RU2218932C1 - Biologically active supplement "dezodorirujuschie" - Google Patents

Abstract

FIELD: medicine, stomatology, phytotherapy. SUBSTANCE: invention relates to parapharmaceutical industry producing preparations for curative and prophylactic designations. Invention proposes preparation for treatment of inflammatory diseases in mouth cavity that contains active and accessory substances. As active substances the preparation contains dried concentrate of peppermint tincture, mint essential oil, cardamom ground fruits, dried concentrate of Saint-John's-wort tincture, dried concentrate of sage herb infusion, cinnamon ground bark, citric acid and also starch, calcium state and sugar as accessory substances taken in the definite ratio of components per a tablet with mass 0.55 g. Invention can be used for breathing refreshing and as an accessory agent in complex treatment of acute and chronic inflammatory diseases of mouth cavity being alternative in cases of individual intolerance of some components. EFFECT: enhanced effectiveness and valuable medicinal properties of supplement. 1 tbl

Description

 The invention relates to medicine, in particular to the parapharmaceutical industry, producing drugs for therapeutic and prophylactic purposes, and can be used to freshen breath and as an adjuvant in the complex treatment of inflammatory diseases of the oral cavity.

 Known biologically active food supplement "Vita spray" / Pilate T.L. (ed.). Federal Register of Biologically Active Food Supplements ", Moscow, Kogelet, 2001, p.250 /, containing plant processing products: mint, garlic, eucalyptus, pygnogenol, bisabolol, stevia concentrate, bromelain, neem tree extract, grapefruit extract, licorice extract, soya lecithin, niacin, panthenol, biotin, thiamine, riboflavin, vitamin B6, vitamin B12. It is used as a multivitamin aerosol of general strengthening effect and for freshness of breath. It is packaged in spray bottles.

 Known biologically active food supplement "Freshness" / Pilate T.L. and other Kazakhstan registry of biologically active food additives, Almaty, Leovit, 2001, p. 250 /, containing peppermint oil, menthol and propolis extract, as well as excipients - excipients and fillers, as it is available in the form of tablets. It is used as an oral freshener, a general strengthening agent, and also as an adjunct in the treatment of inflammatory diseases of the oral cavity.

 Known biologically active food supplement "Sansmile" / Pilate T.L. etc. Kazakhstan registry of biologically active food additives, Almaty, Leovit, 2001, p.250 /, containing plant processing products: acacia wax, menthol, anise powder, cardamom oil, olive leaf extract, as well as xylitol, sorbitol, potassium bicarbonate , calcium peroxide, citric acid, silicon dioxide, hydroxypropyl cellulose, guar gum, flavors and excipients - forming agents and fillers, as it is available in the form of tablets. It is used as an oral freshener, a general strengthening agent, and also as an adjunct in the treatment of inflammatory diseases of the oral cavity.

 The objective of the invention is the development of a new affordable drug - biologically active additives, in tablet form, convenient for use, contributing to the treatment of diseases of the oral cavity and having a more pronounced restorative effect.

 The invention is aimed at expanding the range of medicines used as an oral freshener, a restorative agent, and also as an adjunct in the treatment of inflammatory diseases of the oral cavity, alternative for cases of individual intolerance to individual ingredients.

This is achieved by the fact that the proposed drug for the treatment of auxiliary diseases of the oral cavity, containing as active substances a dry concentrate of tincture of peppermint, peppermint oil, crushed cardamom fruit, dry concentrate of tincture of St. John's wort, dry concentrate of tincture of sage, crushed cinnamon bark, citric acid, and as auxiliary substances - starch, calcium stearate and sugar in the following ratio of components per tablet weighing 0.55 g:
Dry sage herb extract concentrate - 0.000015-0.000060
St. John's wort tincture dry concentrate - 0,00035-0,0028
Dry concentrate of tincture of peppermint - 0,00035-0,0028
Peppermint oil - 0.1 • 10 ^-11 -5.6 • 10 ^-11
Cardamom, fruits (shredded) - 0.0025-0.0200
Cinnamon, bark (chopped) - 0.0050-0.0400
Citric acid - 0.0040-0.0320
Starch - 0.0250-0.1000
Calcium Stearate - 0.0025-0.0100
Sugar - Else
The drug is called - deodorizing dietary supplement.

 The deodorizing dietary supplement freshens breath, helps eliminate bad odors in the oral cavity, has an anti-inflammatory, antimicrobial effect, strengthens periodontal tissues. It is used to freshen breath and as an adjuvant in the complex treatment of inflammatory diseases of the oral cavity.

 Dietary supplement "Deodorizing" in the form of tablets is obtained as follows.

 0.375 kg of pre-crushed sage leaves are weighed on a balance and transferred to an enameled container of 10 l, pour 5 kg of room temperature water, infused in a boiling water bath with frequent stirring for 30 minutes, then cooled at room temperature for 45 minutes. Filter, squeezing the plant material, if necessary, add water to the required amount. Filter through 4 layers of gauze.

 The yield of infusion (1.5% dry) is 3.75 kg.

 Sugar, in the amount of 88.3 kg, is weighed in a bag on a balance, visually checked for mechanical impurities, then, in the absence of impurities, crushed in a mill. To do this, sugar from the bag is loaded in portions into the loading hopper. Crushed sugar through the lower nozzle of the mill is collected in a plastic bag, the ends of which are previously fixed on the nozzle. The bag is placed in the receiver.

 The yield of crushed sugar is 87.4 kg.

 Cardamom, in an amount of 1.0 kg, is weighed on a scale, visually checked for mechanical impurities, then, in the absence of impurities, crushed in a mill. To do this, cardamom is loaded in portions into the loading hopper. The crushed cardamom through the lower nozzle of the mill is collected in a plastic bag, the ends of which are previously fixed on the nozzle. The bag is placed in the receiver.

 The yield of crushed cardamom is 0.94 kg.

 Cinnamon in the amount of 2.0 kg is weighed on a scale, visually checked for mechanical impurities, then, in the absence of impurities, crushed in a mill. To do this, the cinnamon bark is loaded in portions into the feed hopper. The crushed cinnamon bark through the lower nozzle of the mill is collected in a plastic bag, the ends of which are previously fixed on the nozzle. The bag is placed in the receiver.

 The yield of crushed cinnamon bark is 1.9 kg.

 In an enameled container of 10 l, 3.25 kg of infusion of sage leaves are weighed on a scale, brought to a boil. Separately, starch in the amount of 0.35 kg is weighed on a scale, placed in an enameled container of 5 l, add 0.5 kg of infusion. The prepared suspension of starch is introduced into a boiling infusion with constant stirring, brought to a boil.

 The yield of starch paste is 4.07 kg.

 1.5 kg of citric acid is weighed on a scale, 3.75 kg of tincture of hypericum are added, and mixed until the acid is completely dissolved.

 The output is 5.25 kg.

 The crushed sugar, cinnamon, cardamom, starch are sieved on a vibrating unit through a sieve with a hole diameter of 1 mm, calcium stearate is sieved through a sieve with a hole diameter of 0.5 mm. A solution of citric acid in tincture of St. John's wort, tincture of peppermint, peppermint oil is filtered through four layers of gauze.

 20 kg of crushed sugar, 9.95 kg of starch, 1.9 kg of crushed cinnamon bark and 0.94 kg of crushed cardamom are loaded into a mixer with a postcard lid, mixed for 10 minutes. Then add the remaining sugar 67.4 kg, mix for 5 minutes, moisten with a solution of citric acid in a pharmacopeia tincture (3.5% dry) hypericum hypericum 5.23 kg and a pharmacopeia tincture (3.5% dry) peppermint 3.75 kg. The mixture is stirred for 10 minutes and 4.07 kg of starch paste is added. Stir for another 10 minutes.

 The yield of finished product is 113.24 kg.

Moistened tablet mass in the amount of 113.24 kg is laid out on paper in trays, with a layer thickness of 1.5-2 cm. The trays are installed in an oven. Turn on the hot air supply system in the switchgear of the drying cabinet. Set the drying temperature of 40-45 ^o C, with an increase in which the flow of hot air is automatically turned off. The drying process is carried out for 10 hours to constant weight, with periodic stirring. Drying control is carried out in the laboratory by weighing product samples from trays to a constant weight. Product humidity - no more than 2%. The dry tablet mass is sent to dry granulation.

 The yield of dry tablet mass is 102.04 kg.

 The dried mixture in an amount of 102.04 kg is loaded in portions into the installation to obtain granulate from dry tablets. A screw device is turned on, by means of which the mixture is forced through a grid with holes with a diameter of 1.5 mm. Dry granulate is collected in a receiver. From the receiver, dry granulate is loaded with a scoop with the lid open into the mixer. 0.026 kg peppermint oil and 1.03 sieved calcium stearate are added to the dry granular tablet mixture in the mixer. Turn on the stirrer and mix for 10 minutes. The finished granulate is transferred to tableting.

 The yield of finished granulate is 102 kg.

 From the mixer, the dry granulate is sent for tabletting to the loading hopper of the tabletting machine. They include the main drive (network), clutch, feeder, motor. Pre-set engine speed in accordance with the bulk density, the pressing zone and the height of the tablet. When the machine starts, the vacuum cleaner turns on.

The diameter of the tablet is 12.0 ± 0.3 mm;
tablet height - 3.8 ± 0.3 mm;
the average tablet weight is 0.55 ± 0.02 g.

 During tabletting, they monitor the operation of the machine and the quality of the tablets. Every 30 minutes, the disintegration, strength and average weight of the tablets are checked.

 The product yield is 101.5 kg.

 Finished tablets are sieved on a vibrating screen through openings with a diameter of 8 mm, weighed on an 8 kg scale and loaded into clean, dry plastic buckets and packaged. Samples of the finished tablets are transferred to the control and analytical laboratory for analysis. If the tablets comply with the technical documentation standards, the finished tablets are transferred to the packaging stage.

 The yield of finished tablets is 100.0 kg.

 The sequence of operations is the same, regardless of the number of prepared composition.

 Supplement "Deodorizing" contains well-known, approved for use in medical practice drugs, which in the specified combination (see table, examples 1-4) provide a reduction or disappearance of symptoms of diseases of the oral cavity.

 Starch, sugar were used as auxiliary components providing reliability of preservation of the form of pressed tablets in a dry form and short time of their disintegration in a humid environment, and calcium stearate granulate was used to improve the fluidity.

 Available in the form of tablets, which is convenient for use, has a long shelf life (2 years).

Claims (1)

A preparation for the treatment of inflammatory diseases of the oral cavity, containing active and auxiliary substances, characterized in that as active substances it contains a dry concentrate of tincture of peppermint, peppermint oil, ground fruit of cardamom, a dry concentrate of tincture of St. John's wort, a dry concentrate of infusion of sage grass, crushed bark cinnamon, citric acid, and as auxiliary substances - starch, calcium stearate and sugar in the following ratio of components per tablet weighing 0.55 g: Dry sage herb extract concentrate 0.000015-0.000060 Dry concentrate tincture of St. John's wort 0,00035-0,0028 Dry concentrate of tincture of peppermint 0,00035-0,0028 Peppermint oil 0.1 · 10 ^–11 -5.6 · 10 ^-11 Cardamom, fruits (shredded) 0.0025-0.0200 Cinnamon, bark (chopped) 0,0050-0,0400 Citric acid 0.0040-0.0320 Starch 0.0250-0.1000 Calcium Stearate 0.0025-0.0100 Sugar Else

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