RU2277092C2 - Гетероциклические соединения, их применение и фармацевтическая композиция для лечения состояний, опосредованных схсr4 и ccr5 - Google Patents
Гетероциклические соединения, их применение и фармацевтическая композиция для лечения состояний, опосредованных схсr4 и ccr5 Download PDFInfo
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- RU2277092C2 RU2277092C2 RU2003110578/04A RU2003110578A RU2277092C2 RU 2277092 C2 RU2277092 C2 RU 2277092C2 RU 2003110578/04 A RU2003110578/04 A RU 2003110578/04A RU 2003110578 A RU2003110578 A RU 2003110578A RU 2277092 C2 RU2277092 C2 RU 2277092C2
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- Prior art keywords
- methyl
- mmol
- tetrahydroquinolin
- amino
- benzyl
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- 0 *N(Cc1cccc(C(Nc2ccccn2)=O)c1)C1c2ncccc2CCC1 Chemical compound *N(Cc1cccc(C(Nc2ccccn2)=O)c1)C1c2ncccc2CCC1 0.000 description 2
- UJNCXGUGUQKFKX-UHFFFAOYSA-N CS(c1cccc(C=O)c1)(Nc1ccccc1)(O)=O Chemical compound CS(c1cccc(C=O)c1)(Nc1ccccc1)(O)=O UJNCXGUGUQKFKX-UHFFFAOYSA-N 0.000 description 1
- AQFKFPGGMXOZBM-UHFFFAOYSA-N C[n](c(CN(Cc1ccc(CNC(c(c(Cl)cnc2)c2Cl)=O)cc1)C1c2ncccc2CCC1)c1)c2c1cccc2 Chemical compound C[n](c(CN(Cc1ccc(CNC(c(c(Cl)cnc2)c2Cl)=O)cc1)C1c2ncccc2CCC1)c1)c2c1cccc2 AQFKFPGGMXOZBM-UHFFFAOYSA-N 0.000 description 1
- DJTFVJWBPMSQGJ-UHFFFAOYSA-N C[n]1c(CCN(Cc2ccc(CNC(c(c(Cl)cnc3)c3Cl)=O)cc2)C2c3ncccc3CCC2)ncc1 Chemical compound C[n]1c(CCN(Cc2ccc(CNC(c(c(Cl)cnc3)c3Cl)=O)cc2)C2c3ncccc3CCC2)ncc1 DJTFVJWBPMSQGJ-UHFFFAOYSA-N 0.000 description 1
- XFFGMJYGBMACEU-UHFFFAOYSA-N C[n]1c(cccc2)c2nc1CNCCN(Cc1ccc(CNC(c(c(Cl)cnc2)c2Cl)=O)cc1)C1c2ncccc2CCC1 Chemical compound C[n]1c(cccc2)c2nc1CNCCN(Cc1ccc(CNC(c(c(Cl)cnc2)c2Cl)=O)cc1)C1c2ncccc2CCC1 XFFGMJYGBMACEU-UHFFFAOYSA-N 0.000 description 1
- NNXQHDNCPAHSQU-UHFFFAOYSA-N Cc1c(C(NCc2cc(CN(C3CNCC3)C3c4ncccc4CCC3)ccc2)=O)c(C)ncc1 Chemical compound Cc1c(C(NCc2cc(CN(C3CNCC3)C3c4ncccc4CCC3)ccc2)=O)c(C)ncc1 NNXQHDNCPAHSQU-UHFFFAOYSA-N 0.000 description 1
- LSCAYNGPXVIVAS-UHFFFAOYSA-N Cc1c(C(NCc2cc(CN(CCNCc3nc(cccc4)c4[nH]3)C3c4ncccc4CCC3)ccc2)=O)c(C)ncn1 Chemical compound Cc1c(C(NCc2cc(CN(CCNCc3nc(cccc4)c4[nH]3)C3c4ncccc4CCC3)ccc2)=O)c(C)ncn1 LSCAYNGPXVIVAS-UHFFFAOYSA-N 0.000 description 1
- RMUXKNPLDYTGOZ-UHFFFAOYSA-N Cc1c(C(NCc2cc(CN(CCc3cnc[n]3C)C3c4ncccc4CCC3)ccc2)=O)c(C)ncc1 Chemical compound Cc1c(C(NCc2cc(CN(CCc3cnc[n]3C)C3c4ncccc4CCC3)ccc2)=O)c(C)ncc1 RMUXKNPLDYTGOZ-UHFFFAOYSA-N 0.000 description 1
- FZTOERDIWRTDKE-UHFFFAOYSA-N Cc1c(C(NCc2cc(CN(Cc3cnc[n]3C)C3c4ncccc4CCC3)ccc2)=O)c(C)ncc1 Chemical compound Cc1c(C(NCc2cc(CN(Cc3cnc[n]3C)C3c4ncccc4CCC3)ccc2)=O)c(C)ncc1 FZTOERDIWRTDKE-UHFFFAOYSA-N 0.000 description 1
- DJUZTGIVFRIFCB-UHFFFAOYSA-N Cc1c(C(NCc2ccc(CN(C3CCNCC3)C3c4ncccc4CCC3)cc2)=O)c(C)ncn1 Chemical compound Cc1c(C(NCc2ccc(CN(C3CCNCC3)C3c4ncccc4CCC3)cc2)=O)c(C)ncn1 DJUZTGIVFRIFCB-UHFFFAOYSA-N 0.000 description 1
- SDAMFGOICGEJQW-UHFFFAOYSA-N Cc1c(C(NCc2ccc(CN(CCc3nc4ccccc4[nH]3)C3c4ncccc4CCC3)cc2)=O)c(C)ncc1 Chemical compound Cc1c(C(NCc2ccc(CN(CCc3nc4ccccc4[nH]3)C3c4ncccc4CCC3)cc2)=O)c(C)ncc1 SDAMFGOICGEJQW-UHFFFAOYSA-N 0.000 description 1
- RCBWIEZNHSYOGV-UHFFFAOYSA-N Cc1c(C(NCc2ccc(CN(Cc3nc(cccc4)c4[nH]3)C3c4ncccc4CCC3)cc2)=O)c(C)ncn1 Chemical compound Cc1c(C(NCc2ccc(CN(Cc3nc(cccc4)c4[nH]3)C3c4ncccc4CCC3)cc2)=O)c(C)ncn1 RCBWIEZNHSYOGV-UHFFFAOYSA-N 0.000 description 1
- WVVPOANDBYMKBF-UHFFFAOYSA-N Cc1c(C(NCc2ccc(CN(Cc3ncc[nH]3)C3c4ncccc4CCC3)cc2)=O)c(C)ncn1 Chemical compound Cc1c(C(NCc2ccc(CN(Cc3ncc[nH]3)C3c4ncccc4CCC3)cc2)=O)c(C)ncn1 WVVPOANDBYMKBF-UHFFFAOYSA-N 0.000 description 1
- SCHXJWXPSOGUKQ-UHFFFAOYSA-N Cc1c(C(NCc2cccc(CN(CCNCc3ncc[nH]3)C3c4ncccc4CCC3)c2)=O)c(C)ncn1 Chemical compound Cc1c(C(NCc2cccc(CN(CCNCc3ncc[nH]3)C3c4ncccc4CCC3)c2)=O)c(C)ncn1 SCHXJWXPSOGUKQ-UHFFFAOYSA-N 0.000 description 1
- PUPKWLZZOCEICX-UHFFFAOYSA-N Cc1c(C(NCc2cccc(CN(Cc3cnc[o]3)C3c4ncccc4CCC3)c2)=O)c(C)ncc1 Chemical compound Cc1c(C(NCc2cccc(CN(Cc3cnc[o]3)C3c4ncccc4CCC3)c2)=O)c(C)ncc1 PUPKWLZZOCEICX-UHFFFAOYSA-N 0.000 description 1
- APZJERBERDDTAD-UHFFFAOYSA-N Cc1ccnc(C)c1C(NCc1cc(CN(CCc2cnc[o]2)C2c3ncccc3CCC2)ccc1)=O Chemical compound Cc1ccnc(C)c1C(NCc1cc(CN(CCc2cnc[o]2)C2c3ncccc3CCC2)ccc1)=O APZJERBERDDTAD-UHFFFAOYSA-N 0.000 description 1
- UXJHEIVSULXXFW-UHFFFAOYSA-N Cc1nc(CN(Cc2cc(CNC(c(c(Cl)cnc3)c3Cl)=O)ccc2)C2c3ncccc3CCC2)c[o]1 Chemical compound Cc1nc(CN(Cc2cc(CNC(c(c(Cl)cnc3)c3Cl)=O)ccc2)C2c3ncccc3CCC2)c[o]1 UXJHEIVSULXXFW-UHFFFAOYSA-N 0.000 description 1
- MCJKYJLHTBCDCO-UHFFFAOYSA-N Cc1nc(CN(Cc2ccc(CNC(c(c(Cl)cnc3)c3Cl)=O)cc2)C2c3ncccc3CCC2)c[s]1 Chemical compound Cc1nc(CN(Cc2ccc(CNC(c(c(Cl)cnc3)c3Cl)=O)cc2)C2c3ncccc3CCC2)c[s]1 MCJKYJLHTBCDCO-UHFFFAOYSA-N 0.000 description 1
- CFJIMXFDSMWAAG-UHFFFAOYSA-N Cc1ncnc(C)c1C(NCc1cc(CN(Cc2cnc[s]2)C2c3ncccc3CCC2)ccc1)=O Chemical compound Cc1ncnc(C)c1C(NCc1cc(CN(Cc2cnc[s]2)C2c3ncccc3CCC2)ccc1)=O CFJIMXFDSMWAAG-UHFFFAOYSA-N 0.000 description 1
- YCHRXIKGQIXHHL-UHFFFAOYSA-N O=C(c(c(Cl)cnc1)c1Cl)NCc1cc(CN(C2CNCC2)C2c3ncccc3CCC2)ccc1 Chemical compound O=C(c(c(Cl)cnc1)c1Cl)NCc1cc(CN(C2CNCC2)C2c3ncccc3CCC2)ccc1 YCHRXIKGQIXHHL-UHFFFAOYSA-N 0.000 description 1
- FUSKLCXWEZHAHU-UHFFFAOYSA-N O=C(c(c(Cl)cnc1)c1Cl)NCc1cc(CN(C2CNCC2)C2c3ncccc3OCC2)ccc1 Chemical compound O=C(c(c(Cl)cnc1)c1Cl)NCc1cc(CN(C2CNCC2)C2c3ncccc3OCC2)ccc1 FUSKLCXWEZHAHU-UHFFFAOYSA-N 0.000 description 1
- POVNBJIBBAZHOW-UHFFFAOYSA-N O=C(c(c(Cl)cnc1)c1Cl)NCc1cc(CN(CCc2cnc[nH]2)C2c3ncccc3OCC2)ccc1 Chemical compound O=C(c(c(Cl)cnc1)c1Cl)NCc1cc(CN(CCc2cnc[nH]2)C2c3ncccc3OCC2)ccc1 POVNBJIBBAZHOW-UHFFFAOYSA-N 0.000 description 1
- FKVTWISVINIZNL-UHFFFAOYSA-N O=C(c(c(Cl)cnc1)c1Cl)NCc1cc(CN(Cc2nc(-c3ccccc3)c[nH]2)C2c3ncccc3CCC2)ccc1 Chemical compound O=C(c(c(Cl)cnc1)c1Cl)NCc1cc(CN(Cc2nc(-c3ccccc3)c[nH]2)C2c3ncccc3CCC2)ccc1 FKVTWISVINIZNL-UHFFFAOYSA-N 0.000 description 1
- HGONMUPGEJWEIK-UHFFFAOYSA-N O=C(c(c(Cl)cnc1)c1Cl)NCc1ccc(CN(CCNCc2cnc[nH]2)C2c3ncccc3CCC2)cc1 Chemical compound O=C(c(c(Cl)cnc1)c1Cl)NCc1ccc(CN(CCNCc2cnc[nH]2)C2c3ncccc3CCC2)cc1 HGONMUPGEJWEIK-UHFFFAOYSA-N 0.000 description 1
- GSKUCMMVBKADKN-UHFFFAOYSA-N O=C(c(c(Cl)cnc1)c1Cl)NCc1ccc(CN(CCNCc2ncc[nH]2)C2c3ncccc3CCC2)cc1 Chemical compound O=C(c(c(Cl)cnc1)c1Cl)NCc1ccc(CN(CCNCc2ncc[nH]2)C2c3ncccc3CCC2)cc1 GSKUCMMVBKADKN-UHFFFAOYSA-N 0.000 description 1
- VVQIYGHZJONFEM-UHFFFAOYSA-N O=C(c(c(Cl)cnc1)c1Cl)NCc1ccc(CN(Cc2ncc[nH]2)C2c3ncccc3CCC2)cc1 Chemical compound O=C(c(c(Cl)cnc1)c1Cl)NCc1ccc(CN(Cc2ncc[nH]2)C2c3ncccc3CCC2)cc1 VVQIYGHZJONFEM-UHFFFAOYSA-N 0.000 description 1
- DKCJABDEPDXORL-UHFFFAOYSA-N O=C(c1ncccc1)NCC1=CCC(CN(Cc2nc3ccccc3[nH]2)C2c3ncccc3CCC2)C=C1 Chemical compound O=C(c1ncccc1)NCC1=CCC(CN(Cc2nc3ccccc3[nH]2)C2c3ncccc3CCC2)C=C1 DKCJABDEPDXORL-UHFFFAOYSA-N 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23308700P | 2000-09-15 | 2000-09-15 | |
US60/233,087 | 2000-09-15 | ||
US60/234,816 | 2000-09-22 |
Publications (2)
Publication Number | Publication Date |
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RU2003110578A RU2003110578A (ru) | 2004-11-27 |
RU2277092C2 true RU2277092C2 (ru) | 2006-05-27 |
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Application Number | Title | Priority Date | Filing Date |
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RU2003110578/04A RU2277092C2 (ru) | 2000-09-15 | 2001-09-17 | Гетероциклические соединения, их применение и фармацевтическая композиция для лечения состояний, опосредованных схсr4 и ccr5 |
Country Status (2)
Country | Link |
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RU (1) | RU2277092C2 (xx) |
ZA (1) | ZA200301399B (xx) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2482117C2 (ru) * | 2008-02-08 | 2013-05-20 | Зериа Фармасьютикал Ко., Лтд. | Производное 3, 8-диаминотетрагидрохинолина |
-
2001
- 2001-09-17 RU RU2003110578/04A patent/RU2277092C2/ru not_active IP Right Cessation
-
2003
- 2003-02-20 ZA ZA200301399A patent/ZA200301399B/xx unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2482117C2 (ru) * | 2008-02-08 | 2013-05-20 | Зериа Фармасьютикал Ко., Лтд. | Производное 3, 8-диаминотетрагидрохинолина |
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Publication number | Publication date |
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ZA200301399B (en) | 2004-11-22 |
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Effective date: 20070918 |