RU2126700C1 - Method of treating inflammatory diseases of male genital organs and urinary tracts - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method includes simultaneous irradiation from two sides. Irradiation is performed intraosseously in focus localization projection and through light-guide rectal attachment which is introduced into straight intestine. Irradiation is performed in synchronism with rhythm of patient's pulse and breathing. Irradiation intensity is increased at modulation depth of 30% in phases of systole and inhalation. Apparatus "Mustang-bio" type is used for bio-controlled chronophysiotherapy. EFFECT: enhanced treatment efficiency. 3 cl, 3 dwg

Description

 The invention relates to medicine, specifically to urology, and can be used for physiotherapy of inflammatory diseases of the male genital organs and lower urinary tract.

 The purpose of the invention is the reduction of treatment time and the reduction of relapse.

 Known methods of laser therapy of inflammatory diseases of the male genital organs and lower urinary tract using a helium-neon laser and photosensitivity [1]. In recent years, semiconductor infrared lasers with a large pulsed power and deeper radiation penetration into tissues have become widespread [2, 3]. All these methods do not take into account tissue trophism and blood flow rhythms at the site of laser exposure, the dependence of the therapeutic effect on the phases of these rhythms. At the same time, the developed device for biocontrolled chronophysiotherapy [4] allows you to automatically synchronize changes in the intensity of laser irradiation with the rhythms of blood flow — an increase in intensity in the phases of inspiration and systole (increased blood supply) and a decrease in phases of exhalation and diastole (decrease in blood supply). The intensity of laser irradiation is modulated by electrical signals from the patient’s pulse and respiration sensors using a biocontrolled chronophysiotherapy device, in particular, a Mustang-bio apparatus.

 Using this device, due to the coordination of physiotherapeutic effects with blood flow, acceleration of regeneration is achieved, greater efficiency in relieving inflammation and edema, restoration of the spectrum of microcirculation rhythms, the best analgesic, antispasmodic, bacteriostatic and bactericidal effects [5-8]. The increase in efficiency with the help of biocontrolled chronophysiotherapy has been confirmed in the treatment of various diseases for which clinical trials have already been conducted. Biofeedback chronophysiotherapy for inflammatory diseases of the male genital organs and lower urinary tract has not been performed before.

 The method is as follows. Before treatment, all patients determine the level of activity of superoxide dismutase (SOD) of red blood cells and ceruloplasmin of blood plasma. The determination is repeated after each session of laser therapy after 1-2 hours. For this, 0.1 ml is taken from the patient’s finger. blood and determine the level of activity of SOD according to the method of Rainer F. [9]. In the vast majority of patients, this level is significantly lower than normal (normal 206.5 ± 4.03 units / ml.). The normalization of this indicator is used as a control of the effectiveness of treatment. Full normalization of the level of SOD indicates the stability of the therapeutic effect, incomplete - about the possibility of relapse of the disease. Sessions of laser therapy continue even after the complete removal of inflammation until the normalization of the level of SOD or the cessation of its increase.

 Laser therapy sessions are carried out to the patient in the supine position using the Mustang-bio apparatus for biocontrolled laser chronotherapy (serially produced with the permission of the Ministry of Health of the Russian Federation by Tekhnika 105037, Moscow, PO Box 106). The pulse and respiratory sensors of this device are installed on the patient’s body, they turn on the device, setting the pulse power from 60 to 80 W per pulse using a power meter, depending on the degree of fatty deposits of the subcutaneous layer. An array of 10 semiconductor infrared (0.89 μm) lasers with a simultaneous irradiation area of 12.5 sq.cm. placed in the projection of a pre-established localization of the inflammatory focus. Matrix irradiation is performed percutaneously over the area of projection of the site of inflammation. On the second channel of the apparatus using a 20 W laser, irradiation is carried out with a rectal nozzle, on which a condom (single use) is put on, through the rectum. Thus, irradiation was performed on both sides of the site of inflammation of the patient for 256 seconds daily in the morning. In the control group of patients, traditional treatment and laser therapy without biocontrol were used.

 The electrical signals of the pulse and respiration sensors of the Mustang-bio apparatus allow modulating with each modulation depth a 30% intensity of laser radiation with an increase in it in the systole and inspiration phases and decrease in the diastole and expiration phases, thereby synchronizing the laser radiation intensity with blood flow rhythms (blood supply). A frequency of 3 kHz and an additional modulation frequency in elongation and tremor rhythms of 10 Hz are used as the carrier frequency. The duration of the rectangular pulses is 100 ns. The advantages of biocontrolled chronophysiotherapy compared to conventional laser therapy, the justification of these parameters and a description of the device for biocontrolled laser chronotherapy are described in more than 50 works of SD Zaguskin, for example, in [4-8].

 The average time for pain relief was 1-2 days (session), the average time for closing fistulas, relieving inflammation was 3.5 ± 0.6 treatment sessions (days), and the average number of sessions (days) to normalize or stabilize the level of SOD in red blood cells blood of patients 9 ± 1.7 days.

 Studies have shown that, compared with conventional laser therapy with the same parameters, the proposed method of biocontrolled laser chronotherapy of inflammatory diseases of the male genital organs and lower urinary tract using the Mustang-bio apparatus reduces the time for stopping the inflammatory process and the treatment time by 2-3 times , has a positive therapeutic effect in all patients without exception, increases its stability, does not give side effects, individualizes the treatment process due to modulation azernogo irradiation rhythms patient blood via pulse signals and respiration sensors, installed on the body of the patient. Moreover, despite a decrease in the total radiation dose compared with conventional laser therapy due to a decrease in intensity during exhalation and diastole, the therapeutic effect increases.

 The level of SOD activity in the blood erythrocytes of healthy people is 206.5 ± 4.5 units. / ml ; in patients before treatment, 120.0 ± 7.7 units / ml .; after conventional laser therapy in patients with subsequent relapses - 166.7 ± 9.56 units / ml. (P <0.05 compared with normal and before treatment); after biocontrolled laser chronotherapy in patients without relapse for at least 1 year - 201 ± 7.43 units / ml. (P <0.01 compared with the level before treatment and P> 0.05 compared with the norm). Similarly, with the biocontrolled method, the level of CP activity normalized faster and more fully, which also correlated with the stability of the therapeutic effect.

Examples of specific use of the method (extracts from medical records):
Example N1. Patient K., 36 years old. For 3 years suffering from chronic prostatitis. Exacerbation of the disease notes 2-3 times a year. During these periods, pain in the perineum, pack areas, impaired copulative function are disturbing. It was treated stationary 2 times a year for 1-2 months. The treatment was used: antibiotics, antispasmodics, stimulating therapy, microwave therapy, drug phonophoresis. Upon receipt of the analysis of prostate juice - white blood cells 35-40x1. The activity of SOD of red blood cells is 99 units / ml, the activity of serum ceruloplasmin is 1.1 μM / L.

 A course of laser biocontrolled chronotherapy (10 sessions). After treatment, the pain in the perineum and inguinal areas disappeared, copulative function improved. Analysis of prostate juice - leukocytes 3-5x1. The activity of SOD of red blood cells is 177 units / ml. The activity of serum ceruloplasmin is 2.0 μM / L. After six months, the therapeutic effect remains stable.

 Example No. 2. Patient N. 38 years. He entered a urological clinic with a diagnosis of urethro-perineal fistula. Epicystostoma. Chronic urethrocystitis in the acute stage. In 1969, he suffered an injury with rupture of the urethra. He underwent several operations to restore the patency of the urethra, excision of the urethro-perineal fistula. Upon admission, complains of frequent urination, pain in the perineum, inguinal areas. Objectively: in the perineal region, a point urethral fistula is defined, around which there is hyperemia, tissue infiltration. In the suprapubic region, an epicystostomy. Laboratory indicators at admission: analysis of prostate juice - white blood cells in the entire field of view. SOD -116.7 units / ml., CPU - 0.1 μM / L.

 A course of biocontrolled laser chronotherapy using the Mustang-bio apparatus was conducted. After 5 sessions, the fistula on the perineum closed, hyperemia around the fistula disappeared. By the end of treatment, slight tissue infiltration persisted. The pain in the perineum has completely stopped. Indicators after treatment: leukocytes of prostate juice - 30-40x1, SOD - 201 units / ml, CP - 0.7 μM / L.

 Example No. 3. Patient L. 24 years. For 3 years, suffers from inflammatory stricture of the hanging and scrotal urethra. The urethral plastic was performed twice, but after the operation, due to the complication - the formation of the urethral fistula - the disease recurred. The clinic repeatedly performed plastic surgery of the urethra with the skin of the scrotum. The postoperative period was again complicated by the formation of the urethral fistula on the 4th day after the operation. On the 5th day, they prescribed treatment with biocontrolled laser chronotherapy using the Mustang-bio apparatus. Completed 6 sessions. By the end of this treatment, the fistula closed. Discharged from the clinic with the restoration of normal urination. SOD activity as a result of treatment increased from 144 units / ml. up to 180 u / ml., the activity of ceruloplasmin - from 0.8 μM / L. up to 1.5 μM / L.

LITERATURE
1. Guliants E. S. .. Strelnikov V. B. .. Solomonov V. I., Tolmachev G. N. A method of treating urethitis. AS of the USSR N 1146065. Priority 03.11.82.

 2. Kozlov V.I., Builin V.A. Laser therapy with the use of ALT "Mustang", M., 1994.-124 p.

3. The use of low-intensity lasers in medicine. Guidelines. Ryazan, 1992.- 134 p .;
4. Zaguskin S. L. Sabirov Yu.S. Device for physiotherapy. A positive decision on the application N 4733853 / 30-14 from 08.31.90. Priority 4.09.89. Notification of the approval of a patent application dated 12.23.91.

 5. Rusakov V.I., Zaguskin S.L., Slyusarev S.L., Bubnova V.I. A method of treating trophic ulcers. AS USSR N 1750702 dated 03/28/91. Priority from 15.01.90. BI N 28.1992.

 6. Rapoport S.I., Rasulov M.I., Zaguskin S.L., Malinovskaya N.K., Setov I.V. Method for the treatment of gastric ulcer and 12 duodenal ulcer. AS of the USSR from 05.17.91. N1736512. Priority 06.22.90.

 7. Zaguskin S. L. Chronobiology - physiotherapy. // Doctor, 1994. N2.-C. 30-34.

 8. Komarov F.I., Zaguskin S.L., Rapoport S.I. Chronobiological direction in medicine: biocontrolled chronophysiotherapy. // Therapeutic Archive - N8. -1994 -C.3-6.

 9. Rainer F. Enzymatic and non-enzymatic assay ob superoxld dismutase // Biochem. -1975. -v. 57. -p. 657-660.

Claims (3)

 1. A method for laser therapy of inflammatory diseases of the male genital organs and lower urinary tract, characterized in that they irradiate simultaneously from both sides percutaneously in the projection of the localization of the focus and through the fiber-optic rectal nozzle inserted into the rectum, synchronously with the rhythms of the pulse and breathing, increase the intensity with a modulation depth of 30% in the phases of systole and inspiration using a device for biocontrolled chronophysiotherapy such as "Mustangbio". 2. The method according to p. 1, characterized in that the laser irradiation is percutaneously carried out by a matrix of 10 laser infrared emitters (0.89 μm) on an area of at least 12.5 cm ² with a pulse power of 60 to 80 W and through a light guide rectal nozzle - an infrared laser with a pulsed power of at least 20 W daily for at least 264 s.  3. The method according to claims 1 and 2, characterized in that individually optimize the number of sessions to stop after the next session increase or normalization compared to the initial level reduced from the norm before treatment of the level of activity of superoxide dismutase in red blood cells of the patient.