RU2164106C1 - Method of treating hepatic keratitis with ulceration - Google Patents

Abstract

FIELD: ophthalmology. SUBSTANCE: locpheron is injected into eye using magnetophoresis once a day. EFFECT: achieved high-efficiency and rapid epithelization, resorption of infiltration in absence of allergic reactions. 4 cl, 2 ex

Description

 The present invention relates to the field of medicine - ophthalmology and is intended for the treatment of herpetic keratitis.

 Currently, for the treatment of herpetic keratitis with ulceration, along with specific, chemotherapeutic, antiviral and drugs: IMU, Bonaphton, Florenal, Tebrofen, Ara-A, Acyclovir, interferons have long been used (Yu.F. Maychuk. Viral eye diseases, M .: Medicine. - 1981. - S. 272).

 The mechanism of antiviral action of interferons of all three classes (alpha, beta, gamma) is well understood. They are used alone or combined with chemotherapy to enhance the antiviral effect.

 The use of Lokferon for the treatment of herpetic keratitis with the healing of ulceration and resorption of stromal infiltration is known (M.A. Kazachenko et al. Lokferon - new eye drops of interferon in the treatment of viral diseases of the eyes // New Medicines. - 1998. - N 10. - C . 22-25).

 Lockeron - human leukocyte alpha-interferon is developed and produced by the joint stock company "Biomed" named after N.I. Mechnikov. It is a white powder. The vial contains 8.000 ME alpha interferon. The contents of the vial are diluted in 1 ml of distilled water, instillations should be carried out 1 drop 8 times a day in the acute stage, reducing their number to 4 - 2 times a day as the condition of the eye improves. This method is taken as the closest analogue.

 In the treatment of herpetic keratitis, the method of physiotherapy has also been successfully used for a long time - magnetotherapy, which has anti-inflammatory, decongestant and anti-allergic effects, improves blood supply to altered tissues, increases reparative regeneration, activates the rate of collagen biosynthesis in the damaged cornea, increases the transport of certain drugs to the moisture of the anterior chamber and glasses body (Yu.F. Maychuk et al. // Bulletin of Ophthalmology. - 1998. - N 6. - P. 23-25).

 The method of magnetophoresis was developed using experimental clinical trials (Vanstein E.S. et al. "Magnetophoresis" and its experimental justification. // Ophthalmol. Journal. - 1982. - N 4.- P. 245-247).

 A combination of an antiviral drug (interferon) with a magnetic field is known. However, its disadvantages are low antiviral activity and often an allergic reaction.

 Presumably, the combination of Lockeron and magnetophoresis can give a fundamentally new effect based on the high antiviral activity of Lockeron and a deeper penetration of the drug into the cornea against the background of the absence of an allergic reaction as a result of a decrease in the daily dose of Lockeron.

 The technical result of the proposed method is a complete and fast epithelization and resorption of infiltration in the absence of allergic reactions.

 The technical result is achieved by reducing the dose of Lockeron while maintaining the effect of epithelization and resorption of infiltration, introduced once by magnetophoresis.

 The method is as follows.

 The contents of the vial are diluted in 1 ml of distilled water, 2 drops are instilled into the conjunctival cavity, and then the magnetophoresis procedure is carried out in a non-contact manner using, for example, the Polyus-3 apparatus generating a low-frequency rotating magnetic field of the following parameters: induction 10 mT, frequency 25 Hz, the duration of the procedure is 8 minutes, the course of treatment is determined by achieving complete epithelialization of the cornea, the technique is non-contact.

 Depending on the severity of the disease, additional topical administration of symptomatic drugs is possible.

 The results of clinical observations.

 Example 1. Patient I. 66 years old was admitted to the hospital with a diagnosis of herpetic keratouveitis with ulceration of the right eye. Upon admission to the cornea of the right eye in the central zone, the defect in the epithelium and stroma in the form of a “card” 4x4 mm in size is stained with fluorescein. Corneal stroma is infiltrated, swollen; on the endothelium, overlays and precipitates, conjunctiva of the eyelids and eyeball are hyperemic, edematous, mixed injection. Visual acuity of 0.05 n / a.

 Appointed magnetophoresis with Lockeron. Lockferon was prescribed 1 time per day in combination with magnetophoresis.

 On the 3rd day of treatment, the initial signs of corneal epithelization were observed, ending by day 10. The effusion in the anterior chamber, the infiltration of the stroma and the phenomena of iritis decreased.

 At discharge, visual acuity of 0.4. The patient was discharged from the hospital.

 Example 2. Patient S., 71 g. On admission to the left eye, the manifestation of kartoobraznaya herpetic keratitis. Visual acuity is the count of fingers in the face. The epithelial defect is 3/4 of the cornea. It is stained with fluorescein.

 Clinical diagnosis: herpetic carteratic keratitis of the left eye.

 Appointed magnetophoresis of Lockeron. Lockferon was prescribed 1 time per day in combination with magnetophoresis.

 During treatment, the initial signs of epithelization were observed on the 3rd day, and its completion after 10 days. Infiltration of the stroma was completely absorbed after 14 days. By the 15th day of treatment, clinical recovery began. Visual acuity 0.2 b / c.

 Thus, the technical result is achieved during the implementation of the method due to the combination and as a result of enhancing the therapeutic effect of the drug and physiological factor. This leads to a reduction in the healing time of corneal ulcerations, more rapid relief of other inflammatory processes in the sore eye, the disappearance of signs of iritis, resorption of stromal infiltration, and increased visual acuity. Those. in general, acceleration of recovery processes is observed without the additional inclusion of pharmacotherapeutic agents that contribute to the healing of ulcerations characteristic of keratouveitis against the background of a decrease in allergization associated with the use of Lockeron.

Claims (4)

 1. A method for the treatment of herpetic keratitis with ulceration, including local administration of Lokferon, characterized in that Lokferon is administered as magnetophoresis using a low-frequency rotating magnetic field once a day until complete epithelization is achieved.  2. The method according to claim 1, characterized in that they use a low-frequency rotating magnetic field with an induction value of 10 mT, a frequency of 25 Hz.  3. The method according to claim 1, characterized in that Lockferon is injected into the conjunctival cavity.  4. The method according to claim 1, characterized in that Lockferon is administered subconjunctively in the limb region.