RU2180568C2 - Method to treat allergic diseases - Google Patents

Abstract

FIELD: medicine, allergology. SUBSTANCE: any antilambliasic medicinal preparations at usual dosages and modes. The method leads to prolonged and stable remission at different manifestations of cutaneous, respiratory, alimentary and other allergoses. EFFECT: higher efficiency of therapy. 2 ex

Description

 The invention relates to medicine, in particular to pediatrics, allergology and gastroenterology.

 A known method of treating allergic diseases, which involves the use of antihistamines in various regimens and combinations with mast cell calcium channel blockers, with hormone therapy, symptomatic agents (external, bronchodilators, adsorbents) [M. Mashkovsky, 1990], as well as using various elimination and desensitization options. This method is selected as a prototype.

The disadvantages of the prototype method are:
1. Treatment by the prototype method is symptomatic; in some cases ineffective, i.e. does not lead to clinical recovery.

 2. Another disadvantage is that the use of antihistamines does not allow for long-term remission and does not affect the recurrence rate.

 The aim of the present invention is to increase the effectiveness of treatment up to clinical recovery, lengthening the period of remission and preventing relapse.

 This goal is achieved by the fact that, in the treatment of allergic diseases, along with the use of pathogenetic and symptomatic agents, irrespective of the results of routine laboratory examinations (searching for worm eggs and Giardia cysts in feces), they conduct a course of anti-giardic and antihelminthic therapy until the clinical symptoms of helminth-protozoal infection disappear completely. Particular attention should be paid to the presence of bruxism, polydipsia, stabilization of the stool and normalization of liver size. Of the paraclinical research methods, the disappearance of eosinophilia can serve as an indirect sign of rehabilitation. In parallel, the disappearance of the clinical symptoms of allergy is noted. The method involves the use of any drugs that effectively affect parasites, taking into account the individual characteristics of the patient (age, individual tolerance, clinical variant of the manifestation of helminth protozoal infection, etc.). The method also includes conducting periodic anti-relapse courses against the background of the complete disappearance of the clinical symptoms of helminth protozoal infection.

 Long-term clinical observation showed the effectiveness of the proposed method. Under our supervision, for 3-5 years there were 72 patients aged from 6 months to 27 years with various clinical variants of allergies (skin allergies, respiratory allergies, digestive allergies and combinations thereof) after a course of therapy that included treatment with helminth protozoal infection in 59 (81.9%) had a stable remission; 5 (6.9%) had one-time relapses of an allergic disease, 7 (9.7%) had relapses that required a second course of treatment for helminth protozoal infections, and only one (1.4%) child underwent a transformation allergic dermatitis in the focal form of neurodermatitis.

 Examples of the method.

 Example 1. Snezhana Oh, 12 years old. I entered DIB 18 with a diagnosis of bronchial asthma, an attack period.

 From a month of age she received treatment for "staphylococcal enterocolitis." At 6 months after switching to artificial feeding, moderate manifestations of allergic dermatitis were noted. From the age of 7 she was at the dispensary with a diagnosis of bronchial asthma, moderate, allergic dermatitis, food and drug sensitization. During the year she was hospitalized three times with attacks of bronchial asthma, the duration of the post-attack period was 14-20 days. Received ketotifen courses, fencarol. At the age of 8, in close contact with a cat (a long trip in a car with a cat on his lap), an acute attack of expiratory choking began, requiring urgent hospitalization. The disease was regarded as bronchial asthma, an attack period. From the digestive system, an increase in the liver was noted (by 3 cm from under the edge of the costal arch along the media-clavicular line). In the blood test, eosinophilia 16. In a single study in the analysis of stool, no lamblia cysts were detected.

 Simultaneously with emergency measures, the child was prescribed furazolidone (0.05 four times a day) for five days, which allowed to reduce the duration of the post-attack period to 3 days. After being discharged home, the child received a ten-day course of treatment, a course of treatment with Trichopolum (0.25 twice a day), and after five days, a second course of Trichopolum (0.25 twice a day) was performed. Over the next four years, once a year, she received an anti-relapse treatment with trichopolum or furozolidone (7-10 days). Attacks of bronchial asthma were no longer noted. The forecast is favorable.

 Example 2. Pavel B., 9 years old. I was treated on an outpatient basis for common neurodermatitis, a continuously recurring course.

 At the age of 4 months, he was operated on for intussusception, received a massive course of antibiotic therapy (ampiox, chloramphenicol), after which at the age of 5 months there were skin changes in the form of redness of the cheeks and buttocks, at the age of 9 months, reddening and getting wet in the area of the wrist joints and popliteal fossae. Allergic dermatitis was observed with a diagnosis of widespread neurodermatitis at 3 years old. The use of tavegil, ketotifen for long courses for 3 years, as well as external agents, adsorbents, spa treatment (triple stay in Crimea for a period of 2 to 3 months) gave a temporary improvement. Skin manifestations intensified with errors in the diet (chocolate, strawberries, eggs).

 Eosinophilia was determined twice in blood tests (8, 9).

 At the age of six, he received a ten-day course of Trichopolum (0.25 twice a day), and after ten days an anti-relapse ten-day course of Trichopolum in the same dose. Skin changes disappeared within two weeks and did not appear during the next three years of observation.

 Anti-relapse courses were not carried out, as the child was constantly under medical supervision and did not reveal symptoms of helminth protozoan infection. The diet is expanded up to the introduction of obligate allergens. The forecast is favorable.

Thus, the use of a method for the treatment of allergic diseases leads to the following positive effects:
1. Improving the effectiveness of treatment up to clinical recovery, lengthening the period of remission and preventing relapse.

 2. Impact on one of the main etiological factors of allergic diseases - helminthic protozoal infection with the use of the entire spectrum of medical methods for the treatment of helminthic protozoal infection.

 3. The possibility of applying the method for the treatment of all types of allergies (skin, digestive, ENT organs, genitourinary system, respiratory, including bronchial asthma).

Claims (1)

 A method of treating allergic diseases by administering medications, characterized in that they use anti-giardic medications.