RU2098148C1 - Method of psoriasis treatment - Google Patents

Abstract

FIELD: medicine, dermatology. SUBSTANCE: heparin and fibrinolysin were administrated by local route using electrophoresis. Method is used for torpent psoriasis forms treatment. EFFECT: enhanced effectiveness of treatment.

Description

 The invention relates to medicine, in particular to dermatology.

 Known methods of treating psoriasis, which use quartz, ointments, vitamins, subcutaneous administration of heparin. But these methods do not help much in the treatment of torpid forms of psoriasis: palmar-plantar and arthropathic. In addition, subcutaneous injection of heparin into the abdomen causes hematomas, pain, and blood coagulation is mandatory. The remission period is not more than 6 months. Patients are often given a 2nd disability group without the right to work.

 The purpose of the invention is to increase the therapeutic efficacy of treatment.

 To achieve the goal, they act locally on the palms, soles or joints by electrophoresis, and heparin is introduced from the negative electrode (cathode). At the same time, heparin does not break down into components and reaches the site of damage unchanged. For better penetration of heparin and reduce the inflammatory process, dimexide is added.

 Fibrinolysin is introduced from the positive electrode. Fibrinolysin is necessary for the resorption of fibrin adhesions and infiltrates formed at the lesion sites, as well as for the normalization of disseminated intravascular coagulation. The course of treatment consists of 15-20 procedures. After 3-4 months, the treatment is repeated. As a result of treatment, the disability group is reduced from 2 to 3, or disability is not allowed.

 With local administration of heparin by electrophoresis, along with fibrinolysin, intravascular coagulation is normalized at the lesion sites, so there is no need for constant monitoring of blood coagulation.

 The method is as follows: 5-10 thousand IU of heparin sodium salt is dissolved in 25-30 ml of distilled water and 3-5 drops of dimexide are added to the resulting solution. A solution of the preparation is used to moisten a disposable medicinal pad made of one or two layers of filter paper, which is placed between the skin and the cloth hydrophilic pad. Fibrinolysin in an amount of 2000 PIECES (1 bottle) is diluted with distilled water, acidified with hydrochloric acid to a pH of 5.0 to 5.2. The solution obtained is moistened with a medicinal pad and, depending on the size of the lesion, a parallel transverse arrangement of metal electrodes of the same or different area is used. Domestic apparatuses "Potok-1", AGBK-1, AGN-32, etc. are used for electrophoresis. The duration of the procedures is 15-20 minutes daily. The course of treatment consists of 15-20 procedures. After 3-4 months, the treatment is repeated.

 Example 1. Patient A., 35 years old, a driver by profession. Suffers from psoriasis for 6 years. The last 2 years there was a lesion in the area of the palms and soles, not amenable to conventional methods of treatment of psoriasis and not resolved even in the summer under the influence of sunlight. Due to the presence of cracks, pain, impaired function of the hands (squeezing the steering wheel when working as a truck driver), prolonged exposure to outpatient and inpatient treatment, and the lack of prospects for resolving the skin process, the patient was issued a disability group 2.

 Electrophoresis of heparin and fibrinolysin was prescribed with the addition of dimexide for 20 minutes daily on the palmar and plantar surfaces. After 20 procedures, the patient's pain disappeared, cracks became epithelialized, skin infiltration (thickening) in the lesion sites decreased significantly, fingers began to clench into a fist.

 After a repeated course of electrophoresis after 3 months, the patient was transferred to the 3rd disability group, and then with the right to work as a car mechanic.

 Example 2. Patient M., 45 years old. Diagnosis: arthropathic psoriasis (damage to the joints of the fingers).

 The patient was treated by electrophoresis with the combined introduction of heparin and fibrinolysin with the addition of dimexide. 15 procedures were carried out for 15-20 minutes each, in the course of 20 sessions of electrophoresis. During treatment, a gradual weakening of the pain in the joints was observed, first at rest, then with movements (when walking and clenching your fingers into a fist). After 3 months, a second course was carried out, against which the function of the joints was almost normal.

Claims (1)

 A method of treating psoriasis, including the introduction of heparin, characterized in that heparin is administered topically by electrophoresis from the cathode, and fibrinolysin is administered simultaneously from the anode.