RU2161497C2 - Method for treating intestinal dysbacteriosis in children and adults - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method involves administering complex therapy like pectin taken as 3-5% aqueous solution having bactericide activity with respect to pathogenic and conditionally pathogenic intestinal microflora. Both children and adults receive pectin in two cycles - 4 days with 5 days pause and more 4 days treatment in age- dependent dose every 4 h with pause for sleeping time. EFFECT: stable results of treatment; accelerated treatment course.

Description

 The invention relates to medicine, namely to the treatment of dysbacterioses developing in humans as a result of intensive etiotropic therapy (antibiotics, chemotherapy) for infectious and other diseases.

 There is a method of treating dysbiosis, which consists in identifying the leading agent (sharp activation of individual representatives of opportunistic microflora), determining the spectrum of drug resistance of the agent and its immediate elimination. See Petrovskaya V.G., Marko O.P. The microflora of a person is normal and pathological. M. Honey., 1976, p. 109-118 (1). There is also known a method of treating intestinal dysbiosis through the use of complex therapy, including measures aimed directly at the leading factor of dysbiosis, and measures to correct intestinal microflora. See Krasnogolovets V.N. "Dysbacteriosis of the intestine", M., Med., 1989, p. 160-191 (2).

 The disadvantage of the above treatment methods is the high probability of a change in the nature of dysbiosis (replacement of the leading factor, imbalance of the intestinal normoflora), and with prolonged and massive use of antibiotic therapy - the creation of secondary immunodeficiency states, enzymeopathies - all this is associated with the need for further measures to normalize the intestinal microflora and its functions. The process of treating dysbiosis in this way is lengthy and ineffective. See "Secondary Immunodeficiency Conditions," Ed. Fomina V.V. et al., Ekaterinburg, 1997, p. 101-104 (3).

 The aim of the invention is to develop a method for the treatment of intestinal dysbiosis, combining the versatility of exposure to pathogenic and conditionally pathogenic intestinal microflora with minimal damaging effect on the normal microflora of the gastrointestinal tract.

 The problem is solved by introducing pectin in the form of a 3-5% aqueous solution, which exhibits a bactericidal effect on the pathogenic and conditionally pathogenic intestinal microflora, which is not accompanied by a negative effect on the normal intestinal microflora, into the complex therapy of intestinal dysbiosis. See Potievsky E.G. "Pectin preparation for the treatment of diarrheal infections of humans and animals", patent N 2108106 of the Russian Federation dated 10.04.98 (4).

 Clinical trials of pectin have shown its high effectiveness in the treatment of diarrheal diseases in children and adults. See “Recommendations on the use of pectin as a therapeutic food for acute intestinal infections” Approved on October 15, 1996 by the rector of the Omsk State Medical Academy and the head of the State Educational Institution of Administration of the Omsk Region (5).

 The proposed method for the treatment of dysbacteriosis involves the therapeutic nutrition of pectin in combination with restorative and stimulating therapy.

SCHEME OF THE SUGGESTED METHOD FOR TREATING INTESTINAL DYSBACTERIOSIS
For the treatment of children using a 3% aqueous solution of pectin.

Dosage depends on the age of children:
0-3 years - 1 teaspoon (5 ml).

 4-10 years - 1 dessert spoon (10 ml).

 11-14 years - 1 tablespoon (15 ml) per reception.

 For the treatment of adults use a 5% aqueous solution of 2 tablespoons (25 ml) per reception.

 Adults and children receive pectin at an age dosage after 4 hours with a sleep break in two cycles: the first for 4 days, then a break of 5 days and a second course of 4 days.

Therapeutic nutrition of pectin can be carried out in the background (a fragmented method!):
- continuous production of biological products: 2-3 single doses per day with a minimum course of 3 weeks;
- polyenzyme preparations: panzinorm, festal, etc. - with a course of at least 5-7 days;
- vitamin therapy: B5 - 2-week course (exclusion of fermentopathy!), B1, B6, PP, K, C (better as a multivitamin preparation);
- immunostimulants: 6% alcohol solution of propolis (up to 30 days), methyluracil.

 With severe manifestations of colitis, it is advisable to combine oral administration with therapeutic enemas during the first 4-day cycle, for children 0-3 years old - 15-20 ml, 4-14 years old - up to 30 ml, the multiplicity - depending on the severity of the colitic syndrome.

 EXAMPLE 1: Patient V., 8 months old, was admitted with complaints of unstable stool, yellow-green in color with mucus up to 4-5 times a day, decreased appetite, meteors. She suffered acute bronchitis a week ago. From the anamnesis, it is known that at 4 months after an acute respiratory disease complicated by stenosis of the larynx of the 2nd degree, a subcompensated form was revealed at the site of intestinal dysbiosis. Treatment with pyobacteriophage - 1 week and gentamicin 5 days. A temporary improvement was noted, but the appetite remained selective, lagging behind in body weight. Again for intestinal dysbiosis was not examined. At 6 months after acute respiratory infections, liquefied yellow-green stools reappeared up to 3-5 times a day. Given the objective data of the anamnesis and analysis of feces for dysbacteriosis (Kl.pneumoniae and hemolytic E.coli were detected in 10-10), the diagnosis was made: intestinal dysbiosis, decompensated form. Then, gentamicin was administered orally for 5 days; bifidumbacterin - 3 weeks; Activated carbon. Up to 8 months, clinically improved. At 8 months, due to the appearance of an unstable stool and flatulence, the stool was re-analyzed for dysbiosis: Pr.mirabilis, Candida fungi were found. Pectin was prescribed in combination: orally, 1 teaspoon after 4 hours 4 days, then a 5-day break and again 4 days pectin according to the scheme. Additionally, in the first 4-day course, therapeutic enemas with pectin 2 times a day, 20 ml each, multivitamins 10 days, enzymes 5 days, biological products 4 weeks were added.

 In the control analysis of feces for dysbiosis pathogenic and conditionally pathogenic representatives of the intestinal flora were not found. The chair became decorated: without pathological impurities, 1-2 times a day. Control observations over 18 months did not reveal deviations in the state of health: characteristic of dysbiosis.

 EXAMPLE 2: Patient B., 1 year, 20 days, came from a child’s house with complaints of liquefied stools of yellow-green color with an admixture of mucus, 3-4 times a day, flatulence: lag in body weight. When examining feces for dysbiosis, Pr.mirabilis, fungi of the genus Candida, were isolated. Given the history and objective examination, the diagnosis was made: intestinal dysbiosis, subcompensated form. Assigned pectin combined 1 teaspoon after 4 hours and 2 times a day, 20 ml in enemas for 4 days with a five-day break: then 4 days of oral administration of pectin. Therapeutic nutrition of pectin was carried out against the background of enzyme and vitamin therapy and the continuous receipt of biological products. In the control analysis of feces for dysbiosis, deviations from the norm were not detected. Within 12 months of follow-up, repeated complaints and manifestations characteristic of dysbiosis were not detected.

 EXAMPLE 3: Patient M., 1.5 months, parents noted from birth loose stool with greens and mucus up to 5 times a day, decreased appetite, flatulence. In the study of feces for dysbiosis revealed: Kl. pneumoniae and Ctr. Freundi, fungi of the genus Candida, insensitive to antibiotics. Diagnosed with intestinal dysbiosis, subcompensated form. Pectin was prescribed in combination: 1 teaspoon after 4 hours and 2 times 15 ml in an enema for 4 days with a five-day break: then again a 4-day course of pectin. Clinical nutrition was carried out against the background of enzyme and vitamin therapy, as well as the continuous receipt of biological products. In the control analysis of feces for dysbiosis, deviations from the norm were not detected. Subsequently, within 11 months, manifestations characteristic of dysbiosis were not detected.

 The above examples indicate the feasibility and effectiveness of the use of pectin in the complete treatment of dysbiosis.

Literature:
1. Petrovskaya V.G., Marko O.P. "The intestinal microflora is normal and pathological", M., Med., 1976, S. 109-113.

 2. Krasnogolovets V. N. "Dysbacteriosis of the intestine", M., Med., 1989, S. 160-191.

3. "Secondary immunodeficiency conditions." - ed. V.V. Fomina, E.A. Kashuby, Ya.B. Beikina, A.U. Sabitova, Yekaterinburg, 1997, pp. 101-104
4. Potievsky E. G. Pectin preparation for the treatment of diarrheal infections of humans and animals. - Patent N 2108106 of the Russian Federation of 10.04.98

 5. Recommendations for the use of pectin as a therapeutic food

Claims (3)

 1. A method of treating intestinal dysbacterioses in children and adults, which consists in identifying the leading agent (sharp activation of individual representatives of conditionally pathogenic microflora), determining the spectrum of drug resistance of the agent and its immediate elimination, characterized in that the complex treatment of dysbacteriosis includes therapeutic nutrition 3 - 5% aqueous pectin solution according to the following scheme for the treatment of intestinal dysbacteriosis: for the treatment of children use a 3% aqueous pectin solution, depending on the age of the children: up to 3 years - 1 teaspoon (5 ml), 4 - 10 years - 1 dessert spoon (10 ml), 11 - 14 years - 1 tablespoon (15 ml) per reception, for the treatment of adults use a 5% aqueous solution of 2 tablespoons (25 ml) per reception, while both adults and children receive a pectin dietary supplement at an age dosage after 4 hours with a sleep break in two cycles: the first for 4 days, then a break of 5 days and a second course of 4 days, while antibiotics and other etiotropic drugs are completely excluded from complex therapy.  2. The method according to claim 1, characterized in that the therapeutic nutrition is carried out against the background of (divided reception): continuous production of biological products: two to three times a day with a minimum course of 3 weeks; polyenzyme preparations: panzinorm, festal, etc. - with a course of at least 5 - 7 days; vitamin therapy: B5 - a two-week course (exclusion of enzyme therapy), B1, B6, PP, K, C (preferably in the form of a multivitamin preparation); immunostimulants: 6% alcohol solution of propolis (up to 30 days), methyluracil.  3. The method according to claim 1, characterized in that with pronounced manifestations of colitis, oral administration of pectin with therapeutic enemas is combined during the first 4-day cycle: for children under 3 years of age - 15 to 20 ml, 4 to 14 years to 30 ml, adults - up to 50 ml, while the multiplicity is set depending on the severity of the colitic syndrome.