RU2293563C1 - Method for treatment of ophthalmic infectious inflammatory disease - Google Patents

Abstract

FIELD: medicine, ophthalmology.

SUBSTANCE: method involves dropping into conjunctival cavity a medicinal preparation as ophthalmic drops of the following composition: taufon 4% solution, 5 ml; sodium hypochlorite 0.03-0.06% solution, 5 ml, in the dose 1-2 drops, 6-8 times per a day for 7-10 days. Method provides absence of relapses of infectious process being independently of a pathogen type based on high therapeutic activity of the preparation. Invention can be used in treatment of ophthalmic infectious inflammatory diseases.

EFFECT: improved method of treatment.

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Description

The invention relates to medicine, namely to ophthalmology, and can be used to treat infectious inflammatory eye diseases.

A known method of treating ulcerative keratitis, including instillation of a drug in the conjunctival cavity of the eye (see V.I. Morozov, A.A. Yakovlev. Pharmacotherapy of eye diseases. Moscow, Medicine, 2001, p.56-57). The disadvantages of this method are: low therapeutic activity of the drug used, a long period of treatment, the possibility of progression of the infectious process.

The objective of the invention is to provide an effective method for the treatment of infectious inflammatory eye diseases.

The technical result is the high therapeutic activity of the drug used, regardless of the type of pathogen of the infectious inflammatory process, the reduction of treatment time, the absence of relapse of the infectious process. The technical result is achieved due to the fact that:

1) the antimicrobial properties of sodium hypochlorite are combined with the metabolic, regenerating effect and antioxidant properties of taurine;

2) sodium hypochlorite is a broad-spectrum antiseptic, effective against gram-positive and gram-negative bacteria - pathogens of purulent-inflammatory diseases, - a number of viruses, fungi, protozoa, which allows you to use it without identifying microflora;

3) the used concentrations of taurine and sodium hypochlorite are safe for the eye structures and are necessary and sufficient to achieve the specified technical result at a given rate of instillation.

The technical result is achieved by the fact that in the proposed method for the treatment of infectious inflammatory eye diseases, including instillation of a drug in the conjunctival cavity, according to the invention, eye drops of the composition are used as a drug: aqueous solution of taufon 4% - 5 ml; an aqueous solution of sodium hypochlorite 0.03-0.06% - 5 ml, which are instilled into the conjunctival cavity in the amount of 1-2 drops 6-8 times a day for 7-10 days.

The invention is illustrated by the following clinical examples.

Example 1. Patient K., 38 years old. He enrolled in the Kaluga branch of the State Scientific and Research Center "Eye Microsurgery" with complaints of redness, itching, and purulent purulent discharge from the OU for about 5 days. Objectively: The eyes are irritated, severe hyperemia of the conjunctiva of the arches of the veins, follicles are enlarged. Optical media are transparent. The fundus is a pink reflex. Conjunctival swab - St. epidermidis. Diagnosis: Acute conjunctivitis.

Eye drops of the composition were instilled into the patient in the conjunctival cavity: aqueous solution of taufon 4% - 5 ml; an aqueous solution of sodium hypochlorite 0.03% - 5 ml, in the amount of 2 drops 6 times a day for 7 days. A complete relief of the inflammatory process is achieved.

After the course of treatment: subjective complaints disappeared. Objectively: eyes calm OU. Smear - no growth of pathogenic microorganisms was detected.

Example 2. Patient L., 45 years old. Received in the Kaluga branch of the State Research and Technology Center "Eye Microsurgery" with complaints of profuse purulent discharge, redness, lacrimation, photophobia OU. Objectively: eyes are irritated; mixed injection; small spot infiltrates on the cornea; purulent discharge from the conjunctival cavity; clean in the anterior chamber; underlying environments are transparent. The fundus is a pink reflex. A smear from the conjunctival cavity - E. coli. Diagnosis: Acute keratoconjunctivitis OU.

Eye drops of the composition were instilled into the patient in the conjunctival cavity: aqueous solution of taufon 4% - 5 ml; an aqueous solution of sodium hypochlorite 0.05% - 5 ml, in the amount of 1 drop 8 times a day for 10 days.

After treatment: no complaints, eyes calm, conjunctiva pink, transparent cornea. Smear - no growth of pathogenic microorganisms was detected.

Example 3. Patient D., 18 years old. He entered the Kaluga branch of the State Scientific and Research Center "Eye Microsurgery" with complaints of lacrimation, photophobia, redness OD, which appeared the night before. Has been using contact lenses for 2 years. Objectively: the eye is irritated, pericorneal injection; corneal edema, pinpoint infiltrates in the surface layers of the cornea. The anterior chamber is clean, the surrounding environment is transparent. The fundus is a pink reflex. Smear - St.aureus. Diagnosis: Acute keratitis OD.

Eye drops of the composition were instilled into the patient in the conjunctival cavity: aqueous solution of taufon 4% - 5 ml; an aqueous solution of sodium hypochlorite 0.06% - 5 ml, in the amount of 1 drop 6 times a day for 8 days.

After the course of treatment: no complaints. Objectively: OD is calm, the cornea is transparent. Smear - no growth of pathogenic microorganisms was detected.

Example 4. Patient Yu., 47 years old, was admitted to the Kaluga branch of the State Scientific and Research Center "Eye Microsurgery" with complaints of profuse purulent discharge, redness, lacrimation, photophobia OU. Objectively: eyes are irritated; mixed injection; small spot infiltrates on the cornea; purulent discharge from the conjunctival cavity; in PC - clean; underlying environments are transparent. The fundus is a pink reflex. A smear from the conjunctival cavity - E. coli. Diagnosis: Acute keratoconjunctivitis OU.

Eye drops of the composition were instilled into the patient in the conjunctival cavity: aqueous solution of taufon 4% - 5 ml; an aqueous solution of sodium hypochlorite 0.04% - 5 ml, in the amount of 1 drop 7 times a day for 8 days.

After the course of treatment: no complaints. Objectively: OD is calm, the cornea is transparent. Smear - no growth of pathogenic microorganisms was detected.

The proposed method treated 28 patients with keratoconjunctivitis, acute conjunctivitis and acute keratitis. In all cases, the claimed technical result was achieved. In no case was a relapse of the infectious process observed.

The proposed method does not require sophisticated equipment and is easily feasible both in inpatient and outpatient settings.

Thus, the proposed method is characterized by high therapeutic activity of the drug used, regardless of the type of causative agent of the infectious inflammatory process, allows to reduce treatment time, ensures the absence of relapse of the infectious process.

Claims (1)

A method for the treatment of infectious inflammatory eye diseases, including instillation of a drug in the conjunctival cavity of the eye, characterized in that eye drops of the composition are used as a drug: taufon solution 4% - 5 ml, sodium hypochlorite solution 0.03-0.06% - 5 ml, which are instilled into the conjunctival cavity in the amount of 1-2 drops 6-8 times a day for 7-10 days.