RU2359645C1 - Method of treating infectious inflammatory eye diseases - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to ophthalmology, and is intended for treatment of infectious inflammatory eye diseases. Into eye conjunctiva cavity 4-6 times a day during 5-7 days 0.1 ml of gel which has the following composition: water-soluble cellulose derivative with concentration 20 mg/l in amount 7 ml, sodium hypochlorite water solution with concentration 250-300 mg/l in amount 3 ml is applied.

EFFECT: creating maximal concentration of medicinal substance on local area.

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Description

The invention relates to medicine, namely to ophthalmology, and can be used to treat infectious inflammatory eye diseases.

A known method of treating ulcerative keratitis, including the introduction of a drug into the conjunctival cavity of the eye (see V.I. Morozov, A.A. Yakovlev. Pharmacotherapy of eye diseases. M: Medicine, 2001, p. 56-57). The disadvantages of this method are: the inability to create a maximum concentration of the drug in the local area, low therapeutic activity of the drug used, a long treatment period, the need for multiple instillations, the possibility of progression of the infectious process.

The objective of the invention is to provide an effective method for the treatment of infectious inflammatory eye diseases.

The technical result is the creation of a maximum concentration of a drug substance at a local site, its prolonged action, high therapeutic activity regardless of the type of pathogen of the infectious inflammatory process, reduction of treatment time, and the absence of relapse of the infectious process. The technical result is achieved due to the fact that:

1) use a gel based on water-soluble derivatives of cellulose, which allows you to apply the drug locally, use it at a lower concentration and provide a prolonged effect compared with the use of solutions in drops;

2) sodium hypochlorite is a broad-spectrum antiseptic, effective against gram-positive and gram-negative bacteria - pathogens of purulent-inflammatory diseases, - a number of viruses, fungi, protozoa, which allows you to use it without identifying microflora;

3) the used concentrations of sodium hypochlorite are safe for the eye structures and are necessary and sufficient to achieve the specified technical result for a given local application.

The technical result is achieved in that in the proposed method for the treatment of infectious inflammatory diseases of the eye, including the introduction into the conjunctival cavity of a drug, according to the invention, a gel composition is used as a drug: a water-soluble cellulose derivative, for example methyl cellulose or carboxymethyl cellulose, or hydroxyethyl cellulose, with a concentration of 20 mg / l of a volume of 7 ml, an aqueous solution of sodium hypochlorite with a concentration of 250-300 mg / l of a volume of 3 ml, which is laid in the conjuncti cial cavity in a volume of 0.1 ml 4-6 times a day for 5-7 days.

The invention is illustrated by the following clinical examples.

Example 1. Patient O., 38 years old. He entered the Kaluga branch of the Federal State Institution IRTC "Eye Microsurgery" with complaints of redness, itching, and purulent purulent discharge from the OU for about 7 days. Objectively: eyes are irritated, pronounced hyperemia of the conjunctiva of the arches of veins, follicles are enlarged. Optical media are transparent. The fundus is a pink reflex. Conjunctival swab - St. epidermidis. Diagnosis: Acute conjunctivitis.

A gel of the composition was placed in the patient's conjunctival cavity: methyl cellulose with a concentration of 20 mg / L with a volume of 7 ml, an aqueous solution of sodium hypochlorite with a concentration of 250 mg / L with a volume of 3 ml - 6 times a day for 5 days. A complete relief of the inflammatory process is achieved.

After the course of treatment: subjective complaints disappeared. Objectively: eyes calm OU. Smear - no growth of pathogenic microorganisms was detected.

Example 2. Patient L., 40 years old. He entered the Kaluga branch of the Federal State Institution IRTC "Eye Microsurgery" with complaints of profuse purulent discharge, redness, lacrimation, photophobia OU. Objectively: eyes are irritated; mixed injection; small spot infiltrates on the cornea; purulent discharge from the conjunctival cavity; clean in the anterior chamber; underlying environments are transparent. The fundus is a pink reflex. A smear from the conjunctival cavity - E. coli. Diagnosis: Acute keratoconjunctivitis OU.

A gel of the composition was placed into the patient's conjunctival cavity: carboxymethyl cellulose with a concentration of 20 mg / L with a volume of 7 ml, an aqueous solution of sodium hypochlorite with a concentration of 300 mg / L with a volume of 3 ml - 4 times a day for 7 days.

After treatment: no complaints, eyes calm, conjunctiva pink, transparent cornea. Smear - no growth of pathogenic microorganisms was detected.

Example 3. Patient 3., 19 years old. Received in the Kaluga branch of the Federal State Institution IRTC "Eye Microsurgery" with complaints of lacrimation, photophobia, redness OD, appeared the night before. Has been using contact lenses for 2 years. Objectively: the eye is irritated, pericorneal injection; corneal edema, pinpoint infiltrates in the surface layers of the cornea. The anterior chamber is clean, the surrounding environment is transparent. The fundus is a pink reflex. Smear - St. aureus. Diagnosis: Acute keratitis OD.

The patient was placed in the conjunctival cavity with a gel of the composition: hydroxyethyl cellulose with a concentration of 20 mg / L with a volume of 7 ml, an aqueous solution of sodium hypochlorite with a concentration of 280 mg / L with a volume of 3 ml - 5 times a day for 6 days.

After the course of treatment: no complaints. Objectively: OD is calm, the cornea is transparent. Smear - no growth of pathogenic microorganisms was detected.

Example 4. Patient L., 49 years old. Received in the Kaluga branch of the Federal State Institution IRTC “Eye Microsurgery” with complaints of profuse purulent discharge, redness, lacrimation, photophobia OU. Objectively: eyes are irritated; mixed injection; small spot infiltrates on the cornea; purulent discharge from the conjunctival cavity; in PC - clean; underlying environments are transparent. The fundus is a pink reflex. A smear from the conjunctival cavity - E. coli. Diagnosis: Acute keratoconjunctivitis OU.

The patient was placed in the conjunctival cavity with a gel of the composition: methyl cellulose with a concentration of 20 mg / L with a volume of 7 ml, an aqueous solution of sodium hypochlorite with a concentration of 270 mg / L with a volume of 3 ml - 6 times a day for 6 days.

After the course of treatment: no complaints. Objectively: OD is calm, the cornea is transparent. Smear - no growth of pathogenic microorganisms was detected.

The proposed method treated 28 patients with keratoconjunctivitis, acute conjunctivitis and acute keratitis. In all cases, the claimed technical result was achieved. In no case was a relapse of the infectious process observed.

Thus, the proposed method provides the creation of a maximum concentration of a medicinal substance in a local area, its prolonged action, high therapeutic activity regardless of the type of causative agent of the infectious inflammatory process, reducing treatment time, and the absence of relapse of the infectious process.

Claims (1)

A method for the treatment of infectious inflammatory eye diseases, including instillation of a drug into the conjunctival cavity of the eye, characterized in that the gel composition is used as a drug: a water-soluble cellulose derivative with a concentration of 20 mg / l, a volume of 7 ml, an aqueous solution of sodium hypochlorite with a concentration of 250-300 mg / l of 3 ml, which is placed in the conjunctival cavity in a volume of 0.1 ml 4-6 times a day for 5-7 days.