RU2201742C1 - Method for treating lime disease - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method involves administering extremely high frequency therapy in scanning mode every morning during 9-12 days. Biologically active zones in the inferior part of the sternum, right brachial articulation, brachial plexus projection and biologically active points are treated. General purpose radon baths are administered 4-5 h later at 1.5-3.0 kBq/l concentration and 36-37 C temperature during 10 min. EFFECT: enhanced effectiveness of rehabilitation treatment. 3 cl, 2 tbl

Description

 The invention relates to medicine, namely to neurology and physiotherapy.

 Known drug methods for treating Lyme disease in case of damage to the nervous system by using pathogenetic drug therapy: to improve microcirculation in tissues and accelerate remyelination processes, vascular agents (trental, instenol, cavinton), antioxidants (vitamin E, C, solcoseryl, actovegin), as well as drugs stimulating metabolic processes in the nervous tissue (nootropics, B vitamins), non-steroidal anti-inflammatory drugs (indomethacin, piroxicam), analgesics (paracetamol, tramal), drugs that improve f neuromuscular conduction (proserin, oxazil, urebretide), immunomodulator (lycopid) [1]. The disadvantages of this method are toxicity, adverse reactions to the administration of drugs and allergization of the body.

 Also known is a method of treating Lyme disease with damage to the nervous system by using preformed physical factors [2]. However, medical technologies do not take into account the clinical and pathogenetic variants of the course of Lyme disease.

 The objective of the method is to increase the effectiveness of the treatment of Lyme disease with damage to the nervous system.

The problem is solved by using preformed physical and natural factors, moreover, EHF-therapy is used as a preformed physical factor, and common radon baths are used as a natural factor, while EHF-therapy is carried out for 9-12 days in the morning in the scanning mode in the range of 59-63 GHz for biological active zones of the upper third of the sternum, right shoulder joint for 8-10 minutes, for the projection of the brachial plexuses for 4-5 minutes, for biological active points GI ₄ (he-gu), E ₃₆ (tszu -san-li) symmetry well, for 4-5 minutes, then after 4-5 hours, general radon baths with a concentration of 1.5-3.0 kBq / l are carried out, with a temperature of 36-37 ^o C with an exposure of 10 minutes. In one procedure, EHF-therapy affects 2 zones and 2-3 biologically active points with a total procedure time of 21-35 minutes. Radon baths are carried out daily or every other day.

 EHF-therapy acts as a biological component of complex therapy aimed at restoring the functionality of tissue structures damaged or involved in the pathological process [3]. The influence of electromagnetic radiation (EMR) of the extreme high-frequency range (EHF) on cells enhances their functional activity and first leads to the active mobilization of all the ultrastructures present in it (urgent adaptation), and then to the phenomena of hyperplasia (long-term adaptation). Strengthening of hyperplastic processes is a natural structural and adaptive reaction, leading to accelerated updating of structures, which, acquiring new qualitative properties, become more adapted to the current factor. The development of these reactions is a consequence of the interaction of factor energy with nuclear and cytoplasmic ultrastructures of cells, as well as the result of neurohumoral influences of various levels [4].

 According to a number of authors [5], it is known that regulatory systems based on electronic phase transitions of water and membrane lipids function in the cell. Various effects on water lead to a restructuring of its electronic subsystem, accompanied by transitions in intramolecular dynamics. These transitions have very low energies, therefore, they can occur both in water and in lipid membranes under the influence of low-energy exposure, including under the influence of pulsed electromagnetic radiation. A change in the electrostatic characteristics of the membrane can lead to a change in protein-lipid interactions, and, as a consequence, to a change in the structure and functional activity of membrane-bound enzymes.

 A number of experimental studies have proved that EHF radiation affects the functional activity of electrically excitable sections of nerve fibers in the form of changes in the duration of generated action potentials, latent period and amplitude of the impulse response, tactile and pain sensitivity, which is associated with modulation of impulse activity and other functional properties of preterm sections nerve fibers, moreover, when using the pulse mode to change the rhythm of endogenous and spontaneous activity n yronov, efficiency of synaptic activation of reparative processes of the nervous tissue sufficiently short (10 nsec) exposure [6].

 According to generally accepted views, the level of electrical conductivity of the skin reflects the state of the sympathetic nervous system, which is adaptive-trophic in its functions. The prevalence of the sympathicotropic effect during vegetative testing is considered as a characteristic feature of the neurodystrophic process. After the application of EHF-therapy, the electrical conductivity of the skin approached that of healthy people, which indicated the normalization of the tone of the sympathetic part of the autonomic nervous system (ANS), and hence the improvement of capillary-tissue metabolism in the affected area [7].

Thus, the effect of EHF radiation on the biological active zones of the upper third of the sternum, the right shoulder joint for 8-10 minutes, on the projection of the brachial plexuses for 4-5 minutes, on the biological active points GI ₄ (he-gu), E ₃₆ (tszu -san-li) for 4-5 minutes stimulates the development of adaptive reactions in the body with Lyme disease. When the brachial plexuses are affected by the projection of peripheral nerve neuropathies, MM waves play the role of an instrument for influencing the system of regulation of cell growth and cytodifferentiation in order to stimulate reparative processes.

 Radon therapy has a regulatory and normalizing effect on the activity of endocrine organs, nonspecific resistance, immunological reactivity of the body, the sympathetic-adrenal system, on certain aspects of carbohydrate, mineral and lipid metabolism, which is manifested by a sedative, anti-inflammatory, desensitizing, brain-improving effect. Under the influence of radon baths, redox reactions in tissues are normalized, including processes of oxidative phosphorylation, metabolism and nucleic acids, lipids, macro- and microelements [8].

 When irradiated in small doses of living organisms, excitation of biopolymers in a condensed state occurs. The generated excited electrons are delocalized in the electron cloud of the biopolymer, interact with its oscillatory, kinetic energy, forming nonlinear vortex clusters of energy and information ("polaritons"), which, slowly decaying, give coherent "secondary biogenic radiation" (VBI). VBI interconnect, provide mutual information between polymers, subcellular structures, cells, body tissues. Dosed irradiation with radon causes an increase in the body of the intensity of the electromagnetic field formed by nosocomial infections, which leads to the normalization of the relationship of disturbed processes, to better health [9].

 Balneotherapy effects have an adaptogenic, synchronizing effect, which manifests itself in enhancing the internal synchronization of body functions and the coordination of temporal adaptation of the coordination of the studied parameters with external time sensors. In these effects of balneotherapy, the leading role is played by the time of the appointment of procedures [10]. According to a number of authors, a period of 13-17 hours [11] should be recognized as the most adequate for the purposes of balneotherapy for patients. Apparently, the appointment of radon baths in Lyme disease with damage to the nervous system after a specified period of time after EHF-therapy creates the most favorable conditions in the body for optimizing the processes of adaptation and regulation.

The method is as follows. In patients with Lyme disease with damage to the nervous system, EHF-therapy is carried out daily in the morning for 9-12 days in the scanning mode in the range of 59-63 GTZ for biological active zones of the upper third of the sternum, right shoulder joint for 8-10 minutes, the projection of the brachial plexuses for 4-5 minutes, on the biological active points GI ₄ (he-gu), E ₃₆ (tsu-san-li) symmetrically for 4-5 minutes, and in one procedure they act on two zones and 2-3 biologically active points with a total procedure time of 21-35 minutes, after which, after 4-5 hours, general radon baths are carried out concentration of 1.5-3.0 kBq / l, temperature - 36-37 ^o C with an exposure of 10 minutes every day or two.

 For a better understanding of the essence of the method, we offer a specific example.

Example. Patient K., 35 years old, was in the neurological department of Tomsk NIIIKiF from 05/18/99 to 06/11/99 with a diagnosis of Ixodes tick-borne borreliosis (Lyme disease), a manifest form, a chronic recurrent course with a predominant damage to the nervous system as moderate encephalopathy (1 tbsp.) and sensory, mainly algic syndrome, stage of subcompensation. The patient received complaints of severe headache, constant dull pain in the lumbar, cervical spine, shoulder girdle, pain in the knee, ankle, right wrist joints, weakness and numbness of the right arm, dizziness, irritability, fatigue, tingling pain in the heart. From the anamnesis: the suction of the tick was on June 30, 1995 in the right axillary region, around the place of suction there appeared cyanotic erythema up to 3 cm in diameter, which lasted about 1 week. After insolation and emotional stress there was a feeling of heat, temperature up to 40 ^o C, cramps in the calf muscles. Within 24 days she was hospitalized in MSC 1 with a diagnosis of Tick-borne borreliosis (Lyme disease), received antibacterial therapy (penicillin, ampicillin). Upon receipt, the title to Borrelia Burgdorferi - 1: 160. It was discharged in satisfactory condition with a titer of 1:40, which lasted for the next several years. Periodically, the condition worsens, headaches, meteorolability, pain in the spine, limb muscles, increased fatigue, irritability, sleep disturbance began to bother. Upon admission to the neurological department of TNIIKiF, the general condition is satisfactory. Coordination violations are not identified. From FMN (cranial nerves) without pathology. The range of motion in the cervical spine is limited slightly, in the lumbar - full. Movement in the knee, ankle joints is not limited, painful, crunching when moving. Reflexes from the upper extremities are lower on the right than on the left, from the lower extremities - live, symmetrical. Muscle tone saved. There are no pathological, meningial signs. Sensitive disorders of the polyneurotic type: hypersthesia of the type of "high gloves" and "socks". The strength of the hands is 26 kg on the left, 24 kg on the right. HELL 110/70 mm RT. Art. Heart rate 76 per minute. ECG - without pathology. Complete blood count (OAK) - moderate anemia (Hb 116 g / l, red blood cells 3.9 g / l).

 Treatment was prescribed in accordance with the claimed method.

Every day for 12 days in the morning, EHF-therapy was performed from the Stella-2 apparatus in the scanning mode in the range of 59-63 GHz to the biological active zones of the upper third of the sternum, the right shoulder joint for 8-10 minutes, to the projection of the brachial plexuses according to -4-5 minutes, on biological active points GI ₄ (he-gu), E ₃₆ (tsu-san-li) symmetrically, 4-5 minutes, moreover, two zones and 2-3 biologically active points were applied in one procedure at a total procedure time of 21-35 minutes, after which after 4-5 hours general radon baths were carried out with a concentration of 1.5-3.0 kBq / l, tamper ture - 36-37 ^o C with an exposure of 10 minutes every day or two.

 The patient tolerated the treatment well; there was no pathological balneoreaction. On the procedure of EHF-therapy, a sedative effect, a feeling of slight vibration in the fingers were noted. HELL was stable 110/70 mm Hg Heart rate 70 per minute. During the course of treatment, headaches, dizziness, pain in the spine and joints disappeared, stitching pains in the heart disappeared, the feeling of numbness in the right hand, irritability, and fatigue decreased. Objectively: movements in the spine, joints in full, painless. Continued decrease in tendon reflexes from the right upper limb. Hyperesthesia in the lower extremities has disappeared, on the upper - the zone of sensitivity violation has decreased - it remains like a glove. The strength of the right hand increased to 29 kg. Minor anemia persists (Hb 118, red blood cells 3.9 g / l). In the immune status, the number of T-lymphocytes increased from 22 to 27%, the number of B-lymphocytes decreased from 20 to 8%, and the number of T-suppressors increased from 3 to 16%. The caption for Borrelia Burgdorferi is negative.

 According to SEMG (stimulation electromyography), after a course of treatment on the ulnar nerve, the amplitude of the evoked muscle potential (M-response) on the right increased from 2.08 to 2.84 mV at the midpoint, at the proximal point, the amplitude increased from 1.76 to 3.22 mV, the speed of the pulse increased from 55.91 to 63.16 m / s.

 According to the CIG (cardioetervalography), the main indicators of the variational pulsometry used in the Baevsky P.M. method were calculated. (1979) [12], mathematical indicators: Mo (mode) - the most common cardiointerval (in s), characterizing the activity of the humoral channel of heart rhythm regulation; before treatment, the initial vegetative tone (IWT) was increased - sympathicotonia, dX - variational duration of duration (difference between maximum and minimum) of cardio intervals (in s), characterizing the degree of influence of the parasympathetic division of the ANS on the heart rhythm; AMo (fashion amplitude) is a quantitative expression of Mo (in% of the total number of intervals), reflecting the degree of influence of the sympathetic division of the ANS on the heart rhythm; IN (stress index) is an integral indicator of the level of regulation of the heart rhythm (in conventional units).

 Before treatment, the initial vegetative tone (IWT) was increased - sympathicotonia, the stress index (IN) was 120 conventional units, which indicated the tension of the body's regulatory systems. In the course of the course of treatment, IWT returned to normal (eutonia, IN = 54 conventional units), which indicates the normalization of autonomic regulation. The patient was discharged with significant improvement.

 Treatment in accordance with the claimed method received 30 patients with Lyme disease with a primary lesion of the nervous system. The polymorphism of neurological symptoms was dominated by signs of damage to the central nervous system (CNS), mainly in the form of encephalopathy syndrome of 1 tbsp. (upon receipt, subjective disorders dominated in the form of headaches, dullness in the head, increased fatigue, irritability, emotional lability, decreased memory and attention, and sleep disturbance). These phenomena were accompanied by moderate objective neurological disorders in the form of anisoreflexia and impaired coordination. The defeat of the peripheral link of the nervous system was observed in 60% of cases and was represented by various variants of the polyradiculoneuropathy syndrome, sensory (mainly algic, in the form of myalgia, neuralgia, etc.) or amyotrophic (due to damage to the peripheral nerves or spinal roots), with seropositive and a seronegative variant of the immune response.

 All were prescribed with improvement in the form of a significant regression of pathological symptoms from the autonomic nervous system, peripheral nerves, joints. Subjective well-being was confirmed by the positive dynamics of biochemical and immunological parameters.

 In the group with IVT hypersympathicotonia before treatment, a decrease in the parasympathetic effect on the heart was detected (dX = 0.08 + 0.01 s), the proportion of sympathetic regulation was sharply increased (AMo = 42.5 + 2.3%), which accordingly led to increase the overall tension of the regulatory systems of the body (IN = 359.8 + 50.7 srvc) (Table 1).

 After treatment, positive dynamics was noted in the form of an increase in dX (0.13 + 0.01 s, p <0.001), a decrease in AMo (31.8 + 2.6%, p <0.001) and, accordingly, a decrease in IN (166.0 +35.4 srvc units, p <0.001), which indicates a positive corrective effect of the physiotherapy complex on the processes of autonomous regulation of the heart rhythm and, therefore, the whole organism (Table 1).

 In groups with IVT sympathicotonia and normotonia, no significant changes were noted.

 In the vagotonic group, treatment had the opposite effect on heart rate regulation systems. So, dX after treatment decreased significantly (to 0.33 + 0.02 s, after 0.20 + 0.03 s, at p <0.01), while AMo and IN, on the contrary, increased to normal values (to 13.6 + 0.4% and 20.3 + 1.8 conventional units, after 22.0 + 1.5% and 69.0 + 11.5 conventional units, respectively, at p <0.01 ) This indicates that the body, which was previously in a state of oppression, reached a new level of functioning.

According to the data of stimulation electromyography in patients with Lyme disease with damage to the nervous system before treatment, we note a decrease in the amplitudes of evoked muscle potentials (M-responses) during stimulation of the distal (A _d ) and proximal (A _pr ) motor points of the peripheral nerves of the upper extremities - 1.57 mV and 1.15 mV, respectively, and upon stimulation of the motor points of the peripheral nerves of the lower extremities, the amplitudes of the M responses were reduced to 1.78 mV and 900 μV.

The speed of the pulses (SPI _ef ) was reduced along the nerves of the upper extremities to 55.06 m / s, and along the nerves of the lower extremities to 44.03 m / s. Pulse time at the terminals, residual latency (RL) was increased both for neuropathies of the upper extremities - 3.24 ms (normal to 2.5 ms) and for neuropathies of the lower extremities - 4.09 ± 0.27 ms (for normal up to 3 ms) (Table 2).

According to the survey after the treatment, a normalization register conduction velocity of impulses along peripheral nerves Thus IPN _ef neurotransmission upper limbs increased to 62.32 m / s, and the nerves of lower extremities - up to 54.05 m / s (Table 2.). An increase in the amplitude parameters of M-responses was revealed, reflecting the number of functioning motor units in the muscles of the limbs. So, A _d increases 1.5 times with neuropathies of both upper and lower extremities.

 In patients with Lyme disease with demyelinating neuropathies, an increase in the rate of excitation indicates the completeness of remyelination processes of the affected nerve. An increase in the amplitudes of the evoked muscle potentials implies the restoration of neuromuscular connections and the inclusion of previously non-functioning motor units in the act of contraction of the reinnervated muscle.

 The immediate effectiveness of the treatment was 86%.

 Thus, clinical trials have shown that the claimed method of rehabilitation of patients with Lyme disease with damage to the nervous system increases the effectiveness of treatment of patients with this nosology.

 The method is well tolerated by patients, can be used for Lyme disease with damage to the nervous system.

Sources of information
1. Guidelines for the treatment of tick-borne tick-borne borreliosis and tick-borne encephalitis in adults - Siberian State Medical University. - Tomsk, 2000 .-- 126 p.

 2. Epidemiology, etiology, clinical features, diagnosis, treatment and prevention of tick-borne tick-borne borreliosis. Recommendations for doctors. - St. Petersburg, 2000, p. 41.

 3. Sinitsyn N.I., Petrosyan V.I., Elkin V.A. and others. The special role of the system "millimeter waves - water medium" in nature // Biomedical Radioelectronics. -1998.- 1.-C.5-22.

 4. Korolev Yu.N. General laws of the development of ultrastructural reactions under the action of electromagnetic radiation // Vopr. health resort., physiotherapist. and exercise therapy. -1997.-N5.-C.3-6.

5. Dreval V.I., Finashin A.V. The effect of lipid peroxidation of plasma membranes on the activity of Ca ^{2 ±} ATPase // Biophysics. - 1991 .-- 36 (5). - S.799.

 6. Dudkin A. O., Bozhko G. T., Drobchenko E. A. et al. Influence of a weak pulse of electromagnetic and ionizing radiation on the nervous system // Weak and superweak fields and radiation in biology and medicine: Abstract. reports of the I International Congress. - SPb., 1997.-S. 124-125.

 7. Kamenev Yu.F. The use of electromagnetic radiation in traumatology and orthopedics // Millimeter waves in biology and medicine. - 1999 .-- 2 (14). -FROM. 20-24.

 8. Kulikov N.N., Cherevashchenko L.A., Aivazov V.N. Radon baths and laser therapy in the rehabilitation of patients with long-term consequences of combined head and neck trauma // Problems of balneology, physiotherapy and exercise therapy. - 1999. - 1. - C.25-26.

 9. Kuzin A.M. A look at radon therapy in the light of new data on the natural radioactive background // Problems of balneology, physiotherapy and exercise therapy. - 1999. - 1. -C.9-11.

 10. Oransky I.E. Biological rhythms and balneotherapy. - M., Medicine, 1997, S. 99-110.

 11. Chronobiology and chronomedicine. Leadership. -M .: "Medicine", 1989. - p. 343.

Claims (3)

1. A method of treating Lyme disease with damage to the nervous system, including the use of a natural physical factor, characterized in that EHF therapy and then general radon baths are used as a preformed physical factor, while EHF therapy is carried out for 9-12 days in morning hours in the scanning mode in the range of 59-63 GHz on the biological active zones of the upper third of the sternum, the right shoulder joint for 8-10 minutes, on the projection of the brachial plexuses for 4-5 minutes, on the biological active points GI ₄ (he-gu), E ₃₆ (zu-san-li) simme trimester for 4-5 minutes, then after 4-5 hours, general radon baths are carried out with a concentration of 1.5-3.0 kBq / l, a temperature of 36-37 ^o C with an exposure of 10 minutes.  2. The method according to claim 1, characterized in that in one procedure, EHF-therapy affect two zones and 2-3 biologically active points with a total procedure time of 21-35 minutes.  3. The method according to claim 1, characterized in that the common radon baths are carried out daily or every other day.

Images