RU2207143C1 - Biologically active supplement "bronkhoastmin" for prophylaxis and maintenance drug therapy of bronchial asthma and inflammatory diseases of respiratory organs - Google Patents

Abstract

FIELD: medicine, pulmonology, phytotherapy, pharmacy. SUBSTANCE: invention relates to parapharmaceutical industry producing preparations of curative and prophylactic designations and can be used as an accessory agent promoting to regulation of respiratory organs. Invention proposes an active supplement based on medicinal plants comprising licorice roots dry extract, dry aqueous concentrates of elecampane roots, sage herb, hyssop herb, dry concentrate of peppermint tincture, ginger milled roots, zinc sulfate, calcium gluconate, starch, calcium stearate and sugar taken in the definite ratio of components. Invention can be used in treatment of patients with acute and chronic diseases of respiratory organs and alternative cases in individual intolerance of separate components. EFFECT: expanded assortment of medicinal agents, valuable medicinal properties of supplement. 2 tbl

Description

 The invention relates to medicine, in particular to the parapharmaceutical industry, producing drugs for therapeutic and prophylactic purposes, and can be used as an adjuvant used to prevent exacerbation of bronchial asthma and inflammatory diseases of the respiratory system.

 Known biologically active food supplement "Bronchol" (Federal register of biologically active food additives. / Ed. Pilat T.L. - M: Kogelet, 2001, p. 249), containing corn stigmas, hop cones, St. John's wort grass, root dandelion, calamus root, three-leaved watch leaf, yarrow grass, centaury grass, galangal root, fennel fruits, peppermint grass, buckthorn bark. It has a general strengthening, mild expectorant effect, it is used as an anti-inflammatory agent. Available in powder form, packaged in capsules.

 A disadvantage of the known drug is the individual intolerance of the components of the product.

 Known biologically active food supplement "Milona" (Federal register of biologically active food additives. / Ed. Pilat T.L. - M: Kogelet, 2001, p. 248), containing a plantain leaf, grass of the spirit, rhizomes and roots of elecampane , licorice root, thyme grass, St. John's wort grass, yarrow grass, calamus rhizomes, flax seeds, chamomile flowers and excipients - excipients and fillers. Available in tablet form.

 It has a general strengthening effect, including for persons predisposed to diseases of the respiratory system.

 A disadvantage of the known drug is the individual intolerance of the components of the product.

 The objective of the invention is to develop a new available biologically active additives in tablet form, convenient for use, as well as contributing to the regulation of respiratory function and with a pronounced strengthening effect.

 The invention is aimed at expanding the range of drugs for the treatment of acute and chronic respiratory diseases, alternative for cases of individual intolerance to individual ingredients.

The problem is solved in that the proposed biologically active additive contains dry licorice root extract, dry water concentrates of elecampane root, sage herbs, hyssop herbs, dry concentrate of peppermint tincture, crushed ginger root, zinc sulfate, calcium gluconate, starch, calcium stearate and sugar in the following ratio of ingredients per tablet weighing 0.55 g, g:
Dry licorice root extract - 0.0075-0.0600
Dry water concentrate of elecampane roots - 0.00002-0.00016
Dry water sage herb concentrate - 0.00001-0.00008
Dry aqueous concentrate of hyssop herb - 0.00002-0.000060
Dry concentrate of tincture of peppermint - 0.000175-0.0014
Ground ginger root - 0.0040-0.0500
Zinc sulfate - 0.0025-0.0200
Calcium Gluconate - 0.0100-0.0600
Starch - 0.0250-0.1000
Calcium Stearate - 0.0025-0.0100
Sugar - Else
The dietary supplement is called "Bronchoastmin" and has a hypoallergenic, antispasmodic, expectorant, mucolytic, sedative effect, relaxing the muscles of the bronchi, helping to reduce swelling and inflammation in the lungs. It is used to prevent exacerbation of bronchial asthma and inflammatory diseases of the respiratory system.

 It is recommended as an adjunct in acute and chronic respiratory diseases accompanied by severe cough syndrome: acute respiratory infections, nasopharyngitis, pharyngolaryngitis, bronchitis, tracheitis, tracheobronchitis, pneumonia; with difficult separation of sputum.

 The invention is illustrated by the following example.

 0.37 kg of pre-ground elecampane roots are weighed into a 15-liter enameled container, 12.0 kg of water are poured at room temperature, insisted on a boiling water bath with frequent stirring for 35 minutes, then 0.37 kg of pre-ground hyssop grass and 0 are added. 18 kg of sage herb and continue to insist on a boiling water bath for another 25 minutes. Cool at room temperature for 60 minutes. The broth is filtered, squeezing the plant material. If necessary, add water to the required volume. Filter through 4 layers of gauze.

 The output of the broth (2% dry) 9.25 kg.

 Sugar is examined for the presence of impurities and mechanical impurities, weighed on a scale of 83.2 kg and ground in a mill. The yield of crushed sugar is 82.4 kg.

 Calcium gluconate is examined for the presence of impurities and mechanical impurities, weighed on a balance of 3.7 kg and ground in a mill. The yield of crushed calcium gluconate is 3.67 kg.

 Ginger root is examined for impurities and mechanical impurities, weighed on a balance of 0.2 kg and ground in a mill. The yield of crushed ginger root is 0.18 kg.

 Crushed sugar, ginger root, starch, calcium gluconate and zinc sulfate are sieved through a sieve with a hole diameter of 1.0 mm, calcium stearate is sieved through a sieve with a hole diameter of 0.5 mm. Peppermint tincture is filtered through a funnel and 4 layers of gauze.

 In an enameled container of 15 l, bring to a boil 6.25 kg of broth. Separately, 0.5 kg of starch and 1.0 kg of broth are mixed, mixed thoroughly and added to a boiling broth with constant stirring. The solution was brought to a boil.

 Yield 7.7 kg.

 3.65 kg of dry licorice extract is weighed on the scales and transferred to an enameled container of 15 l, 2.0 kg of broth is added and mixed. If necessary, heat. Filter through a funnel and 4 layers of gauze.

 The output of 5.62 kg.

 9.6 kg of starch, 3.67 kg of calcium gluconate, 0.92 kg of zinc sulfate and 0.18 kg of ginger root are loaded into the mixer, stirred for 10 minutes, then crushed sugar is added 82.4 kg in three portions (two portions of 30, 0 kg, one 22.4 kg), stirring after adding each serving of sugar for 3 minutes. Then moisturize with a solution of licorice root extract of 5.62 kg, mix for 5 minutes, add 1.84 kg of pharmacopeia tincture (3.5% dry) peppermint, mix for 5 minutes and add 7.7 kg of starch paste, mix for 10 minutes.

 The yield of 111.93 kg.

 The wet mass in the amount of 111.93 is loaded in portions into the installation to obtain wet granules from wet tablets. Turn on a screw device, with which the mixture is rubbed through a mesh with holes with a diameter of 4-5 mm. Wet granulate is collected in a receiver. Wet granulate is transferred from the receiver to the dryer.

 The yield of 111.4 kg.

The moistened tablet mass in an amount of 111.4 kg is laid out on paper in trays with a layer thickness of 1.5-2 cm. The trays are installed in an oven. Turn on the hot air supply system in the switchgear of the drying cabinet. Set the drying temperature of 40-45 ^o C, with an increase in which the flow of hot air is automatically turned off. The drying process is carried out for 10 hours to constant weight with periodic stirring (at least 3 times). Drying control is carried out in the laboratory by weighing product samples from trays to a constant weight. Product humidity not more than 2%. The dry tablet mass is sent to dry granulation.

 The yield of dry tablet mass of 100.5 kg

 The dried mixture in an amount of 100.5 kg is loaded with scoops in portions into the installation to obtain granulate from dry tablets. A screw device is turned on, by means of which the mixture is pressed through a mesh with holes with a diameter of 1.5-2.0 mm. To the obtained tablet mass in the mixer add 1.01 kg of sifted calcium stearate, turn on the stirrer and mix for 10 minutes. The finished granulate is transferred to tableting.

 The yield of finished granulate is 101.0 kg.

 From the mixer, the dry granulate is sent for tabletting to the loading hopper of the tabletting machine. Pre-set engine speed in accordance with the bulk density, the pressing zone and the height of the tablet. When the machine starts, the vacuum cleaner turns on.

The diameter of the tablet is 12.0 ± 0.3 mm;
tablet height 3.8 ± 0.3 mm;
the average tablet weight is 0.55 ± 0.055 mm.

 During tabletting, they monitor the operation of the machine and the quality of the tablets. Every 30 minutes, the disintegration, strength and average weight of the tablets are checked. Inadequate tablets are discarded and sent for recycling. At the end of the process, the machine is turned off in the reverse order. The tablets are collected in a receiver and sent for dust removal.

 The product yield of 100.5 kg.

 Finished tablets are sieved through a sieve with a hole diameter of 8 mm, weighed on scales of 8.0 kg and loaded into clean, dry plastic barrels or buckets. Samples of the finished tablets are transferred to the control and analytical laboratory for analysis. When the tablets comply with the technical documentation standards, the finished tablets are transferred to the packaging stage.

 The yield of finished tablets is 100.0 kg.

 The sequence of operations is the same regardless of the number of prepared composition.

 Bronchoastmin dietary supplement contains well-known medicinal products approved for use in medical practice, which in the indicated combination (Table 1, Examples 1-4) provide a reduction or disappearance of symptoms of respiratory diseases.

 Starch, sugar were used as auxiliary components ensuring the reliability of maintaining the shape of the pressed tablets in a dry form and their short disintegration time in a humid environment, and calcium stearate was used to improve the fluidity of the granulate.

 Available in the form of tablets, which is convenient for use, has a long shelf life (2 years).

 In the course of clinical trials, Bronchoastmin dietary supplement was prescribed to patients aged 2 to 70 years with ENT pathology and non-specific inflammatory lung diseases. The following diseases were distinguished by nosological forms: acute nasopharyngitis, acute pharyngolaryngitis, exacerbation of chronic pharyngolaryngitis, acute pneumonia, acute tracheobronchitis.

 In patients with ENT pathology with a disease duration of 2 to 12 days, against the background of adding Bronchoastmin to the basic therapy, nasal congestion stopped by 5-8 days. In all patients of this group, a repeated study showed an improvement in nasal mucociliary clearance, an average of 4.8 minutes.

 In patients with bronchopulmonary pathology from the first days, pronounced positive dynamics of the drainage function of the bronchi was noted, which was facilitated by liquefaction and softening of the secret. In this regard, the structure of the cough changed. By day 3, the cough becomes moist, with intensive expectoration of sputum. From this moment, there has been a decrease in the frequency of cough with its complete cessation by 10 days. Against this background, in patients with shortness of breath or shortness of breath, obvious improvements were noted. By 4 days, breathing in patients receiving dietary supplements becomes calm, deep. Normalization of auscultatory data was noted on days 10-14 (Table 2).

 Improvements in the respiratory tract have contributed to improving the overall condition of patients. In a subjective assessment of feelings of weakness, weakness, and general malaise, patients did not already notice by 4-7 days.

Claims (1)

Dietary supplement for the prevention and maintenance treatment of bronchial asthma and inflammatory diseases of the respiratory system based on medicinal plants, characterized in that it contains dry extract of licorice root, dry aqueous concentrates of elecampane root, sage herb, hyssop herb, dry concentrate of tinted peppermint, ground ginger root, zinc sulfate, calcium gluconate, starch, calcium stearate and sugar in the following ratio of ingredients per tablet weighing 0.55 g, g:
Dry licorice root extract - 0.0075-0.0600
Dry water concentrate of elecampane roots - 0.00002-0.00016
Dry water sage herb concentrate - 0.00001-0.00008
Dry aqueous concentrate of hyssop herb - 0.00002-0.000060
Dry concentrate of tincture of peppermint - 0.000175-0.0014
Ground ginger root - 0.0040-0.0500
Zinc sulfate - 0.0025-0.0200
Calcium Gluconate - 0.0100-0.0600
Starch - 0.0250-0.1000
Calcium Stearate - 0.0025-0.0100
Sugar - Rest

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