RU2201245C2 - Method for supplementary therapy and prophylaxis of gastro-intestinal diseases in chick youngsters - Google Patents

Abstract

FIELD: veterinary science. SUBSTANCE: for therapy and prophylaxis of gastro-intestinal diseases in chick youngsters with symptomocomplex of diarrhea, colibacillosis, predominantly, one should apply antidiarrhin at the dosage of 0.2-0.5 g/kg body weight thrice daily for 5-7 d. The suggested method provides the increase of curative-prophylactic efficiency by 7% and body weight gain by 10%. EFFECT: higher efficiency. 2 ex, 6 tbl

Description

 The invention relates to veterinary medicine, relates to a method of adjuvant therapy and prevention of gastrointestinal diseases of young chickens with a symptom complex of diarrhea, mainly colibacteriosis, and can be used to increase nonspecific resistance, reduce the effects of stress and accelerate growth.

 The use of auxiliary therapy and prophylaxis means is due to the need to activate the defenses of the bird's body due to the fact that the "cleansing" of the body of pathogenic microorganisms weakened by drugs is provided using natural defense mechanisms.

 Known methods of adjuvant therapy and prevention using vitamins and vitamin complexes (e.g., trivitamin, solvimin, vitaperutin, polvita) (1), PABA (2), plant bitterness (e.g., dandelion root, nettle grass, yarrow grass (3).

 The closest in technical essence to the claimed object is a method of adjunctive therapy and prevention using oak bark preparations (4).

 A common disadvantage of the known methods is the lack of effectiveness due to the limited pharmacological effects. So, vitamins normalize metabolic processes, performing enzymatic functions of catalysts for metabolic processes; PABA activates the microflora of the gastrointestinal tract; plant bitterness increases the enzymatic activity of the intestine and improves blood circulation, and oak bark has an anti-inflammatory effect.

 The purpose of the invention is improving efficiency.

 This goal is achieved by the use of the drug antidiarin.

 Antidiarin is a complex preparation, which is an extraction product of the bark of coniferous and deciduous trees, containing condensed polyphenols (tanides), soluble monosaccharides, and phlebophenes with P-vitamin activity. Antidiarin is a fine, odorless brown powder with an astringent taste, it is soluble in water (5).

According to the level of acute toxicity when introduced into the stomach, antidiarin belongs to the IY hazard class according to GOST 12.1.007-76 (LD ₅₀ could not be determined due to low toxicity). It does not have cumulative properties, skin-resorptive and sensitizing effect. In recommended doses, the drug does not cause complications and has no contraindications; slaughter for meat is carried out without restrictions associated with its use.

 An analysis of the data in the scientific, technical and patent literature did not reveal methods of adjuvant therapy and prophylaxis of colibacillosis of young chickens using a herbal preparation containing condensed tanides, soluble monosaccharides, phlebophenes with P-vitamin activity, which indicates compliance with the "novelty" criterion.

 In the claimed technical solution, the use of the antidiarin drug provides a wide range of pharmacological effects, which leads to the activation of humoral factors of natural resistance as a result of normalization of metabolic processes and activation of physiological functions of the blood. The foregoing allows us to conclude that there is a "inventive step" in the claimed technical solution.

 The method of auxiliary therapy and prevention is as follows.

 In conjunction with veterinary and sanitary measures, young chickens are administered the antidiarin preparation inside, which is mixed with dry food or a wet mash at a dose of 0.2-0.5 g / kg live weight 3 times a day for 5-7 days.

 The essence of the method is illustrated by examples.

 Example 1. The effectiveness in the treatment of colibacteriosis of young chickens was determined in the conditions of the Balakhna poultry farm in the Nizhny Novgorod region on broilers of 70 days of age with signs of colienteritis (depression, lethargy, lack of appetite, diarrhea). The diagnosis of colibacteriosis was confirmed pathologically (serous-fibrinous pericarditis, perihepatitis, the lungs are hyperemic, the walls of the air sacs are thickened; in the intestine there are grayish-whitish feces with an admixture of mucus and blood, the intestinal mucosa is thickened) and the enteropathy is isolated. 3 groups of chickens were formed, which were treated with antibiotics and nitrofuran preparations in therapeutic doses. Chickens of the 1st group additionally used antidiarin, which was mixed with dry food at a dose of 0.5 g / kg body weight, 3 times a day until recovery. Chickens of the 2nd group additionally used oak bark. Group 3 chickens were not additionally treated with drugs, and they served as a control. Table 1 shows the effectiveness of antidiarin in the treatment of colibacteriosis of broiler chickens in comparison with the analogue. In the table. 2 and 3 show the biochemical parameters of blood serum and morphological parameters of blood in experimental (1 group) and control (3 group) chickens.

 As can be seen from table 1, the treatment efficacy in group 1 was 98.4% compared with 93.4% in group 2 (analogue) and 92.8% in group 3 (control) with a reduction in treatment time (time of illness) by 1.5 days compared to the analogue and 1.25 days compared to the control and increase in live weight gain by 35% compared with 26% (analogue) and 20% (control). As can be seen from Tables 2 and 3, at the end of the experiment, normalization of metabolic processes was noted. Thus, the accumulation of albumin (19.4 ± 1.7 compared to 15.1 ± 1.5 g / l) provided an increase in the total protein (58.8 ± 5.0 compared to 45.7 ± 4.5 g / l), which indicated the activation of the intensity of protein metabolism. In the experimental group, an improvement in the physiological functions of the blood was observed. So, in the experimental group, all morphological parameters of blood are higher, and an increase in ALS (45.6 ± 1.5 and 43.3 ± 3.4%) and lysozyme activity (46.6 ± 1.0 and 40.4 ± 0 , 74%) indicated the stimulation of the body's defenses.

 Example 2. The effectiveness in the prevention of colibacteriosis of broiler chickens was determined in the conditions of the Black-Ramen poultry factory of the Nizhny Novgorod region on broiler chickens of 35 days of age with an average live weight of 775 g, which were divided into 3 groups. All broiler chickens were kept in the same conditions and received antibiotics and nitrofuran drugs for prophylactic purposes. Group 1 chickens were additionally mixed with dry food Antidiarin at a dose of 0.2 g / kg live weight 3 times a day for 5 days. Chickens of the 2nd group were additionally mixed with dry fodder of oak bark. Chickens of the 3rd group did not receive additional drugs; they served as a control.

 Table 4 shows the effectiveness of antidiarin in the prevention of colibacteriosis of broiler chickens in comparison with the analogue. Tables 5 and 6 show the biochemical parameters of blood serum and morphological parameters of blood in experimental (1 group) and control (3 group) chickens.

 As can be seen from the table. 4, the prophylaxis efficiency in group 1 was 96.0% compared with 89.0% in group 2 (analogue) and 88.9% in group 3 (control) with an increase in live weight gain of 45.5% compared to 40 , 0% (analogue) and 35.0% (control). As can be seen from tables 5 and 6, in the experimental group an increase in natural resistance was established (ALS 43.5 ± 1.6 compared to 40.0 ± 4.9%) as a result of activation of the physiological functions of the blood. So, the hemoglobin level at the end of the experiment was 92.9 ± 5.6 compared to 80.0 ± 1.8 g / l, the number of red blood cells and white blood cells 3.9 ± 0.3 and 23.7 ± 1.3 compared with 3.1 ± 0.13 and 22.4 ± 1.6, respectively.

 Tests have confirmed the effectiveness of the claimed method of auxiliary therapy and prevention for colibacillosis of young chickens. Thus, an increase in efficiency in the prevention and treatment, a reduction in the duration of the disease, an increase in the safety of the livestock and an increase in live weight gain were noted. The reduction in feed consumption as a result of the normalization of metabolic processes and the cost of medicines as a result of a reduction in the duration of treatment indicate the efficiency of the method. Reducing the use of other therapeutic agents, especially antibiotics, leading to disruption of the intestinal microecology and an increase in the circulation density of highly pathogenic antibiotic-resistant strains of microorganisms, ensures environmental safety.

Sources of information
1. Veterinary medicine, 1996, 2, p. 47-48.

 2. Veterinary drugs / Ed. A.D. Tretyakova. M .: Agropromizdat, 1985, p.168-169.

 3. Chervyakov D.K., Evdokimov L.D., Vishker A.S. Medicines in veterinary medicine. - M .: Kolos, 1977, p.113-117.

 4. Lipnitsky S. S., Pilui A. F., Lipps L. B. Green pharmacy in veterinary medicine. - Minsk: Harvest, 1987, p.76 - prototype.

 5. TU (9973-727-00281074-00).

Claims (1)

 The method of adjunctive therapy and prevention of gastrointestinal diseases of young chickens, including feeding a herbal preparation, characterized in that the antidiarin preparation is used as a herbal preparation in a dose of 0.2-0.5 g / kg live weight 3 times a day for 5-7 days.

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