RU2129858C1 - Biologically active additive for cosmetic agents of regenerating action and regenerating cream on its base - Google Patents

Abstract

FIELD: cosmetic industry. SUBSTANCE: biologically active additive is larvas of bee drones (drone brood). Cream based on additive contains ground insects larva, biologically active substances of vegetable and animal origin. The components are used in the following ratio, mas.%: bee drones larvas (drone brood), 0.5-3.5; biologically active substances of vegetable and animal origin including vegetable oils and bacteriostatic additives, or vegetable oils, bacteriostatic and tonic additives, or vegetable oils, bacteriostatic and calming additives, not more 24.0; base, the balance. EFFECT: higher nourishing and regenerating action. 3 cl

Description

 The invention relates to the cosmetic industry and can be used as skin care products.

 In the production of cosmetic preparations, various biologically active substances of both animal and plant origin are widely used. By activating the metabolism, they improve the physiological condition of the skin and prevent its aging.

 Known biologically active additive, which is a powder of insect larvae (drones of bees), collected on the tenth day after the unfertilized eggs were laid in the comb, as well as the nutritional content of the honeycombs (UK application N 2079602, MKI A 61 K 35/64, publ. . 1982).

 However, bee drone larvae are used in medicine for introduction into the human body and their use in cosmetics is not known.

 The closest analogue (prototype) is a biologically active additive based on the larvae of coleid insects (US patent N 3995025, MKI A 61 K 7/06, publ. 1976).

 However, cosmetics based on this additive have insufficient nutritional and regenerative effects, are poorly absorbed into the skin.

 Known drug with apitherapeutic activity, containing a mixture of drone brood at the age of larvae of 6-9 days and honey in a ratio of 1: 1 (International application (WO) N 81/02106, MKI A 61 K 35/64, publ. 1981.

 A disadvantage of the known drug is that it is not intended for application to the skin (its use as a cosmetic product is not known), because it does not contain the necessary components (fat or gel base, fragrance, preservative, etc. )

 The closest technical solution (prototype) is a cosmetic product containing a base, crushed larvae of insects (klopeidnyh), glycerin or lanolin (US patent N 3995025, MKI A 61 K 7/06, 7/32, publ. 1976). The product is used as a trophic cosmetic cream for the skin.

 However, this cosmetic product has insufficient nutritional and regenerative effects, is poorly absorbed into the skin.

 The objective of the invention is the creation of such a cosmetic product for skin care based on insect larvae, which would provide a higher nutritional and regenerative effect, restoring the equilibrium process of formation of the epidermal layer of cells that is disturbed during aging.

 This problem is solved by the fact that as a biologically active additive to cosmetic regenerating creams, bee drone larvae (drone brood) are used.

In addition, this problem is solved in that the cosmetic regenerating cream for skin care containing a base and crushed insect bites according to the invention, the cream further comprises biologically active substances of plant and animal origin, including bacteriostatic and nutritional supplements, or bacteriostatic, nutritional and tonic additives, or bacteriostatic, nourishing and sedative additives, and as insect larvae use bee drones larvae (drone brood), p In the following quantitative ratio of cream components wt.%:
Bee drone larvae (drone brood) - 0.5-3.5
Biologically active substances of plant and animal origin, including bacteriostatic and nutritional supplements, or bacteriostatic, nutritional and tonic supplements, or bacteriostatic nutritional and soothing additives - Not more than 24.0
Basis - Else
A polyethylene oxide gel is used as a base.

 To obtain the honey dew regenerating cream mask, biologically active substances of plant and animal origin are used extracts of May leaves of birch or bird cherry, palm and olive oils, propolis extract, geranium oil and clary sage oil.

 To obtain a massage toning cream "Uslada" as biologically active substances of plant and animal origin use egg yolks, sweet clover tinctures, calendula, flaxseed, coltsfoot, St. John's wort, fir oil, burdock oil, palm oil and olive oil, extracts propolis and may birch leaves.

 To obtain a Renaissance tonic cream, biologically active substances of plant and animal origin use chicken egg yolks, bee honey, mummy, propolis extract, pantocrine, flower pollen, rosehip oil, lavender and palm oil, calamus root tinctures, calendula, and Rhodiola rosea , licorice root broth, onion juice.

 To obtain the preventive (calming) cream “Golden Sandman”, biologically active substances of plant and animal origin use decoctions of valerian, parsley, chamomile, motherwort, chamomile oil and sunflower oil, beeswax (zabrus), bee honey, chicken eggs, aronia juice mountain ash and tincture of bird cherry leaves.

 The crushed drone brood is a white liquid containing the optimal ratio of essential amino acids, vitamins, trace elements, enzymes, hormones and other substances necessary to maintain cell activity. Drone brood slows down the aging process of the skin associated with the extinction of the mitotic activity of the epidermal basal cells.

A mixture of the extract of May leaves of bird cherry or birch and propolis extract provides a reliable bacteriostatic effect. Shelf life of the cream without the introduction of chemical stabilizers is at least 6 months at +7 ^o C. In addition, the extract of bird cherry leaves and propolis extract also exhibit antioxidant, embalming properties, as well as anti-inflammatory and local anesthetic effects.

 To obtain an emulsion, olive, sunflower, lavender, burdock, fir and palm oils are used as vegetable oils. Vegetable oils soften and fortify the skin, preventing the mechanisms of its aging associated with the course of oxidative processes (antioxidant effect), make up for the loss of sebum when washing, adverse atmospheric effects, and also have a mild deodorizing effect.

 Lavender, geranium and clary sage oils have a pleasant smell and serve as a perfume.

 The mummy in its composition contains about 28 chemical elements, 30 macro- and microelements, metal oxides, amino acids, a number of vitamins, essential oils and tar-like substances. Mummy promotes the regeneration of epithelial cells, has an embalming, anti-inflammatory and nourishing effect.

 Pantocrine is obtained by alcohol extraction of substances from non-ossified antlers (antlers) of red deer, red deer or sika deer. It has a tonic and division-stimulating effect on skin cells.

 Flower pollen is plant sperm, which contains all the basic substances necessary for the construction, development and existence of a living organism: proteins, fats, carbohydrates, vitamins, amino acids, glucoside rutin, antibiotics, growth stimulants, etc.

 Honey has a softening and nourishing effect on the skin, eliminates dryness and peeling.

 Decoctions of valerian, motherwort, chamomile and parsley have a calming effect.

 The gel of polyethylene oxide (TU 9154-004-11821987-93) gives the product a gel-like state, has a stabilizing effect on the biologically active substances included in the cosmetic product and increases the usability of the specified tool. In addition, the polyethylene oxide gel itself softens and moisturizes the skin, promotes better penetration of nutrients and enzymes through the skin barrier.

 The specified combination of the components of the agent exhibits a noticeable synergy in the effect on the skin in comparison with individual substances.

 The invention meets the criteria of patentability, in particular, the inventive step, since larvae of drone brood of bees were first introduced into the composition of the cosmetic cream as a biologically active additive.

 The following are examples of the compositions of the proposed cosmetic products.

Example 1. Cream for skin care "Honey dew"
Drone larvae (drone brood) - 150 ml 1.9 (wt.%)
Infusion of May leaves of bird cherry or birch - 300 ml 3.8 (wt.%)
Propolis Extract - 500 ml 6.2 (wt.%)
Palm oil - 100 ml 1.3 (wt.%)
Olive oil - 600 ml 7.4 (wt.%)
Glycerin - 200 ml 2.5 (wt.%)
Hanks balanced salt composition - 150 g 1.87 (wt.%)
Geranium oil - 1 ml 0.01 (wt.%)
Clary sage oil - 2 ml 0.02 (wt.%)
Polyethylene oxide gel - 6000 g 75.0 (wt.%)
Cream for skin care "Honey dew" is a regenerating cream mask that restores the equilibrium process of formation of the epidermal layer of cells ("grows" the epidermis) and improves skin elasticity.

Example 2. Cream for skin care "Delight"
Drones larvae (drone brood) - 200 ml 2.5 (wt.%)
Infusion of May birch leaves - 400 ml 5.0 (wt.%)
Propolis Extract - 300 ml 3.7 (wt.%)
Palm oil - 350 ml 4.2 (wt.%)
Olive oil - 200 ml 2.5 (wt.%)
Burdock oil - 20 ml 0.25 (wt.%)
Fir oil - 20 ml 0.25 (wt.%)
Chicken egg yolks - 164 g 2.0 (wt.%)
Tinctures: sweet clover, or calendula, or flax, or coltsfoot, or St. John's wort - 500 ml 6.1 (wt.%)
Polyethylene oxide gel - 6000 g 73.0 (wt.%)
Means for skin care "Delight" is used as a massage tonic cream.

Example 3. Cream for skin care "Renaissance"
drones larvae (drones brood) - 100 g 1.4 (wt.%)
egg yolks - 200 g 2.7 (wt.%)
bee honey - 50 g 0.7 (wt.%)
mummy - 5 g 0.07 (wt.%)
pantocrine - 50 ml 0.07 (wt.%)
flower pollen - 10 g 0.12 (wt.%)
alcohol onion juice - 30 ml 0.4 (wt.%)
tinctures:
calamus root - 50 ml 0.7 (wt.%)
calendula - 50 ml 0.7 (wt.%)
Rhodiola rosea - 50 ml 0.7 (wt.%)
licorice root - 100 ml 1.4 (wt.%)
propolis extract - 200 ml 2.8 (wt.%)
palm oil - 200 ml 2.8 (wt.%)
rosehip oil - 20 ml of 0.26 (wt.%)
lavender oil - 2 ml (0.03 wt.%)
perfume - 1 ml 0.02 (wt.%)
polyethylene oxide gel - 6000 g 84.5 (wt.%)
The product for skin care "Renaissance" when applied to the skin has a regenerating, nourishing and tonic effect on it.

Example 4. Preventive cream for skin care "Golden Sandman"
Drones larvae (drone brood) - 50 ml 0.6 (wt.%)
Valerian broth - 100 ml 1.3 (wt.%)
Parsley broth - 100 ml 1.3 (wt.%)
Chamomile broth - 100 ml 1.3 (wt.%)
Motherwort broth - 100 ml 1.3 (wt.%)
Chamomile oil - 1 g 0.01 (wt.%)
Sunflower oil - 400 ml 5.19 (wt.%)
Beeswax (zabrus) - 80 g 1.0 (wt.%)
Bee honey - 100 g 1.3 (wt.%)
Chicken eggs - 200 g 2.5 (wt.%)
Aronia juice - 50 ml 0.6 (wt.%)
Tincture of May leaves of bird cherry - 600 ml 7.6 (wt.%)
Polyethylene oxide gel - 6000 g 76.0 (wt.%)
The Golden Sand Preventive Cream, when applied to the skin, has a nourishing, regenerating and soothing effect.

 Example 5. The technology of preparation of cream for skin care.

 In the manufacture of the drug, simple technological equipment is used, equipped with a reactor with a stirrer.

To prepare the cream, a polyethylene oxide gel is loaded into a stirred reactor at a temperature of + (18-20) ^o C and the following components are added with stirring according to the above recipe (examples 1-3): drone brood larvae, glycerin, biologically active substances of plant and animal origin , Hanks salts, vegetable oils, sodium benzoate and perfume. After mixing the components of the composition for 20-30 minutes, measure the pH of the mixture. If the pH of the mixture is below 7.2 ± 0.2 (the polyethylene oxide gel has an acidic environment), a phosphate-salt additive (Na ₂ HPO ₄ x 12H ₂ O) is added to the composition in an amount sufficient to maintain a pH of 7.2 ± 0.2. Next, the mixture is homogenized again in the reactor for 20-30 minutes, the finished cosmetic product is packaged in a container and stored at a temperature of +7 ^o C.

 The cold method of preparing the cream allows you to maximize the activity of its constituents.

 Example 6. Data on clinical trials.

 Clinical trials of the proposed creams "Honey dew", "Uslada" and "Renaissance" were carried out on several groups of healthy women from 15-20 people aged 30-50 years old with dry, aging and normal skin type. On examination (before the experiment), some patients showed dry skin, peeling, sagging, i.e. signs of premature skin aging. To identify individual sensitivity to creams, their prolonged use was initially preceded by preliminary tests, including applying one or two drops of one of the creams to a clean surface of the elbow bend and monitoring the condition of the skin for 0.5 - 1 hour. If the surface of the skin at the place of application of the cream has not changed, then proceed to apply patchwork samples on the skin with an exposure of 24 hours. In the case of a negative patch test, the cream is then used for 3 weeks by applying a thin layer to the skin of the face and neck 1 time per day for 25-30 minutes or more. The remaining cream is removed with a napkin. When testing the cream, its effect on skin color, the presence of wrinkles, fat content and vascular reactions are noted.

 In all patients, patchwork samples were negative. It has been established that with prolonged use, the absorbency of creams is good, they soften the skin, relieve the effects of dryness, peeling, inflammation, have a hydrant effect and preserve the natural matte surface of the skin.

 Recommended use of creams. In the daytime version, one of the creams in an amount of 0.2-0.5 g is distributed by light massaging movements on the surface of the face (neck) until it is almost completely absorbed (1-2 minutes). After this, the application of decorative cosmetics is possible. In the evening, the cream is easily removed from the skin surface with warm water.

 In the evening version, the cream in an amount of 0.2-0.5 g is distributed over the surface of the face (neck) until it is almost completely absorbed (1-2 minutes). After this, the procedure is repeated. In the morning, the cream is easily removed from the skin surface with warm water.

 Thus, compared with the prototype, the proposed creams have a wider spectrum of biological activity with a pronounced regenerative effect. The products have hydratant, photoprotective, antioxidant, proliferative, anti-inflammatory effects on the skin and are well absorbed. There are no side effects.

 Creams "Honey Dew", "Renaissance" and "Delight" are designed to prevent wilting and aging of the skin of the face and neck (for any skin type), as well as to maintain a more favorable condition for a long period of time and can be recommended for use with 35-40 years old.

 Industrial applicability. The invention can be used in cosmetics and medicine.

Claims (2)

 1. The use of bee larvae of drones (drone brood) as a biologically active additive for the production of regenerative cosmetics. 2. Cosmetic regenerating cream containing a base and crushed insect larvae, characterized in that the cream additionally contains biologically active substances of plant and animal origin, including vegetable oils and bacteriostatic additives, or vegetable oils, bacteriostatic and tonic additives, or vegetable oils, bacteriostatic and soothing additives, and as larvae of insects use larvae of drones of bees (drone brood) in the following quantitative ratio to . Mponentov lotions, wt%:
Bee drone larvae (drone brood) - 0.5 - 3.5
Biologically active substances of plant and animal origin, including vegetable oils and bacteriostatic additives, or vegetable oils, bacteriostatic and tonic additives, or vegetable oils, bacteriostatic and soothing additives - Not more than 24.0
Basis - Else
3. The cream according to claim 2, characterized in that a polyethylene oxide gel is used as a base.