RU2203888C2 - Способы получения метансульфонат тригидрата и d-(-)-тартратной соли (1s,2s)-1-(4-гидроксифенил)-2-(4-гидрокси-4-фенилпиперидин-1-ил)-1- пропанола - Google Patents

Способы получения метансульфонат тригидрата и d-(-)-тартратной соли (1s,2s)-1-(4-гидроксифенил)-2-(4-гидрокси-4-фенилпиперидин-1-ил)-1- пропанола Download PDF

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RU2203888C2
RU2203888C2 RU2001111947/04A RU2001111947A RU2203888C2 RU 2203888 C2 RU2203888 C2 RU 2203888C2 RU 2001111947/04 A RU2001111947/04 A RU 2001111947/04A RU 2001111947 A RU2001111947 A RU 2001111947A RU 2203888 C2 RU2203888 C2 RU 2203888C2
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Russia
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formula
hydroxyphenyl
hydroxy
phenylpiperidin
propanol
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RU2001111947/04A
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English (en)
Russian (ru)
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RU2001111947A (ru
Inventor
Джозеф Филип РЭЙНВИЛЛ (US)
Джозеф Филип РЭЙНВИЛЛ
Терри Джин мл. СИНЭЙ (US)
Терри Джин Мл. СИНЭЙ
Стэнли Уолтер ВАЛИНСКИ (US)
Стэнли Уолтер ВАЛИНСКИ
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Пфайзер Продактс Инк.
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Publication of RU2001111947A publication Critical patent/RU2001111947A/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
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  • Hematology (AREA)
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  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
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RU2001111947/04A 2000-04-28 2001-04-27 Способы получения метансульфонат тригидрата и d-(-)-тартратной соли (1s,2s)-1-(4-гидроксифенил)-2-(4-гидрокси-4-фенилпиперидин-1-ил)-1- пропанола RU2203888C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20067300P 2000-04-28 2000-04-28
US60/200,673 2000-04-28

Publications (2)

Publication Number Publication Date
RU2203888C2 true RU2203888C2 (ru) 2003-05-10
RU2001111947A RU2001111947A (ru) 2003-05-20

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001111947/04A RU2203888C2 (ru) 2000-04-28 2001-04-27 Способы получения метансульфонат тригидрата и d-(-)-тартратной соли (1s,2s)-1-(4-гидроксифенил)-2-(4-гидрокси-4-фенилпиперидин-1-ил)-1- пропанола

Country Status (27)

Country Link
US (1) US6645986B2 (OSRAM)
EP (2) EP1477479A1 (OSRAM)
JP (2) JP3615496B2 (OSRAM)
KR (1) KR100442718B1 (OSRAM)
CN (2) CN1590373A (OSRAM)
AR (1) AR028376A1 (OSRAM)
AT (1) ATE277014T1 (OSRAM)
AU (1) AU781436B2 (OSRAM)
BR (1) BR0101630A (OSRAM)
CA (1) CA2345582C (OSRAM)
CZ (1) CZ20011471A3 (OSRAM)
DE (1) DE60105689T2 (OSRAM)
DK (1) DK1151995T3 (OSRAM)
ES (1) ES2227071T3 (OSRAM)
HK (1) HK1040246B (OSRAM)
HU (1) HUP0101723A3 (OSRAM)
ID (1) ID30006A (OSRAM)
IL (1) IL142705A0 (OSRAM)
IN (1) IN191027B (OSRAM)
PL (1) PL347298A1 (OSRAM)
PT (1) PT1151995E (OSRAM)
RU (1) RU2203888C2 (OSRAM)
SI (1) SI1151995T1 (OSRAM)
TR (1) TR200402696T4 (OSRAM)
TW (1) TW200505858A (OSRAM)
YU (1) YU27701A (OSRAM)
ZA (1) ZA200103320B (OSRAM)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7892854B2 (en) * 2000-06-21 2011-02-22 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US6743921B2 (en) 2002-01-24 2004-06-01 Dsm Catalytica Pharmaceuticals, Inc. Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol compounds
US7754500B2 (en) 2003-11-21 2010-07-13 Anp Technologies, Inc. Asymmetrically branched polymer conjugates and microarray assays
EP2208998A3 (en) 2005-05-02 2011-03-16 ANP Technologies, Inc. Polymer conjugate enhanced bioassays

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272160A (en) * 1989-05-17 1993-12-21 Pfizer Inc 2-piperidino-1-alkanol derivatives as antiischemic agents
WO1997007098A1 (en) * 1995-08-11 1997-02-27 Pfizer Inc. (1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanolmethanesulfonate trihydrate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272160A (en) * 1989-05-17 1993-12-21 Pfizer Inc 2-piperidino-1-alkanol derivatives as antiischemic agents
WO1997007098A1 (en) * 1995-08-11 1997-02-27 Pfizer Inc. (1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanolmethanesulfonate trihydrate
US6008233A (en) * 1995-08-11 1999-12-28 Pfizer Inc (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylipiperidin-1-yl)-1-propanolmethanesulfonate trihydrate

Also Published As

Publication number Publication date
HK1040246A1 (en) 2002-05-31
JP3615496B2 (ja) 2005-02-02
TR200402696T4 (tr) 2004-11-22
HK1040246B (zh) 2005-10-28
KR100442718B1 (ko) 2004-08-02
EP1477479A1 (en) 2004-11-17
ES2227071T3 (es) 2005-04-01
PT1151995E (pt) 2004-11-30
PL347298A1 (en) 2001-11-05
CA2345582C (en) 2006-05-30
ATE277014T1 (de) 2004-10-15
AR028376A1 (es) 2003-05-07
AU3889601A (en) 2001-11-01
JP2001354651A (ja) 2001-12-25
DK1151995T3 (da) 2004-12-13
SI1151995T1 (en) 2004-12-31
YU27701A (sh) 2003-04-30
CN1321638A (zh) 2001-11-14
IL142705A0 (en) 2002-03-10
EP1151995B1 (en) 2004-09-22
US20020016465A1 (en) 2002-02-07
BR0101630A (pt) 2001-12-04
TW200505858A (en) 2005-02-16
IN191027B (OSRAM) 2003-09-13
ID30006A (id) 2001-11-01
CN1590373A (zh) 2005-03-09
HU0101723D0 (en) 2001-07-30
EP1151995A1 (en) 2001-11-07
HUP0101723A3 (en) 2003-03-28
CN1210262C (zh) 2005-07-13
DE60105689D1 (de) 2004-10-28
ZA200103320B (en) 2002-10-24
CA2345582A1 (en) 2001-10-28
AU781436B2 (en) 2005-05-26
HUP0101723A2 (hu) 2002-02-28
CZ20011471A3 (cs) 2002-02-13
DE60105689T2 (de) 2005-11-10
KR20010098960A (ko) 2001-11-08
US6645986B2 (en) 2003-11-11
JP2004196823A (ja) 2004-07-15

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