RU2401123C2 - Method of treating psoriasis in children - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: treating psoriasis in children is ensured by the pulmonary administration of 0.025% Thymodepressin in dosage 0.5 ml per one inhalation. The therapeutic course makes 10 to 15 procedures. The intrabronchial administration is ensured by using an apparatus to transform a drug preparation into a fine nebulous dosage form.

EFFECT: higher clinical effectiveness for psoriasis in children; the method is noninvasive and effective when used in a single agent therapy.

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Description

The invention relates to medicine, namely to methods for treating psoriasis in children.

It is already known the treatment of psoriasis in children with numerous drugs, including those that affect the immune system (N.V. Kungurov, Psoriatic disease, 2002, p. 105). In particular, the most common treatment of psoriasis in children involves complex therapy, including hyposensitizing, antihistamines, angiotrophic, immunomodulating agents in combination with external treatment, which usually includes ultraviolet radiation (N.G. Korotky, V.Yu. Ujuhu, Papular dermatoses Moscow, 2000, pp. 52-55).

Also known are the immunological drugs considered to be the most effective in treating psoriasis in children today: tactivin, polyoxidonium, administered parenterally at age-related doses (N.V. Kungurov, Psoriatic disease, 2002, p. 105).

The aim of the present invention is to increase the effectiveness of the treatment of psoriasis in children, including young children, by non-invasive methods of administration.

This goal is achieved by the fact that the treatment is carried out with the drug Timodepressin inhaled in doses of 0.5 ml of a 0.025% solution for one inhalation, in courses of 10 to 15 procedures.

With intrabronchial administration, an apparatus is used that converts the drug substance into a finely dispersed, foggy form.

The method is illustrated by the following clinical observations.

Example 1

Orlova Elena, 17 years old, looked at the Department of Dermatoallergology of the Russian Children's Clinical Hospital on 04/20/2006 with a diagnosis of Vulgar psoriasis, moderate.

Anamnesis of life: a child from the first, normal pregnancy, was born on time.

Past diseases: acute respiratory infections up to 2 times a year, rubella, chickenpox, furunculosis.

An allergic history is not burdened, there are no drug intolerances.

Heredity is not burdened.

Anamnesis of the disease: Sick from 12 years, when there were rashes on the lower extremities, then after 3 months on the scalp. She underwent treatment at the place of residence (vitamins B1, B6, external therapy) - without effect. Gradually, rashes spread throughout the skin. In December 2002, she was first hospitalized at the Russian Children's Clinical Hospital where she undergoes treatment 2 times a year.

Admission Condition:

Pathological skin process of sub-inflammatory nature, common, symmetrical. It is localized on the scalp, trunk, limbs. It is represented by papules and plaques of a rounded shape, pink in color, with clear borders, sizes from 0.2 to 2 cm, covered with easily detachable silver-white scales. The psoriatic triad is positive. Hair and nails are not changed.

The treatment with the drug Timodepressin was inhaled in doses of 0.5 ml of 0.025% solution for one inhalation, with a course of 15 procedures with a positive effect. In the second week of treatment, papules and plaques turned pale, peeling and infiltration decreased significantly, by the third week there was a complete disappearance of the clinical manifestations of the disease, hypopigmented spots remained on the site of resolved papules and plaques, there were no new rashes.

Example 2

Karazhelevskaya Julia, 13 years old, was admitted to the Department of Dermatoallergology of the Russian Children's Clinical Hospital on 04/11/2006 with a diagnosis of Vulgar psoriasis, severe course.

Anamnesis of life:

A child from the first, normal pregnancy, was born on time.

Past diseases: acute respiratory infections up to 4-6 times a year, tonsillitis up to 2 times a year, chickenpox, bronchitis.

An allergic history is not burdened, there are no drug intolerances.

Heredity burdened: maternal grandmother has psoriasis.

Medical history:

Sick since September 2005, when there were rashes on the scalp, then the process spread throughout the skin. She was treated in the Kaluga Regional Hospital in September and November 2005 (T-activin, suprastin, erius, vitamins B1, B12, sodium thiosulfate, lipoic acid, external therapy, including corticosteroid ointments) - without effect.

Admission Condition:

Pathological skin process of an inflammatory nature, common, symmetrical. It is localized throughout the skin, including on the scalp. It is represented by papules of rounded shape, bright pink in color, with clear borders, sizes from 0.2 to 0.5 cm, covered with easily detachable silver-white scales and plaques up to 2 cm in size on the scalp. The psoriatic triad is positive.

Considering the complete absence of the clinical effect of the treatment carried out in the hospital of the regional police department and the present manifestation of the disease, treatment with Timodepressin was prescribed in doses of 0.5 ml of 0.025% solution for one inhalation, with a course of 15 procedures with a positive effect. In the first week of therapy, subjective sensations and peeling decreased, the elements turned pale, new elements did not appear; in the second week of treatment, infiltration decreased significantly, by the third week, single, barely noticeable papules and plaques were noted, the pathological process was represented mainly by spots on the sites of the former rashes.

Example 3

Gorokhov Nikita, 14 years old, was admitted to the Department of Dermatoallergology of the Russian Children's Clinical Hospital on 04.04.2006 with a diagnosis of moderate psoriasis.

Anamnesis of life:

The child from the first, normal pregnancy, was born on time.

Past diseases: acute respiratory infections up to 2 times a year, tonsillitis up to 2 times a year.

An allergic history is not burdened, there are no drug intolerances.

Heredity: mother has psoriasis.

Medical history:

Sick since 5 years, when there were rashes on the scalp, then the process spread to the trunk and limbs. He underwent treatment at the place of residence with a temporary effect. In the summer notes a significant improvement in the skin process. Hospitalized at the RCCH for the first time.

Admission Condition:

Pathological skin process of an inflammatory nature, common, symmetrical. It is localized on the scalp, trunk, limbs. It is represented by papules and plaques of rounded shape, pink in color, with clear borders, sizes from 0.5 to 15 cm, covered with easily detachable silver-white scales. The psoriatic triad is positive. Hair and nails are not changed.

The treatment with the drug Timodepressin was inhaled in doses of 0.5 ml of a 0.025% solution for one inhalation, with a course of 13 procedures with a positive effect. At the end of the first week of therapy, peeling decreased, the elements turned pale, in the second week of treatment the infiltration decreased, by the third week the papules and plaques were pale pink, flat in the center, along the edges a significant decrease in the infiltration of elements, Voronov's pseudoatrophic rim was noted. There were no new rashes.

In total, in our clinic according to the claimed method 13 patients were treated at the age of 5 to 17 years with various clinical forms, duration and severity of psoriasis. In all cases, a persistent positive result was obtained:

Full name Age Diagnosis Severity Treatment result Karpova Svetlana 5 years Exudative psoriasis average clinical remission Kashtanova Svetlana 10 years Vulgar psoriasis average clinical remission Sviridov Sergey 15 years Vulgar psoriasis average clinical remission Zykova Maria 6 years Palm.-soles. psoriasis average clinical remission Utkin Dmitry 15 years Vulgar psoriasis average clinical remission Orlova Elena 17 years Vulgar psoriasis average clinical remission Kravchenko Nina 15 years Vulgar psoriasis average clinical remission Mitina Alena 12 years Vulgar psoriasis average clinical remission Gorokhov Nikita 14 years Vulgar psoriasis average clinical remission Soloviev Alexander 15 years Vulgar psoriasis average clinical remission Kuzyat Dmitry 14 years Vulgar psoriasis heavy significant improvement Nikishina Ksenia 12 years Vulgar psoriasis average clinical remission Karazhelevskaya Julia 13 years old Vulgar psoriasis heavy significant improvement

The claimed invention is not obvious to specialists working in this field.

All known treatment regimens for children with psoriasis usually involved invasive treatment, often complex and long-term. The terms of treatment achieved by us are two times shorter - no more than three weeks.

For the first time, it was proposed to treat children from 2 years with very good results in a non-invasive way of administering the drug, and practically in the form of monotherapy.

Claims (2)

1. A method of treating psoriasis in children, characterized in that the treatment is carried out with the drug Timodepressin inhaled in doses of 0.5 ml of a 0.025% solution for one inhalation, in courses of 10 to 15 procedures. 2. The method according to claim 1, characterized in that for intrabronchial administration, an apparatus is used that converts the drug substance into a finely divided, foggy form.