RU2287160C2 - Количественный диагностический анализ гипертензии - Google Patents
Количественный диагностический анализ гипертензии Download PDFInfo
- Publication number
- RU2287160C2 RU2287160C2 RU2003130071/15A RU2003130071A RU2287160C2 RU 2287160 C2 RU2287160 C2 RU 2287160C2 RU 2003130071/15 A RU2003130071/15 A RU 2003130071/15A RU 2003130071 A RU2003130071 A RU 2003130071A RU 2287160 C2 RU2287160 C2 RU 2287160C2
- Authority
- RU
- Russia
- Prior art keywords
- snp
- hypertension
- exon
- hsgk1
- gene
- Prior art date
Links
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Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/723—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10113876.8 | 2001-03-21 | ||
| DE10113876A DE10113876A1 (de) | 2001-03-21 | 2001-03-21 | Quantitative diagnostische Analyse der Hypertonie |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2003130071A RU2003130071A (ru) | 2005-04-10 |
| RU2287160C2 true RU2287160C2 (ru) | 2006-11-10 |
Family
ID=7678460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2003130071/15A RU2287160C2 (ru) | 2001-03-21 | 2002-03-21 | Количественный диагностический анализ гипертензии |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20060127892A1 (enExample) |
| EP (1) | EP1390531B1 (enExample) |
| JP (1) | JP2004528032A (enExample) |
| CN (1) | CN1306040C (enExample) |
| AT (1) | ATE331043T1 (enExample) |
| AU (1) | AU2002244751B2 (enExample) |
| CA (1) | CA2441314C (enExample) |
| CY (1) | CY1105566T1 (enExample) |
| DE (2) | DE10113876A1 (enExample) |
| DK (1) | DK1390531T3 (enExample) |
| ES (1) | ES2266463T3 (enExample) |
| HU (1) | HUP0303491A3 (enExample) |
| MX (1) | MXPA03008522A (enExample) |
| PL (1) | PL364387A1 (enExample) |
| PT (1) | PT1390531E (enExample) |
| RU (1) | RU2287160C2 (enExample) |
| WO (1) | WO2002074987A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003053363A2 (en) * | 2001-12-19 | 2003-07-03 | Millennium Pharmaceuticals, Inc. | Human diacylglycerol acyltransferase 2 (dgat2) family members and uses therefor |
| US6830911B2 (en) * | 2002-02-08 | 2004-12-14 | Applera Corporation | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof |
| DE10305213A1 (de) * | 2003-02-07 | 2004-08-26 | Florian Prof. Dr.med. Lang | Verwendung eines neuen Polymorphismus im hsgk1-Gen zur Diagnose der Hypertonie und Verwendung der sgk-Genfamilie zur Diagnose und Therapie des Long-Q/T-Syndroms |
| JP4762552B2 (ja) * | 2003-03-03 | 2011-08-31 | フロリアン ラング、 | 診断用および治療用標的としてのｓｇｋ１ |
| DE10346913A1 (de) | 2003-10-09 | 2005-05-04 | Merck Patent Gmbh | Acylhydrazonderivate |
| RU2261442C2 (ru) * | 2003-12-09 | 2005-09-27 | Государственное образовательное учреждение высшего профессионального образования "Нижегородская Государственная Медицинская академия" МЗ РФ (ГОУ ВПО НижГМА) | Способ диагностики артериальной гипертензии |
| WO2007025792A1 (de) * | 2005-09-02 | 2007-03-08 | Florian Lang | Verfahren zur diagnose von hypertonie |
| CN102654893A (zh) * | 2011-03-04 | 2012-09-05 | 苏州卫生职业技术学院 | 分析高尿酸血症和高血压患病率关系的方法 |
| WO2023114714A1 (en) * | 2021-12-14 | 2023-06-22 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Sgk1 inhibitory compositions and methods |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19917990A1 (de) * | 1999-04-20 | 2000-11-02 | Florian Lang | Arzneimittel enthaltend Hemmstoffe der zellvolumenregulierten humanen Kinase h-sgk |
-
2001
- 2001-03-21 DE DE10113876A patent/DE10113876A1/de not_active Withdrawn
-
2002
- 2002-03-21 MX MXPA03008522A patent/MXPA03008522A/es active IP Right Grant
- 2002-03-21 AT AT02712954T patent/ATE331043T1/de active
- 2002-03-21 EP EP02712954A patent/EP1390531B1/de not_active Expired - Lifetime
- 2002-03-21 PT PT02712954T patent/PT1390531E/pt unknown
- 2002-03-21 JP JP2002574375A patent/JP2004528032A/ja active Pending
- 2002-03-21 HU HU0303491A patent/HUP0303491A3/hu unknown
- 2002-03-21 ES ES02712954T patent/ES2266463T3/es not_active Expired - Lifetime
- 2002-03-21 DK DK02712954T patent/DK1390531T3/da active
- 2002-03-21 RU RU2003130071/15A patent/RU2287160C2/ru not_active IP Right Cessation
- 2002-03-21 WO PCT/EP2002/003180 patent/WO2002074987A2/de not_active Ceased
- 2002-03-21 CN CNB028086481A patent/CN1306040C/zh not_active Expired - Fee Related
- 2002-03-21 PL PL02364387A patent/PL364387A1/xx not_active Application Discontinuation
- 2002-03-21 US US10/472,622 patent/US20060127892A1/en not_active Abandoned
- 2002-03-21 CA CA2441314A patent/CA2441314C/en not_active Expired - Fee Related
- 2002-03-21 DE DE50207305T patent/DE50207305D1/de not_active Expired - Lifetime
- 2002-03-21 AU AU2002244751A patent/AU2002244751B2/en not_active Ceased
-
2006
- 2006-07-28 CY CY20061101052T patent/CY1105566T1/el unknown
Non-Patent Citations (1)
| Title |
|---|
| WAERNTGES S. et al., Transcriptional upregulation of the human serine-threonine Kinase hSGK1 in glomerulonephritis, Kidney and blood pressure zesearch, 2000, v.23, №3-5, seite 246. * |
Also Published As
| Publication number | Publication date |
|---|---|
| HK1063338A1 (en) | 2004-12-24 |
| CN1306040C (zh) | 2007-03-21 |
| RU2003130071A (ru) | 2005-04-10 |
| CY1105566T1 (el) | 2010-07-28 |
| HUP0303491A3 (en) | 2005-12-28 |
| WO2002074987A3 (de) | 2003-12-04 |
| DK1390531T3 (da) | 2006-10-23 |
| EP1390531A2 (de) | 2004-02-25 |
| MXPA03008522A (es) | 2005-03-07 |
| CA2441314C (en) | 2011-11-08 |
| JP2004528032A (ja) | 2004-09-16 |
| AU2002244751C1 (en) | 2002-10-03 |
| US20060127892A1 (en) | 2006-06-15 |
| ATE331043T1 (de) | 2006-07-15 |
| CN1503848A (zh) | 2004-06-09 |
| PL364387A1 (en) | 2004-12-13 |
| ES2266463T3 (es) | 2007-03-01 |
| HUP0303491A2 (hu) | 2004-08-30 |
| CA2441314A1 (en) | 2002-09-26 |
| DE10113876A1 (de) | 2002-09-26 |
| EP1390531B1 (de) | 2006-06-21 |
| PT1390531E (pt) | 2006-09-29 |
| WO2002074987A2 (de) | 2002-09-26 |
| AU2002244751B2 (en) | 2007-01-11 |
| DE50207305D1 (de) | 2006-08-03 |
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