RU2238321C2 - Последовательность днк и получение аллергена злаковых рекомбинантным способом - Google Patents

Последовательность днк и получение аллергена злаковых рекомбинантным способом Download PDF

Info

Publication number
RU2238321C2
RU2238321C2 RU2001130165A RU2001130165A RU2238321C2 RU 2238321 C2 RU2238321 C2 RU 2238321C2 RU 2001130165 A RU2001130165 A RU 2001130165A RU 2001130165 A RU2001130165 A RU 2001130165A RU 2238321 C2 RU2238321 C2 RU 2238321C2
Authority
RU
Russia
Prior art keywords
polypeptide
allergen
fragment
pollen allergy
recombinant dna
Prior art date
Application number
RU2001130165A
Other languages
English (en)
Russian (ru)
Other versions
RU2001130165A (ru
Inventor
Роланд ЗУКК (DE)
Роланд ЗУКК
Хельмут ФИБИГ (DE)
Хельмут ФИБИГ
Оливер КРОМВЕЛЛЬ (DE)
Оливер КРОМВЕЛЛЬ
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of RU2001130165A publication Critical patent/RU2001130165A/ru
Application granted granted Critical
Publication of RU2238321C2 publication Critical patent/RU2238321C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
RU2001130165A 1999-04-23 2000-04-12 Последовательность днк и получение аллергена злаковых рекомбинантным способом RU2238321C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19918682A DE19918682A1 (de) 1999-04-23 1999-04-23 DNA-Sequenz und rekombinante Herstellung eines Graminaen-Allergens
DE19918682.0 1999-04-23

Publications (2)

Publication Number Publication Date
RU2001130165A RU2001130165A (ru) 2003-07-20
RU2238321C2 true RU2238321C2 (ru) 2004-10-20

Family

ID=7905749

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001130165A RU2238321C2 (ru) 1999-04-23 2000-04-12 Последовательность днк и получение аллергена злаковых рекомбинантным способом

Country Status (15)

Country Link
US (1) US7241450B1 (enExample)
EP (1) EP1171604B1 (enExample)
JP (1) JP4588888B2 (enExample)
CN (1) CN1203179C (enExample)
AT (1) ATE338126T1 (enExample)
AU (1) AU781275B2 (enExample)
CA (1) CA2370393C (enExample)
CZ (1) CZ20013796A3 (enExample)
DE (2) DE19918682A1 (enExample)
ES (1) ES2270828T3 (enExample)
HU (1) HUP0200883A2 (enExample)
PL (1) PL201818B1 (enExample)
PT (1) PT1171604E (enExample)
RU (1) RU2238321C2 (enExample)
WO (1) WO2000065060A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19939982A1 (de) 1999-08-24 2001-03-01 Merck Patent Gmbh Verfahren zur Isolierung und Aufreinigung von Gräserpollenallergenen
AUPR779201A0 (en) * 2001-09-20 2001-10-11 University Of Melbourne, The Immunotherapeutic and immunoprophylactic reagents
SE0200946D0 (sv) * 2002-03-27 2002-03-27 Pharmacia Diagnostics Ab Novel Allergen
US7731970B2 (en) * 2002-08-19 2010-06-08 Merck Patent Gmbh Variants of the major allergen Phl p 1 from timothy grass
JP4782671B2 (ja) 2003-06-04 2011-09-28 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 低減したアレルギー誘発性および保持されたＴ細胞反応性を有するＰｈｌｐ５ａ誘導体
DE10359351A1 (de) * 2003-12-16 2005-07-21 Merck Patent Gmbh DNA-Sequenz und rekombinante Herstellung von Gruppe-4 Majorallergenen aus Getreiden
DE102004035337A1 (de) * 2004-07-21 2006-03-16 Merck Patent Gmbh Varianten der Gruppe 1-Allergene aus Poaceae mit reduzierter Allergenität und erhaltener T-Zellreaktivität
EP2523684A1 (de) * 2010-01-14 2012-11-21 Merck Patent GmbH Varianten der gruppe 6-allergene der süssgräser mit reduzierter allergenität durch mutagenese von prolinresten

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5736362A (en) * 1990-10-26 1998-04-07 The University Of Melbourne Ryegrass pollen allergen

Also Published As

Publication number Publication date
WO2000065060A3 (de) 2001-03-01
EP1171604A2 (de) 2002-01-16
EP1171604B1 (de) 2006-08-30
HUP0200883A2 (hu) 2003-07-28
JP2002542783A (ja) 2002-12-17
CZ20013796A3 (cs) 2002-01-16
CN1203179C (zh) 2005-05-25
CA2370393A1 (en) 2000-11-02
DE50013400D1 (de) 2006-10-12
PL201818B1 (pl) 2009-05-29
WO2000065060A2 (de) 2000-11-02
US7241450B1 (en) 2007-07-10
ES2270828T3 (es) 2007-04-16
JP4588888B2 (ja) 2010-12-01
PL356055A1 (en) 2004-06-14
PT1171604E (pt) 2007-01-31
ATE338126T1 (de) 2006-09-15
CA2370393C (en) 2010-09-14
AU4547700A (en) 2000-11-10
DE19918682A1 (de) 2000-10-26
AU781275B2 (en) 2005-05-12
CN1351664A (zh) 2002-05-29

Similar Documents

Publication Publication Date Title
US9789178B2 (en) DNA sequence, and recombinant preparation of the grass pollen allergen Lol p 4
EP1221317A1 (en) Vaccines containing hybrid polypeptides consisting of at least two different allergenic proteins
AU781275B2 (en) DNA sequence and recombinant production of a Gramineae allergen
JP5363441B2 (ja) 低減したアレルギー誘発性および保持されたＴ細胞反応性を有するＰｈｌｐ５ａ誘導体
US9309297B2 (en) DNA sequence, and recombinant preparation of group 4 major allergens from cereals
RU2327739C2 (ru) ПОСЛЕДОВАТЕЛЬНОСТЬ ДНК И ПОЛУЧЕНИЕ АЛЛЕРГЕНА ПЫЛЬЦЫ ТРАВ Phl p 4 С ПОМОЩЬЮ РЕКОМБИНАНТНЫХ СПОСОБОВ
AU776154B2 (en) Method for isolating and purifying grass pollen allergens
RU2409589C2 (ru) ВАРИАНТ АЛЛЕРГЕНА ГРУППЫ I ИЗ Роасеае, ХАРАКТЕРИЗУЮЩИЙСЯ СНИЖЕННОЙ АЛЛЕРГЕННОСТЬЮ И СОХРАНЕННОЙ Т-КЛЕТОЧНОЙ РЕАКТИВНОСТЬЮ (ВАРИАНТЫ), КОДИРУЮЩАЯ ЕГО МОЛЕКУЛА ДНК И ЕГО ПРИМЕНЕНИЕ
AU2012205288B2 (en) DNA-sequence and recombinant production of group 4 major allergens from cereals
JP2008504004A5 (enExample)
AU2013204574B2 (en) DNA-sequence and recombinant production of group 4 major allergens from cereals
HK1050015A (en) Method for isolating and purifying grass pollen allergens

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20180413