | BRPI0211439B1 (en:Method) |
| CA (1) | CA2454449C (en:Method) |
| DE (1) | DE60211916T2 (en:Method) |
| ES (1) | ES2266502T3 (en:Method) |
| MX (1) | MXPA04000666A (en:Method) |
| RU (1) | RU2304981C2 (en:Method) |
| WO (1) | WO2003011253A1 (en:Method) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6620900B2 (en) * | 2002-02-07 | 2003-09-16 | Isp Investments Inc. | Proliferous copolymer of vinyl pyrrolidone and vinyl acetate |
| JP4776233B2 (ja) * | 2002-11-12 | 2011-09-21 | エラン ファーマ インターナショナル，リミティド | 摩損しにくくかつプルランを含む速崩壊性固形製剤 |
| US7704528B2 (en) * | 2003-05-05 | 2010-04-27 | Isp Investments Inc. | Binder composition and method for processing poorly compressible drugs into tablets of predetermined hardness and friability |
| US20070036859A1 (en) * | 2005-08-11 | 2007-02-15 | Perry Ronald L | Sustained release antihistamine and decongestant composition |
| US8168219B2 (en) * | 2005-11-30 | 2012-05-01 | Isp Investments Inc. | Synergistic binder composition, method for making same, and tablets of an active and said binder having advantageous hardness and friability |
| ES2738182T3 (es) * | 2013-03-12 | 2020-01-20 | Hercules Llc | Composición polimérica revestida de sílice coprocesada |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4434152A (en) * | 1981-04-28 | 1984-02-28 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | Time-release |
| US5912013A (en) * | 1991-07-23 | 1999-06-15 | Shire Laboratories, Inc. | Advanced drug delivery system and method of treating psychiatric, neurological and other disorders with carbamazepine |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6824996A (en) * | 1995-08-17 | 1997-03-12 | Dyer, Alison Margaret | Controlled release products |
| AT413647B (de) * | 1998-11-26 | 2006-04-15 | Sandoz Ag | Verwendung eines copolymerisats aus 1-vinyl-2-pyrrolidon und vinylacetat zur herstellung von cefuroximaxetil-hältigen tabletten |
-
2001
- 2001-07-25 US US09/915,057 patent/US6524617B1/en not_active Expired - Lifetime
-
2002
- 2002-05-10 DE DE60211916T patent/DE60211916T2/de not_active Expired - Lifetime
- 2002-05-10 RU RU2004105268/15A patent/RU2304981C2/ru active
- 2002-05-10 CN CNB028185161A patent/CN1268320C/zh not_active Expired - Lifetime
- 2002-05-10 CA CA2454449A patent/CA2454449C/en not_active Expired - Lifetime
- 2002-05-10 EP EP02734286A patent/EP1416918B1/en not_active Expired - Lifetime
- 2002-05-10 BR BRPI0211439-9A patent/BRPI0211439B1/pt not_active IP Right Cessation
- 2002-05-10 AT AT02734286T patent/ATE327738T1/de not_active IP Right Cessation
- 2002-05-10 ES ES02734286T patent/ES2266502T3/es not_active Expired - Lifetime
- 2002-05-10 JP JP2003516485A patent/JP4805537B2/ja not_active Expired - Lifetime
- 2002-05-10 MX MXPA04000666A patent/MXPA04000666A/es active IP Right Grant
- 2002-05-10 WO PCT/US2002/014586 patent/WO2003011253A1/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4434152A (en) * | 1981-04-28 | 1984-02-28 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | Time-release |
| US5912013A (en) * | 1991-07-23 | 1999-06-15 | Shire Laboratories, Inc. | Advanced drug delivery system and method of treating psychiatric, neurological and other disorders with carbamazepine |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2004105268A (ru) | 2005-03-10 |
| EP1416918B1 (en) | 2006-05-31 |
| US6524617B1 (en) | 2003-02-25 |
| CA2454449A1 (en) | 2003-02-13 |
| WO2003011253A1 (en) | 2003-02-13 |
| CN1268320C (zh) | 2006-08-09 |
| BR0211439A (pt) | 2004-07-20 |
| BRPI0211439B1 (pt) | 2017-09-19 |
| CN1556695A (zh) | 2004-12-22 |
| CA2454449C (en) | 2010-10-26 |
| DE60211916T2 (de) | 2007-01-04 |
| US20030031708A1 (en) | 2003-02-13 |
| EP1416918A4 (en) | 2004-08-18 |
| BRPI0211439B8 (en:Method) | 2021-05-25 |
| ATE327738T1 (de) | 2006-06-15 |
| ES2266502T3 (es) | 2007-03-01 |
| EP1416918A1 (en) | 2004-05-12 |
| JP4805537B2 (ja) | 2011-11-02 |
| JP2005501049A (ja) | 2005-01-13 |
| DE60211916D1 (de) | 2006-07-06 |
| MXPA04000666A (es) | 2004-04-05 |
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