RU2226390C2 - Combined preparation for treating acute gastrointestinal diseases with signs of diarrhea in calves - Google Patents

Abstract

FIELD: veterinary science. SUBSTANCE: the suggested preparation contains furasolidone as bacteriostatic, levomycetin and polymyxin M as bacteriolytics and ethonium as detoxicating surface- active and antiviral preparation at the following ratio of components, g/l: polymyxin M 0.1-0.2, levomycetin 0.4- 0.6, furasolidone 0.2-0.3, ethonium 0.4-0.6. The suggested preparation is of high efficiency at treating calves with acute gastrointestinal diseases accompanied by diarrhea signs. EFFECT: higher efficiency of therapy. 1 tbl

Description

The invention relates to veterinary medicine, in particular to the treatment of gastrointestinal diseases of calves occurring with signs of diarrhea.

Diarrhea of calves represents a large group of diverse polyetiological diseases, the etiopathogenesis of which is caused by factors of non-infectious and infectious nature, occurring with the same symptom complex and pathological changes (1, 2, 3, 4, 5). Enterotoxigenic strains of Escherichia coli, proteus vulgaris, cytrobacter, Salmonella and other pathogenic and conditionally pathogenic microorganisms, as well as viruses, play a predominant role in the development of the pathological process with diarrhea of calves. The latter cause the initial development of the pathological process, which is subsequently complicated by the bacterial flora. The disease can be caused simultaneously by several pathogens, or one etiological factor can be replaced by another during the development of the epizootic process. Due to the polyetiological character of diarrhea, it is not always possible to establish the true value of individual microorganisms or viruses and their associations in the development of the disease, and to solve this problem, long-term studies are not always available for most practical laboratories. In this regard, it is not always possible to take effective control measures in a timely manner, taking into account the sensitivity of pathogens to the drugs used. As a result, not all cases give the desired results and numerous well-known methods and means of treating sick calves, including antibiotics, sulfonamides, nitrofurans, enveloping and astringents, blood substitutes, natural gastric juice, nonspecific globulins, etc. Most often, the establishment of a diet, the use of oral and parenteral solutions of salt mixtures (according to Sharabrin, Voloskov, Kolesov, etc.), blood products, especially whey protein hydrolysates, adsorbents (lignin, lers, etc.), various decoctions and are recommended. infusions of plant origin.

In such a situation, the researchers ’desire to construct a universal (combined) tool that allows equally effective treatment of calves with diarrhea regardless of their etiology is not surprising.

In the practice of veterinary medicine, for this purpose, well-known drugs such as ampiox, biovit, vitatetrin, noroleandomixin, terravetin-500, ethocane, phthacid, thiofuzole, sulfogen, nifulin, etc. are used. (6). In principle, all of them are mixtures of: or one antibiotic with a vitamin (biovit, tetracycline); an antibiotic with powdered sugar or glucose (terravetin-500); an antibiotic with etonium, citric acid and powdered sugar (ethocane) or 2 antibiotics (ampiox) with normulfazole (noroleandomixin); a mixture of furozolidone, nitazole, biovit and cornmeal (biofusol), etc.

The closest in technical essence of the claimed invention is noroleandomixin, which includes 2 antibiotics (polymyxin M, oleandomycin phosphate) and norsulfazole.

A disadvantage of the known drug is a one-sided narrow spectrum of antibacterial and bacteriostatic effects of its constituent preparations. So, norsulfazole acts mainly on coccal forms (strepto-, pneumo-, meningo- and staphylococci) and partly on Escherichia coli. The spectrum of action of oleandomycin phosphate is almost similar to norsulfazole. Polymyxin M acts mainly on gram-negative extracellular located, and less active, gram-positive microorganisms. Thus, the components of the prototype components do not have a significant effect on many pathogenic and conditionally pathogenic microorganisms, as well as viruses that cause diarrhea in calves, such as proteus vulgaris, cytrobacter, perfringens and other bacteria and viruses.

The aim of the invention is to increase the efficiency of treatment of patients with gastrointestinal diseases of calves with acute digestive upset and diarrhea by creating a combined drug by expanding the spectrum of bactericidal, bacteriostatic, antiviral and detoxifying effects of the drug.

This goal is achieved in that the drug for the treatment of diarrhea containing norsulfazole as a bacteriostatic, oleandomycin phosphate, which acts mainly on cocci, and polymyxin M, contains furazolidone as a bacteriostatic, and levomycetin and polymyxin M as bacteriolytics are additionally introduced detoxifying, surfactant and antiviral substance - etonium in the following ratio of components, g / l:

Polymyxin M 0.1-0.2

Chloramphenicol 0.4-0.6

Furazolidone 0.2-0.3

Etonius 0.4-0.6

Comparative analysis with the prototype allows us to conclude that the claimed composition of the drug differs from the prototype in the introduction of new components, namely leovmecetin, furazolidone and ethonia. Thus, the claimed technical solution meets the criterion of "novelty." Analysis of the known compositions of the combined preparations (6, 7) used for diarrhea showed that all the components introduced into the claimed solution are known. However, their use in these drugs in combination with other components does not provide the combined drugs with the properties that they show in the claimed solution, namely, a significant expansion of the bactericidal, bacteriostatic, antiviral and detoxifying ability of the combined drug and, as a result, the fastest and most significant release of the body calves from pathogenic and conditionally pathogenic microflora. Thus, this composition of the components betrays new properties to the combined preparation, which allows us to conclude that the proposed solution meets the criterion of "significant differences".

When developing a combined preparation, the sensitivity of microorganisms isolated from sick and dead calves to antibacterial drugs was studied. A high sensitivity (more than 90%) of strains of E. coli and cytobacter, all strains of aeruginosis to polymyxin was established. Most strains of Escherichia coli, azotobacter and proteus vulgaris, coccal forms were sensitive to chloramphenicol. The bacteriological effect of furazolidone extends to various strains of Proteus, staphilo- and streptococci, to gram-negative and gram-positive bacteria. Being a surfactant, etonium enhances the direct effect of antibiotics on the microflora located on the mucous membrane of the gastrointestinal tract.

For experimental verification of the claimed composition were prepared 5 mixtures of ingredients, 3 of which showed optimal results (see table).

The components of each variant of the tested preparations were thoroughly mixed on a laboratory stirrer and tableted. Before giving the calves, one tablet of the drug was dissolved with a liter of warm water and evaporated through a rubber bottle.

From the table it follows that the preparation of the claimed composition has a significantly higher efficiency than the analogue and prototype, which accordingly provides a significant reduction in calf mortality by 28-30%.

The use of the inventive combined preparation will increase the efficiency of treatment of calves of patients with acute gastrointestinal diseases with signs of diarrhea by more than 30%.

Sources of information:

1. Zarosa V.G. Escherichiosis of calves. - M., 1991.

2. Kolyakov Y.E., Gitelson S.S., Kavruk L.S. Colibacteriosis of calves. - M., 1970.

3. Mishchenko V.A. et al. Some aspects of the pathogenesis of diarrhea of newborn calves. // Veterinary medicine, 1999, No. 9.

4. Sidorov M.A. Colibacteriosis (coli infection, colidiarrhea) of newborn calves. / Results of science and technology // Livestock and veterinary medicine. - M., 1980, v. 13.

5. Feldman I.I. Conditionally pathogenic infections of open cavities of the body and features of the epizootology of diarrhea of newborn calves. In the book: Prevention of diseases of young animals / Sat. scientific tr IEVS and DV. - Novosibirsk, 1990.

6. Veterinary drugs. Directory. / Ed. Tretyakova A.

7. Lunchin D., Parenti F. Antibiotics. - M .: Mir, 1985, p.272.

Claims (1)

A combined preparation for the treatment of gastrointestinal diseases of calves with diarrhea, containing polymyxin M as an antibiotic, characterized in that it contains furazolidone, additionally as an antibiotic - chloramphenicol, and as a detoxifying and antiviral substance - etonium with the following ratios of components, g / l: Polymyxin M 0.1-0.2 Chloramphenicol 0.4-0.6 Furazolidone 0.2-0.3 Etonius 0.4-0.6