RU2171108C1 - Method for carrying out pesticide enterosorption in the cases of chronic gastroduodenitis in children - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method involves administering Zosterin on the background of dietotherapy applied. Zosterin is administered one quarter in year using treatment approaches consisting of three courses as 2% aqueous solution in 100 ml given once a day in the morning 30 min before taking meals during 5 days with 3 days long pause. EFFECT: enhanced effectiveness in removing pesticides from organism; reduced frequency of disease recurrence. 6 tbl

Description

 The invention relates to medicine and can be used as a remedy for gastroenterological diseases.

 Among the enterosorption methods used for prophylactic and therapeutic purposes, the purpose of various sorbents designed to remove harmful substances from the body is justified.

 The healing effect of the sorbent is achieved due to the physicochemical properties of the sorbent substance, which is able to bind and remove toxic products from the body from their places of application, as well as methods of its use.

 An analogue (Rimarchuk GV et al., 1998 [1]) of the proposed method of enterosorption in gastroenterological diseases is the use, in particular, SUMSa-1 in children with digestive diseases. The authors prescribed for patients with chronic gastroduodenitis SUMS-1 according to the scheme 0.5 g of dry matter per 1 kg of body weight 3 times a day every day for 7 days 1.5 hours after eating. As a result, it was shown that with a high clinical effect, endoscopic improvement was achieved only in 25% of patients, confirmed by histological studies.

 The prototype (Semisotova EF et al., 1997 [2]) of the proposed method for enterosorption in gastroenterological diseases is the use of zosterol as a therapeutic agent for diseases of the gastrointestinal tract.

 At the same time, the authors included in the treatment complex (against the background of dietary and drug therapy) a 0.5% aqueous solution of zosterol inside 200 ml 2 times a day - in the morning on an empty stomach 20-30 minutes before meals and 2-3 hours after dinner before departure to sleep for 2-3 weeks.

 The results of the use of the drug showed that in gastroenterological patients earlier (for 3-4 days), relief of pain and dyspeptic syndromes occurs with a parallel improvement in objective indicators detected during the control ultrasound examination. The use of zosterol in this method of treatment does not affect the level of calcium and total cholesterol in blood serum.

 Our studies of paraclinical indicators revealed an insufficient effect of the use of zosterol according to this scheme.

 The aim of the work was to increase the effectiveness of treatment of children with chronic gastroenterological diseases living in areas contaminated with pesticides.

Tasks:
1. improve the clinical condition of patients and their quality of life;
2. reduce serum pesticides;
3. to reduce during the treatment process the activity of enzymes-markers of the membrane-pathological process - xanthine oxidase (CO), superoxide dismutase (SOD), ATPase;
4. improve the morphological state of the gastric mucosa;
5. lengthen periods of remission;
6. reduce the recurrence rate of the disease.

 The essence of the invention lies in the fact that patients with gastroenterological diseases on the background of diet are prescribed zosterol by administering treatment regimens 1 time per quarter, consisting of 3 courses of administration of a 2% aqueous solution of zosterol 100 ml 1 time per day in the morning on an empty stomach for 30 minutes before meals for 5 days with an interval of 3 days.

 The method is as follows. Children, for example, with chronic gastroduodenitis aged 5-14 years, living in rice and grain-growing areas of the Krasnodar Territory with a high intensity of pesticides and who applied for medical help to the regional children's diagnostic center, were prescribed diet food and zosterin according to the "Essence" indicated way. We proceeded from the fact that pesticides that entered the body at the cellular level initiate a pathological process in the mucous membrane of the stomach and duodenum.

 All patients were divided into 2 groups: I (112 people) - children receiving zosterol; II (40 people) - children who received placebo (distilled water at a dose of 50 ml per day). The studied groups did not practically differ by sex, age, and age of the disease (Table 1).

Clinical trials of the proposed method of enterosorption included the following purposes:
1. medical nutrition - table N 1;
2. zosterol in the form of a 2% aqueous solution of 100 ml once a day in the morning on an empty stomach 30 minutes before meals for 5 days with an interval of 3 days every quarter for a year.

 An analysis of changes in the symptoms of the disease showed a significant effect achieved with treatment with zosterol and consisting in the rapid disappearance of subjective and objective signs of inflammation in the gastrointestinal tract (Table 2).

 In studies, it was found that when using zosterol, there is a tendency to a decrease in the activity of markers of the membrane-pathological process. The ratio of antioxidant (SOD) and prooxidant (KO) enzymes changes in the direction of increasing antioxidant activity in children receiving zosterol, in contrast to patients using placebo (Table 3).

 In the table. 4 presents data on the enterosorbent properties of zosterol, which is confirmed by the elimination of DDT, α-HCH, γ-HCH in the main group of patients during treatment.

 To solve the problem of the effect of zosterol on the state of the gastric mucosa, an endoscopic examination was performed in all children during treatment. A stimulating effect of zosterol on cytoprotection and regeneration of the gastric mucosa, which is manifested by a decrease in erosive, atrophic, and hyperplastic gastritis and the predominance of erythematous, was found. In patients receiving placebo, such changes did not occur (table. 5).

 Elimination from the body of children of pesticides, which are a supporting factor in the painful process in the stomach, a decrease in the activity of prooxidant enzymes and an increase in antioxidant enzymes, and an increase in regenerative processes in the mucous membrane are the pathogenetic basis for improving the clinical condition and reducing the recurrence rate of chronic gastroduodenitis in children living in areas with high pesticidal load (table 6).

 Example.

 Natasha P., 12 years old. I turned to the Krasnodar Territory Children's Diagnostic Center for examination and treatment from the Timashevsky region of the region, which is characterized by a high intensity of pesticides (3 kg / ha). The girl complained of pain in the epigastric region, heartburn, belching, tendency to constipation, increased fatigue.

 Objectively: the tongue is coated with a white coating. Visible mucous membranes and skin are clean, pink. Respiratory rate - 22 in 1 min. Percussion above the lungs determines a clear pulmonary sound, auscultation - vesicular breathing. Heart sounds are clear, pure. Heart rate - 74 in 1 min. The abdomen is soft, palpation is accessible, painful in the epigastric region. There, the definition of the anterior abdominal wall defance is also determined. Bubble symptoms are negative. The liver and spleen are not enlarged. The chair is irregular, decorated, 2 times a week. Urination is not impaired.

 General analysis of blood and urine without pathological changes. Fractional study of the stomach: fasting gastric secretion - 40 ml, in the I phase - 50 ml, in the II phase - 90 ml, flow rate - HCl in the 1 phase - 40.5 mg / h, in the II phase - 150.4 mg / h ; the titer of antibodies to the gastric mucosa was 1:80. The level of KO was 290.4 μm / l / s, SOD - 1.75 srvc. units, Ca-Mg-ATPase -1.55 mM / l / s. The amount of DDT in the blood serum was 0.10 mg / L, α-HCH - 0.07 mg / L, γ-HCH - 0.05 mg / L.

 An endoscopic examination of the stomach revealed hyperplastic gastroduodenitis. An ultrasound examination of the abdominal organs revealed no pathology.

The child was assigned
1. zosterol in the form of a 2% aqueous solution of 100 ml once a day in the morning on an empty stomach 30 minutes before meals for 5 days 3 courses with an interval of 3 days every quarter for a year;
2. diet table N 1.

 After treatment in January, April, July, October, a second examination of the patient was carried out. The girl did not complain. An objective examination of the pathology did not reveal. Fractional study of the stomach: the amount of gastric secretion on an empty stomach is 28 ml, in the I phase - 31 ml, in the II phase - 70 ml, the debit-HCl in the I phase - 33 mg / h, in the II phase - 85 mg / h; the titer of antibodies to the gastric mucosa corresponded to 1: 30. The level of KO was 120 μM / l / s, SOD - 1.0 srvc. units, Ca-Mg-ATPase - 1.20 mmol / l / s.

 DDT, α-HCH - γ-HCH in serum were not detected. The endoscopic examination of the stomach and ultrasound of the abdominal organs did not reveal any pathology. Follow-up observation for two years showed the absence of exacerbations of the disease.

Medical and social effectiveness is
- in improving the physical condition of patients and their quality of life;
- elimination of pesticides from the body;
- a decrease in the activity of membrane pathological enzymes;
- normalization of the gastric mucosa;
- lengthening periods of remission;
- 3 times reduction in the recurrence rate of the disease.

Literature
1. Rimarchuk G.V., Ursova N.I., Polyakova S.I., Domnikova O.S., Plaksina G.V. Modern principles of efferent therapy of diseases of the digestive system // Ecological and hygienic problems of pediatrics: Mater. III Congress of Pediatricians of Russia. -M., 1998.-p. 46-48.

 2. Semisotova E. F., Gelzer B. I., Belyakova V. P., Loenko Yu.N. Practical recommendations for doctors according to the results of a clinical trial of the preparation of zosterol-pectin /// 2 3osterin. -Vladivostok, Dalnauka. -1997. -from. 199-204.

Claims (1)

 A method of enterosorption of pesticides in chronic gastroduodenitis in children, including the use of zosterol as an enterosorbent against the background of dietary nutrition, with the administration of a 2% aqueous solution of zosterol 100 ml once a quarter 1 time per day on an empty stomach in the morning 30 minutes before food for 5 days with an interval of 3 days.

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