RU2130306C1 - Antianemic and growth-stimilating preparation "hemovit-c" for animals - Google Patents

Abstract

FIELD: veterinary science, fur farming, animal husbandry. SUBSTANCE: preparation "Hemovit-C" consists of the following components, wt.-%: ethylenediamine-N, N'-disuccinic acid disodium or dipotassium salt, 15-25; iron (III), 3.0-5.0; manganese (II), 0.5-2.5; copper (II), 0.25-0.5; cobalt (II), 0.1-0.3; zinc (II), 0.1-1.5; selenium (IV), 0.03-0.06;and water, the balance. The use of preparation promotes normalization of metabolism and stimulates animal growth. Preparation is effective in treatment and prophylaxis of hair shearing in fur animals and white-muscle disease in cattle. EFFECT: enhanced effectiveness of the preparation. 2 cl, 2 tbl

Description

 The invention relates to animal husbandry and fur farming and can be used in veterinary medicine for the prevention and treatment of iron deficiency anemia and enhance the growth of animals, the treatment of a number of specific diseases.

 Known means for the prevention and treatment of iron deficiency anemia in fur animals - hemovit (RU, 1702568, A 61 K 31/295, 31/30, 1991). The hemovit preparation consists of a complex of iron, copper, cobalt and zinc with a disodium salt of ethylenediamine-N, N'-di-succinic acid. The drug reliably prevents anemia in fur animals, however, the lack of manganese in its composition reduces its effectiveness when used, in particular, on pigs and poultry.

The use of sodium selenite (Na ₂ SeO ₃ ) in veterinary medicine is also known. The substance has an antitoxic effect, prevents the development and cures a number of diseases, for example, toxic dystrophy of the liver (Chervyakov D.K., Evdokimov P.D., Vishker A.S., Medicines in veterinary medicine. M., Kolos, 1970, p. 338-339). Sodium selenite is prescribed intramuscularly and subcutaneously, which is associated with great complexity and cost. Aqueous solutions of sodium selenite for injection are unstable, do not withstand boiling, should be used within one day, which causes certain difficulties in use.

 Also known antianemic and growth-promoting drug for animals - hemovit-M (RU, 2097045, 11.27.97, Bull. N 33, A 61 K 31/295, 33/32). The preparation includes a complex of iron, manganese, cobalt and zinc in the following ratio of components, wt.%: Disodium or dipotassium salt of ethylene diamine-N, N'-di-succinic acid 15-25; iron (III) 3.0-5.0; manganese (II) 0.5 to 2.5; copper (II) 0.25-0.5: cobalt (II) 0.1-0.3: zinc (II) 0.1-1.5; water the rest.

 The drug Gemovit-M eliminates the deficiency of microelements in the body of animals and helps to normalize metabolism. In piglets and birds, erythropoiesis is normalized and the growth energy of animals increases.

 However, the Gemovit-M preparation is not effective enough in the treatment and prevention of such a common disease in fur animals as “hair cut”, expressed in a sharp decrease in hair length in fur animals, as well as disease of young cattle - “white muscle disease”.

 The objective of the invention is to obtain an effective drug with optimal ratios of trace elements for the treatment and prevention of a number of specific diseases in animals.

 To solve this problem, a preparation based on a complex of iron, manganese, copper, cobalt and zinc with disodium or dipotassium salt of ethylenediamine-N, N'-disuccinic acid additionally contains selenium in the following ratio of components, wt.%: Disodium or dipotassium salt of ethylenediamine-N N'-disuccinic acid 15-25; iron (III) 3.0-5.0; manganese (II) 0.5 to 2.5; copper (II) 0.25-0.5; cobalt (II) 0.1-0.3; zinc (II) 0.1 to 1.5; selenium (IV) 0.03 - 0.06; water the rest.

 As a source of selenium (IV), sodium selenous acid or selenic acid is used. The preparation of hemovit-M preparation that does not contain selenium has been previously described (RU 2097045, 11.27.97, Bull. N 33, A 61 K 33/32, 31/295 and TU 9337-005-00480141-96).

 According to the invention, sodium selenic acid or selenic acid is added to the known hemovit-M preparation at the stage of the introduction of trace elements, having previously dissolved the calculated amount of salt in a small amount of water for better homogenization.

 The resulting preparation hemovit-C is a dark brown liquid (pH 6-8, mass fraction of iron 3-5%). Hemovit-C is unlimitedly soluble in water and not soluble in organic solvents. The solution of the drug should be stored in glass or plastic bottles. Storage in containers made of ferrous metals or aluminum is unacceptable due to its corrosive activity. By evaporating the solution under reduced pressure, the preparation can be obtained in the form of a paste (dark brown paste, solution pH 6-8, mass fraction of iron 4-6%) or powder (brown powder, solution pH 6-8, mass fraction of iron 6-8 %). The preparation in the form of a paste or powder is hygroscopic, therefore it is stored in a hermetically sealed container.

Acute toxicity and the maximum tolerated dose of the drug for white rats are determined according to the guidelines for determining the toxic properties of drugs used in veterinary medicine and animal husbandry, approved by the USSR Ministry of Health, VASKHNIL, GUV Gosagroprom of the USSR. The maximum tolerated, i.e. the threshold dose, was 15,000 mg / kg m. LD ₅₀ = 26,250 mg / kg, LD ₁₆ = 22,000 mg / kg, LD ₈₄ = 30,500 mg / kg. According to the accepted classification, the drug is low toxic.

 In ordinary aqueous solutions, sodium selenate and selenic acid is an unstable compound, selenium (IV) is oxidized to a hexavalent state. To obtain hemovit-C, sodium selenite is introduced into the solution after adding all trace elements, which makes the selenium (IV) compound stable due to the reducing medium of the solution of the complex of trace elements with ethylenediamine-N, N'-disuccinic acid.

 Moreover, the effectiveness of selenium (IV) in the complex with a ligand and trace elements increases up to 6 months.

 The effectiveness of the use of the drug hemovit-C for the prevention and treatment of diseases in fur animals "section of the hairline" can be illustrated by the following examples.

 Example 1

Animal husbandry at 1.07. had 31,000 heads of young mink, of which 8180 goals were in violation of fur formation (haircuts). From 07.20. a livestock of minks was given daily hemovit-C preparation with food. After 4 weeks, the animals began to grow hair. K 1.11. all affected livestock overgrown, with the exception of 50 goals. The dynamics of the hemoglobin level in animals was, g%:
June - 13.5
July - 15.7
August - 16.5
September - 19.5
October - 20.3
Hemovit-C had a positive therapeutic effect on the fur formation of young mink, while the physiological condition of the animals improved.

 Example 2

 A study of the effectiveness of the hemovit-C preparation in the treatment of the disease “hairline cross-section” in comparison with hemovitis (RU 1702568, A 61 K 31/295, 31/30, 1991) was carried out on a standard mink breeding stock. 1 control group received a general diet consistent with modern feeding standards and containing vitamin supplements. The 2nd control group received hematitis in recommended doses (at the rate of 1 mg of iron per 1 kg of oil.m.) The experimental group received hematitis-C at the rate of 1 mg of iron per 1 kg of oil.m.

 Throughout the experiment, experimental minks were clinically healthy, well-fed food, safety in all groups was 100%. As a result, at the time of slaughter in the experimental group receiving hemovit-C, the average live weight of males exceeded the control by 5.8%, females - by 1.7%, which, accordingly, leads to an increase in the size of the skins.

Commission examination of animals for the course of autumn-summer molting (August, September, October) in the control groups revealed animals with the disease cross-section of the hairline (striguns) in the following quantity:
on 08/28.

1 counter, males - 5.5%
females - 1.1%
2 control, males - 4.5%
females - 7.1%
on 10/25.

1 counter, males - 11.1%
females - 7.7%
2 control, males - 10.9%
females - 8.6%
In the experimental group receiving hemovit-C, not a single beast with sheared fur was found. Perhaps this is due to the normalization of animal metabolism with a balanced diet with trace elements.

 Example 3

 A study of the effectiveness of the hemovit-C preparation was carried out on a standard mink breeding stock during preparation for the rut, during the rut, pregnancy, puppies, lactation of females, growth and development of young animals against the background of a general economic diet that complies with modern feeding standards containing vitamin supplements. Adult females (2nd and 3rd year of use) received supplements from 12.25., Young females (1st year of use) from 3.08. The control group received hemovit with feed at the rate of 1 mg of iron per 1 kg of oil; the animals of the 1st experimental group received hemovit-C, the 2nd experimental group received hemovit-M at the rate of 1 mg of iron per 1 kg m Inclusion in the feed mixture of preparations was carried out daily, after diluting with water 10 times for its more uniform distribution in the feed. Throughout the experiment, the experimental animals were clinically healthy, well-fed food, deviations in their behavior compared with the control was not found. There were no cases of diseases and deaths of animals treated with hemovit-C. It should be noted the good clinical condition of females after whelping. Gon, pregnancy and whelping of the animals proceeded normally. The reproductive results of females in the age aspect are presented in table. 1 and 2 (see the end of the description).

 As can be seen from the data table. 1 and 2, the introduction of the hemovit-C preparation has a stimulating effect on the reproductive abilities of females, and the long-term use of the complex, starting from the moment of young growth, has a more favorable effect - the reproductive performance of young females increases, reaching the level of adult females, and in terms of puppies yield the main female is superior to them. Whelping of young females of the 1st experimental group is active, in a shorter time. Throughout the entire puppy period, the percentage of whelping females was 10-19% higher compared to the control. Hemovit-C helps to reduce the infertility of animals - the number of safely mating females among young women increases by 9.9%, adults by 3.2% and the fertility of females increases.

 The hemovit-C preparation can also be used for the treatment and prevention of diseases of young cattle - white muscle disease.

 Thus, the inclusion of the hemovit-C preparation in the animal diet, which contains a number of vital microelements in the form of a complex with an organic ligand and balanced in composition, eliminates the deficiency of these microelements in animals, helps to normalize metabolism, increase the reproductive abilities of females, and allows to treat a number of specific diseases in animals.

Claims (1)

1. Antianemic and growth-stimulating preparation for animals, including a complex of iron, manganese, copper, cobalt and zinc with disodium or dipotassium salt of ethylenediamine-N, N'-disuccinic acid and water, characterized in that it additionally contains selenium in the following ratio of components, wt.%:
Disodium or dipotassium salt of ethylenediamine-N, N'-di-succinic acid - 15 - 25
Iron (III) - 3.0 - 5.0
Manganese (II) - 0.5 - 2.5
Copper (II) - 0.25 - 0.5
Cobalt (II) - 0.1 - 0.3
Zinc (II) - 0.1 - 1.5
Selenium (IV) - 0.03 - 0.06
Water - Else
2. The drug according to claim 1, characterized in that as the source of selenium (IV) use selenic acid sodium or selenic acid.

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