RU2277420C1 - Preparation for treating inflammatory skin diseases - Google Patents

Abstract

FIELD: medicine, pharmaceutical industry.

SUBSTANCE: the suggested preparation for treating inflammatory skin diseases contains mud volcano mud as an active substance to be introduced into polymeric mixture, moreover, the mud should be introduced into swollen polymers during mixing and homogenization till the development of homogeneous gel mass at the ratio of 15-30:1.5-2.5 in weight portions, and, also, a conservant and a pharmaceutically acceptable solvent. Additionally, the preparation contains plant and/or mineral oils and an emulsifier.

EFFECT: higher efficiency of therapy.

4 cl, 4 ex

Description

The invention relates to pharmacology, medicine, biology, and in particular to means for the treatment of skin diseases.

In cosmetology and medicine, native therapeutic muds are widely used in the form of applications, body wraps, application to the face in the form of masks. The remedies are usually native muds with the addition of vegetable or essential oils, plant extracts, etc. or emulsion or gel forms with the addition of various extracts from mud.

However, the use of native muds and agents representing native muds with additives for the treatment of inflammatory skin diseases have several disadvantages. A detailed study of the composition and action of native muds showed that the biological effects associated with the healing, improving microcirculation, antihistamine and therapeutic effect depend not only on the quantitative content of biologically active substances (trace elements, vitamins, humic acids, etc.) in the mud, but also from the ability of these biologically active substances to release into the skin.

A well-known “mud” mask containing silt mud, stearic acid, triethanolamine, emulsion wax, linseed oil, corn oil, agidol, nipagin, nipazole, kaolin, water-alcohol extracts of plant materials: chamomile, yarrow, mint, licorice, lavender oil, glycerin ( RF №2145839, publ. 02.27.2000).

Known tool containing a mixture of Tambukan therapeutic mud, sapropel, blue clay, kaolin, emulsifiers, antioxidants (RF patent No. 2180213, publ. 10.03.2002).

Known tool for the treatment of skin diseases, which is a mixture of crushed mineral shungite and zinc paste of water (RF patent No. 2109508, publ. 04/27/1998).

The disadvantages of the known funds is the unevenness of applying them to the skin and the need for a thick layer of these funds, as well as the low release of biologically active substances in the skin and possible irritating effects.

The use of dirt itself (or with additives) as a tool is also limited due to the high microbial contamination (for all dirt) - not more than 100,000 CFU per 1 g. Whereas for cosmetics it should not exceed 1000 CFU per 1 g (according to SanPiN - No. 1.2681-97).

Known dirt for the treatment of patients, which is a mixture of crushed mineral shungite and drinking water (RF patent No. 2109507, publ. 04/27/1998).

This invention is the closest and is selected as a prototype.

Polymer-based products with the addition of any extracts from mud do not provide a comprehensive effect in the treatment of allergic dermatitis and acne, which gives native mud.

In contrast to the known, the claimed tool is a mud of mud rich in minerals and microelements (calcium, lithium, boron, bromine, iodine, vanadium, molybdenum, zinc, copper, sodium, chlorine, manganese, selenium, cobalt, silver, etc.) . Mud mud is especially attractive because of its biological purity, biological activity and effective effect on the skin.

The healing effect of the mud is explained by the action of colloidal particles and ions contained in it. The active components of the mud affect the receptors of the skin. In this case, all physiological systems from the cellular level to the central nervous system respond. Mud therapy mobilizes energy cellular resources, improves tissue and cell trophism, helps to weaken inflammatory processes, improves skin immunity, and improves blood circulation to the skin. Mineral salts and organic substances in the mud of the mud have anti-inflammatory and keratolytic effects.

The claimed invention allows to create a tool with high efficiency, biological activity and gentle skin effect.

The proposed tool has anti-inflammatory, antibacterial, absorbable effect, and also cures acne and allergic dermatitis.

As a result of the use of the proposed agent for the treatment of inflammatory skin diseases, the microcirculation and metabolic processes in the skin improve, the skin heals without irritating and allergenic effects due to the content of trace elements, humic and fulvic acids of mucous mud.

The proposed tool can be used for hardware procedures, they are sufficiently ionized, well washed off with water, do not have microbial contamination. Hopping mud does not lose its active effect on the skin after heat treatment (up to 100 ° C) due to the predominant mineral composition.

The proposed mud mud is mud mud volcanoes, which is a semi-liquid clay formation of gray color, is an environmentally friendly product.

There is a hygienic certificate for dirt issued by the Anapa Center of Sanitary Inspection.

A balneological report on hay mud of the Russian Scientific Center for Rehabilitation and Physiotherapy is recommended for the treatment of inflammatory skin diseases such as allergic rashes (allergic dermatitis), acne caused by metabolic disorders (in the acute stage and in chronic rashes).

The problem is solved in that the agent for the treatment of inflammatory skin diseases, containing natural biologically active dirt and a pharmaceutically acceptable solvent, contains as an active principle a nozzle dirt stabilized in a mixture of polymers, while the mud warms up to 100 ° C, cools and is introduced into swollen polymers with stirring and homogenization at a ratio of 15-30: 1.5-2.5 in parts by weight, as well as a preservative.

As polymers it contains neutralized polymeric sulfonic acid and water-soluble cellulose derivatives - carboxymethyl cellulose, hydroxyethyl cellulose.

Additionally, the proposed tool contains vegetable and / or mineral oils and an emulsifier.

It contains olive and / or petroleum jelly as a vegetable and / or mineral oil, and as an emulsifier it contains ethoxylated castor oil or ethoxylated glycerides of coconut oil acids.

For therapeutic purposes, nozzle mud is selected with the optimal size of colloidal particles that do not penetrate into the pores, rich in mineral composition and high biological activity.

The action of the proposed tool is carried out due to trace elements, humic and fulvic acids in the mud, stabilized in a mixture of polymers, which provide better release of trace elements, salts, etc. into the aqueous part of the gel matrix and then into the skin, respectively.

Get the tool according to the following technology.

The polymer is filled with water, swells. The mud warms up to 100 ° C, cools and is introduced into the polymer with stirring and homogenization. Then the remaining ingredients are added: a preservative and additionally vegetable and / or mineral oils, an emulsifier, with a ratio of active principle and polymers of 15-30: 1.5-2.5 in parts by weight. A preservative is added.

Specific examples of the invention are presented below. The examples presented are not limited to the list of funds received.

Example 1. The agent obtained, as described above, intended for the treatment of allergic dermatitis, contains mucosal dirt, a mixture of polymers and a preservative katon 0.05 parts by weight, with a ratio of active principle and polymers 15: 1.5 parts by weight.

As a stabilizer, the product contains polymers :, neutralized polymer sulfonic acid, carboxymethyl cellulose.

This tool has a balanced composition. The tool was applied to inflamed skin for 5-10 minutes, then washed off, without waiting for drying, daily for 12-15 days. After its use, a positive result was noted: itching disappeared, rashes disappeared. In addition, the skin touch it became more elastic and resilient. It was noted the elimination of peeling. After the cycle of application of the product, the color and moisture of the skin improved.

Example 2. The tool, as described in example 1, intended for the treatment of acne, additionally contains olive oil and an emulsifier, with a ratio of active principle and polymers of 15: 2.5.

As a stabilizer, the product contains polymers :, neutralized polymer sulfonic acid, hydroxyethyl cellulose. In addition, the product contains a vegetable component of olive oil in an amount of 1.0-2.0 parts by weight. As an emulsifier, the product contains ethoxylated castor oil in an amount of from 0.05-1 parts by weight.

This tool was applied to skin areas affected by acne for 10-15 minutes, then washed off, without waiting for drying, daily for 15-20 days. After its application, a positive result was noted: fat content decreased, the skin acquired a healthy fresh look, acne decreased, in addition, it became more elastic and elastic to the touch.

Example 3. The tool, as described in example 1, intended for the treatment of acne, additionally contains vaseline oil and emulsifier, with a ratio of active principle and polymers of 20: 1.5.

As a stabilizer, the product contains polymers :, neutralized polymer sulfonic acid, hydroxyethyl cellulose. In addition, the product contains mineral oil - vaseline oil in an amount of 0.5-1.5 parts by weight

As an emulsifier, the product contains ethoxylated glycerides of coconut oil acids.

Example 4. The tool, as described in example 1, intended for the treatment of acne, additionally contains olive oil and liquid paraffin in an amount of 1.5-2 parts by weight, emulsifier.

As a stabilizer, the product contains polymers: neutralized polymer sulfonic acid, hydroxyethyl cellulose.

As an emulsifier, the product contains ethoxylated castor oil.

The proposed tool acts healthily on the deeper layers of the skin, exhibiting anti-inflammatory and regenerative properties.

From the above examples, the universality of the active principle, the accessibility and cheapness of its preparation, and the invaluable effect in the treatment of inflammatory skin diseases are visible.

Specialists of dermatocosmetologists who conducted clinical trials, as well as the subjects themselves, noted that the proposed tool is convenient in practical use, including when using hardware methods. The product was created at the modern technological and raw materials level using biologically active substances such as polymeric base mud, natural vegetable and mineral oils, which in the aggregate have a healing and gentle effect on the skin and contribute to its recovery.

It is noted that the drug does not cause side effects and can be recommended for the treatment of inflammatory skin diseases.

Claims (5)

1. An agent for the treatment of inflammatory skin diseases, containing natural biologically active dirt and a pharmaceutically acceptable solvent, characterized in that as an active principle contains nozzle dirt introduced into the polymer mixture, while the dirt is introduced into the swollen polymers with stirring and homogenization to form homogeneous gel mass at a ratio of 15-30: 1.5-2.5 in weight parts, as well as a preservative. 2. The tool according to claim 1, characterized in that the polymers contain neutralized polymer sulfonic acid, hydroxyl ethyl cellulose, carboxymethyl cellulose. 3. The tool according to claim 1, characterized in that it further comprises vegetable and / or mineral oils and an emulsifier. 4. The tool according to claim 3, characterized in that as a vegetable and / or mineral oil contains olive and / or liquid paraffin, and as an emulsifier contains ethoxylated castor oil or ethoxylated glycerides of coconut oil acids. 5. The tool according to claim 1, characterized in that, with increased microbiological contamination, the nozzle mud is heated to 100 ° C and cooled to 30 ° C before being introduced into the polymers.