RU2255940C2 - Плюрафлавины, способ их получения и композиция на их основе - Google Patents

Плюрафлавины, способ их получения и композиция на их основе Download PDF

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Publication number
RU2255940C2
RU2255940C2 RU2002124772/04A RU2002124772A RU2255940C2 RU 2255940 C2 RU2255940 C2 RU 2255940C2 RU 2002124772/04 A RU2002124772/04 A RU 2002124772/04A RU 2002124772 A RU2002124772 A RU 2002124772A RU 2255940 C2 RU2255940 C2 RU 2255940C2
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RU
Russia
Prior art keywords
formula
physiologically acceptable
compound
compounds
acceptable salt
Prior art date
Application number
RU2002124772/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2002124772A (ru
Inventor
Ласло ВЕРТЕШИ (DE)
Ласло Вертеши
Клаус ЭРЛИХ (DE)
Клаус ЭРЛИХ
Мартин КНАУФ (DE)
Мартин КНАУФ
Йоахим ВИНК (DE)
Йоахим ВИНК
Фрэнсис П БАРБОУН (US)
Фрэнсис П БАРБОУН
Элейн А. ПАУЭРС (US)
Элейн А. ПАУЭРС
Элизабет А. КЭШМЕН (US)
Элизабет А. КЭШМЕН
Original Assignee
Авентис Фарма Дойчланд Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Авентис Фарма Дойчланд Гмбх filed Critical Авентис Фарма Дойчланд Гмбх
Publication of RU2002124772A publication Critical patent/RU2002124772A/ru
Application granted granted Critical
Publication of RU2255940C2 publication Critical patent/RU2255940C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/58—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound through only acyclic carbon atoms to a non-saccharide heterocyclic ring, e.g. bleomycin, phleomycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
RU2002124772/04A 2000-02-18 2001-02-15 Плюрафлавины, способ их получения и композиция на их основе RU2255940C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00103540A EP1125944A1 (fr) 2000-02-18 2000-02-18 Pluraflavine et ses dérivés, procédé de préparation et utilisation
EP00103540.1 2000-02-18

Publications (2)

Publication Number Publication Date
RU2002124772A RU2002124772A (ru) 2004-02-20
RU2255940C2 true RU2255940C2 (ru) 2005-07-10

Family

ID=8167898

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2002124772/04A RU2255940C2 (ru) 2000-02-18 2001-02-15 Плюрафлавины, способ их получения и композиция на их основе

Country Status (31)

Country Link
US (1) US6500936B2 (fr)
EP (2) EP1125944A1 (fr)
JP (1) JP4801307B2 (fr)
KR (1) KR100743380B1 (fr)
CN (1) CN1162441C (fr)
AR (1) AR027436A1 (fr)
AT (1) ATE255120T1 (fr)
AU (2) AU2001242404B2 (fr)
BR (1) BR0108128A (fr)
CA (1) CA2400237C (fr)
CZ (1) CZ303810B6 (fr)
DE (1) DE60101313T2 (fr)
DK (1) DK1259523T3 (fr)
EE (1) EE05137B1 (fr)
ES (1) ES2207609T3 (fr)
HK (1) HK1052709B (fr)
HR (1) HRP20020672B1 (fr)
HU (1) HU228332B1 (fr)
IL (2) IL151216A0 (fr)
ME (1) ME00179B (fr)
MX (1) MXPA02006919A (fr)
NO (1) NO323413B1 (fr)
PL (1) PL204842B1 (fr)
PT (1) PT1259523E (fr)
RS (1) RS49991B (fr)
RU (1) RU2255940C2 (fr)
SI (1) SI1259523T1 (fr)
SK (1) SK286691B6 (fr)
TR (1) TR200302180T4 (fr)
WO (1) WO2001060832A2 (fr)
ZA (1) ZA200206795B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6989386B2 (en) * 2002-04-30 2006-01-24 Dana-Farber Cancer Institute Pharmaceutically active ornithine derivatives, ammonium salts thereof and methods of making same
CN101921300B (zh) * 2009-06-10 2014-04-02 上海来益生物药物研究开发中心有限责任公司 一种异黄酮苷类化合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847387A (en) * 1986-07-21 1989-07-11 Kyowa Hakko Kogyo Co., Ltd. Antibiotic compounds DC-92B and DC-92D
AU623923B2 (en) * 1988-07-22 1992-05-28 Masco Corporation A small hand-held shower head for domestic sinks connected to a faucet
US5001058A (en) * 1988-09-19 1991-03-19 Bristol-Myers Company BU-3839T antibiotic
PT93070A (pt) * 1989-02-07 1990-08-31 Abbott Lab Processo de preparacao de altromicinas e de composicoes farmaceuticas que as contem
US5168100A (en) * 1990-03-16 1992-12-01 Sapporo Breweries Limited Hp530 compounds and process for preparing the same
MX2009014082A (es) * 2007-07-06 2010-03-01 Rite Hite Holding Corp Barreras de seguridad retráctiles y sus métodos de operación.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Y.SATO et al, J. Antibiotics,1989,42, c.149. G.M. BRILL et al, J.Antibiotics, 1990, 43,c.229-237. G.M. BRILL et al, J.Antibiotics, 1994, 47,c.1160-1164. *

Also Published As

Publication number Publication date
HK1052709A1 (en) 2003-11-21
AU4240401A (en) 2001-08-27
RU2002124772A (ru) 2004-02-20
CN1404484A (zh) 2003-03-19
EP1259523B1 (fr) 2003-11-26
HU228332B1 (en) 2013-03-28
NO20023845D0 (no) 2002-08-14
CA2400237A1 (fr) 2001-08-23
DE60101313D1 (de) 2004-01-08
NO20023845L (no) 2002-10-10
US20020028921A1 (en) 2002-03-07
CZ20022826A3 (cs) 2002-11-13
YU57602A (sh) 2005-11-28
RS49991B (sr) 2008-09-29
WO2001060832A3 (fr) 2002-01-31
MEP28608A (en) 2010-10-10
SK11802002A3 (sk) 2003-02-04
US6500936B2 (en) 2002-12-31
PL204842B1 (pl) 2010-02-26
CN1162441C (zh) 2004-08-18
NO323413B1 (no) 2007-04-30
EE200200438A (et) 2003-12-15
SI1259523T1 (en) 2004-04-30
HUP0204393A3 (en) 2007-10-29
PT1259523E (pt) 2004-04-30
CA2400237C (fr) 2008-12-30
IL151216A (en) 2009-12-24
AR027436A1 (es) 2003-03-26
DK1259523T3 (da) 2004-03-22
JP2003523346A (ja) 2003-08-05
BR0108128A (pt) 2003-02-25
ZA200206795B (en) 2003-11-19
EP1259523A2 (fr) 2002-11-27
SK286691B6 (sk) 2009-03-05
PL358297A1 (en) 2004-08-09
IL151216A0 (en) 2003-04-10
EP1125944A1 (fr) 2001-08-22
EE05137B1 (et) 2009-02-16
KR20020086539A (ko) 2002-11-18
KR100743380B1 (ko) 2007-07-30
WO2001060832A2 (fr) 2001-08-23
HK1052709B (zh) 2005-02-04
ME00179B (fr) 2011-02-10
JP4801307B2 (ja) 2011-10-26
ATE255120T1 (de) 2003-12-15
DE60101313T2 (de) 2004-09-30
HUP0204393A2 (hu) 2003-07-28
HRP20020672B1 (en) 2010-12-31
CZ303810B6 (cs) 2013-05-15
HRP20020672A2 (en) 2004-12-31
TR200302180T4 (tr) 2004-03-22
AU2001242404B2 (en) 2005-04-14
MXPA02006919A (es) 2004-04-05
ES2207609T3 (es) 2004-06-01

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Effective date: 20180216